Kuritzkes DR, Marschner I, Johnson VA, Bassett R, Eron JJ, Fischl MA, Murphy RL, Fife K, Maenza J, Rosandich ME, Bell D, Wood K, Sommadossi JP, Pettinelli C. Lamivudine in Combination with Zidovudine, Stavudine, or Didanosine in Patients with HIV-1 Infection. A Randomized, Double-Blind, Placebo-Controlled Trial. AIDS. 1999 Apr 16;13(6):685-94.
Kuritzkes DR, Bassett RL, Hazelwood JD, Barrett H, Rhodes RA, Young RK, Johnson VA; Adult ACTG Protocol 306 370 Teams. Rate of Thymidine Analogue Resistance Mutation Accumulation with Zidovudine- or Stavudine-based Regimens. JAIDS. 2004 May 1;36(1):600-3.

PR Data in HIVDB
RT Data in HIVDB

Nucleotide sequences in fasta format
ACTG306_PR_fasta.txt,   ACTG306_RT_fasta.txt
Composite alignment (of sequences at baseline)
ACTG306_PR_composite.html,   ACTG306_RT_composite.html
List of sequences with stop codon, ambiguity codon and unusual residues
ACTG306_PR_QA.txt,   ACTG306_RT_QA.txt

Method: Direct PCR, Dideoxy terminator sequencing
Sample: Plasma
Timing: Multiple timepoints

Integrated view of ARV, genotypes, RNA and CD4 on 122 patients

Phylogenetic tree (RT) Phylogenetic tree (RT) from PAUP

The dataset includes data on 122 patients for whom sequences and ARV histories are available and contains data on mutations, RNA levels and CD4 counts.

• Treatment history: ACTG306_RX.html (excel-frendly version ACTG306_RX.txt)
• Sequences :
  • ACTG306_PR.html (excel-frendly version ACTG306_PR.txt)
  • ACTG306_RT.html (excel-frendly version ACTG306_RT.txt)
• Outcomes:
  • ACTG306_RNA.html (excel-frendly version ACTG306_RNA.txt)
    
  • ACTG306_CD4.html (excel-frendly version ACTG306_CD4.txt)