Clinical Trial Datasets
ACTG 384 clinical trial (revised April 24, 2008)
References
Shafer RW, Smeaton LM, Robbins GK, De Gruttola V, Snyder SW, D'Aquila RT, Johnson VA, Morse GD,
Nokta MA, Martinez AI, Gripshover BM, Kaul P, Haubrich R, Swingle M, McCarty SD, Vella S, Hirsch MS,
Merigan TC; AIDS Clinical Trials Group 384 Team.
Comparison of four-drug regimens and pairs of sequential three-drug regimens as initial therapy for HIV-1 infection. N Engl J Med. 2003 Dec 11;349(24):2304-15.
Robbins GK, De Gruttola V, Shafer RW, Smeaton LM, Snyder SW, Pettinelli C, Dube MP, Fischl MA,
Pollard RB, Delapenha R, Gedeon L, van der Horst C, Murphy RL, Becker MI, D'Aquila RT, Vella S,
Merigan TC, Hirsch MS; AIDS Clinical Trials Group 384 Team.
Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection.
N Engl J Med. 2003 Dec 11;349(24):2293-303.Sequence Quality
22 RT sequences from 18 patients have been excluded from the viewable/downloadable datasets because of
quality issues. The excluded sequences are listed here:
excluded.html
excluded.txt
Sequences
Nucleotide sequences in fasta format
ACTG384_PR_fasta.txt, ACTG384_RT_fasta.txt Composite alignment (of sequences at baseline) ACTG384_PR_composite.html, ACTG384_RT_composite.html List of sequences with stop codon, ambiguity codon and unusual residues ACTG384_PR_QA.txt, ACTG384_RT_QA.txt Method: Direct PCR, Dideoxy terminator sequencing Sample: Plasma Timing: Multiple timepoints Revision Note
Previously, there was uncertain treatment
data on 63 patients. Treatment data on these 63 patients are now available. In addition, more complete
treatment history on many other patients were made available. Besides treatment history data, the
study arm assignments were made for the 63 patients and have changed for 12 other
patients. No other data has changed due to this revision.
Browse
Integrated view of ARV, genotypes, RNA and CD4 on
902 patients
Study Arms (based on first regimen) Arm A (Group 1) Arm B (Group 2) Arm C (Group 3) Arm D (Group 4) Arm E (Group 5) Arm F (Group 6) Patient-Study Arms: patient_arm_mapping.html excel-friendly version patient_arm_mapping.txt Dataset
The dataset includes data on the 839 patients for whom sequences and ARV histories are available
and the 63 patients for whom sequences are available but the ARV history is uncertain.
Both sets contain data on mutations, RNA levels and CD4 counts.
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