HIV Drug Resistance Database

HIV Treatment Websites

Clinical Guidelines and Drug Information
Antiretroviral Drug Prescribing Information
Educational and CME Sites
Biomedical Journals
HIV-Related Scientific Meetings and Conferences
HIV/AIDS Research Databases
Clinical Trials
Telephone Consultation Services

Last updated: 10/12/09

Clinical Guidelines and Drug Information

Site/URL	Description
DHHS: AIDSinfo Clinical Guidelines	Guidelines from the Department of Health and Human Services, including: Adult/adolescent Pediatric Perinatal Post-exposure prophylaxis Opportunistic infections Testing
AIDSinfo Drug Database	Choose an FDA-approved or investigational anti-HIV drug and find links to guideline tables and drug records.
CDC Guidelines	Includes CDC guidelines for community planning, counseling and testing, evaluation, occupational and non-occupational post-exposure prophylaxis, patient care, prevention, surveillance, and treatment.
CDC recommendations for HIV testing	2006 recommendations for testing of adults, adolescents, and pregnant women.
WHO HIV/AIDS Guidelines	World Health Organization guidelines including post-exposure prophylaxis, prevention of mother-to-child transmission, surveillance and public health recommendations, TB-HIV co-management, and the UNAIDS/WHO AIDS Epidemic Update 2007.
IAPAC Drug Guide 2007	Clear, concise summaries of all FDA-approved drugs, including visuals.
HIV Drug Interactions	Check for drug interactions and pharmacology resources. Developed and maintained by the University of Liverpool.
PDR.net	Comprehensive drug information including the full text of package inserts. Downloadable drug interactions to PDA available. Registration required (free).
HIV Drug Resistance Program	National Cancer Institute-funded program on HIV drug resistance
BHIVA Guidelines	British HIV Association guidelines including management of HIV infection in pregnant women, immunization and treatment, HIV associated malignancies, and HBV-HIV, HCV-HIV, and TB-HIV co-infection.
Medical Management of HIV Infection	Manual of diagnosis and treatment by Drs. John G. Bartlett and Joel E. Gallant, Johns Hopkins University. Requires log-in (free).
IDSA Practice Guidelines for the Treatment of Tuberculosis	Infectious Disease Society of America guidelines, published 2003.

Drug Prescribing Information

Drug Name(s)	Trade Name(s) and Package Inserts*	Additional names	Manufacturer**
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
abacavir	Ziagen®	ABC	GSK
didanosine	Videx®	ddI	BMS
emtricitabine	Emtriva®	FTC	Gilead
lamivudine	Epivir®	3TC	GSK
stavudine	Zerit®	d4T	BMS
tenofovir	Viread®	TDF, PMPA	Gilead
zalcitabine	HIVID®	ddC	Roche
zidovudine	Retrovir®	AZT, ZDV	GSK
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
delavirdine	Rescriptor®	DLV	Pfizer
efavirenz	Sustiva®	EFV	BMS
etravirine	Intelence®	ETV	Tibotec
nevirapine	Viramune®	NVP	Boehringer Ingelheim
Protease Inhibitors (PIs)
amprenavir (discontinued)	Agenerase®		GSK
atazanavir	Reyataz®	ATV	BMS
darunavir	Prezista®	DRV	Tibotec
lopinavir and ritonavir	Kaletra®	LPV/r	Abbott
fosamprenavir	Lexiva®	FPV	GSK
indinavir	Crixivan®	IDV	Merck
nelfinavir	Viracept®	NFV	Pfizer
ritonavir	Norvir®	RTV	Abbott
saquinavir	Invirase®	SQV	Roche
tipranavir	Aptivus®	TPV	Boehringer Ingelheim
Fusion Inhibitors
enfurvirtide	Fuzeon®	T-20, ENF	Roche
Entry Inhibitors
maraviroc	Selzentry®	MVC	Pfizer
Integrase Inhibitors (INIs)
raltegravir	Isentress®	RAL	Merck
Fixed Dose Combinations
abacavir and lamivudine	Epzicom®	ABC/3TC	GSK
zidovudine and lamivudine	Combivir®	AZT/3TC	GSK
abacavir, lamivudine, and zidovudine	Trizivir®	ABC/3TC/AZT	GSK
tenofovir and emtricitabine	Truvada®	TDF/FTC	Gilead
tenofovir, emtricitabine, and efavirenz	Atripla®	TDF/FTC/EFV	Gilead, BMS
Generic Fixed Dose Combinations
lamivudine and zidovudine	Duovir	3TC/ZDV	Cipla
nevirapine, lamivudine, and zidovudine	Duovir-N	NVP/3TC/ZDV	Cipla
nevirapine, lamivudine, and stavudine	Triomune	NVP/3TC/d4T	Cipla

* See Drugs@FDA to search approval/label history and related documents by brand name.

** GSK = GlaxoSmithKline; BMS = Bristol-Myers Squibb.

Educational and CME Sites

Site/URL	Description
Clinical Care Options for HIV	HIV treatment updates, conference coverage, slide sets, and tools. Registration required (free).
National AIDS Treatment Advocacy Project (NATAP)	Comprehensive coverage of publications and news on HIV treatment.
HIVandHepatitis.com	Up to date news coverage and conference highlights.
Medscape HIV/AIDS	Extensive resource centers, journals, and news on a number of conditions. Registration required (free).
IAS-USA	International AIDS Society-USA resources, including CME course offerings, online case-based CME modules, full-text electronic versions of Topics in HIV Medicine issues, and other resources
Johns Hopkins AIDS Service	POC-IT HIV Guide. Registration required (free).
AIDS Education Global Information System (AEGIS)	Patient newsletters, physician-oriented review journals
The Body	News, conference coverage, patient education, "Ask the Experts"
Physicians Research Network	Registration required (free).
International Association of Physicians in AIDS Care (IAPAC)	Comprehensive listing for both IAPAC members and non-IAPAC conferences.
Aidsmap	Community-based organization in the UK.
Project Inform	Patient education, Hotline, Outreach programs

Biomedical Journals Publishing Clinical and Scientific HIV Studies

Journal/URL	Archives	Access Policy
AIDS	Full text since 1988	Open access 1 year after publication, to articles back to 1997. Other access requires subscription.
AIDS Research and Human Retroviruses	Full text since 1999	Full text requires a subscription or single-paper purchase.
AIDS Reviews	Full text since 1999	Open access to all but the two most recent issues, which require a subscription.
Annals of Internal Medicine	Full text since 1993	Free access to full text 6 months after publication, as well as to select new articles. Access to most newly published articles requires a subscription.
Antimicrobial Agents and Chemotherapy	Full text since 1998, pdf since 1972	Free access to full text 4 months after publication. Access to newly published articles requires a subscription.
Antiviral Therapy	Full text since 1999	Subscription needed for full access.
British Medical Journal (BMJ)	Full text since 1994	Articles since 1994 can be accessed for free 1 year after publication from the website; back-issues to 1963 are available from PubMed Central. Access to newly published articles requires a subscription.
Clinical Infectious Diseases	Full text since 1997	Full issues cannot be downloaded; subscription necessary to view full text or to order back-issues.
HIV Clinical Trials	Full text since 2000	Subscription needed for full access.
HIV Medicine	Full text since 1999	Full text requires a subscription.
Journal of Acquired Immune Deficiency Syndromes (JAIDS)	Full text since 1996	Free access to full text 1 year after publication. Access to newly published articles requires a subscription.
Journal of Clinical Microbiology	Full text since 1998, pdf since 1975	Free access to full text 4 months after publication. Access to newly published articles requires a subscription.
Journal of Infectious Dieases	Selected full text since 1997	Full issues cannot be downloaded; subscription necessary to view full text or to order back-issues.
Journal of the American Medical Association (JAMA)	Full text since 1998, selected pdfs since 1992	Most full text requires one-time access purchase or a subscription.
Journal of Virology	Full text since 1998, pdf since 1967	Free access to full text 4 months after publication. Access to newly published articles requires a subscription.
Lancet	Full text since 1996	Access to all abstracts and selected full text with free registration. Subscription needed for full access.
MMWR Reports on HIV/AIDS	Full text since 1981	Open access.
Nature	Full text since 1869	A personal subscription will give you access to the archive dating back to January 1997. Access via a site license includes a minimum of four years; institutions can add additional archived content to their license at any time. Articles can also be published individually.
Nature Medicine	Full text since 1995	Some content is freely available without restrictions; some is free but requires registration. Full access requires a subscription.
New England Journal of Medicine (NEJM)	Full text since 1993	Subscription needed to view full text.
Proceedings of the National Academy of Sciences (PNAS)	Full text since 1915	Open access.
Public Library of Science (PLOS) PLOS Biology PLOS Medicine *PLOS Pathogens	Full text since 2003 Full text since 2004 Full text since 2005	Open access.
Retrovirology	Full text since 2004	Open access.
Science	Full text since 1997, pdf since 1880	Full text since 1997, 1 year after publication with free registration.
Topics in HIV Medicine	Full text since 2000	Open access.

Meeting/URL	Description
Conference on Retroviruses and Opportunistic Infections (CROI)	Sponsored by the Foundation of Retroviral and Human Health, NIAID and CDC. Abstracts (1997 - 2008), Posters (1999 - 2008), and selected presentations (1999 - 2008) are online.
IAS Conferences	International AIDS Conferences in Mexico City, 2008 and Cape Town, 2009 sponsored by the International AIDS Society (IAS).
International HIV Drug Resistance Workshop	Sponsored by Informed Horizons. See also www.informedhorizons.com for past and future conferences.
Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)	American Society for Microbiology. Site contains resources from ICAAC 2002-2009.
Infectious Diseases Society of America (IDSA)	Abstracts and videotapes can be ordered online.
International Workshop of HIV Dynamics and Evolution	Sponsored by the University of California, San Diego. Submit abstracts and register online.
HIV Drug Resistance Program Symposium: Antiviral Drug Resistance	Sponsored by the HIV Drug Resistance Program, National Cancer Institute. Abstracts available online.
European AIDS Conference	Sponsored by the European AIDS Clinical Society (EACS). Information on previous conferences can be found here.
European HIV Drug Resistance Workshop	Abstracts and presentations from 2008 and 2007 available online.
HIV Pathogenesis	Keystone Symposia.
Frontiers in Drug Development for Antiretroviral Therapies (HIV DART)	Sponsored by Informed Horizons. See also www.informedhorizons.com for past or future conferences.
Virology Education	Large number of medical workshops, conferences, and courses.
South African HIV Drug resistance and bioinformatics workshops	HIV-1 drug resistance and bioinformatics workshops organized in South Africa. It organizes the 4th South African HIV Drug Resistance and Treatment Monitoring Workshop in 2009

HIV/AIDS Research Databases

Database	Description
HIV Drug Resistance Database	Maintained at Stanford University. Annotated collection of reverse transcriptase and protease sequences linked to drug treatment histories and drug susceptibility test results
Los Alamos National Laboratories	Maintained by the Theoretical Biology Group at LANL. HIV Molecular Immunology Database: Contains an annotated searchable collection of HIV-1 cytotoxic and helper T-cell epitopes and antibody binding sites. HIV Sequence Database: Contains curated HIV sequence alignments, analysis research tools and technical reviews. HIV Drug Resistance Database: Compilation of drug resistance mutations Vaccine Trials Database: NIH-funded database of HIV/SIV vaccine trials in nonhuman primates.
NIAID sites	Anti-HIV Compounds: chemical structures and in vitro activity of approved and experimental compounds. AIDS Research & Reference Reagent Program: maintains and provides laboratory reserach reagents including cell lines, viruses, proteins.
NCBI Sites	HIV-1, Human Protein Interaction Database: maintained by the NCBI in collaboration with the Southern Research Institute, initiated by NIAID. Entrez PubMed: NLM bibliographic database, integrates sequence data with MEDLINE and Protein Data Bank (PDB) GenBank: contains genetic sequence data. Retrovirus resources (Hot Spots) referenced to HIV-1 and HIV-2.
HIV Structural Database	Structural database maintained at the NCI devoted to HIV and SIV protease and RT
BioAfrica (Bioinformatics for HIV Research in Africa)	Contains information on HIV proteomics, subtype C distribution, and the REGA HIV-1 subtype tool

Clinical Trials

Institution/URL	Description
AIDS Treatment Data Network	Guide for health-care personnel and patients. Information on AIDS Drug Assistance Programs (ADAP).
AIDSinfo	DHHS. Browse and search through clinical trials. Summary of completed and ongoing trials.
ClinicalTrials.gov	NIH database of ongoing clinical research trials. Search engine.
The Adult AIDS Clinical Trials Group (ACTG)	Password required for ACTG protocols, technical documents (e.g. ACTG Virology Manual), member directory. Public site; www.aactg.org
Centers for AIDS Research (CFAR)	Links to each of the CFAR sites.
Bulletin of Experimental Treatments for AIDS (BETA)	Bulletin of clinical trials and other resources.

Telephone Consultation Services

Title/URL	Description
National Clinicians' Post-Exposure Prophylaxis Hotline	24-Hour advice on managing occupational exposures to HIV, hepatitis, and other blood borne pathogens. "PEPline" (888-HIV-4911)
National HIV Telephone Consultation Service	Case consultation for physicians, nurses, and other health-care givers. "Warmline" (800-933-3413)
National Perinatal HIV Consultation and Referral Service	24-Hour advice on treating infected pregnant women and infants (888-448-8765)

HIV Treatment Websites

Team

Resources