Riddler SA, Haubrich R, DiRienzo AG, Peeples L, Powderly WG, Klingman KL, Garren KW, George T, Rooney JF, Brizz B, Lalloo UG, Murphy RL, Swindells S, Havlir D, Mellors JW; AIDS Clinical Trials Group Study A5142 Team. Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med. 2008 May 15;358(20):2095-106.

PR Data in HIVDB
RT Data in HIVDB

Nucleotide sequences in fasta format
ACTGA5142_PR_fasta.txt,   ACTGA5142_RT_fasta.txt
Composite alignment (of sequences at baseline)
ACTGA5142_PR_composite.html,   ACTGA5142_RT_composite.html
List of sequences with stop codon, ambiguity codon and unusual residues
ACTGA5142_PR_QA.txt,   ACTGA5142_RT_QA.txt

Method: Direct PCR, Dideoxy terminator sequencing
Sample: Plasma
Timing: Multiple timepoints

Integrated view of ARV, genotypes, RNA and CD4 on 190 patients

Downloadable data files

• Treatment history: ACTGA5142_RX.html (excel-frendly version ACTGA5142_RX.txt)
• Sequences :
  • ACTGA5142_PR.html (excel-frendly version ACTGA5142_PR.txt)
  • ACTGA5142_RT.html (excel-frendly version ACTGA5142_RT.txt)
• Outcomes:
  • ACTGA5142_RNA.html (excel-frendly version ACTGA5142_RNA.txt)
    
  • ACTGA5142_CD4.html (excel-frendly version ACTGA5142_CD4.txt)

Sixteen patients without RNA level provided where excluded from the data set. Changes are described in detail in ACTGA5142Dataset.txt.