Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Clinical Trial Datasets

ACTG 5208 clinical trial
Lockman S, Hughes MD, McIntyre J, Zheng Y, Chipato T, Conradie F, Sawe F, Asmelash A, Hosseinipour MC, Mohapi L, Stringer E, Mngqibisa R, Siika A, Atwine D, Hakim J, Shaffer D, Kanyama C, Wools-Kaloustian K, Salata RA, Hogg E, Alston-Smith B, Walawander A, Purcelle-Smith E, Eshleman S, Rooney J, Rahim S, Mellors JW, Schooley RT, Currier JS; OCTANE A5208 Study Team. Antiretroviral therapies in women after single-dose nevirapine exposure. N Engl J Med. 2010 Oct 14;363(16):1499-509
Lockman S, Hughes M, Sawe F, Zheng Y, McIntyre J, Chipato T, Asmelash A, Rassool M, Kimaiyo S, Shaffer D, Hosseinipour M, Mohapi L, Ssali F, Chibowa M, Amod F, Halvas E, Hogg E, Alston-Smith B, Smith L, Schooley R, Mellors J, Currier J; OCTANE (Optimal Combination Therapy After Nevirapine Exposure) ACTG A5208/OCTANE Study Team. Nevirapine- versus lopinavir/ritonavir-based initial therapy for HIV-1 infection among women in Africa: a randomized trial. PLoS Med. 2012;9(6):e1001236
PR Data in HIVDB
RT Data in HIVDB
Nucleotide sequences in fasta format
ACTG5208_PR_fasta.txt,   ACTG5208_RT_fasta.txt
Composite alignment (of sequences at baseline)
ACTG5208_PR_composite.html,   ACTG5208_RT_composite.html
List of sequences with stop codon, ambiguity codon and unusual residues
ACTG5208_PR_QA.txt,   ACTG5208_RT_QA.txt

Method: Direct PCR, Dideoxy terminator sequencing
Sample: Plasma
Timing: Multiple timepoints

Integrated view of ARV, genotypes, RNA and CD4 on 415 patients
Downloadable data files