HIV Drug Resistance Database

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INI Mutation Pattern & Susceptibility

94 patterns of major drug resistance mutations (defined here) from 20458 clinical isolates obtained from 19740 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2018-9-28). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation Patterns	Number of Sequences	RAL			EVG			DTG
Mutation Patterns	Number of Sequences	fold_n	Q1	Q3	fold_n	Q1	Q3	fold_n	Q1	Q3
None	19312	1₆₂₀	0.9	1.2	1.4₆₁₆	1.1	1.9	0.9₁₁₀	0.7	1.1
155H	303	18₃₂	12	32	45₂₇	30	67	1.7₁₅	1.3	2
140S,148H	241	143₃₀	136	147	150₂₂	150	150	4.1₂₉	2.5	13
143R	89	79₂₂	22	150	6.2₁₈	2.9	29	1.2₈	1	1.4
92Q	43	4.5₂₂	3.8	6	40₂₁	31	56	1.4₇	1.3	1.7
143C	39	15₂₀	5.5	91	3.5₁₈	1.9	25	1₇	0.8	1.5
138K	38	0.8₆	0.8	0.9	0.8₆	0.7	1	0.8₄	0.8	0.8
263K	29	1.1₉	1	1.6	4.6₉	2.8	34	2₈	1.8	3.8
92Q,155H	27	139₈	93	147	150₅	110	158	3₄	2.1	3.8
140S,148R	25	143₅	115	175	150₂			6.2₃	4	17
138A,140S,148H	24	143₁			150₁			10₁
148R	22	30₁₀	29	34	92₇	81	118	1₄	0.7	1.1
138K,140S,148H	21	143₃	143	143	150₃	141	150	9.2₄	4.5	13
66I	18	0.9₇	0.8	1.4	15₇	9.7	30	0.4₄	0.3	0.5
138K,148R	13	65₄	53	77	132₂			2₃	1.7	2.1
138K,147G,148R	13	34₂			165₂
66A	12	0.9₂			7.6₂			0.3₂
140A,148R	12	116₄	83	147	150₃	114	150	2.8₃	2.2	8.8
143C,155H	10
147G	9	1.1₇	1	2.5	8₈	4.1	14	1₃	1	1.1
143H	8	5.5₁₄	2.7	13	2.5₁₄	1.8	4.4	0.9₂
138A	7	1.1₁			1.3₁			0.9₁
140S,148H,155H	6
121Y	6	9.4₆	5.3	14	27₆	16	74	1.1₅	0.6	1.4
138K,140C,148R	5	143₁			150₁			8.6₁
140S	5	1.4₅	0.6	1.8	4.2₅	3.5	5	0.6₃	0.5	0.8
92Q,140S,148K,155H	5
118R	4	13₇	6.2	20	6₇	4.9	8.6	10₆	8.2	16
140S,143H,148H	4
148H	4	19₈	17	20	5.3₅	4.9	6	0.4₄	0.4	0.6
143H,155H	4
145S	4	0.7₁			28₁			0.3₁
138K,140A,148K	4	143₁			150₁			63₁
138A,140A,148R	4
140C,148R	3	86₂			174₂			9.1₁
143R,155H	3
138K,140S,148R	3
148R,155H	3	102₃	99	103	114₃	94	229	4.3₂
66I,92Q,155H	3
138K,148R,263K	3
138K,147G,155H	3	150₃	150	150	150₃	150	150	55₃	37	64
92Q,143R	2
138K,140A,148R,155H	2
146P	2	0.8₁			6.5₁			0.5₁
92Q,143H	2
66A,155H	2
138K,148R,155H	2
66I,92Q	2	23₂			120₂			0.6₁
140S,148K,155H	2
92Q,140S,148R,155H	2
138A,140S,143H,148H	2
155S	2
147G,263K	2	2.2₂			4.8₂			6.3₂
140S,147G,148K	2
66A,92Q	2

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