Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Genotype-Phenotype Correlations

Queries

1. Drug-Resistance Positions
2. Detailed Phenotype Queries
 

Data Summaries

1. Patterns of Drug-Resistance Mutations
2. Downloadable Reference Dataset
 
Drug susceptibility results (PhenoSense assay) defined as fold-decreased susceptibility compared to wildtype of viruses containing a mutation at the user-selected position. Results are aggregated by the pattern of accompanying nonpolymorphic established drug-resistance mutations. Sequences containing electrophoretic mixtures at a drug-resistance position are excluded from the results. Median, Interquartile Range, and No. of tests per pattern are shown. The pages with aggregate results contain links to each individual result.
 
Drug susceptibility results (fold-decreased susceptibility) of viruses containing one or more user-specfied mutations. Users can retrieve all results on isolates containing the specified mutations or only those results with exact matches (at nonpolymorphic established drug-resistance positions) to the specified mutations. Users can specify the type of assay (PhenoSense, Antivirogram, Other) and whether or not results on isolates with mixtures will be returned. Queries will return both graphical and tablular results. Drug susceptibility results defined as fold-decreased susceptibility.
 
Drug susceptibility results (PhenoSense assay) of viruses containing the most common patterns of mutations in the database. Results are aggregated by the pattern of accompanying nonpolymorphic established drug-resistance mutations. Sequences containing electrophoretic mixtures at a drug-resistance position are excluded from the results. Median, Interquartile Range, and No. of tests per pattern are shown.
 
User-defined downloadable datasets containing complete access to all genotype-phenotype correlations in HIVRT&PrDB. Users select assay type and the extent to which viruses with mixtures at nonpolymorphic DRP will be included in the dataset. Users can also define the fields to be included in the output file. A currated dataset containing for correlating between genotype and pheotype. Last updated on 11/2004.