Prevalence of NNRTI DRMs in ARV-Naive Patients

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Prevalence of NNRTI DRMs in ARV-Naive Patients

Last updated on 2015-2-9

Major NNRTI DRMs

L100I, K101P, K103N/S, V106A/M, Y181C/I/V, Y188C/H/L, G190A/E/Q/S, M230L

Table 6a. Prevalence of major NNRTI DRMs in ARV-naive patients by region

Sub-Saharan Africa n=11628 361 with major DRMs			South/Southeast Asia n=6830 146 with major DRMs			Latin America n=5715 225 with major DRMs			Upper-income countries n=24898 1089 with major DRMs
DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum
K103N	57.5	57.5	Y181C	41.4	41.4	K103N	63.0	63.0	K103N	67.0	67.0
Y181C	20.6	73.7	K103N	37.4	76.8	Y181C	17.3	77.2	Y181C	14.7	78.0
G190A	18.0	86.8	G190A	17.2	84.8	G190A	13.6	85.8	G190A	11.7	86.4
L100I	3.1	89.5	V106M	5.1	88.9	Y188L	6.2	91.4	Y188L	5.1	90.5
G190E	2.2	91.7	V106A	2.0	90.9	G190S	3.7	94.4	K103S	3.4	92.2
K103S	3.1	93.4	K103S	7.1	92.9	K103S	4.3	96.3	Y188H	1.6	93.6
Y188L	1.3	94.7	G190E	2.0	94.9	Y188C	1.2	97.5	Y188C	1.4	94.9
V106M	1.3	95.6	Y188L	2.0	97.0	M230L	4.9	98.8	V106A	1.6	96.0
V106A	0.9	96.5	M230L	1.0	98.0	V106M	1.2	99.4	V106M	1.1	97.0
Y188C	1.3	97.4	G190S	2.0	99.0	Y181V	0.6	100.0	G190S	1.3	97.8
Y181I	0.9	98.2	Y181I	1.0	100.0	L100I	1.2	-	G190E	0.8	98.7
Y188H	0.9	99.1	Y188C	1.0	-	K101P	1.2	-	M230L	0.8	99.2
M230L	0.4	99.6	L100I	0.0	-	V106A	0.6	-	Y181I	1.0	99.6
G190S	0.4	100.0	G190Q	0.0	-	Y188H	0.6	-	L100I	2.4	99.9
Y181V	0.9	-	K101P	0.0	-	G190Q	0.0	-	K101P	1.1	100.0
K101P	0.4	-	Y181V	0.0	-	G190E	0.0	-	Y181V	0.1	-
G190Q	0.0	-	Y188H	0.0	-	Y181I	0.0	-	G190Q	0.0	-

Footnotes:

The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients

Table 6b. Prevalence of major NNRTI DRMs in ARV-naive patients by subtype

A n=3408 39 with major DRMs			B n=26882 644 with major DRMs			C n=7519 72 with major DRMs			D n=1295 21 with major DRMs			G n=1450 11 with major DRMs			01 n=5499 35 with major DRMs			02 n=2706 28 with major DRMs
DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum	DRM	DRM%	DRM% Sum
K103N	53.4	53.4	K103N	67.8	67.8	K103N	53.3	53.3	K103N	45.7	45.7	K103N	52.4	52.4	Y181C	43.2	43.2	K103N	68.3	68.3
Y181C	28.8	100	Y181C	13.6	100	Y181C	23.7	100	G190A	28.3	100	Y181C	23.8	100	K103N	38.3	100	Y181C	22.0	100
G190A	9.6	100	G190A	11.4	100	G190A	17.8	100	Y181C	19.6	100	Y188L	19.0	100	G190A	17.3	100	G190A	14.6	100
Y181I	2.7	100	Y188L	5.4	100	V106M	5.9	100	L100I	6.5	100	G190A	9.5	100	G190E	3.7	100	G190E	4.9	100
Y181V	2.7	100	K103S	4.0	100	K103S	4.4	100	Y188H	4.3	100	Y188C	4.8	-	G190S	3.7	100	G190S	2.4	-
Y188C	2.7	100	L100I	2.3	100	Y181I	3.0	100	G190E	2.2	100	G190E	0		V106M	3.7	100	G190Q	0
G190E	1.4	100	G190S	1.8	100	L100I	1.5	100	K103S	2.2	-	G190Q	0		M230L	2.5	100	K101P	0
L100I	1.4	100	Y188H	1.7	100	Y188L	1.5	100	G190Q	0		G190S	0		Y188C	2.5	100	K103S	0
V106A	1.4	100	V106A	1.6	100	G190E	0.7	100	G190S	0		K101P	0		V106A	1.2	100	L100I	0
Y188L	1.4	100	M230L	1.2	100	G190S	0.7	100	K101P	0		K103S	0		Y181I	1.2	100	M230L	0
K101P	1.4	-	Y188C	1.2	100	Y188C	0.7	100	M230L	0		L100I	0		K103S	3.7	-	V106A	0
K103S	1.4	-	K101P	1.1	100	K101P	0.7	-	V106A	0		M230L	0		L100I	1.2	-	V106M	0
M230L	1.4	-	G190E	0.8	100	M230L	0.7	-	V106M	0		V106A	0		G190Q	0		Y181I	0
G190Q	0		V106M	0.7	100	G190Q	0		Y181I	0		V106M	0		K101P	0		Y181V	0
G190S	0		Y181I	0.5	100	V106A	0		Y181V	0		Y181I	0		Y181V	0		Y188C	0
V106M	0		Y181V	0.2	100	Y181V	0		Y188C	0		Y181V	0		Y188H	0		Y188H	0
Y188H	0		G190Q	0		Y188H	0		Y188L	0		Y188H	0		Y188L	0		Y188L	0

Footnotes:

The prevalence of all DRMs including those with lower scores can be queried using the form at the following page: Prevalence of DRMs in ARV-Naive Patients

Prevalence of NNRTI DRMs in ARV-Naive Patients

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