<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Database Statistics

as of 10/2014

Genotype-Treatment
Number of individuals according to subtype and drug-class experienced1
Subtype 2proteaseRTintegrase
PI-NaivePI-TreatedRTI-NaiveRTI-TreatedINI-NaiveINI-Treated
B29,6799,55727,42129,8003,840191
A4,9282624,1921,2853371
C10,4661,2088,7097,7741,1542
D1,9812991,6037781386
F1,1111,5267287322284
G1,5843391,5932,0031531
CRF01_AE6,1721865,6403,8521,1191
CRF02_AG4,2782152,9571,7795492
Other1,6422611,9743,063264 
Total61,84113,85354,81751,0667,782208
1 Well-characterized treatment history is available for 92,113 individuals from whom 81,175 protease, 88,286 RT and 8,519 integrase isolates have been sequenced and published; "Mutation Prevalence According to Subtype and Treatment" page analyzes sequences obtained from the individuals for each subtype and summarizes the frequency of each mutation from treated individuals in comparison to the frequency of that mutation from untreated individuals.
2 "Other" subtypes include CRFs other than "CRF01_AE" and "CRF02_AG". Appendix II lists the CRFs available in HIVdb and how each CRF was mapped to a subtype for each gene for analysis.

Number of individuals according to regimen received
NRTI componentNNRTI component PI componentNRTI + PI or NNRTI regimen
AZT (2,111)
DDI (764)
D4T (744)
3TC (275)
ABC (223)
DDC (220)
TDF (36)
FTC (3)

D4T/3TC (5,348)
AZT/3TC (4,749)
AZT/DDI (1,796)
DDI/D4T (1,699)
AZT/DDC (808)
3TC/TDF (531)
3TC/ABC (510)
FTC/TDF (420)
DDI/3TC (251)
D4T/ABC (201)
DDI/ABC (138)
AZT/D4T (86)
DDI/TDF (80)
AZT/ABC (77)
DDC/D4T (75)
DDC/3TC (61)
D4T/TDF (30)
ABC/TDF (21)
AZT/TDF (21)
DDI/DDC (12)
DDC/ABC (10)
DDC/TDF (5)
DDI/FTC (3)


AZT/3TC/ABC (565)
AZT/D4T/3TC (463)
AZT/DDI/3TC (269)
D4T/3TC/ABC (159)
DDI/D4T/3TC (107)
DDI/D4T/ABC (90)
3TC/ABC/TDF (88)
AZT/DDC/3TC (72)
AZT/3TC/TDF (63)
DDI/3TC/TDF (49)
D4T/3TC/TDF (45)
AZT/DDI/DDC (31)
DDI/3TC/ABC (25)
AZT/DDI/D4T (17)
DDI/ABC/TDF (16)
DDI/D4T/TDF (15)
AZT/DDI/ABC (11)
DDI/FTC/TDF (8)
DDC/D4T/3TC (8)
AZT/DDC/D4T (6)
DDI/DDC/3TC (3)
AZT/DDC/ABC (3)
DDI/DDC/D4T (2)
ABC/FTC/TDF (2)
D4T/FTC/TDF (2)
AZT/FTC/TDF (2)
DDC/D4T/ABC (2)
AZT/DDI/TDF (2)
D4T/ABC/TDF (2)


AZT/DDI/D4T/3TC (31)
AZT/3TC/ABC/TDF (31)
DDI/3TC/ABC/TDF (13)
DDI/D4T/3TC/ABC (13)
AZT/DDI/3TC/ABC (7)
DDI/D4T/3TC/TDF (6)
AZT/DDC/D4T/3TC (6)
AZT/DDI/DDC/3TC (4)
D4T/3TC/ABC/TDF (4)
AZT/D4T/3TC/ABC (4)
AZT/DDI/3TC/TDF (4)
AZT/DDC/3TC/ABC (2)


AZT/DDI/DDC/D4T/3TC (7)
DDI/D4T/3TC/ABC/TDF (3)
AZT/DDI/D4T/3TC/ABC (2)

NVP (4,683)
EFV (4,453)
DLV (193)
RPV (18)
ETR (11)
NFV (2,350)
IDV (2,219)
LPVr (1,509)
SQV (935)
SQVr (747)
RTV (572)
IDVr (371)
APV (217)
ATVr (197)
APVr (140)
ATV (70)
DRVr (44)
TPVr (18)
DRV (3)

NFV/SQV (212)
APV/LPVr (58)
IDV/SQV (51)
NFV/IDV (46)
NFV/RTV (27)
LPVr/SQV (23)
NFV/APV (14)
IDV/LPVr (13)
APV/SQV (12)
NFV/LPVr (8)
APV/IDV (7)
LPVr/ATV (3)
IDV/ATV (2)
LPVr/TPV (2)


NFV/RTV/SQV (19)
RTV/APV/SQV (16)
RTV/IDV/SQV (12)
NFV/RTV/IDV (11)
RTV/APV/LPVr (5)
NFV/IDV/SQV (5)
RTV/APV/ATV (4)
RTV/APV/IDV (2)
RTV/LPVr/SQV (2)
RTV/IDV/LPVr (2)


NFV/RTV/IDV/SQV (4)

D4T/3TC/NVP (1,655)
D4T/3TC/EFV (1,555)
AZT/3TC/IDV (954)
AZT/3TC/EFV (876)
AZT/3TC/NVP (849)
D4T/3TC/IDV (695)
AZT/3TC/NFV (629)
D4T/3TC/NFV (620)
AZT/D4T/3TC/NVP/EFV (404)
AZT/3TC/SQV (347)
DDI/D4T/NFV (343)
D4T/3TC/LPVr (305)
DDI/D4T/EFV (293)
3TC/TDF/EFV (290)
AZT/3TC/LPVr (240)
3TC/ABC/EFV (229)
FTC/TDF/EFV (224)
DDI/D4T/NVP (219)
D4T/3TC/SQV (199)
AZT/3TC/RTV (190)
D4T/3TC/SQVr (170)
AZT/DDI/LPVr (160)
D4T/3TC/RTV (149)
DDI/D4T/IDV (138)
AZT/DDI/NVP (132)
AZT/3TC/SQVr (123)
DDI/D4T/SQVr (120)
AZT/DDC/SQV (113)
3TC/TDF/LPVr (106)
D4T/NFV/NVP (104)
AZT/3TC/ABC/EFV (102)
3TC/TDF/NVP (98)
AZT/3TC/IDVr (95)
3TC/ABC/LPVr (95)
3TC/ABC/ATVr (83)
FTC/TDF/ATVr (76)
D4T/3TC/IDVr (73)
D4T/3TC/NFV/NVP (69)
DDI/D4T/LPVr (69)
DDI/D4T/NFV/EFV (69)
AZT/DDI/NFV (60)
AZT/DDI/IDV (56)
FTC/TDF/LPVr (54)
AZT/DDI/SQV (53)
DDI/D4T/SQV (51)
AZT/DDI/EFV (49)
DDI/D4T/NFV/NVP (49)
D4T/SQVr (48)
AZT/3TC/NFV/EFV (47)
AZT/DDC/IDV (46)
DDI/D4T/RTV (45)
DDI/3TC/IDV (45)
AZT/3TC/ABC/LPVr (41)
DDI/D4T/IDVr (41)
D4T/IDV (39)
AZT/DDI/RTV (39)
DDI/TDF/EFV (38)
D4T/ABC/EFV (37)
D4T/3TC/ABC/LPVr (37)
FTC/TDF/NVP (37)
DDI/NFV/NVP (36)
AZT/3TC/NFV/NVP (36)
AZT/DDI/3TC/LPVr (35)
D4T/3TC/NFV/SQV (33)
AZT/SQV (33)
DDI/3TC/NFV (33)
D4T/NFV (32)
DDI/3TC/EFV (31)
Genotype-Phenotype
Number of isolates according to phenotype method and drug resistance mutation1
Method2NRTINNRTIPIINI
WTMTTotalWTMTTotalWTMTTotalWTMTTotal
PhenoSense4361,5031,9399791,0792,0587801,3652,14557166223
Antivirogram1779501,1276469491,5952891,1391,42812582207
Others402022421031052086524731254147201
1 Phenotypic resistance test results are available for 11,685 isolates including 10,266 clinical isolates and 1,419 lab isolates; for each ARV drug class, the number of isolates are shown in WT (wildtype) and MT (mutants) isolates; WT genotypes are defined as lacking any of major drug resistance mutations (DRMs) listed here: PI-associated DRMs for PI, NRTI-associated for NRTI, NNRTI-associated for NNRTI and INI-associated DRMs for INI.
2 PhenoSense - Monogram, South San Francisco; Antivirogram - Virco, Belgium;
Appendixes: HIV-1 Group M virus
Number of virus samples according to geographical region and subtype
ContinentRegionsSubtypes
Africa
(n = 24,937)
South Africa (7,267), Uganda (3,130), Cameroon (2,667), Kenya (1,502), Nigeria (1,166), Zambia (1,026), Zimbabwe (633), Tanzania (615), Mozambique (593), Angola (477), Cote d'Ivoire (469), Burkina Faso (433), Senegal (416), Botswana (409), Ghana (392), DRC (387), Mali (377), Morocco (366), Malawi (333), Rwanda (321), Ethiopia (284), Gabon (222), Burundi (172), Algeria (142), Central African Republic (132), Benin (128), Togo (127), CAR (124), Niger (99), Guinea (91), Equatorial Guinea (86), Chad (79), Africa (49), Swaziland (47), Seychelles (42), Libya (36), Madagascar (31), Sudan (30), Zaire (10), Guinea-Bissau (7), Congo-Brazzaville (6), Dijibouti (4), Liberia (4), Somalia (3), Gambia (3)C (8,805), CRF02_AG (4,018), (3,524), A1 (2,446), D (1,920), G (1,277), A (808), B (406), CRF06_cpx (332), CRF01_AE (317), CRF11_cpx (179), K (153), U (109), H (102), F (89), F2 (84), F1 (72), J (65), CRF13_cpx (38), CRF09_cpx (38), CRF10_CD (37), A2 (22), F1 (F2) (16), CRF37_cpx (14), CRF45_cpx (10), CRF26_AU (10), CRF18_cpx (9), CRF22_01A1 (9), CRF05_DF (5), CRF25_cpx (4), CRF49_cpx (3), CRF21_A2D (3), CRF27_cpx (3), CRF36_cpx (2), CRF16_A2D (2), CRF14_BG (2), CRF30_0206 (1), F1 (F) (1), A3 (1), CRF43_02G (1)
Asia
(n = 20,187)
China (4,003), Japan (3,433), Thailand (3,056), India (1,580), Taiwan (1,444), Vietnam (1,426), Cambodia (1,303), Israel (977), Korea (625), Malaysia (622), Singapore (366), Philippines (315), Hong Kong (290), Republic Of Georgia (201), Uzbekistan (154), Iran (102), Kazakhstan (93), Saudi Arabia (60), Indonesia (56), Lebanon (25), Yemen (19), Afghanistan (15), Myanmar (9), Turkey (7), Nepal (6)CRF01_AE (5,952), B (5,552), (5,326), C (2,130), CRF07_BC (419), A1 (361), CRF08_BC (137), A (80), CRF02_AG (71), G (40), D (35), CRF33_01B (14), U (12), CRF35_AD (10), CRF06_cpx (10), F (7), CRF34_01B (5), F1 (5), CRF43_02G (5), CRF25_cpx (4), K (3), CRF03_AB (2), CRF12_BF (2), CRF10_CD (2), A2 (1), CRF18_cpx (1), H (1)
Europe
(n = 31,053)
Germany (4,143), France (4,014), Italy (3,943), Spain (3,787), Greece (2,505), Portugal (2,321), Russia (1,180), Sweden (1,026), Ireland (923), U.K. (872), Denmark (736), Romania (664), Estonia (640), Belgium (610), Switzerland (503), Luxembourg (363), Poland (360), Europe (339), Slovenia (268), Cyprus (221), Ukraine (190), Serbia (187), Czech Republic (182), Austria (141), Netherlands (135), Norway (119), Republic of Latvia (117), Finland (97), Bulgaria (83), Greenland (75), Latvia (72), Albania (66), Azerbaijan (41), Yugoslavia (33), Hungary (30), Slovakia (26), Croatia (15), Lithuania (11), Belarus (9), Moldova (6)B (17,727), (3,860), G (2,124), A1 (1,445), CRF02_AG (1,317), C (1,268), CRF01_AE (813), F1 (656), A (580), CRF06_cpx (410), D (300), F (131), K (93), U (57), H (35), CRF12_BF (34), J (27), CRF11_cpx (23), CRF14_BG (23), CRF04_cpx (18), CRF42_BF (17), CRF05_DF (15), CRF03_AB (14), F2 (13), A2 (12), CRF13_cpx (12), F1 (F) (6), CRF47_BF (5), CRF23_BG (4), CRF18_cpx (4), A1 (A2) (3), CRF09_cpx (2), CRF10_CD (2), F1 (F2) (1), CRF27_cpx (1), CRF19_cpx (1)
North America
(n = 47,626)
U.S. (39,511), Canada (4,528), Mexico (1,835), Cuba (1,029), Honduras (336), El Salvador (207), Trinidad (63), Barbados (27), Puerto Rico (25), Dominican Republic (18), Haiti (16), Antigua (8), Saint Vincent (6), Saint Lucia (5), Grenada (4), Jamaica (3), Dominica (3), Montserrat (1), Panama (1)B (39,108), (6,553), C (652), CRF02_AG (266), D (188), CRF01_AE (176), A (141), G (122), A1 (87), CRF19_cpx (83), F (47), CRF18_cpx (39), K (24), CRF20_BG (24), F1 (24), CRF24_BG (22), U (21), H (17), CRF06_cpx (8), CRF23_BG (7), CRF12_BF (6), J (6), F1 (F2) (1), F2 (1), CRF08_BC (1), CRF09_cpx (1), CRF10_CD (1)
Oceania
(n = 881)
Australia (881)B (443), (428), D (3), K (3), A1 (2), A (1), CRF06_cpx (1)
South America
(n = 9,669)
Brazil (5,237), Argentina (3,496), Peru (426), Venezuela (281), Chile (162), Colombia (37), Uruguay (13), Guyana (6), Suriname (5), Ecuador (4), Bolivia (2)B (4,430), (3,344), C (732), F1 (485), CRF12_BF (411), U (112), F (87), D (17), F1 (F) (13), CRF31_BC (8), CRF02_AG (7), CRF29_BF (4), CRF38_BF1 (4), A (3), A1 (2), CRF28_BF (2), CRF16_A2D (2), K (1), CRF05_DF (1), CRF44_BF (1), CRF07_BC (1), CRF17_BF (1), CRF06_cpx (1)

Mapping CRF subtypes from viruses to each genes
CRFsNo. virusesMapped subtype
proteaseRTintegrase
CRF01_AE7,465CRF01_AE (5,097)CRF01_AE (6,665)CRF01_AE (416)
CRF02_AG5,687CRF02_AG (4,878)CRF02_AG (4,631)CRF02_AG (557)
CRF03_AB16A (15)B (15)B (3)
CRF04_cpx18CRF04_cpx (14)CRF04_cpx (15)CRF04_cpx (4)
CRF05_DF21CRF05_DF (21)CRF05_DF (21)CRF05_DF (3)
CRF06_cpx762CRF06_cpx (604)CRF06_cpx (533)CRF06_cpx (111)
CRF07_BC420B (420)CRF07_BC (420)C (5)
CRF08_BC138C (137)CRF08_BC (138)C (4)
CRF09_cpx41CRF09_cpx (38)CRF09_cpx (39)CRF09_cpx (6)
CRF10_CD42D (41)CRF10_CD (41)CRF10_CD (4)
CRF11_cpx202CRF11_cpx (183)CRF11_cpx (160)CRF11_cpx (22)
CRF12_BF453F (440)CRF12_BF (438)F (29)
CRF13_cpx50CRF13_cpx (45)CRF13_cpx (39)CRF13_cpx (10)
CRF14_BG25G (22)G (24)G (5)
CRF16_A2D4A (4)A (4)A (1)
CRF17_BF1CRF17_BF (1)CRF17_BF (1)F (1)
CRF18_cpx53CRF18_cpx (51)CRF18_cpx (50)CRF18_cpx (6)
CRF19_cpx84D (83)D (83)CRF19_cpx (4)
CRF20_BG24CRF20_BG (24)CRF20_BG (24)G (3)
CRF21_A2D3D (3)CRF21_A2D (3)A (3)
CRF22_01A19A (2)A (1)A (7)
CRF23_BG11CRF23_BG (11)CRF23_BG (11)G (2)
CRF24_BG22CRF24_BG (22)CRF24_BG (22)G (3)
CRF25_cpx8F (6)B (6)B (7)
CRF26_AU10F (10)CRF29_BF (10)F (4)
CRF27_cpx4CRF27_cpx (4)CRF27_cpx (4)CRF27_cpx (3)
CRF28_BF2F (2)B (2)B (2)
CRF29_BF4F (4)CRF29_BF (4)F (4)
CRF30_02061CRF30_0206 (1)CRF30_0206 (0)CRF30_0206 (0)
CRF31_BC8C (8)CRF31_BC (8)C (0)
CRF33_01B14CRF33_01B (14)CRF33_01B (14)CRF01_AE (3)
CRF34_01B5B (5)CRF01_AE (5)CRF01_AE (3)
CRF35_AD10CRF35_AD (9)CRF35_AD (10)A (4)
CRF36_cpx2CRF36_cpx (2)CRF36_cpx (2)CRF36_cpx (2)
CRF37_cpx14G (12)CRF37_cpx (3)CRF37_cpx (4)
CRF38_BF14CRF38_BF1 (4)CRF38_BF1 (4)CRF38_BF1 (4)
CRF42_BF17CRF42_BF (17)CRF42_BF (17)CRF42_BF (17)
CRF43_02G6CRF43_02G (5)CRF43_02G (4)CRF43_02G (5)
CRF44_BF1CRF44_BF (1)CRF44_BF (1)CRF44_BF (1)
CRF45_cpx10CRF45_cpx (10)CRF45_cpx (10)CRF45_cpx (4)
CRF47_BF5CRF47_BF (5)CRF47_BF (5)CRF47_BF (2)
CRF49_cpx3CRF49_cpx (3)CRF49_cpx (3)CRF49_cpx (3)