Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Position	Cons	AA	FPV/r	IDV/r	NFV	SQV/r	LPV/r	ATV/r	TPV/r	DRV/r
10	L	F	10	10	10	0	5	0	0	5
10	L	I	0	0	0	0	0	0	0	0
10	L	R	0	0	0	0	0	0	0	0
10	L	V	0	0	0	0	0	0	0	0
10	L	Y	0	0	0	0	0	0	0	0
11	V	I	5	0	0	0	0	0	0	5
11	V	L	5	0	0	0	0	0	0	5
13	I	V	0	0	0	0	0	0	0	0
20	K	I	0	0	10	0	0	0	0	0
20	K	M	0	0	0	0	0	0	0	0
20	K	R	0	0	0	0	0	0	0	0
20	K	T	5	5	10	0	0	5	0	0
20	K	V	0	0	5	0	0	0	0	0
23	L	I	0	0	15	0	0	0	0	0
24	L	I	10	10	10	10	10	10	-5	0
24	L	F	5	5	5	5	5	5	0	0
24	L	M	5	5	5	5	5	5	0	0
30	D	N	0	0	60	0	0	0	0	0
32	V	I	30	15	15	0	15	15	5	15
33	L	F	10	0	5	0	5	5	10	5
33	L	V	0	0	0	0	0	0	0	0
33	L	I	0	0	0	0	0	0	0	0
35	E	G	0	0	5	0	0	0	5	0
36	M	I	0	0	0	0	0	0	0	0
36	M	L	0	0	0	0	0	0	0	0
36	M	V	0	0	0	0	0	0	0	0
36	M	T	0	0	0	0	0	0	0	0
43	K	T	0	0	0	0	0	0	10	0
46	M	I	10	10	20	5	10	10	5	0
46	M	L	10	10	20	5	10	10	10	0
46	M	V	10	10	20	5	5	10	5	0
47	I	V	30	15	15	0	15	5	30	10
47	I	A	60	15	30	0	60	5	30	10
48	G	V	0	10	30	60	10	30	0	0
48	G	M	0	10	30	60	10	30	0	0
48	G	A	0	10	30	60	10	10	0	0
48	G	S	0	10	30	60	10	10	0	0
48	G	T	0	10	30	60	10	10	0	0
48	G	Q	0	10	30	60	10	10	0	0
48	G	L	0	10	30	60	10	10	0	0
50	I	V	60	0	15	15	30	0	-5	20
50	I	L	-5	-5	-5	-5	-10	60	-5	-10
53	F	L	0	0	0	15	0	10	0	0
53	F	Y	0	0	0	0	0	0	0	0
54	I	L	60	10	20	15	15	15	-10	20
54	I	M	60	15	20	15	15	15	20	20
54	I	S	10	15	20	15	10	15	20	0
54	I	T	10	15	20	15	10	15	20	0
54	I	V	10	15	20	15	15	15	20	0
54	I	A	10	15	20	15	10	15	20	0
58	Q	E	0	0	5	0	0	5	15	0
63	L	P	0	0	0	0	0	0	0	0
71	A	T	0	0	0	0	0	0	0	0
71	A	V	0	0	0	0	0	0	0	0
71	A	I	5	0	5	5	0	5	0	0
71	A	L	5	0	5	5	0	5	0	0
73	G	C	5	10	15	15	5	10	0	0
73	G	S	5	10	15	15	5	10	0	0
73	G	T	5	10	15	15	5	10	0	0
73	G	A	5	10	15	15	5	10	0	0
73	G	V	5	5	5	5	5	5	0	0
74	T	P	10	10	15	10	5	10	20	5
74	T	S	0	0	15	0	0	0	0	0
76	L	V	60	30	0	-5	30	-5	-5	20
77	V	I	0	0	0	0	0	0	0	0
82	V	A	15	30	30	15	30	15	0	0
82	V	F	30	30	30	10	30	15	0	15
82	V	I	0	0	0	0	0	0	0	0
82	V	S	10	30	30	10	25	25	25	0
82	V	T	10	30	30	10	25	25	45	0
82	V	M	10	30	30	10	25	10	10	0
82	V	L	15	10	10	10	10	10	45	0
82	V	C	10	10	10	10	10	10	10	0
83	N	D	0	10	10	10	0	10	20	0
84	I	A	60	60	60	60	60	60	60	30
84	I	V	60	60	60	60	30	60	30	15
84	I	C	60	60	60	60	30	60	30	10
85	I	V	0	0	0	0	0	0	0	0
88	N	D	0	0	30	5	0	5	0	0
88	N	S	-10	15	60	15	0	60	0	-5
88	N	T	0	0	30	0	0	15	0	0
88	N	G	0	0	30	0	0	15	0	0
89	L	V	5	5	5	0	0	0	0	5
89	L	I	0	0	0	0	0	0	0	0
89	L	M	0	0	0	0	0	0	0	0
89	L	T	0	0	0	0	0	0	0	0
90	L	M	20	30	60	40	15	25	0	0
93	I	L	0	0	0	0	0	0	0	0

There are 46 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
ATV/r	46ILV+82ATSFMCL	10
ATV/r	46ILV+90M	10
ATV/r	53L+90M	10
ATV/r	54AVSTLM+82ATSFMCL	10
ATV/r	73STCA+90M	10
ATV/r	82ATSFMCL+90M	10
DRV/r	32I+47VA	5
DRV/r	32I+54ML	10
DRV/r	47VA+54ML	5
FPV/r	10F+82ATSLCM	10
FPV/r	32I+82ATSLCM	10
FPV/r	33F+82ATSLCM	10
FPV/r	46ILV+82ATSLCM	10
FPV/r	47V+82ATSLCM	10
FPV/r	54AVST+82ATSLCM	10
FPV/r	89V+82ATSLCM	10
IDV/r	24IFM+82ATSFMCL	10
IDV/r	32I+47VA	15
IDV/r	32I+54M	15
IDV/r	46IL+76V	10
IDV/r	46ILV+82ATSFMCL	10
IDV/r	46ILV+90M	10
IDV/r	47VA+54M	15
IDV/r	54AVSTLM+82ATSFMC	10
IDV/r	73STCA+90M	10
LPV/r	32I+47V	10
LPV/r	32I+54ML	10
LPV/r	46IL+76V	10
LPV/r	46ILV+82AFSTMC	5
LPV/r	47V+54ML	10
LPV/r	54VSTAML+82AFSTMC	10
LPV/r	82AFSTMC+24IFM	10
LPV/r	90M+82AFSTMC	5
LPV/r	90M+84V	5
NFV	46IL+76V	10
NFV	46ILV+82AFSTMC	10
NFV	54VSTAML+82AFSTMC	10
SQV/r	53L+90M	10
SQV/r	54AVSTLM+82ATSFMC	10
SQV/r	54AVSTLM+90M	5
SQV/r	73STCA+90M	10
SQV/r	82ATSFMC+90M	10
TPV/r	74P+47VA	10
TPV/r	74P+84VC	10
TPV/r	83D+47VA	10
TPV/r	83D+84VC	10