Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Clinical Trial Datasets

ACTG 320 clinical trial
Hammer SM, Squires KE, Hughes MD, Grimes JM, Demeter LM, Currier JS, Eron JJ Jr, Feinberg JE, Balfour HH Jr, Deyton LR, Chodakewitz JA, Fischl MA.AIDS Clinical Trials Group 320 Study Team. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N Engl J Med. 1997 Sep 11;337(11):725-33.
Demeter LM, Hughes MD, Coombs RW, Jackson JB, Grimes JM, Bosch RJ, Fiscus SA, Spector SA, Squires KE, Fischl MA, Hammer SM.Predictors of virologic and clinical outcomes in HIV-1-infected patients receiving concurrent treatment with indinavir, zidovudine, and lamivudine. AIDS Clinical Trials Group Protocol 320. Ann Intern Med. 2001 Dec 4;135(11):954-64.
Nucleotide sequences in fasta format
ACTG320_PR_fasta.txt,   ACTG320_RT_fasta.txt
Composite alignment (of sequences at baseline)
ACTG320_PR_composite.html,   ACTG320_RT_composite.html
List of sequences with stop codon, ambiguity codon and unusual residues
ACTG320_PR_QA.txt,   ACTG320_RT_QA.txt

Method: Direct PCR, Dideoxy terminator sequencing
Sample: Plasma
Timing: Following study

Integrated view of ARV, genotypes, RNA and CD4 on 356 patients
Complete Dataset
The Microsoft Access database ACTG320Summary.mdb was created on 356 patients for whom sequences and ARV histories are available and contains tables with treatment, mutations, RNA levels and CD4 counts. (Note: for some of these patients, the treatment history indicate that they had placebos and this is how the placebos were handled.)

The files contained ACTG320Summary.mdb (the description of each file)