Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

INI Mutation Pattern & Susceptibility

94 patterns of major drug resistance mutations (defined here) from 20458 clinical isolates obtained from 19740 persons infected with HIV-1 Group M virus are arranged in decreasing prevalence in the table (updated on 2018-9-28). Sequences containing a mixture at one of the major drug resistance positions were excluded from the table. For each pattern, drug susceptibility data on isolates matching the specific mutation pattern is shown on the left side. The analysis was originally published in Rhee et al. 2004.

The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug.The number of sequences with each pattern is indicated, as well as the median fold resistance, as assayed by the ViroLogic PhenoSense assay, to each of several individual members of the selected drug class. Subscripts indicate the number of sequences assayed for resistance to the designated drug. The Q1 and Q3 indicate the first and third quartile.

Mutation PatternsNumber of
Sequences
RALEVGDTG
foldnQ1Q3foldnQ1Q3foldnQ1Q3
None1931216200.91.21.46161.11.90.91100.71.1
155H30318321232452730671.7151.32
140S,148H24114330136147150221501504.1292.513
143R897922221506.2182.9291.2811.4
92Q434.5223.86402131561.471.31.7
143C3915205.5913.5181.925170.81.5
138K380.860.80.90.860.710.840.80.8
263K291.1911.64.692.834281.83.8
92Q,155H271398931471505110158342.13.8
140S,148R2514351151751502  6.23417
138A,140S,148H241431  1501  101  
148R223010293492781118140.71.1
138K,140S,148H21143314314315031411509.244.513
66I180.970.81.41579.7300.440.30.5
138K,148R1365453771322  231.72.1
138K,147G,148R13342  1652     
66A120.92  7.62  0.32  
140A,148R1211648314715031141502.832.28.8
143C,155H10         
147G91.1712.5884.1141311.1
143H85.5142.7132.5141.84.40.92  
138A71.11  1.31  0.91  
140S,148H,155H6         
121Y69.465.31427616741.150.61.4
138K,140C,148R51431  1501  8.61  
140S51.450.61.84.253.550.630.50.8
92Q,140S,148K,155H5         
118R41376.220674.98.61068.216
140S,143H,148H4         
148H419817205.354.960.440.40.6
143H,155H4         
145S40.71  281  0.31  
138K,140A,148K41431  1501  631  
138A,140A,148R4         
140C,148R3862  1742  9.11  
143R,155H3         
138K,140S,148R3         
148R,155H31023991031143942294.32  
66I,92Q,155H3         
138K,148R,263K3         
138K,147G,155H3150315015015031501505533764
92Q,143R2         
138K,140A,148R,155H2         
146P20.81  6.51  0.51  
92Q,143H2         
66A,155H2         
138K,148R,155H2         
66I,92Q2232  1202  0.61  
140S,148K,155H2         
92Q,140S,148R,155H2         
138A,140S,143H,148H2         
155S2         
147G,263K22.22  4.82  6.32  
140S,147G,148K2         
66A,92Q2