<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Database Statistics

as of 4/2013

Genotype-Treatment
Number of individuals according to subtype and drug-class experienced1
Subtype 2proteaseRTintegrase
PI-NaivePI-TreatedRTI-NaiveRTI-TreatedINI-NaiveINI-Treated
B24,0139,21122,12124,0692,623150
A3,9611883,2148672641
C8,4134497,6843,5738161
D1,5452181,1835471246
F1,0291,4326785211782
G1,3192561,3131,1031281
CRF01_AE3,7821123,4242,1604821
CRF02_AG3,5051352,5899333712
Other1,1642251,593531193 
Total48,73112,22643,79934,3045,179164
1 Well-characterized treatment history is available for 71,282 individuals from whom 66,138 protease, 68,990 RT and 5,846 integrase isolates have been sequenced and published; "Mutation Prevalence According to Subtype and Treatment" page analyzes sequences obtained from the individuals for each subtype and summarizes the frequency of each mutation from treated individuals in comparison to the frequency of that mutation from untreated individuals.
2 "Other" subtypes include CRFs other than "CRF01_AE" and "CRF02_AG". Appendix II lists the CRFs available in HIVdb and how each CRF was mapped to a subtype for each gene for analysis.

Number of individuals according to regimen received
NRTI componentNNRTI component PI componentNRTI + PI or NNRTI regimen
AZT (2,110)
DDI (762)
D4T (743)
3TC (275)
ABC (222)
DDC (220)
TDF (35)
FTC (3)

AZT/3TC (4,364)
D4T/3TC (4,171)
DDI/D4T (1,667)
AZT/DDI (1,572)
AZT/DDC (807)
DDI/3TC (235)
3TC/TDF (196)
D4T/ABC (180)
3TC/ABC (163)
DDI/ABC (130)
AZT/D4T (86)
DDC/D4T (75)
DDI/TDF (72)
FTC/TDF (63)
AZT/ABC (60)
DDC/3TC (60)
D4T/TDF (30)
ABC/TDF (16)
DDI/DDC (12)
AZT/TDF (11)
DDC/ABC (9)
DDC/TDF (4)


AZT/3TC/ABC (538)
AZT/DDI/3TC (225)
D4T/3TC/ABC (125)
DDI/D4T/3TC (102)
DDI/D4T/ABC (89)
3TC/ABC/TDF (86)
AZT/DDC/3TC (72)
AZT/D4T/3TC (58)
DDI/3TC/TDF (46)
AZT/3TC/TDF (39)
D4T/3TC/TDF (31)
AZT/DDI/DDC (31)
DDI/3TC/ABC (24)
AZT/DDI/D4T (17)
DDI/ABC/TDF (16)
DDI/D4T/TDF (15)
AZT/DDI/ABC (11)
DDC/D4T/3TC (8)
DDI/FTC/TDF (7)
AZT/DDC/D4T (6)
DDI/DDC/3TC (3)
AZT/DDC/ABC (3)
DDI/DDC/D4T (2)
ABC/FTC/TDF (2)
D4T/FTC/TDF (2)
AZT/FTC/TDF (2)
DDC/D4T/ABC (2)
D4T/ABC/TDF (2)


AZT/DDI/D4T/3TC (31)
AZT/3TC/ABC/TDF (31)
DDI/3TC/ABC/TDF (13)
DDI/D4T/3TC/ABC (13)
AZT/DDI/3TC/ABC (7)
DDI/D4T/3TC/TDF (6)
AZT/DDC/D4T/3TC (6)
AZT/DDI/DDC/3TC (4)
D4T/3TC/ABC/TDF (4)
AZT/D4T/3TC/ABC (4)
AZT/DDI/3TC/TDF (4)
AZT/DDC/3TC/ABC (2)


AZT/DDI/DDC/D4T/3TC (7)
DDI/D4T/3TC/ABC/TDF (3)
AZT/DDI/D4T/3TC/ABC (2)

NVP (4,292)
EFV (2,921)
DLV (191)
ETR (11)
RPV (1)		NFV (2,339)
IDV (2,212)
SQV (935)
SQVr (745)
LPVr (654)
RTV (573)
IDVr (370)
APV (213)
APVr (122)
ATV (68)
ATVr (55)
DRVr (43)
TPVr (18)
FPVr (17)
FPV (6)
DRV (3)

NFV/SQV (212)
APV/LPVr (55)
IDV/SQV (51)
NFV/IDV (45)
NFV/RTV (27)
LPVr/SQV (20)
NFV/APV (14)
IDV/LPVr (13)
APV/SQV (12)
FPV/LPVr (8)
APV/IDV (7)
NFV/LPVr (4)
LPVr/ATV (3)
IDV/ATV (2)


NFV/RTV/SQV (19)
RTV/APV/SQV (16)
NFV/RTV/IDV (11)
RTV/IDV/SQV (11)
RTV/APV/LPVr (5)
NFV/IDV/SQV (5)
RTV/FPV/ATV (4)
RTV/APV/IDV (2)
RTV/APV/ATV (2)
RTV/IDV/LPVr (2)


NFV/RTV/IDV/SQV (4)

D4T/3TC/NVP (1,504)
AZT/3TC/IDV (950)
AZT/3TC/EFV (790)
D4T/3TC/EFV (743)
AZT/3TC/NVP (706)
D4T/3TC/IDV (692)
AZT/3TC/NFV (621)
D4T/3TC/NFV (620)
AZT/3TC/SQV (346)
DDI/D4T/NFV (343)
DDI/D4T/EFV (290)
DDI/D4T/NVP (219)
D4T/3TC/SQV (199)
AZT/3TC/RTV (191)
D4T/3TC/SQVr (169)
D4T/3TC/RTV (149)
DDI/D4T/IDV (138)
AZT/3TC/SQVr (123)
DDI/D4T/SQVr (120)
AZT/DDC/SQV (113)
D4T/NFV/NVP (104)
AZT/3TC/ABC/EFV (101)
AZT/3TC/LPVr (98)
AZT/3TC/IDVr (95)
D4T/3TC/LPVr (78)
D4T/3TC/IDVr (72)
DDI/D4T/NFV/EFV (69)
D4T/3TC/NFV/NVP (68)
AZT/DDI/NVP (68)
3TC/TDF/EFV (59)
AZT/DDI/NFV (58)
AZT/DDI/IDV (56)
3TC/TDF/NVP (53)
AZT/DDI/SQV (53)
DDI/D4T/SQV (51)
DDI/D4T/NFV/NVP (49)
3TC/TDF/LPVr (49)
D4T/SQVr (47)
AZT/3TC/NFV/EFV (47)
AZT/DDC/IDV (46)
DDI/D4T/RTV (45)
DDI/3TC/IDV (45)
DDI/D4T/LPVr (41)
DDI/D4T/IDVr (41)
AZT/DDI/EFV (39)
D4T/IDV (39)
AZT/DDI/RTV (39)
DDI/TDF/EFV (38)
DDI/NFV/NVP (36)
3TC/ABC/EFV (36)
AZT/3TC/NFV/NVP (35)
D4T/ABC/EFV (33)
D4T/3TC/NFV/SQV (33)
AZT/SQV (33)
DDI/3TC/NFV (33)
D4T/NFV (32)
DDI/3TC/EFV (31)
Genotype-Phenotype
Number of isolates according to phenotype method and drug resistance mutation1
Method2NRTINNRTIPIINI
WTMTTotalWTMTTotalWTMTTotalWTMTTotal
PhenoSense3521,2851,6378269091,7355381,1871,72570146216
Antivirogram1769511,1276399421,5812891,1391,4286847115
Others422082501001052056524731249127176
1 Phenotypic resistance test results are available for 10,507 isolates including 9,185 clinical isolates and 1,322 lab isolates; for each ARV drug class, the number of isolates are shown in WT (wildtype) and MT (mutants) isolates; WT genotypes are defined as lacking any of major drug resistance mutations (DRMs) listed here: PI-associated DRMs for PI, NRTI-associated for NRTI, NNRTI-associated for NNRTI and INI-associated DRMs for INI.
2 PhenoSense - Monogram, South San Francisco; Antivirogram - Virco, Belgium;
Appendixes: HIV-1 Group M virus
Number of virus samples according to geographical region and subtype
ContinentRegionsSubtypes
Africa
(n = 17,718)		South Africa (4,524), Cameroon (2,367), Uganda (2,289), Kenya (960), Nigeria (790), Zambia (660), Zimbabwe (621), Cote d'Ivoire (469), Botswana (418), Tanzania (390), Burkina Faso (385), Mali (377), Malawi (333), Ghana (294), Morocco (249), Angola (236), Mozambique (227), Senegal (222), DRC (217), Algeria (142), Ethiopia (134), Central African Republic (132), Benin (128), CAR (124), Burundi (123), Gabon (116), Niger (99), Guinea (91), Equatorial Guinea (86), Togo (81), Rwanda (81), Chad (79), Africa (49), Swaziland (47), Seychelles (42), Libya (36), Madagascar (31), Sudan (30), Zaire (12), Guinea-Bissau (7), Congo-Brazzaville (6), Dijibouti (4), Liberia (4), Somalia (3), Gambia (3)C (7,398), CRF02_AG (3,469), A1 (2,458), D (1,526), G (929), B (383), CRF06_cpx (332), A (210), CRF11_cpx (179), U (110), CRF01_AE (101), K (90), F2 (84), F1 (72), H (61), J (52), CRF13_cpx (38), CRF09_cpx (38), CRF10_CD (37), F (33), A2 (22), F1 (F2) (16), CRF37_cpx (14), CRF45_cpx (10), CRF26_AU (10), CRF18_cpx (9), CRF22_01A1 (9), CRF05_DF (5), CRF25_cpx (4), CRF49_cpx (3), CRF21_A2D (3), CRF27_cpx (3), CRF36_cpx (2), CRF16_A2D (2), CRF14_BG (2), CRF30_0206 (1), F1 (F) (1), A3 (1), CRF43_02G (1)
Asia
(n = 10,473)		Thailand (1,588), China (1,521), India (1,483), Taiwan (1,444), Vietnam (1,295), Japan (641), Korea (550), Cambodia (547), Singapore (366), Israel (317), Malaysia (221), Uzbekistan (154), Kazakhstan (93), Saudi Arabia (60), Iran (55), Republic Of Georgia (44), Lebanon (25), Yemen (19), Afghanistan (15), Indonesia (13), Myanmar (9), Turkey (7), Nepal (6)CRF01_AE (4,400), B (3,121), C (1,798), CRF07_BC (419), A1 (362), CRF08_BC (137), CRF02_AG (52), A (48), D (31), G (28), CRF33_01B (15), U (12), CRF35_AD (10), CRF06_cpx (10), CRF34_01B (5), F1 (5), CRF43_02G (5), CRF25_cpx (4), CRF03_AB (2), CRF12_BF (2), CRF10_CD (2), F (1), K (1), A2 (1), CRF18_cpx (1), H (1)
Europe
(n = 17,676)		Spain (2,837), France (2,463), Italy (1,911), Germany (1,373), Portugal (1,279), Ireland (868), U.K. (838), Sweden (754), Denmark (566), Romania (547), Russia (536), Belgium (473), Estonia (396), Greece (382), Europe (339), Switzerland (327), Luxembourg (311), Ukraine (190), Netherlands (131), Slovenia (126), Poland (121), Republic of Latvia (117), Cyprus (116), Austria (101), Norway (95), Bulgaria (81), Greenland (75), Serbia (68), Albania (66), Finland (60), Azerbaijan (41), Yugoslavia (33), Hungary (30), Slovakia (10), Belarus (9), Moldova (6)B (10,947), A1 (1,446), G (1,392), C (1,011), CRF02_AG (755), F1 (719), CRF06_cpx (410), CRF01_AE (293), D (257), K (57), U (57), A (47), CRF12_BF (34), F (28), H (27), CRF11_cpx (23), CRF14_BG (23), CRF04_cpx (18), J (18), CRF42_BF (17), CRF05_DF (15), CRF03_AB (14), F2 (13), A2 (12), CRF13_cpx (12), F1 (F) (8), CRF47_BF (5), CRF23_BG (4), CRF18_cpx (4), A1 (A2) (3), CRF09_cpx (2), CRF10_CD (2), F1 (F2) (1), CRF27_cpx (1), CRF19_cpx (1)
North America
(n = 39,144)		U.S. (35,440), Canada (2,517), Cuba (551), Honduras (336), Mexico (187), Trinidad (33), Barbados (27), Puerto Rico (25), Antigua (8), Saint Vincent (6), Saint Lucia (5), Grenada (4), Dominica (3), Montserrat (1), Panama (1)B (38,165), C (305), CRF02_AG (106), A1 (87), CRF19_cpx (83), CRF01_AE (76), D (73), G (56), CRF18_cpx (39), CRF20_BG (24), F1 (24), CRF24_BG (22), U (21), H (13), F (10), CRF06_cpx (8), CRF23_BG (7), A (7), CRF12_BF (6), K (5), J (2), F1 (F2) (1), F2 (1), CRF08_BC (1), CRF09_cpx (1), CRF10_CD (1)
Oceania
(n = 458)		Australia (458)B (448), D (3), K (3), A1 (2), A (1), CRF06_cpx (1)
South America
(n = 6,314)		Brazil (4,142), Argentina (1,286), Peru (376), Venezuela (281), Chile (162), Colombia (37), Uruguay (13), Guyana (6), Suriname (5), Ecuador (4), Bolivia (2)B (4,425), C (731), F1 (485), CRF12_BF (411), U (112), F (82), D (17), F1 (F) (13), CRF31_BC (8), CRF02_AG (7), CRF29_BF (4), CRF38_BF1 (4), A (3), A1 (2), CRF28_BF (2), CRF16_A2D (2), K (1), CRF05_DF (1), CRF44_BF (1), CRF07_BC (1), CRF17_BF (1), CRF06_cpx (1)

Mapping CRF subtypes from viruses to each genes
CRFsNo. virusesMapped subtype
proteaseRTintegrase
CRF01_AE4,889CRF01_AE (3,583)CRF01_AE (4,400)CRF01_AE (326)
CRF02_AG4,392CRF02_AG (3,805)CRF02_AG (3,373)CRF02_AG (537)
CRF03_AB16A (15)B (15)B (3)
CRF04_cpx18CRF04_cpx (14)CRF04_cpx (15)CRF04_cpx (4)
CRF05_DF21CRF05_DF (21)CRF05_DF (21)CRF05_DF (3)
CRF06_cpx762CRF06_cpx (604)CRF06_cpx (533)CRF06_cpx (111)
CRF07_BC420B (420)CRF07_BC (420)C (5)
CRF08_BC138C (137)CRF08_BC (138)C (4)
CRF09_cpx41CRF09_cpx (38)CRF09_cpx (39)CRF09_cpx (6)
CRF10_CD42D (41)CRF10_CD (41)CRF10_CD (4)
CRF11_cpx202CRF11_cpx (183)CRF11_cpx (160)CRF11_cpx (22)
CRF12_BF453F (440)CRF12_BF (438)F (29)
CRF13_cpx50CRF13_cpx (45)CRF13_cpx (39)CRF13_cpx (10)
CRF14_BG25G (22)G (24)G (5)
CRF16_A2D4A (4)A (4)A (1)
CRF17_BF1CRF17_BF (1)CRF17_BF (1)F (1)
CRF18_cpx53CRF18_cpx (51)CRF18_cpx (50)CRF18_cpx (6)
CRF19_cpx84D (83)D (83)CRF19_cpx (4)
CRF20_BG24CRF20_BG (24)CRF20_BG (24)G (3)
CRF21_A2D3D (3)CRF21_A2D (3)A (3)
CRF22_01A19A (2)A (1)A (7)
CRF23_BG11CRF23_BG (11)CRF23_BG (11)G (2)
CRF24_BG22CRF24_BG (22)CRF24_BG (22)G (3)
CRF25_cpx8F (6)B (6)B (7)
CRF26_AU10F (10)CRF29_BF (10)F (4)
CRF27_cpx4CRF27_cpx (4)CRF27_cpx (4)CRF27_cpx (3)
CRF28_BF2F (2)B (2)B (2)
CRF29_BF4F (4)CRF29_BF (4)F (4)
CRF30_02061CRF30_0206 (1)CRF30_0206 (0)CRF30_0206 (0)
CRF31_BC8C (8)CRF31_BC (8)C (0)
CRF33_01B15CRF33_01B (14)CRF33_01B (14)CRF01_AE (3)
CRF34_01B5B (5)CRF01_AE (5)CRF01_AE (3)
CRF35_AD10CRF35_AD (9)CRF35_AD (10)A (4)
CRF36_cpx2CRF36_cpx (2)CRF36_cpx (2)CRF36_cpx (2)
CRF37_cpx14G (12)CRF37_cpx (3)CRF37_cpx (4)
CRF38_BF14CRF38_BF1 (4)CRF38_BF1 (4)CRF38_BF1 (4)
CRF42_BF17CRF42_BF (17)CRF42_BF (17)CRF42_BF (17)
CRF43_02G6CRF43_02G (5)CRF43_02G (4)CRF43_02G (5)
CRF44_BF1CRF44_BF (1)CRF44_BF (1)CRF44_BF (1)
CRF45_cpx10CRF45_cpx (10)CRF45_cpx (10)CRF45_cpx (4)
CRF47_BF5CRF47_BF (5)CRF47_BF (5)CRF47_BF (2)
CRF49_cpx3CRF49_cpx (3)CRF49_cpx (3)CRF49_cpx (3)

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