Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Position	Cons	AA	3TC	FTC	ABC	AZT	D4T	DDI	TDF
40	E	F	5	5	5	5	5	5	5
41	M	L	5	5	10	15	15	10	10
44	E	D	0	0	0	0	0	0	0
44	E	A	0	0	0	0	0	0	0
62	A	V	5	5	5	5	5	5	5
65	K	R	30	30	45	-15	45	60	60
65	K	N	15	15	25	-10	25	25	25
65	K	E	0	0	10	0	10	10	10
67	D	N	0	0	5	15	15	5	5
67	D	E	0	0	5	10	10	5	5
67	D	G	0	0	5	10	10	5	5
67	D	S	0	0	5	10	10	5	5
67	D	T	0	0	5	10	10	5	5
67	D	H	0	0	5	10	10	5	5
67	D	delete	15	15	30	30	30	30	30
69	T	insert	30	30	45	45	45	45	45
69	T	delete	15	15	15	0	15	15	15
69	T	D	0	0	0	0	10	30	0
69	T	N	0	0	0	5	5	10	0
69	T	G	0	0	10	0	10	10	5
70	K	R	0	0	10	30	15	10	10
70	K	G	10	10	15	-10	15	15	15
70	K	E	10	10	15	-10	15	15	15
70	K	T	10	10	10	0	10	10	10
70	K	S	10	10	10	0	10	10	10
70	K	N	10	10	10	0	10	10	10
70	K	Q	10	10	10	0	10	10	10
74	L	I	0	0	30	0	0	60	0
74	L	V	0	0	30	0	0	60	0
75	V	I	5	5	5	5	5	5	5
75	V	M	0	0	0	10	40	15	0
75	V	T	0	0	10	0	60	30	0
75	V	S	0	0	0	0	10	10	0
75	V	A	0	0	0	0	10	10	0
75	V	L	0	0	0	0	10	10	0
77	F	L	5	5	10	10	10	10	5
115	Y	F	0	0	45	0	0	0	15
116	F	Y	5	5	10	10	10	10	5
118	V	I	0	0	0	0	0	0	0
151	Q	L	10	10	30	30	30	30	10
151	Q	M	15	15	60	60	60	60	15
184	M	I	60	60	15	-10	-10	10	-10
184	M	V	60	60	15	-10	-10	10	-10
210	L	W	5	5	10	15	15	10	10
215	T	Y	5	5	15	45	45	15	15
215	T	F	5	5	15	45	45	15	15
215	T	C	0	0	10	20	20	10	5
215	T	D	0	0	10	20	20	10	5
215	T	E	0	0	10	20	20	10	5
215	T	I	0	0	10	20	20	10	5
215	T	V	0	0	10	20	20	10	5
215	T	S	0	0	10	20	20	10	5
215	T	N	0	0	10	20	20	10	5
215	T	A	0	0	10	20	20	10	5
215	T	L	0	0	10	20	20	10	5
219	K	Q	0	0	5	10	10	5	5
219	K	E	0	0	5	10	10	5	5
219	K	N	0	0	5	10	10	5	5
219	K	R	0	0	5	10	10	5	5
219	K	W	0	0	5	10	10	5	5
348	N	I	0	0	0	10	10	0	0

There are 74 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
3TC	118I+41L+215YF	5
3TC	40F+41L+215YF	5
3TC	44DA+118I	10
3TC	44DA+41L+215YF	5
3TC	67NG+70R+219QENR	10
ABC	118I+41L+215YF	5
ABC	184VI+74VI	15
ABC	210W+215FY	10
ABC	210W+215SCDEIVNAL	5
ABC	40F+41L+215YF	5
ABC	41L+210W	10
ABC	41L+215FY	10
ABC	41L+215SCDEIVNAL	5
ABC	44DA+118I	10
ABC	44DA+41L+215YF	5
ABC	67NG+70R+219QENR	10
AZT	118I+41L+215YF	5
AZT	151M+184VI	10
AZT	210W+215FY	10
AZT	210W+215SCDEIVNAL	5
AZT	40F+41L+215YF	5
AZT	41L+210W	10
AZT	41L+215FY	10
AZT	41L+215SCDEIVNAL	5
AZT	44DA+118I	10
AZT	44DA+41L+215YF	5
AZT	65R+151M	25
AZT	67NG+70R+219QENR	10
D4T	118I+41L+215YF	5
D4T	151M+184VI	10
D4T	210W+215FY	10
D4T	210W+215SCDEIVNAL	5
D4T	40F+41L+215YF	5
D4T	41L+210W	10
D4T	41L+215FY	10
D4T	41L+215SCDEIVNAL	5
D4T	44DA+118I	10
D4T	44DA+41L+215YF	5
D4T	65N+184VI	10
D4T	65R+184VI	10
D4T	67NG+70R+219QENR	10
D4T	70EGQ+184VI	10
DDI	118I+41L+215YF	5
DDI	210W+215FY	10
DDI	210W+215SCDEIVNAL	5
DDI	40F+41L+215YF	5
DDI	41L+210W	10
DDI	41L+215FY	10
DDI	41L+215SCDEIVNAL	5
DDI	44DA+118I	10
DDI	44DA+41L+215YF	5
DDI	67NG+70R+219QENR	10
FTC	118I+41L+215YF	5
FTC	40F+41L+215YF	5
FTC	44DA+118I	10
FTC	44DA+41L+215YF	5
FTC	67NG+70R+219QENR	10
TDF	115F+184VI	10
TDF	118I+41L+215YF	5
TDF	210W+215FY	10
TDF	210W+215SCDEIVNAL	5
TDF	40F+41L+215YF	5
TDF	41L+210W	10
TDF	41L+215FY	10
TDF	41L+215SCDEIVNAL	5
TDF	44DA+118I	10
TDF	44DA+41L+215YF	5
TDF	65N+184VI	10
TDF	65R+115F	15
TDF	65R+151M	15
TDF	65R+184VI	10
TDF	65R+62V	10
TDF	67NG+70R+219QENR	10
TDF	70EGQ+184VI	10