Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

NNRTI Mutation Pattern & Susceptibility

361 patterns of major drug resistance mutations (defined here) from 152595 clinical isolates obtained from 145378 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2018-9-28). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation PatternsNumber of
Sequences
NVPEFVETRRPVDOR
foldnQ1Q3foldnQ1Q3foldnQ1Q3foldnQ1Q3foldnQ1Q3
None1143900.79120.41.10.69140.410.92460.61.31.11030.71.91.516149
103N1270551222261282123210430.9680.51.31.1230.61.43111.25.5
181C347420079852001.88913.85.5353.8102.2201.85481.46
103N,181C222320057200200316713656.4193.4103.3122.6114.883.25.3
100I,103N1922716238129200682002008.1343.91215169.1488.494.515
188L1534200432002007750441711.9201.43.46.9114.4151165103149
190A148412936602008.5403.8201130.71.61.160.71.31.8313.6
181C,190A12102002420020058271220014134.1712.62  32  
101E,190A90920091912008012401202.561.83.42.551.231.830.83.3
103N,190A7962002  12571252000.550.41.10.450.411.951.22.8
101E,181C,190A785200192002008622462008.966.4155.743.6142.22  
103N,181C,190A6602008200200200101252006.243.38.42.32  32  
106M615656261141018842000.870.82.10.750.41.1512  
103N,106M5172001  2001           
103N,230L51520011200200200112002003.852.49.8443.24.9   
190S4332001513420010719472000.5110.40.90.440.30.65.2438.4
101E4325.2122.6102.1131.43.22.581.442.1101.43.24.51  
101E,190S386200820020020072002001.230.56.10.51     
103S,190A38520071712006086.81220.330.20.50.42  1.21  
106A381200142002004.8173.9660.850.71.11311.52837.1210
103N,188L3752009200200200131252003.8102.35.870630721254125125
101P,103N35420015200200200152002003892482200551200   
101E,181C,190S2742002  20031252009.638.662232  181  
106M,190A271               
101E,181C24620052002004531081033.22005.92     
190E237200820020020082002001103942002837.3200   
181C,190S220200720020020072002006.51        
181I210200131882001.1130.62.218714571371028   
181V17520052002002.1713.653340612039.4255.12  
101E,106M,190A1692001  2001  11        
190Q15120062002002006200200         
101E,103N,190A149               
106M,188C140               
101E,103N1322001  2001  1.41  8.21     
103N,106A12620062002002006682000.42  0.61     
106A,190A1192001  662  0.71  1.21  1061  
106M,181C115               
101P,103S114200520020020052002001571  2001     
103N,188H10120032002002003592000.21        
230L1012548.51209.84419211  181     
103S983535385.552.871.130.81.41.230.81.32.42  
106M,188L92               
188C8219953120024632000.530.21.30.31  0.31  
101E,106M81               
101P,190A812002  2002  31  2001     
188L,190A80               
101P74171590189505201305.264.46.6232     
106M,181C,190A72               
106M,230L71               
103S,106M70               
103N,190S68               
181C,230L6820032002001047.1191082  821  1111  
181C,188L662002  962  221  9.81     
103N,188C65               
101E,188L632002  2002  1.11        
236L5621  0.530.310.62  0.62  2.82  
100I532.641.7151076.8141.7101.32.90.860.611.530.62.7
106A,181C51               
188H503.61  5.62  0.31  0.21  2.81  
101E,106M,181C,190A48               
101E,103N,181C,190A44               
100I,188L442002  2002  1172  2001     
103N,181I41               
100I,103N,181C392001  2001           
101E,190C38               
190A,230L35               
103T33               
103N,106M,181C33               
103N,106A,181C28               
103N,181C,230L272002  2002  1502  2001     
190C271852  1852           
100I,103N,230L26               
103N,181V25               
101E,181I25               
103S,181C,190A24               
103N,106M,230L24               
101E,103N,181C24               
100I,103N,190A22               
106A,181C,190A22               
101E,106M,181C21               
103N,106M,190A20               
103H,181C,190A20               
101P,188L20               
103N,106A,190A19               
103S,181C19               
103N,181C,188C18               
100I,103N,181I18               
106M,188H18               
101E,188L,190A17               
106M,188C,190A16               
100I,103N,181C,190A16               
103S,106M,190A16               
103N,181C,188L152001  2001  1541  2001     
103N,236L141651  51           
101E,181V142001  22  301        
101E,190V14               
101E,181I,190A13               
101E,190E13               
103N,181C,190S13               
100I,103S12211  15001  6.51  171     
103N,106M,188C12               
100I,101E,190A12               
181C,188C12               
106M,190A,230L12               
101E,181V,190A112001  2001           
103N,106A,181C,190A10               
100I,230L102001  2001  5.81  921     
101E,106A,190A9               
103N,106M,181C,190A9               
103S,106A92001  5.81  0.71  21     
101E,103N,190S9               
100I,103N,106M9               
101P,103S,190A8               
101E,106A8               
101E,103N,106M8               
101E,188H,190A8               
181C,188L,190A82002  2002           
190S,230L7               
100I,103N,188H7               
181C,236L7               
190V72002  2002           
101E,103N,188L7               
181I,190A7               
101E,181C,190A,230L7               
100I,101E,103N7               
101E,181C,230L71732  232  722  911     
100I,181I6               
101E,103S,190A62001  2001  1.51  3.41     
103N,181C,188H6               
188C,230L6               
188L,230L6               
101E,188C6               
103N,190E6               
100I,181C62002  252  282        
103N,188L,230L6               
106A,230L6               
101P,181C6               
181C,188H51441  121  441  191     
103T,230L5               
101E,230L5               
101E,106M,190A,230L5               
181C,190C5               
190A,236L5               
188H,190S5               
103N,181V,190A5               
103N,188C,190A5               
101E,190A,230L5               
100I,190A5               
101E,181C,188L,190A5               
103S,190S5               
101P,190S5               
181C,190T5               
101E,181I,190S5               
103T,106A5               
103T,181C5               
101E,106A,181C,190A5               
101E,181C,188L5               
101P,103N,190A5               
101E,106M,181V,190A4               
103N,188C,230L4               
188C,190A4               
101E,190Q4               
100I,103N,188C4               
100I,181C,190A4               
103T,190A4               
188H,190A4               
188L,236L4               
103S,106M,230L4               
101E,106M,188C4               
103N,106M,188L4               
103N,181I,190A4               
103N,188H,190A4               
103N,190A,230L4               
101E,190S,230L32001  2001           
101E,181V,190S3               
101E,188H3               
101P,230L32001  2001           
100I,101E,190S3               
101P,103S,106M3               
100I,101E,181I,190A3               
106M,181C,230L3               
101E,190T3               
101P,106M3               
106M,181C,190S3               
103N,106M,188H3               
100I,101E,103N,190A3               
101E,103N,106M,190A3               
100I,101E3               
101E,103N,106A3               
106M,181C,188C3               
181V,190A3               
181I,188L3               
103S,181V32001  4.21  2001  2001     
101E,190A,236L3               
181C,190V3               
100I,190S3               
100I,103N,188L3               
101E,103N,106A,190A3               
103S,106M,181C3               
181I,190E3               
100I,103N,106A3               
101E,181I,188L,190A3               
106A,181C,188C2               
101E,103N,181I2               
100I,190E2               
100I,188L,190A2               
103S,190A,236L2               
181V,188L2               
106M,181V2               
100I,181I,190A2               
181C,190A,230L22001  471  431        
100I,103S,190A2               
100I,101E,106M2               
103S,188H,190A22001  2001           
101E,106A,190V2               
100I,106M,181C2               
103N,106A,230L2               
181I,230L2               
101E,103H,190A2               
101E,188C,190A2               
100I,181C,188L2               
101E,106M,230L2               
106A,188C2               
190T22001  1501           
101E,103T2               
106A,190S2               
181V,230L2               
181I,190S2               
103S,106A,190A2               
101E,103H,181C,190A2               
101E,103N,106A,181C,190A2               
101P,188C2               
181C,190E2               
103N,188L,190A2               
181V,190S2               
100I,188H2               
101E,103N,236L2               
101E,106M,181C,190S2               
101P,103N,230L2               
106M,181C,188L2               
101E,106M,190A,236L2               
101E,106M,181V2