Protease Treatment Profile
Enter number and name of antiretroviral drugs to retrieve a summary of mutation frequencies in treated viruses. Comparing the frequency of mutation at a specific position between the designated isolates and a user-selected reference profile of treated or untreated virus allows the user to assess whether a mutation is truly correlated with treatment or if it can be accounted for by natural sequence variation.
Selecting only one drug will allow the user to assess the effect of that drug alone; selecting no drugs will show the natural variation found in the user-specified subtype. 1-9 will return mutation frequencies for isolates exposed to any drug or drug combination, and 0-9 will calculate mutation frequencies using both treated and untreated isolates.
Mutation frequencies greater than the reference sequence at any position may correlate with particular treatments. User may specify viral subtype and exclude infrequent or single mutations.
To retrieve summary protease mutation data according to treatment and subtype