Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

361 patterns of major drug resistance mutations (defined here) from 152595 clinical isolates obtained from 145378 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2018-9-28). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. Interquartile ranges are available by clicking here. Data on the 30 most common mutation patterns is also available in a PDF format.

Mutation PatternsNumber of
Sequences
NVP
foldn
EFV
foldn
ETR
foldn
RPV
foldn
DOR
foldn
None1143900.79120.69140.92461.11031.516
103N1270551222212320.9681.123311
181C3474200791.8895.5352.22048
103N,181C22232005731676.4193.3124.88
100I,103N19227162200688.13415168.49
188L15342004377501.9206.9111165
190A1484129368.5401131.161.83
181C,190A121020024582714132.6232
101E,190A909200980122.562.551.83
103N,190A796200212570.550.451.95
101E,181C,190A7852001986228.965.742.22
103N,181C,190A6602008200106.242.3232
106M61565610180.870.75512
103N,106M51720012001   
103N,230L51520011200113.8544 
190S43320015107190.5110.445.24
101E4325.2122.1132.582.1104.51
101E,190S386200820071.230.51 
103S,190A38520076080.330.421.21
106A381200144.8170.8513283
103N,188L3752009200133.8107061254
101P,103N35420015200153892005 
101E,181C,190S274200220039.63232181
106M,190A271     
101E,181C2462005451035.92 
190E237200820081103283 
181C,190S220200720076.51  
181I210200131.113187137 
181V17520052.175332035.12
101E,106M,190A1692001200111  
190Q15120062006   
101E,103N,190A149     
106M,188C140     
101E,103N132200120011.418.21 
103N,106A126200620060.420.61 
106A,190A11920016620.711.211061
106M,181C115     
101P,103S1142005200515712001 
103N,188H101200320030.21  
230L1012549.84211181 
103S983535.551.131.232.42
106M,188L92     
188C8219952460.530.310.31
101E,106M81     
101P,190A8120022002312001 
188L,190A80     
101P7417155055.26232 
106M,181C,190A72     
106M,230L71     
103S,106M70     
103N,190S68     
181C,230L68200310410828211111
181C,188L6620029622219.81 
103N,188C65     
101E,188L63200220021.11  
236L56210.530.620.622.82
100I532.641071.7100.861.53
106A,181C51     
188H503.615.620.310.212.81
101E,106M,181C,190A48     
101E,103N,181C,190A44     
100I,188L442002200211722001 
103N,181I41     
100I,103N,181C3920012001   
101E,190C38     
190A,230L35     
103T33     
103N,106M,181C33     
103N,106A,181C28     
103N,181C,230L272002200215022001 
190C2718521852   
100I,103N,230L26     
103N,181V25     
101E,181I25     
103S,181C,190A24     
103N,106M,230L24     
101E,103N,181C24     
100I,103N,190A22     
106A,181C,190A22     
101E,106M,181C21     
103N,106M,190A20     
103H,181C,190A20     
101P,188L20     
103N,106A,190A19     
103S,181C19     
103N,181C,188C18     
100I,103N,181I18     
106M,188H18     
101E,188L,190A17     
106M,188C,190A16     
100I,103N,181C,190A16     
103S,106M,190A16     
103N,181C,188L152001200115412001 
103N,236L14165151   
101E,181V14200122301  
101E,190V14     
101E,181I,190A13     
101E,190E13     
103N,181C,190S13     
100I,103S12211150016.51171 
103N,106M,188C12     
100I,101E,190A12     
181C,188C12     
106M,190A,230L12     
101E,181V,190A1120012001   
103N,106A,181C,190A10     
100I,230L10200120015.81921 
101E,106A,190A9     
103N,106M,181C,190A9     
103S,106A920015.810.7121 
101E,103N,190S9     
100I,103N,106M9     
101P,103S,190A8     
101E,106A8     
101E,103N,106M8     
101E,188H,190A8     
181C,188L,190A820022002   
190S,230L7     
100I,103N,188H7     
181C,236L7     
190V720022002   
101E,103N,188L7     
181I,190A7     
101E,181C,190A,230L7     
100I,101E,103N7     
101E,181C,230L71732232722911 
100I,181I6     
101E,103S,190A6200120011.513.41 
103N,181C,188H6     
188C,230L6     
188L,230L6     
101E,188C6     
103N,190E6     
100I,181C62002252282  
103N,188L,230L6     
106A,230L6     
101P,181C6     
181C,188H51441121441191 
103T,230L5     
101E,230L5     
101E,106M,190A,230L5     
181C,190C5     
190A,236L5     
188H,190S5     
103N,181V,190A5     
103N,188C,190A5     
101E,190A,230L5     
100I,190A5     
101E,181C,188L,190A5     
103S,190S5     
101P,190S5     
181C,190T5     
101E,181I,190S5     
103T,106A5     
103T,181C5     
101E,106A,181C,190A5     
101E,181C,188L5     
101P,103N,190A5     
101E,106M,181V,190A4     
103N,188C,230L4     
188C,190A4     
101E,190Q4     
100I,103N,188C4     
100I,181C,190A4     
103T,190A4     
188H,190A4     
188L,236L4     
103S,106M,230L4     
101E,106M,188C4     
103N,106M,188L4     
103N,181I,190A4     
103N,188H,190A4     
103N,190A,230L4     
101E,190S,230L320012001   
101E,181V,190S3     
101E,188H3     
101P,230L320012001   
100I,101E,190S3     
101P,103S,106M3     
100I,101E,181I,190A3     
106M,181C,230L3     
101E,190T3     
101P,106M3     
106M,181C,190S3     
103N,106M,188H3     
100I,101E,103N,190A3     
101E,103N,106M,190A3     
100I,101E3     
101E,103N,106A3     
106M,181C,188C3     
181V,190A3     
181I,188L3     
103S,181V320014.2120012001 
101E,190A,236L3     
181C,190V3     
100I,190S3     
100I,103N,188L3     
101E,103N,106A,190A3     
103S,106M,181C3     
181I,190E3     
100I,103N,106A3     
101E,181I,188L,190A3     
106A,181C,188C2     
101E,103N,181I2     
100I,190E2     
100I,188L,190A2     
103S,190A,236L2     
181V,188L2     
106M,181V2     
100I,181I,190A2     
181C,190A,230L22001471431  
100I,103S,190A2     
100I,101E,106M2     
103S,188H,190A220012001   
101E,106A,190V2     
100I,106M,181C2     
103N,106A,230L2     
181I,230L2     
101E,103H,190A2     
101E,188C,190A2     
100I,181C,188L2     
101E,106M,230L2     
106A,188C2     
190T220011501   
101E,103T2     
106A,190S2     
181V,230L2     
181I,190S2     
103S,106A,190A2     
101E,103H,181C,190A2     
101E,103N,106A,181C,190A2     
101P,188C2     
181C,190E2     
103N,188L,190A2     
181V,190S2     
100I,188H2     
101E,103N,236L2     
101E,106M,181C,190S2     
101P,103N,230L2     
106M,181C,188L2     
101E,106M,190A,236L2     
101E,106M,181V2