Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Prevalence of Major DRMs in Patients Starting an Initial Therapy and Failing on a Standard FirstLine Regimen

Last updated on 2014-12-29

Major DRMs

K65R, D67d, T69i, K70R, L74I/V, L100I, K101P, K103N/S, V106A/M, Y115F, Q151M, Y181C/I/V, M184I/V, Y188C/H/L, G190A/E/Q/S, T215F/Y, M230L

Table 14a. Prevalence of major RTI DRMs in patients starting an initial therapy
DRM% in ARV-Naive Pts
with Major DRMs
(1761 of 51220)		%Cumulative
K103N
50.0
50.0
M184V
21.9
65.6
Y181C
14.0
74.7
G190A
10.3
80.2
K70R
8.4
84.7
T215Y
9.8
87.9
Y188L
3.4
89.9
K103S
2.8
90.9
K65R
2.0
91.8
Y188C
1.1
92.7

Table 14b. Prevalence of major RTI DRMs in patients failing on first-line
DRM% in First-Line Pts
with Major DRMs
(3996 of 4926)		%Cumulative
M184V
81.6
81.6
K103N
47.3
91.3
Y181C
25.3
95.0
V106M
16.2
96.8
K65R
9.7
97.7
G190A
19.4
98.5
M184I
3.9
98.9
G190S
3.4
99.2
K70R
12.4
99.3
Y188L
5.5
99.5

    Footnotes:
  1. DRMs are ordered according to their incremental contribution to the %cumulative column.

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