Albrecht MA, Hughes MD, Liou SH, Katzenstein DA, Murphy R, Balfour HH, Para MF, Valdez H, Hammer SM. AIDS Clinical Trials Group 302 Study Team. Effect of Lamivudine in HIV-Infected Persons with Prior Exposure to Zidovudine/Didanosine or Zidovudine/Zalcitabine. AIDS Res Hum Retroviruses. 2000 Sep 20;16(14):1337-44.

Nucleotide sequences in fasta format
ACTG303_PR_fasta.txt,   ACTG303_RT_fasta.txt
Composite alignment (of sequences at baseline)
ACTG303_PR_composite.html,   ACTG303_RT_composite.html
List of sequences with stop codon, ambiguity codon and unusual residues
ACTG303_PR_QA.txt,   ACTG303_RT_QA.txt

Method: Direct PCR, Dideoxy terminator sequencing
Sample: Plasma
Timing: Following study

Integrated view of ARV, genotypes, RNA and CD4 on 37 patients

The Microsoft Access database ACTG303Summary.mdb was created on 356 patients for whom sequences and ARV histories are available and contains tables with treatment, mutations, RNA levels and CD4 counts.

The files contained ACTG303Summary.mdb (the description of each file)

• Treatment history: ACTG303_RX.html (excel-frendly version ACTG303_RX.txt)
• Sequences :
  • ACTG303_PR.html (excel-frendly version ACTG303_PR.txt)
  • ACTG303_RT.html (excel-frendly version ACTG303_RT.txt)
• Outcomes:
  • ACTG303_RNA.html (excel-frendly version ACTG303_RNA.txt)
    
  • ACTG303_CD4.html (excel-frendly version ACTG303_CD4.txt)