Resistance Matrix

Resistance Mutation Comments

Resistance Mutation Scores

Position	Cons	AA	RAL	EVG	DTG
51	H	Y	15	15	10
66	T	I	15	60	0
66	T	A	15	60	0
66	T	K	60	60	10
68	L	V	0	0	0
74	L	M	10	10	5
92	E	Q	30	60	10
92	E	V	30	60	5
92	E	G	15	30	5
95	Q	K	10	10	0
97	T	A	15	10	5
114	H	Y	0	0	0
118	G	R	30	30	10
121	F	Y	30	30	5
128	A	T	0	0	0
138	E	K	15	15	10
138	E	A	15	15	10
138	E	D	0	0	0
140	G	S	30	30	10
140	G	A	30	30	10
140	G	C	30	30	10
143	Y	C	60	10	0
143	Y	R	60	10	0
143	Y	H	60	10	0
143	Y	K	60	10	0
143	Y	S	60	10	0
143	Y	G	60	10	0
143	Y	A	60	10	0
145	P	S	0	60	0
146	Q	P	0	60	0
147	S	G	0	60	0
148	Q	H	60	60	20
148	Q	K	60	60	20
148	Q	R	60	60	20
151	V	I	0	0	0
151	V	A	15	30	0
151	V	L	30	60	15
153	S	Y	0	15	10
153	S	F	0	10	10
155	N	H	60	60	10
155	N	S	30	30	0
155	N	T	30	30	0
157	E	Q	15	15	0
163	G	R	15	15	0
163	G	K	15	15	0
230	S	R	15	15	0
263	R	K	15	30	15

There are 9 combination rules below conditional on several mutations.
If triggered, their scores are added to the total score from the individual mutations above.

Drug Name	Combination Rule	Score
DTG	148HRK+138AK	25
DTG	148HRK+140SAC	25
DTG	148HRK+163RK	5
DTG	148HRK+74M	5
DTG	148HRK+97A	5
EVG	143CRSGA+163R	5
EVG	143CRSGA+230R	5
EVG	143CRSGA+74MI	5
EVG	143CRSGA+97A	5