Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

172 patterns of major drug resistance mutations (defined here) from 45962 clinical isolates obtained from 44741 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2025-9-10). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Data is also available for download in a tab-delimited format. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsRAL
foldn		EVG
foldn		DTG
foldn		BIC
foldn		CAB
foldn
140S,143H,148H2001    
138A,140S,148H166215748.72648.58
138K,147G,155H15031503371  
140S,148R147615095.143.299.513
140S,148H14338150444.8272.5341453
138K,140S,148H1433141115.332.6112411
138K,140A,148K14311374631234944
138K,140C,148R143113748.6154724
92Q,155H13981505341.822.510
140A,148R116413762.832.166.29
138K,140A,148R10511141131181532
138K,148K105311415.124.411303
148R,155H102311434.322.11412
140C,148R86217429.118.41256
143R79246.2201.1101.161.217
138K,148R6541235231.858.112
66I,148R5319413.41  
138A,148R43115012.211.71122
148K3776950.840.923.13
138K,147G,148R3421652  1.66
148R3114118140.910194.818
143G2912712  12
66I,92Q23212020.61 11
143S2112512   
66I,155H1919411.11  
148H1985.550.640.711.82
118R,138K17252102  
155H174036401.5231.3211.949
151L1522021.620.912.51
143C15222.9190.97150.87
92G,155H1311171   
118R1398.21013132.8383
121Y9.462761.150.841.54
66K834031.731.4134
92Q,147G6.431603   
92Q4.82640251.4111.281.814
118R,138K,263K4.41101111  
143H4.1152.5150.930.911.11
92G1.64134131.31 
140S1.64540.820.8116
146R1.624.921.421.311.73
147G1.3118121715 
66I1.11215120.490.360.48
263K1.1114.5112101.622.512
138A1.121.320.920.713.31
146L121521.321.411.82
None16191.36120.91550.9911.1115
66A0.937.630.330.410.32
138K0.970.970.850.821.25
146P0.826.520.520.314.31
145S0.722820.320.210.41
140S,148N0.623.620.62  
138T,140S,148H  1191 1001
138K,140S,148H,155H  1071 1001
66I,118R  191 401
140R  2.21 0.93
138K,140A,147G,148K    19491
140S,147G,148K    7001
138A,140A,148R    4291
138K,148R,263K    1003
121C    771
138T    492
143R,155H    302
138K,147G,148K    9.81
147G,155H    6.41
138K,140S,148R    5.41
143H,155H    3.42
155S    1.51
155T    1.51
138A,140S,143H,148H     
138A,147G,148R,155H     
138A,143K     
138K,140A,148R,155H     
138K,140A,147G,148R     
138K,140A,147G,148R,155H     
138K,140S,143R,148H     
138K,155H     
138K,148R,155H     
138K,147G,155H,263K     
138K,147G,148R,155H     
138K,143C     
138K,143R     
92Q,138K,155H     
92Q,138K,147G,155H     
92Q,138K,147G,155H,263K     
92Q,140S,148K,155H     
92Q,140S,148R,155H     
92Q,148R,155H     
92Q,147G,155H     
92Q,143H     
92Q,143R     
121Y,155H     
118R,138A     
118R,138A,263K     
118R,263K     
140S,148H,155H     
140S,148K,155H     
155H,263K     
146R,148R     
66A,92Q     
66A,118R     
66A,118R,138A     
66A,118R,138K     
66A,118R,138K,263K     
66A,155H     
66A,147G     
66I,92Q,155H     
66I,118R,138K     
143C,155H     
143S,155H     

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