Prevalence of NRTI DRMs in ARV-Naive Patients

Last updated on 2015-2-9

Major NRTI DRMs

K65R, D67d, T69i, K70R, L74I/V, Y115F, Q151M, M184I/V, T215F/Y

Table 5a. Prevalence of major NRTI DRMs in ARV-naive patients by region

Sub-Saharan Africa n=11628 87 with major DRMs			South/Southeast Asia n=6830 67 with major DRMs			Latin America n=5715 131 with major DRMs			Upper-income countries n=24898 782 with major DRMs
DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum
M184V	64.3	64.3	M184V	54.1	54.1	M184V	68.8	68.8	M184V	52.1	52.1
K70R	20.2	72.6	L74I	13.1	65.6	K70R	24.0	81.2	T215Y	31.4	72.1
Y115F	7.1	79.8	M184I	13.1	77.0	T215Y	24.0	91.7	K70R	24.4	87.5
K65R	7.1	86.9	K70R	13.1	86.9	M184I	5.2	94.8	K65R	5.3	91.2
M184I	6.0	92.9	K65R	13.1	95.1	T215F	12.5	97.9	T215F	10.8	94.1
L74I	4.8	95.2	Y115F	1.6	96.7	L74I	2.1	99.0	L74V	6.8	95.8
T215Y	19.0	97.6	L74V	4.9	98.4	K65R	2.1	100.0	M184I	3.5	97.4
L74V	6.0	98.8	T215F	6.6	100.0	L74V	3.1	-	Q151M	3.3	98.7
T215F	11.9	100.0	T215Y	13.1	-	Q151M	1.0	-	L74I	4.8	99.8
Q151M	0.0	-	Q151M	4.9	-	D67d	0.0	-	Y115F	2.9	100.0
D67d	0.0	-	D67d	0.0	-	T69i	0.0	-	D67d	0.0	-
T69i	0.0	-	T69i	0.0	-	Y115F	0.0	-	T69i	0.0	-

Footnotes:

The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients

Table 5b. Prevalence of major NRTI DRMs in ARV-naive patients by subtype

A n=3408 27 with major DRMs			B n=26882 275 with major DRMs			C n=7519 29 with major DRMs			D n=1295 19 with major DRMs			G n=1450 9 with major DRMs			01 n=5499 33 with major DRMs			02 n=2706 7 with major DRMs
DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum
M184V	67.5	67.5	M184V	53.7	53.7	M184V	60.4	60.4	M184V	79.2	79.2	M184V	60.0	60.0	M184V	61.1	61.1	M184V	50.0	50.0
T215F	15.0	100	T215Y	29.7	100	T215Y	18.8	100	T215Y	41.7	100	T215Y	20.0	100	K65R	13.0	100	K70R	28.6	100
T215Y	15.0	100	K70R	26.0	100	T215F	14.6	100	K70R	29.2	100	K65R	13.3	100	K70R	13.0	100	Y115F	28.6	100
K70R	12.5	100	T215F	10.5	100	K70R	10.4	100	Y115F	4.2	100	L74I	6.7	100	L74I	11.1	100	T215Y	14.3	100
K65R	7.5	100	L74V	6.4	100	M184I	10.4	100	T215F	8.3	-	M184I	6.7	100	T215Y	11.1	100	M184I	7.1	100
L74I	7.5	100	M184I	4.5	100	K65R	8.3	100	L74I	4.2	-	Y115F	6.7	100	M184I	5.6	100	L74I	14.3	-
M184I	7.5	100	K65R	4.3	100	L74V	6.2	100	D67d	0		K70R	13.3	-	T215F	5.6	100	L74V	7.1	-
L74V	2.5	100	L74I	4.3	100	L74I	4.2	100	K65R	0		T215F	13.3	-	L74V	3.7	100	T215F	7.1	-
Y115F	2.5	100	Q151M	3.3	100	Y115F	2.1	100	L74V	0		L74V	6.7	-	Q151M	3.7	-	D67d	0
D67d	0		Y115F	2.3	100	D67d	0		M184I	0		Q151M	6.7	-	D67d	0		K65R	0
Q151M	0		D67d	0		Q151M	0		Q151M	0		D67d	0		T69i	0		Q151M	0
T69i	0		T69i	0		T69i	0		T69i	0		T69i	0		Y115F	0		T69i	0

Footnotes:

The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients