Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Position	Cons	AA	EFV	NVP	ETR	RPV
90	V	I	0	0	0	0
98	A	G	10	30	10	15
100	L	I	45	45	30	60
100	L	V	30	30	10	15
101	K	E	15	30	15	30
101	K	P	60	60	45	60
101	K	Q	0	0	0	0
101	K	H	15	15	10	10
101	K	N	0	0	0	0
103	K	N	60	60	0	0
103	K	R	0	0	0	0
103	K	S	45	60	0	0
103	K	T	15	60	0	0
103	K	Q	0	0	0	0
103	K	E	0	0	0	0
103	K	H	60	60	0	0
106	V	A	45	60	0	0
106	V	M	60	60	0	0
106	V	I	0	0	0	0
108	V	I	10	15	0	0
138	E	A	0	0	10	15
138	E	K	10	10	10	30
138	E	Q	10	10	10	15
138	E	G	10	10	10	15
138	E	R	10	10	10	15
179	V	D	10	10	10	10
179	V	E	10	10	10	10
179	V	T	10	10	10	10
179	V	L	10	10	10	15
179	V	I	0	0	0	0
179	V	F	10	15	15	15
181	Y	C	30	60	30	30
181	Y	I	30	60	60	60
181	Y	V	30	60	60	60
181	Y	S	15	60	15	15
181	Y	F	15	60	30	30
181	Y	G	15	60	30	30
188	Y	C	60	60	0	0
188	Y	H	30	60	0	0
188	Y	L	60	60	15	60
188	Y	F	60	30	0	30
190	G	A	45	60	15	15
190	G	S	60	60	15	15
190	G	E	60	60	45	45
190	G	Q	60	60	45	45
190	G	C	60	60	10	10
190	G	V	60	60	10	10
190	G	T	60	60	10	10
221	H	Y	10	10	10	10
225	P	H	30	30	0	0
227	F	C	30	30	30	30
227	F	L	15	30	0	0
230	M	L	45	60	30	45
230	M	I	15	30	15	30
234	L	I	0	0	0	0
236	P	L	0	0	0	0
238	K	T	30	60	0	0
238	K	N	10	10	0	0
318	Y	F	10	30	0	0
348	N	I	10	15	0	0

There are 10 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
EFV	103R+179DE	20
EFV	106A+227L	15
ETR	181C+179F	15
ETR	181C+190ASCVT	10
NVP	103R+179DE	20
RPV	101E+184I	20
RPV	103R+179D	15
RPV	138K+184I	30
RPV	181C+179F	15
RPV	181C+190ASCVT	10