<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Database Statistics

as of 6/2016

Genotype-Treatment
Number of individuals according to subtype and drug-class experienced1
Subtype 2proteaseRTintegrase
PI-NaivePI-TreatedRTI-NaiveRTI-TreatedINI-NaiveINI-Treated
B35,50714,95032,24030,0485,1291,003
A5,4683854,3661,8733383
C11,6112,08310,2079,0901,7664
D2,2125221,6938941508
F1,3322,55599574022812
G1,8953401,8002,2251401
CRF01_AE9,3231928,5744,3201,5033
CRF02_AG4,7242553,2231,8955644
Other1,7153312,0133,083241 
Total73,78721,61365,11154,16810,0591,038
1 Well-characterized treatment history is available for 114,072 individuals from whom 100,938 protease, 107,792 RT and 11,730 integrase isolates have been sequenced and published; "Mutation Prevalence According to Subtype and Treatment" page analyzes sequences obtained from the individuals for each subtype and summarizes the frequency of each mutation from treated individuals in comparison to the frequency of that mutation from untreated individuals.
2 "Other" subtypes include CRFs other than "CRF01_AE" and "CRF02_AG". Appendix II lists the CRFs available in HIVdb and how each CRF was mapped to a subtype for each gene for analysis.

Number of individuals according to regimen received
NRTI componentNNRTI component PI componentNRTI + PI or NNRTI regimen
AZT (2,111)
DDI (765)
D4T (744)
3TC (275)
ABC (222)
DDC (220)
TDF (36)
FTC (3)

D4T/3TC (5,762)
AZT/3TC (5,207)
AZT/DDI (1,808)
DDI/D4T (1,704)
AZT/DDC (808)
3TC/TDF (704)
3TC/ABC (565)
FTC/TDF (450)
DDI/3TC (275)
D4T/ABC (201)
DDI/ABC (141)
AZT/D4T (86)
DDI/TDF (80)
AZT/ABC (78)
DDC/D4T (75)
DDC/3TC (61)
D4T/TDF (30)
ABC/TDF (21)
AZT/TDF (21)
DDI/DDC (12)
DDC/ABC (10)
DDC/TDF (5)
DDI/FTC (3)


AZT/3TC/ABC (571)
AZT/D4T/3TC (463)
AZT/DDI/3TC (279)
D4T/3TC/ABC (159)
DDI/D4T/3TC (111)
DDI/D4T/ABC (90)
3TC/ABC/TDF (88)
AZT/DDC/3TC (72)
AZT/3TC/TDF (69)
DDI/3TC/TDF (49)
D4T/3TC/TDF (46)
AZT/DDI/DDC (31)
DDI/3TC/ABC (26)
AZT/DDI/D4T (17)
DDI/ABC/TDF (16)
DDI/D4T/TDF (15)
AZT/DDI/ABC (11)
DDC/D4T/3TC (9)
DDI/FTC/TDF (8)
AZT/DDC/D4T (6)
DDI/DDC/3TC (3)
AZT/DDC/ABC (3)
DDI/DDC/D4T (2)
ABC/FTC/TDF (2)
D4T/FTC/TDF (2)
AZT/FTC/TDF (2)
DDC/D4T/ABC (2)
AZT/DDI/TDF (2)
D4T/ABC/TDF (2)


AZT/DDI/D4T/3TC (31)
AZT/3TC/ABC/TDF (31)
DDI/3TC/ABC/TDF (13)
DDI/D4T/3TC/ABC (13)
AZT/DDI/3TC/ABC (7)
DDI/D4T/3TC/TDF (6)
AZT/DDC/D4T/3TC (6)
AZT/DDI/DDC/3TC (4)
D4T/3TC/ABC/TDF (4)
AZT/D4T/3TC/ABC (4)
AZT/DDI/3TC/TDF (4)
AZT/DDC/3TC/ABC (2)


AZT/DDI/DDC/D4T/3TC (7)
DDI/D4T/3TC/ABC/TDF (3)
AZT/DDI/D4T/3TC/ABC (2)

NVP (5,139)
EFV (5,025)
DLV (193)
RPV (18)
ETR (11)
NFV (2,361)
IDV (2,219)
LPVr (1,610)
SQV (937)
SQVr (746)
RTV (595)
IDVr (371)
APV (229)
ATVr (197)
APVr (140)
ATV (80)
DRVr (44)
TPVr (18)
DRV (3)

NFV/SQV (212)
APV/LPVr (58)
IDV/SQV (51)
NFV/IDV (46)
NFV/RTV (27)
LPVr/SQV (23)
NFV/APV (14)
IDV/LPVr (13)
APV/SQV (12)
NFV/LPVr (8)
APV/IDV (7)
LPVr/ATV (3)
IDV/ATV (2)
LPVr/TPV (2)


NFV/RTV/SQV (19)
RTV/APV/SQV (16)
RTV/IDV/SQV (12)
NFV/RTV/IDV (11)
RTV/APV/LPVr (5)
NFV/IDV/SQV (5)
RTV/APV/ATV (4)
RTV/APV/IDV (2)
RTV/LPVr/SQV (2)
RTV/IDV/LPVr (2)


NFV/RTV/IDV/SQV (4)

D4T/3TC/NVP (1,808)
D4T/3TC/EFV (1,803)
AZT/3TC/EFV (1,108)
AZT/3TC/NVP (1,024)
AZT/3TC/IDV (954)
D4T/3TC/IDV (695)
AZT/3TC/NFV (638)
D4T/3TC/NFV (620)
AZT/D4T/3TC/NVP/EFV (404)
3TC/TDF/EFV (360)
D4T/3TC/LPVr (356)
AZT/3TC/SQV (348)
DDI/D4T/NFV (343)
DDI/D4T/EFV (295)
AZT/3TC/LPVr (271)
3TC/ABC/EFV (252)
FTC/TDF/EFV (247)
DDI/D4T/NVP (222)
3TC/TDF/NVP (204)
D4T/3TC/SQV (199)
AZT/3TC/RTV (191)
D4T/3TC/RTV (171)
D4T/3TC/SQVr (170)
AZT/DDI/LPVr (162)
DDI/D4T/IDV (138)
AZT/DDI/NVP (137)
AZT/3TC/SQVr (123)
DDI/D4T/SQVr (120)
AZT/DDC/SQV (113)
3TC/TDF/LPVr (106)
D4T/NFV/NVP (104)
3TC/ABC/LPVr (104)
AZT/3TC/ABC/EFV (102)
AZT/3TC/IDVr (95)
3TC/ABC/ATVr (83)
FTC/TDF/ATVr (76)
D4T/3TC/IDVr (73)
D4T/3TC/NFV/NVP (69)
DDI/D4T/LPVr (69)
DDI/D4T/NFV/EFV (69)
AZT/DDI/NFV (61)
AZT/DDI/IDV (56)
FTC/TDF/LPVr (54)
AZT/DDI/SQV (53)
AZT/DDI/EFV (52)
DDI/D4T/SQV (51)
DDI/D4T/NFV/NVP (49)
D4T/SQVr (48)
AZT/3TC/NFV/EFV (47)
AZT/DDC/IDV (46)
DDI/D4T/RTV (45)
DDI/3TC/IDV (45)
FTC/TDF/NVP (43)
AZT/3TC/ABC/LPVr (42)
DDI/D4T/IDVr (41)
DDI/3TC/EFV (41)
D4T/IDV (39)
AZT/DDI/RTV (39)
DDI/TDF/EFV (38)
D4T/ABC/EFV (37)
D4T/3TC/ABC/LPVr (37)
DDI/NFV/NVP (36)
AZT/3TC/NFV/NVP (36)
AZT/DDI/3TC/LPVr (35)
DDI/3TC/LPVr (34)
D4T/3TC/NFV/SQV (33)
AZT/SQV (33)
3TC/ABC/NVP (33)
DDI/3TC/NFV (33)
D4T/NFV (32)
AZT/3TC/APV (32)
Genotype-Phenotype
Number of isolates according to phenotype method and drug resistance mutation1
Method2NRTINNRTIPIINI
WTMTTotalWTMTTotalWTMTTotalWTMTTotal
PhenoSense4361,5021,9389791,0782,0577801,3652,145549233782
Antivirogram1779501,1276469491,5952891,1391,42812582207
Others402012411031042076524731269209278
1 Phenotypic resistance test results are available for 12,317 isolates including 10,821 clinical isolates and 1,496 lab isolates; for each ARV drug class, the number of isolates are shown in WT (wildtype) and MT (mutants) isolates; WT genotypes are defined as lacking any of major drug resistance mutations (DRMs) listed here: PI-associated DRMs for PI, NRTI-associated for NRTI, NNRTI-associated for NNRTI and INI-associated DRMs for INI.
2 PhenoSense - Monogram, South San Francisco; Antivirogram - Virco, Belgium;
Appendixes: HIV-1 Group M virus
Number of virus samples according to geographical region and subtype
ContinentRegionsSubtypes
Africa
(n = 28,135)
South Africa (8,032), Uganda (3,172), Cameroon (2,836), Kenya (1,978), Nigeria (1,207), Zambia (1,116), Botswana (1,057), Tanzania (743), Zimbabwe (633), Mozambique (593), Angola (477), Cote d'Ivoire (469), DRC (443), Ethiopia (438), Burkina Faso (433), Senegal (416), Ghana (392), Rwanda (391), Malawi (383), Mali (377), Algeria (370), Morocco (366), Gabon (222), Liberia (215), Burundi (172), Central African Republic (132), Benin (128), Togo (127), CAR (124), Niger (99), Guinea (91), Equatorial Guinea (86), Chad (79), Congo-Brazzaville (71), Africa (49), Swaziland (47), Seychelles (42), Libya (36), Madagascar (31), Sudan (30), Guinea-Bissau (13), Zaire (9), Dijibouti (4), Somalia (3), Gambia (3)C (10,620), CRF02_AG (4,419), (3,524), A1 (2,446), D (2,097), G (1,426), A (1,156), CRF01_AE (487), B (472), CRF06_cpx (332), K (182), CRF11_cpx (179), F (117), H (111), U (109), F2 (84), F1 (72), J (71), CRF13_cpx (38), CRF09_cpx (38), CRF10_CD (37), A2 (22), F1 (F2) (16), CRF37_cpx (14), CRF45_cpx (10), CRF26_AU (10), CRF18_cpx (9), CRF22_01A1 (9), CRF05_DF (5), CRF25_cpx (4), CRF49_cpx (3), CRF21_A2D (3), CRF27_cpx (3), CRF36_cpx (2), CRF16_A2D (2), CRF14_BG (2), CRF30_0206 (1), F1 (F) (1), A3 (1), CRF43_02G (1)
Asia
(n = 27,043)
China (8,651), Japan (4,050), Thailand (3,450), Vietnam (1,846), Taiwan (1,727), India (1,600), Cambodia (1,303), Israel (993), Korea (756), Malaysia (635), Singapore (366), Hong Kong (322), Philippines (320), Republic Of Georgia (201), Uzbekistan (154), Iran (142), Indonesia (133), Kazakhstan (93), Myanmar (91), Armenia (78), Saudi Arabia (60), Lebanon (25), Yemen (19), Afghanistan (15), Turkey (7), Nepal (6)CRF01_AE (9,214), B (7,952), (5,326), C (3,236), CRF07_BC (419), A1 (361), A (142), CRF08_BC (137), CRF02_AG (78), D (51), G (42), CRF33_01B (14), U (12), CRF35_AD (10), CRF06_cpx (10), F (7), CRF34_01B (5), CRF43_02G (5), F1 (5), K (4), CRF25_cpx (4), CRF03_AB (2), CRF12_BF (2), CRF10_CD (2), A2 (1), CRF18_cpx (1), H (1)
Europe
(n = 33,218)
Germany (4,256), Italy (4,049), France (4,045), Spain (3,841), Portugal (2,610), Greece (2,499), Russia (1,226), Poland (1,196), Sweden (1,098), Ireland (923), U.K. (872), Romania (802), Denmark (736), Belgium (680), Estonia (640), Switzerland (519), Bulgaria (388), Luxembourg (363), Europe (339), Slovenia (268), Cyprus (221), Netherlands (203), Ukraine (190), Serbia (187), Czech Republic (182), Austria (141), Norway (119), Republic of Latvia (117), Finland (97), Greenland (75), Latvia (72), Albania (66), Azerbaijan (41), Lithuania (38), Yugoslavia (33), Hungary (30), Slovakia (26), Croatia (15), Belarus (9), Moldova (6)B (19,065), (3,860), G (2,276), CRF02_AG (1,461), A1 (1,445), C (1,381), CRF01_AE (959), F1 (656), A (648), CRF06_cpx (410), D (355), F (271), K (94), U (57), H (36), CRF12_BF (34), J (34), CRF11_cpx (23), CRF14_BG (23), CRF04_cpx (18), CRF42_BF (17), CRF05_DF (15), CRF03_AB (14), F2 (13), A2 (12), CRF13_cpx (12), F1 (F) (6), CRF47_BF (5), CRF23_BG (4), CRF18_cpx (4), A1 (A2) (3), CRF09_cpx (2), CRF10_CD (2), F1 (F2) (1), CRF27_cpx (1), CRF19_cpx (1)
North America
(n = 52,949)
U.S. (44,625), Canada (4,570), Mexico (1,835), Cuba (1,121), Honduras (336), El Salvador (207), Jamaica (78), Trinidad (63), Barbados (27), Puerto Rico (25), Dominican Republic (18), Haiti (16), Antigua (8), Saint Vincent (6), Saint Lucia (5), Grenada (4), Dominica (3), Montserrat (1), Panama (1)B (44,341), (6,552), C (682), CRF02_AG (279), D (202), CRF01_AE (184), A (146), G (129), A1 (87), CRF19_cpx (83), F (54), CRF18_cpx (39), K (30), CRF20_BG (24), F1 (24), CRF24_BG (22), U (21), H (18), CRF06_cpx (8), CRF23_BG (7), CRF12_BF (6), J (6), F1 (F2) (1), F2 (1), CRF08_BC (1), CRF09_cpx (1), CRF10_CD (1)
Oceania
(n = 894)
Australia (894)B (456), (428), D (3), K (3), A1 (2), A (1), CRF06_cpx (1)
South America
(n = 18,654)
Brazil (13,918), Argentina (3,496), Peru (426), French Guiana (304), Venezuela (281), Chile (162), Colombia (37), Uruguay (13), Guyana (6), Suriname (5), Ecuador (4), Bolivia (2)B (11,555), (3,344), C (1,548), F (1,082), F1 (485), CRF12_BF (411), U (112), D (28), CRF02_AG (21), K (14), F1 (F) (13), CRF31_BC (8), G (6), A (4), CRF29_BF (4), CRF38_BF1 (4), CRF01_AE (3), A1 (2), CRF28_BF (2), CRF16_A2D (2), CRF05_DF (1), CRF44_BF (1), CRF07_BC (1), CRF17_BF (1), H (1), CRF06_cpx (1)

Mapping CRF subtypes from viruses to each genes
CRFsNo. virusesMapped subtype
proteaseRTintegrase
CRF01_AE11,157CRF01_AE (8,315)CRF01_AE (10,162)CRF01_AE (807)
CRF02_AG6,277CRF02_AG (5,271)CRF02_AG (4,961)CRF02_AG (589)
CRF03_AB16A (15)B (15)B (3)
CRF04_cpx18CRF04_cpx (14)CRF04_cpx (15)CRF04_cpx (4)
CRF05_DF21CRF05_DF (21)CRF05_DF (21)CRF05_DF (3)
CRF06_cpx762CRF06_cpx (604)CRF06_cpx (533)CRF06_cpx (111)
CRF07_BC420B (420)CRF07_BC (420)C (5)
CRF08_BC138C (137)CRF08_BC (138)C (4)
CRF09_cpx41CRF09_cpx (38)CRF09_cpx (39)CRF09_cpx (6)
CRF10_CD42D (41)CRF10_CD (41)CRF10_CD (4)
CRF11_cpx202CRF11_cpx (183)CRF11_cpx (160)CRF11_cpx (22)
CRF12_BF453F (440)CRF12_BF (438)F (29)
CRF13_cpx50CRF13_cpx (45)CRF13_cpx (39)CRF13_cpx (10)
CRF14_BG25G (22)G (24)G (5)
CRF16_A2D4A (4)A (4)A (1)
CRF17_BF1CRF17_BF (1)CRF17_BF (1)F (1)
CRF18_cpx53CRF18_cpx (51)CRF18_cpx (50)CRF18_cpx (6)
CRF19_cpx84D (83)D (83)CRF19_cpx (4)
CRF20_BG24CRF20_BG (24)CRF20_BG (24)G (3)
CRF21_A2D3D (3)CRF21_A2D (3)A (3)
CRF22_01A19A (2)A (1)A (7)
CRF23_BG11CRF23_BG (11)CRF23_BG (11)G (2)
CRF24_BG22CRF24_BG (22)CRF24_BG (22)G (3)
CRF25_cpx8F (6)B (6)B (7)
CRF26_AU10F (10)CRF29_BF (10)F (4)
CRF27_cpx4CRF27_cpx (4)CRF27_cpx (4)CRF27_cpx (3)
CRF28_BF2F (2)B (2)B (2)
CRF29_BF4F (4)CRF29_BF (4)F (4)
CRF30_02061CRF30_0206 (1)CRF30_0206 (0)CRF30_0206 (0)
CRF31_BC8C (8)CRF31_BC (8)C (0)
CRF33_01B14CRF33_01B (14)CRF33_01B (14)CRF01_AE (3)
CRF34_01B5B (5)CRF01_AE (5)CRF01_AE (3)
CRF35_AD10CRF35_AD (9)CRF35_AD (10)A (4)
CRF36_cpx2CRF36_cpx (2)CRF36_cpx (2)CRF36_cpx (2)
CRF37_cpx14G (12)CRF37_cpx (3)CRF37_cpx (4)
CRF38_BF14CRF38_BF1 (4)CRF38_BF1 (4)CRF38_BF1 (4)
CRF42_BF17CRF42_BF (17)CRF42_BF (17)CRF42_BF (17)
CRF43_02G6CRF43_02G (5)CRF43_02G (4)CRF43_02G (5)
CRF44_BF1CRF44_BF (1)CRF44_BF (1)CRF44_BF (1)
CRF45_cpx10CRF45_cpx (10)CRF45_cpx (10)CRF45_cpx (4)
CRF47_BF5CRF47_BF (5)CRF47_BF (5)CRF47_BF (2)
CRF49_cpx3CRF49_cpx (3)CRF49_cpx (3)CRF49_cpx (3)