Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Summary of Sequences from Patients Receiving NRTI/NNRTI First-Line Regimens

Last updated on 2015-4-7

Number of patients receiving a firstline regimen with available RT sequences

4926

Table 7a. Number of patients with available RT sequences by regimen and subtype

RegimenNo. PtsNo. ReferencesABC0102DGFOthers
AZT/3TC/EFV
644
53
14.8
21.9
32.6
8.7
6.5
3.6
9.9
1.2
0.8
D4T/3TC/EFV
1318
44
2.1
6.0
86.7
2.4
0.9
0.3
0.6
0.3
0.6
TDF/3TC/EFV
251
16
2.0
15.9
72.9
0.4
4.0
0
4.4
0.4
0
TDF/FTC/EFV
349
11
6.0
39.3
20.9
8.6
5.2
2.0
15.5
1.4
1.1
ABC/3TC/EFV
113
9
5.3
13.3
75.2
0
2.7
0
3.5
0
0
AZT/3TC/NVP
673
54
17.8
8.9
25.0
10.1
13.7
9.1
11.9
0.7
2.8
D4T/3TC/NVP
1385
50
6.1
2.7
25.1
38.7
11.5
2.4
8.7
0.8
4.0
TDF/3TC/NVP
85
12
2.4
11.8
45.9
3.5
18.8
2.4
15.3
0
0
TDF/FTC/NVP
87
9
9.2
31.0
16.1
6.9
8.0
3.4
25.3
0
0
ABC/3TC/NVP
21
7
19.0
33.3
4.8
4.8
19.0
0
19.0
0
0
Total
4926
95
7.6
11.2
46.0
14.9
7.4
2.7
7.7
0.7
1.8

Table 7b. Proportion of patients with genotypic NRTI or NNRTI resistance associated with intermediate- or high-level resistance to one or more RTIs

RegimenNo. PtsRTI resistanceNRTI resistanceNNRTI resistance
NoYesNoYesNoYes
AZT/3TC/EFV
644
143
501
221
423
168
476
D4T/3TC/EFV
1318
191
1127
310
1008
220
1098
TDF/3TC/EFV
251
45
206
68
183
51
200
TDF/FTC/EFV
349
137
212
197
152
141
208
ABC/3TC/EFV
113
16
97
29
84
17
96
AZT/3TC/NVP
673
122
551
171
502
130
543
D4T/3TC/NVP
1385
153
1232
234
1151
173
1212
TDF/3TC/NVP
85
10
75
16
69
12
73
TDF/FTC/NVP
87
14
73
23
64
15
72
ABC/3TC/NVP
21
4
17
7
14
6
15
Total
4926
835
4091
1276
3650
933
3993

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