<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Database Statistics

as of 2/2014

Genotype-Treatment
Number of individuals according to subtype and drug-class experienced1
Subtype 2proteaseRTintegrase
PI-NaivePI-TreatedRTI-NaiveRTI-TreatedINI-NaiveINI-Treated
B25,4659,43323,32223,7413,372191
A4,1552143,4448993371
C9,9741,0638,5136,5681,1162
D1,6492411,2885561386
F1,0841,5226955342224
G1,3802601,3701,1111511
CRF01_AE5,8271155,3792,4691,0971
CRF02_AG3,6941402,7259595462
Other1,5512511,9092,929236 
Total54,77913,23948,64539,7667,215208
1 Well-characterized treatment history is available for 79,949 individuals from whom 73,421 protease, 76,308 RT and 7,952 integrase isolates have been sequenced and published; "Mutation Prevalence According to Subtype and Treatment" page analyzes sequences obtained from the individuals for each subtype and summarizes the frequency of each mutation from treated individuals in comparison to the frequency of that mutation from untreated individuals.
2 "Other" subtypes include CRFs other than "CRF01_AE" and "CRF02_AG". Appendix II lists the CRFs available in HIVdb and how each CRF was mapped to a subtype for each gene for analysis.

Number of individuals according to regimen received
NRTI componentNNRTI component PI componentNRTI + PI or NNRTI regimen
AZT (2,111)
DDI (764)
D4T (743)
3TC (275)
ABC (223)
DDC (220)
TDF (35)
FTC (3)

D4T/3TC (4,975)
AZT/3TC (4,612)
AZT/DDI (1,731)
DDI/D4T (1,699)
AZT/DDC (808)
3TC/TDF (444)
3TC/ABC (415)
DDI/3TC (249)
FTC/TDF (223)
D4T/ABC (199)
DDI/ABC (138)
AZT/D4T (86)
DDI/TDF (78)
DDC/D4T (75)
AZT/ABC (71)
DDC/3TC (61)
D4T/TDF (30)
AZT/TDF (21)
ABC/TDF (17)
DDI/DDC (12)
DDC/ABC (10)
DDC/TDF (5)
DDI/FTC (3)


AZT/3TC/ABC (565)
AZT/D4T/3TC (462)
AZT/DDI/3TC (269)
D4T/3TC/ABC (158)
DDI/D4T/3TC (106)
DDI/D4T/ABC (90)
3TC/ABC/TDF (87)
AZT/DDC/3TC (72)
AZT/3TC/TDF (62)
DDI/3TC/TDF (49)
D4T/3TC/TDF (41)
AZT/DDI/DDC (31)
DDI/3TC/ABC (25)
AZT/DDI/D4T (17)
DDI/ABC/TDF (16)
DDI/D4T/TDF (15)
AZT/DDI/ABC (11)
DDI/FTC/TDF (8)
DDC/D4T/3TC (8)
AZT/DDC/D4T (6)
DDI/DDC/3TC (3)
AZT/DDC/ABC (3)
DDI/DDC/D4T (2)
ABC/FTC/TDF (2)
D4T/FTC/TDF (2)
AZT/FTC/TDF (2)
DDC/D4T/ABC (2)
AZT/DDI/TDF (2)
D4T/ABC/TDF (2)


AZT/DDI/D4T/3TC (31)
AZT/3TC/ABC/TDF (31)
DDI/3TC/ABC/TDF (13)
DDI/D4T/3TC/ABC (13)
AZT/DDI/3TC/ABC (7)
DDI/D4T/3TC/TDF (6)
AZT/DDC/D4T/3TC (6)
AZT/DDI/DDC/3TC (4)
D4T/3TC/ABC/TDF (4)
AZT/D4T/3TC/ABC (4)
AZT/DDI/3TC/TDF (4)
AZT/DDC/3TC/ABC (2)


AZT/DDI/DDC/D4T/3TC (7)
DDI/D4T/3TC/ABC/TDF (3)
AZT/DDI/D4T/3TC/ABC (2)

NVP (4,445)
EFV (3,977)
DLV (193)
ETR (11)
RPV (1)
NFV (2,340)
IDV (2,219)
LPVr (1,342)
SQV (935)
SQVr (746)
RTV (572)
IDVr (371)
APV (217)
ATVr (197)
APVr (140)
ATV (69)
DRVr (44)
TPVr (18)
DRV (3)

NFV/SQV (212)
APV/LPVr (58)
IDV/SQV (51)
NFV/IDV (46)
NFV/RTV (27)
LPVr/SQV (22)
NFV/APV (14)
IDV/LPVr (13)
APV/SQV (12)
NFV/LPVr (7)
APV/IDV (7)
LPVr/ATV (3)
IDV/ATV (2)
LPVr/TPV (2)


NFV/RTV/SQV (19)
RTV/APV/SQV (16)
RTV/IDV/SQV (12)
NFV/RTV/IDV (11)
RTV/APV/LPVr (5)
NFV/IDV/SQV (5)
RTV/APV/ATV (4)
RTV/APV/IDV (2)
RTV/LPVr/SQV (2)
RTV/IDV/LPVr (2)


NFV/RTV/IDV/SQV (4)

D4T/3TC/NVP (1,582)
D4T/3TC/EFV (1,331)
AZT/3TC/IDV (954)
AZT/3TC/EFV (871)
AZT/3TC/NVP (745)
D4T/3TC/IDV (695)
AZT/3TC/NFV (621)
D4T/3TC/NFV (620)
AZT/D4T/3TC/NVP/EFV (404)
AZT/3TC/SQV (347)
DDI/D4T/NFV (343)
DDI/D4T/EFV (293)
3TC/TDF/EFV (232)
AZT/3TC/LPVr (224)
DDI/D4T/NVP (219)
D4T/3TC/LPVr (214)
D4T/3TC/SQV (199)
AZT/3TC/RTV (190)
D4T/3TC/SQVr (169)
3TC/ABC/EFV (167)
AZT/DDI/LPVr (159)
D4T/3TC/RTV (149)
DDI/D4T/IDV (138)
AZT/3TC/SQVr (123)
DDI/D4T/SQVr (120)
AZT/DDC/SQV (113)
D4T/NFV/NVP (104)
AZT/3TC/ABC/EFV (102)
3TC/TDF/LPVr (102)
AZT/3TC/IDVr (95)
3TC/ABC/ATVr (83)
FTC/TDF/EFV (76)
FTC/TDF/ATVr (76)
3TC/TDF/NVP (74)
D4T/3TC/IDVr (73)
D4T/3TC/NFV/NVP (69)
DDI/D4T/LPVr (69)
AZT/DDI/NVP (69)
DDI/D4T/NFV/EFV (69)
3TC/ABC/LPVr (62)
AZT/DDI/NFV (59)
AZT/DDI/IDV (56)
AZT/DDI/SQV (53)
DDI/D4T/SQV (51)
AZT/DDI/EFV (49)
DDI/D4T/NFV/NVP (49)
D4T/SQVr (48)
FTC/TDF/LPVr (48)
AZT/3TC/NFV/EFV (47)
AZT/DDC/IDV (46)
DDI/D4T/RTV (45)
DDI/3TC/IDV (45)
AZT/3TC/ABC/LPVr (41)
DDI/D4T/IDVr (41)
D4T/IDV (39)
AZT/DDI/RTV (39)
DDI/TDF/EFV (38)
D4T/ABC/EFV (37)
DDI/NFV/NVP (36)
D4T/3TC/ABC/LPVr (36)
AZT/DDI/3TC/LPVr (35)
AZT/3TC/NFV/NVP (35)
D4T/3TC/NFV/SQV (33)
AZT/SQV (33)
DDI/3TC/NFV (33)
D4T/NFV (32)
DDI/3TC/EFV (31)
Genotype-Phenotype
Number of isolates according to phenotype method and drug resistance mutation1
Method2NRTINNRTIPIINI
WTMTTotalWTMTTotalWTMTTotalWTMTTotal
PhenoSense3551,2891,6448379251,7625381,1871,72557166223
Antivirogram1769511,1276469491,5952891,1391,42812582207
Others392032421031052086524731254147201
1 Phenotypic resistance test results are available for 10,674 isolates including 9,255 clinical isolates and 1,419 lab isolates; for each ARV drug class, the number of isolates are shown in WT (wildtype) and MT (mutants) isolates; WT genotypes are defined as lacking any of major drug resistance mutations (DRMs) listed here: PI-associated DRMs for PI, NRTI-associated for NRTI, NNRTI-associated for NNRTI and INI-associated DRMs for INI.
2 PhenoSense - Monogram, South San Francisco; Antivirogram - Virco, Belgium;
Appendixes: HIV-1 Group M virus
Number of virus samples according to geographical region and subtype
ContinentRegionsSubtypes
Africa
(n = 22,509)
South Africa (6,862), Cameroon (2,531), Uganda (2,514), Kenya (1,284), Zambia (1,026), Nigeria (840), Zimbabwe (633), Tanzania (615), Mozambique (593), Cote d'Ivoire (469), Burkina Faso (433), Botswana (409), Mali (377), Morocco (366), Malawi (333), Senegal (292), Ghana (291), Ethiopia (284), DRC (245), Angola (236), Gabon (222), Rwanda (202), Burundi (172), Algeria (142), Central African Republic (132), Benin (128), Togo (127), CAR (124), Niger (99), Guinea (91), Equatorial Guinea (86), Chad (79), Africa (49), Swaziland (47), Seychelles (42), Libya (36), Madagascar (31), Sudan (30), Zaire (10), Guinea-Bissau (7), Congo-Brazzaville (6), Dijibouti (4), Liberia (4), Somalia (3), Gambia (3)C (8,214), CRF02_AG (3,616), (3,578), A1 (2,446), D (1,549), G (972), B (396), CRF06_cpx (332), A (311), CRF11_cpx (179), CRF01_AE (150), K (116), U (109), F2 (84), F1 (72), H (63), J (53), CRF13_cpx (38), CRF09_cpx (38), F (38), CRF10_CD (37), A2 (22), F1 (F2) (16), CRF37_cpx (14), CRF45_cpx (10), CRF26_AU (10), CRF18_cpx (9), CRF22_01A1 (9), CRF05_DF (5), CRF25_cpx (4), CRF49_cpx (3), CRF21_A2D (3), CRF27_cpx (3), CRF36_cpx (2), CRF16_A2D (2), CRF14_BG (2), CRF30_0206 (1), F1 (F) (1), A3 (1), CRF43_02G (1)
Asia
(n = 16,553)
China (3,862), Thailand (3,055), India (1,580), Taiwan (1,444), Vietnam (1,426), Japan (1,136), Israel (639), Korea (625), Malaysia (616), Cambodia (605), Singapore (366), Philippines (315), Hong Kong (290), Uzbekistan (154), Iran (102), Kazakhstan (93), Saudi Arabia (60), Indonesia (56), Republic Of Georgia (48), Lebanon (25), Yemen (19), Afghanistan (15), Myanmar (9), Turkey (7), Nepal (6) (5,326), CRF01_AE (4,759), B (3,304), C (2,000), CRF07_BC (419), A1 (361), CRF08_BC (137), CRF02_AG (53), A (50), D (33), G (31), CRF33_01B (14), U (12), CRF35_AD (10), CRF06_cpx (10), CRF34_01B (5), F1 (5), CRF43_02G (5), CRF25_cpx (4), F (3), K (3), CRF03_AB (2), CRF12_BF (2), CRF10_CD (2), A2 (1), CRF18_cpx (1), H (1)
Europe
(n = 22,049)
Spain (3,536), France (3,413), Italy (2,073), Germany (1,743), Portugal (1,279), Ireland (923), Sweden (885), U.K. (866), Denmark (736), Romania (664), Estonia (640), Belgium (587), Russia (579), Switzerland (503), Greece (480), Poland (359), Europe (339), Luxembourg (320), Slovenia (268), Cyprus (221), Ukraine (190), Serbia (187), Czech Republic (182), Austria (141), Netherlands (135), Norway (119), Republic of Latvia (117), Finland (97), Bulgaria (83), Greenland (75), Latvia (72), Albania (66), Azerbaijan (41), Yugoslavia (33), Hungary (30), Slovakia (26), Croatia (15), Lithuania (11), Belarus (9), Moldova (6)B (11,213), (3,860), G (1,616), A1 (1,445), C (1,017), CRF02_AG (760), F1 (656), CRF06_cpx (410), CRF01_AE (318), D (260), A (86), K (59), U (57), CRF12_BF (34), F (34), H (30), CRF11_cpx (23), CRF14_BG (23), CRF04_cpx (18), J (18), CRF42_BF (17), CRF05_DF (15), CRF03_AB (14), F2 (13), A2 (12), CRF13_cpx (12), F1 (F) (6), CRF47_BF (5), CRF23_BG (4), CRF18_cpx (4), A1 (A2) (3), CRF09_cpx (2), CRF10_CD (2), F1 (F2) (1), CRF27_cpx (1), CRF19_cpx (1)
North America
(n = 46,524)
U.S. (38,687), Canada (4,528), Mexico (1,835), Cuba (751), Honduras (336), El Salvador (207), Trinidad (63), Barbados (27), Puerto Rico (25), Dominican Republic (18), Haiti (16), Antigua (8), Saint Vincent (6), Saint Lucia (5), Grenada (4), Jamaica (3), Dominica (3), Montserrat (1), Panama (1)B (38,906), (6,553), C (348), CRF02_AG (118), A1 (87), CRF01_AE (87), CRF19_cpx (83), D (74), G (59), CRF18_cpx (39), CRF20_BG (24), F1 (24), CRF24_BG (22), U (21), F (17), A (15), H (13), CRF06_cpx (8), CRF23_BG (7), CRF12_BF (6), K (5), J (3), F1 (F2) (1), F2 (1), CRF08_BC (1), CRF09_cpx (1), CRF10_CD (1)
Oceania
(n = 881)
Australia (881)B (443), (428), D (3), K (3), A1 (2), A (1), CRF06_cpx (1)
South America
(n = 9,658)
Brazil (5,226), Argentina (3,496), Peru (426), Venezuela (281), Chile (162), Colombia (37), Uruguay (13), Guyana (6), Suriname (5), Ecuador (4), Bolivia (2)B (4,425), (3,344), C (731), F1 (485), CRF12_BF (411), U (112), F (82), D (17), F1 (F) (13), CRF31_BC (8), CRF02_AG (7), CRF29_BF (4), CRF38_BF1 (4), A (3), A1 (2), CRF28_BF (2), CRF16_A2D (2), K (1), CRF05_DF (1), CRF44_BF (1), CRF07_BC (1), CRF17_BF (1), CRF06_cpx (1)

Mapping CRF subtypes from viruses to each genes
CRFsNo. virusesMapped subtype
proteaseRTintegrase
CRF01_AE5,521CRF01_AE (3,906)CRF01_AE (4,861)CRF01_AE (366)
CRF02_AG4,562CRF02_AG (3,977)CRF02_AG (3,542)CRF02_AG (537)
CRF03_AB16A (15)B (15)B (3)
CRF04_cpx18CRF04_cpx (14)CRF04_cpx (15)CRF04_cpx (4)
CRF05_DF21CRF05_DF (21)CRF05_DF (21)CRF05_DF (3)
CRF06_cpx762CRF06_cpx (604)CRF06_cpx (533)CRF06_cpx (111)
CRF07_BC420B (420)CRF07_BC (420)C (5)
CRF08_BC138C (137)CRF08_BC (138)C (4)
CRF09_cpx41CRF09_cpx (38)CRF09_cpx (39)CRF09_cpx (6)
CRF10_CD42D (41)CRF10_CD (41)CRF10_CD (4)
CRF11_cpx202CRF11_cpx (183)CRF11_cpx (160)CRF11_cpx (22)
CRF12_BF453F (440)CRF12_BF (438)F (29)
CRF13_cpx50CRF13_cpx (45)CRF13_cpx (39)CRF13_cpx (10)
CRF14_BG25G (22)G (24)G (5)
CRF16_A2D4A (4)A (4)A (1)
CRF17_BF1CRF17_BF (1)CRF17_BF (1)F (1)
CRF18_cpx53CRF18_cpx (51)CRF18_cpx (50)CRF18_cpx (6)
CRF19_cpx84D (83)D (83)CRF19_cpx (4)
CRF20_BG24CRF20_BG (24)CRF20_BG (24)G (3)
CRF21_A2D3D (3)CRF21_A2D (3)A (3)
CRF22_01A19A (2)A (1)A (7)
CRF23_BG11CRF23_BG (11)CRF23_BG (11)G (2)
CRF24_BG22CRF24_BG (22)CRF24_BG (22)G (3)
CRF25_cpx8F (6)B (6)B (7)
CRF26_AU10F (10)CRF29_BF (10)F (4)
CRF27_cpx4CRF27_cpx (4)CRF27_cpx (4)CRF27_cpx (3)
CRF28_BF2F (2)B (2)B (2)
CRF29_BF4F (4)CRF29_BF (4)F (4)
CRF30_02061CRF30_0206 (1)CRF30_0206 (0)CRF30_0206 (0)
CRF31_BC8C (8)CRF31_BC (8)C (0)
CRF33_01B14CRF33_01B (14)CRF33_01B (14)CRF01_AE (3)
CRF34_01B5B (5)CRF01_AE (5)CRF01_AE (3)
CRF35_AD10CRF35_AD (9)CRF35_AD (10)A (4)
CRF36_cpx2CRF36_cpx (2)CRF36_cpx (2)CRF36_cpx (2)
CRF37_cpx14G (12)CRF37_cpx (3)CRF37_cpx (4)
CRF38_BF14CRF38_BF1 (4)CRF38_BF1 (4)CRF38_BF1 (4)
CRF42_BF17CRF42_BF (17)CRF42_BF (17)CRF42_BF (17)
CRF43_02G6CRF43_02G (5)CRF43_02G (4)CRF43_02G (5)
CRF44_BF1CRF44_BF (1)CRF44_BF (1)CRF44_BF (1)
CRF45_cpx10CRF45_cpx (10)CRF45_cpx (10)CRF45_cpx (4)
CRF47_BF5CRF47_BF (5)CRF47_BF (5)CRF47_BF (2)
CRF49_cpx3CRF49_cpx (3)CRF49_cpx (3)CRF49_cpx (3)