<!--#set var="title" value="Database Statistics" --> <!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Database Statistics

As of 2020-02-11

Genotype-Treatment
Number of individuals according to subtype and drug-class experienced1
Subtype 2proteaseRTintegrase
PI-NaivePI-TreatedRTI-NaiveRTI-TreatedINI-NaiveINI-Treated
B51,80320,05645,77736,8279,7041,414
A8,3061,5327,3025,5911,55643
C22,5343,48515,86721,1713,48573
D2,5933892,0141,81450728
F1,6531,5661,50491228619
G3,5234011,5493,11825810
CRF01_AE16,34670814,6256,3292,1643
CRF02_AG8,1123805,6984,8611,09751
Other4,9282,1778,5713,61269516
Total119,79830,694102,90784,23519,7521,657
1 Well-characterized treatment history is available for 182,800 individuals from whom 159,149 protease, 168,508 RT and 22,477 integrase isolates have been sequenced and published; "Mutation Prevalence According to Subtype and Treatment" page analyzes sequences obtained from the individuals for each subtype and summarizes the frequency of each mutation from treated individuals in comparison to the frequency of that mutation from untreated individuals.
2 "Other" subtypes include CRFs other than "CRF01_AE" and "CRF02_AG". Appendix II lists the CRFs available in HIVdb and how each CRF was mapped to a subtype for each gene for analysis.

Number of individuals according to regimen received
NRTI componentNNRTI component PI componentNRTI + PI or NNRTI regimen
AZT (2,145)
DDI (778)
D4T (747)
3TC (292)
ABC (229)
DDC (220)
TDF (54)
FTC (4)

D4T/3TC (6,870)
AZT/3TC (6,606)
3TC/TDF (3,313)
FTC/TDF (2,022)
AZT/DDI (1,889)
DDI/D4T (1,721)
3TC/ABC (990)
AZT/DDC (813)
DDI/3TC (288)
D4T/ABC (196)
DDI/ABC (155)
DDI/FTC (100)
AZT/ABC (90)
DDI/TDF (89)
AZT/D4T (87)
DDC/D4T (75)
DDC/3TC (61)
AZT/TDF (39)
D4T/TDF (36)
ABC/TDF (26)
DDI/DDC (12)
3TC/FTC (11)
DDC/ABC (10)
D4T/FTC (5)
DDC/TDF (5)
AZT/FTC (2)


AZT/3TC/ABC (586)
AZT/DDI/3TC (308)
AZT/D4T/3TC (143)
D4T/3TC/ABC (131)
AZT/3TC/TDF (125)
DDI/D4T/3TC (114)
3TC/ABC/TDF (99)
DDI/D4T/ABC (91)
AZT/DDC/3TC (73)
DDI/3TC/TDF (51)
D4T/3TC/TDF (41)
AZT/DDI/DDC (31)
DDI/3TC/ABC (29)
AZT/FTC/TDF (23)
AZT/DDI/D4T (18)
DDI/ABC/TDF (17)
DDI/D4T/TDF (17)
DDI/FTC/TDF (12)
AZT/DDI/ABC (11)
DDC/D4T/3TC (9)
AZT/DDC/D4T (6)
D4T/FTC/TDF (6)
AZT/DDI/TDF (3)
AZT/DDC/ABC (3)
ABC/FTC/TDF (3)
D4T/ABC/TDF (3)
DDI/DDC/3TC (3)
AZT/ABC/TDF (2)
DDI/DDC/D4T (2)
3TC/FTC/TDF (2)
DDC/D4T/ABC (2)


AZT/3TC/ABC/TDF (33)
AZT/DDI/D4T/3TC (31)
DDI/D4T/3TC/ABC (14)
DDI/3TC/ABC/TDF (13)
AZT/DDI/3TC/ABC (7)
AZT/DDC/D4T/3TC (6)
DDI/D4T/3TC/TDF (6)
AZT/D4T/3TC/ABC (5)
D4T/3TC/ABC/TDF (4)
AZT/DDI/DDC/3TC (4)
AZT/DDI/3TC/TDF (4)
3TC/ABC/FTC/TDF (3)
AZT/DDC/3TC/ABC (2)


AZT/DDI/DDC/D4T/3TC (7)
DDI/D4T/3TC/ABC/TDF (4)
AZT/DDI/D4T/3TC/ABC (2)

EFV (8,962)
NVP (6,685)
DLV (193)
ETR (59)
RPV (25)		LPVr (2,676)
NFV (2,375)
IDV (2,280)
SQV (939)
SQVr (758)
RTV (622)
ATVr (438)
IDVr (377)
ATV (249)
APV (231)
DRVr (223)
APVr (149)
DRV (31)
TPVr (20)

NFV/SQV (212)
APV/LPVr (65)
IDV/SQV (51)
NFV/IDV (47)
LPVr/SQV (29)
NFV/RTV (28)
IDV/LPVr (15)
NFV/APV (14)
APV/SQV (13)
LPVr/ATV (8)
NFV/LPVr (8)
APV/IDV (7)
LPVr/TPV (2)
ATV/DRV (2)
IDV/ATV (2)


RTV/APV/SQV (19)
NFV/RTV/SQV (19)
RTV/IDV/SQV (12)
NFV/RTV/IDV (11)
RTV/LPVr/SQV (6)
RTV/APV/LPVr (5)
NFV/IDV/SQV (5)
RTV/APV/ATV (4)
RTV/APV/IDV (2)
RTV/IDV/LPVr (2)


NFV/RTV/IDV/SQV (5)

D4T/3TC/EFV (2,484)
3TC/TDF/EFV (2,185)
D4T/3TC/NVP (2,124)
AZT/3TC/NVP (1,574)
AZT/3TC/EFV (1,573)
FTC/TDF/EFV (1,191)
AZT/3TC/IDV (1,003)
D4T/3TC/IDV (703)
3TC/TDF/NVP (672)
AZT/3TC/NFV (645)
D4T/3TC/NFV (624)
AZT/3TC/LPVr (586)
D4T/3TC/LPVr (468)
3TC/ABC/EFV (444)
AZT/3TC/SQV (350)
DDI/D4T/NFV (346)
3TC/TDF/LPVr (306)
DDI/D4T/EFV (298)
3TC/ABC/LPVr (264)
FTC/TDF/NVP (244)
DDI/D4T/NVP (223)
AZT/DDI/LPVr (220)
D4T/3TC/SQV (199)
AZT/3TC/RTV (193)
FTC/TDF/ATVr (181)
D4T/3TC/RTV (174)
D4T/3TC/SQVr (173)
DDI/D4T/IDV (140)
AZT/DDI/NVP (137)
FTC/TDF/LPVr (127)
AZT/3TC/SQVr (126)
FTC/TDF/DRVr (123)
DDI/D4T/SQVr (121)
AZT/DDC/SQV (114)
AZT/3TC/ABC/EFV (104)
D4T/NFV/NVP (104)
AZT/3TC/IDVr (98)
3TC/ABC/ATVr (96)
DDI/FTC/ATV (96)
3TC/TDF/ATVr (91)
AZT/D4T/3TC/NVP/EFV (78)
D4T/3TC/IDVr (74)
DDI/D4T/LPVr (70)
D4T/3TC/NFV/NVP (69)
DDI/D4T/NFV/EFV (69)
AZT/DDI/EFV (67)
AZT/DDI/NFV (61)
AZT/3TC/TDF/LPVr (60)
AZT/DDI/3TC/LPVr (56)
AZT/DDI/IDV (56)
AZT/DDI/SQV (53)
3TC/ABC/NVP (52)
DDI/D4T/SQV (51)
DDI/D4T/NFV/NVP (49)
D4T/SQVr (48)
AZT/3TC/NFV/EFV (47)
DDI/3TC/IDV (46)
DDI/D4T/RTV (46)
AZT/DDC/IDV (46)
DDI/3TC/EFV (44)
AZT/3TC/ABC/LPVr (42)
DDI/D4T/IDVr (41)
D4T/IDV (39)
DDI/TDF/EFV (39)
AZT/DDI/RTV (39)
DDI/3TC/LPVr (38)
D4T/ABC/EFV (38)
DDI/ABC/LPVr (37)
3TC/TDF/ATV (37)
AZT/3TC/NFV/NVP (36)
DDI/NFV/NVP (36)
DDI/3TC/NFV (34)
D4T/3TC/NFV/SQV (33)
AZT/SQV (33)
D4T/NFV (32)
DDI/SQVr (32)
AZT/3TC/ATV (32)
AZT/3TC/APV (32)
Genotype-Phenotype
Number of isolates according to phenotype method and drug resistance mutation1
Method2NRTINNRTIPIINI
WTMTTotalWTMTTotalWTMTTotalWTMTTotal
PhenoSense4411,4961,9379591,2092,1687841,3652,1496194411,060
Antivirogram1819461,1276379581,5952891,1391,42812285207
Others5221827011417729169266335171456627
1 Phenotypic resistance test results are available for 13,194 isolates including 11,255 clinical isolates and 1,939 lab isolates; for each ARV drug class, the number of isolates are shown in WT (wildtype) and MT (mutants) isolates; WT genotypes are defined as lacking any of major drug resistance mutations (DRMs) listed here: PI-associated DRMs for PI, NRTI-associated for NRTI, NNRTI-associated for NNRTI and INI-associated DRMs for INI.
2 PhenoSense - Monogram, South San Francisco; Antivirogram - Virco, Belgium;
Appendixes: HIV-1 Group M virus
Number of virus samples according to geographical region and subtype
ContinentRegionsSubtypes
Africa
(n = 49,885)		South Africa (15,204), Uganda (6,341), Cameroon (4,696), Kenya (3,489), Nigeria (2,548), Tanzania (1,638), Zimbabwe (1,310), Ethiopia (1,241), Botswana (1,228), Zambia (1,176), Mozambique (799), Cote d'Ivoire (798), Senegal (766), Morocco (761), Togo (712), Mali (647), Burkina Faso (643), Malawi (603), Angola (482), DRC (476), Africa (459), Ghana (458), Algeria (450), Burundi (416), Rwanda (415), Central African Republic (255), Gabon (222), Liberia (216), Tunisia (196), Guinea-Bissau (167), Benin (159), Guinea (127), Cape Verde (122), Niger (99), Equatorial Guinea (87), Chad (77), Swaziland (68), Mauritania (67), Congo-Brazzaville (67), Gambia (48), Seychelles (42), Libya (36), Madagascar (31), Sudan (30), Zaire (6), Dijibouti (4), Somalia (3)C (23,491), CRF02_AG (8,151), A (7,885), D (3,448), G (2,083), B (1,480), CRF01_AE (455), CRF06_cpx (384), HIV-2 Group A (383), F (330), CRF45_cpx (284), J (246), CRF35_AD (204), CRF18_cpx (201), CRF09_cpx (148), CRF11_cpx (100), H (94), HIV-2 Group B (80), CRF05_DF (76), CRF13_cpx (59), A + G (48), CRF10_CD (43), G + J (22), K (21), Unknown (17), CRF49_cpx (16), CRF37_cpx (16), HIV-2 CRF01_AB (14), CRF22_01A1 (10), CRF25_cpx (7), A + J (7), A + D (7), CRF43_02G (6), CRF26_AU (6), CRF04_cpx (6), CRF69_01B (5), CRF36_cpx (4), CRF63_02A1 (4), A + CRF02_AG (4), C + D (4), NA (4), CRF07_BC (3), CRF56_cpx (3), G + CRF02_AG (3), G + Unknown (3), CRF27_cpx (2), CRF12_BF (2), CRF03_AB (2), CRF29_BF (2), CRF21_A2D (2), CRF47_BF (1), G + H + J (1), HIV-2 Group D (1), CRF08_BC (1), CRF20_BG (1), CRF52_01B (1), B + CRF01_AE (1), HIV-2 Group I (1), HIV-2 Group H (1), HIV-2 Group G (1)
Asia
(n = 49,017)		China (15,751), Japan (8,673), Thailand (5,700), India (4,089), Vietnam (3,854), Israel (1,839), Taiwan (1,724), Cambodia (1,325), Malaysia (1,015), Korea (958), Hong Kong (609), Uzbekistan (598), Indonesia (445), Philippines (424), Singapore (388), Iran (338), Republic Of Georgia (321), Kazakhstan (268), Mongolia (123), Myanmar (122), Armenia (115), Kuwait (83), Saudi Arabia (60), Pakistan (54), Nepal (41), Kyrgyzstan (37), Lebanon (26), Yemen (19), Afghanistan (15), Turkey (2), Sri Lanka (1)CRF01_AE (19,404), B (18,518), C (6,011), A (1,720), CRF07_BC (834), CRF02_AG (410), CRF08_BC (370), B + C (320), CRF35_AD (303), CRF63_02A1 (206), CRF33_01B (172), B + CRF01_AE (157), G (101), CRF55_01B (96), A + CRF02_AG (42), HIV-2 Group A (40), D (38), F (32), CRF74_01B (28), Unknown (23), CRF52_01B (19), CRF67_01B (18), CRF45_cpx (17), CRF68_01B (13), CRF06_cpx (13), CRF12_BF (12), CRF83_cpx (12), CRF69_01B (10), CRF03_AB (8), CRF56_cpx (7), CRF82_cpx (7), CRF36_cpx (6), CRF05_DF (5), CRF09_cpx (4), CRF64_BC (4), CRF34_01B (4), CRF62_BC (3), HIV-2 CRF01_AB (3), HIV-2 Group B (2), CRF18_cpx (2), A + D (2), CRF61_BC (2), G + J (2), B + F (2), CRF48_01B (1), CRF20_BG (1), CRF24_BG (1), CRF43_02G (1), CRF16_A2D (1), CRF59_01B (1), A + B (1), H (1), CRF53_01B (1), J (1), CRF65_cpx (1), CRF78_cpx (1), CRF22_01A1 (1), CRF44_BF (1), K (1)
Central America
(n = 7,256)		Mexico (2,043), Puerto Rico (1,994), Cuba (1,261), Panama (631), Honduras (474), Dominican Republic (227), El Salvador (207), Haiti (183), Jamaica (118), Trinidad (63), Barbados (27), Antigua (8), Saint Vincent (6), Saint Lucia (5), Grenada (4), Dominica (3), Martinique (1), Montserrat (1)B (6,458), G (229), D (225), CRF18_cpx (116), C (69), CRF19_cpx (31), CRF20_BG (28), H (16), CRF02_AG (15), F (14), A (13), CRF01_AE (9), CRF45_cpx (8), CRF24_BG (7), CRF12_BF (3), B + F (3), J (2), CRF23_BG (2), A + G (1), CRF06_cpx (1), CRF35_AD (1), HIV-2 Group A (1), CRF05_DF (1), B + G (1), K (1), CRF04_cpx (1)
Europe
(n = 52,822)		Germany (8,002), Spain (6,712), France (5,738), U.K. (5,423), Italy (4,852), Portugal (2,800), Russia (2,693), Greece (2,597), Belgium (1,984), Denmark (1,652), Poland (1,218), Sweden (1,202), Ireland (923), Romania (868), Estonia (859), Switzerland (842), Ukraine (639), Slovenia (452), Austria (431), Luxembourg (418), Bulgaria (388), Europe (324), Netherlands (270), Cyprus (221), Serbia (187), Czech Republic (182), Croatia (134), Norway (119), Republic of Latvia (117), Hungary (112), Finland (97), Greenland (75), Latvia (72), Albania (66), Azerbaijan (41), Lithuania (38), Yugoslavia (33), Slovakia (26), Belarus (9), Moldova (6)B (34,122), A (5,166), CRF02_AG (3,526), C (2,514), G (2,489), F (1,447), CRF01_AE (946), CRF06_cpx (615), HIV-2 Group A (574), D (493), CRF12_BF (82), CRF45_cpx (77), CRF11_cpx (73), CRF09_cpx (57), HIV-2 Group B (52), J (51), CRF18_cpx (47), CRF05_DF (45), CRF35_AD (45), H (44), B + F (31), CRF63_02A1 (30), CRF04_cpx (25), B + CRF02_AG (19), CRF25_cpx (17), NA (17), CRF47_BF (16), CRF13_cpx (15), CRF49_cpx (15), A + G (13), CRF03_AB (12), U (12), CRF50_A1D (9), G + J (9), K (8), HIV-2 CRF01_AB (7), CRF20_BG (6), A + CRF02_AG (6), CRF19_cpx (5), CRF60_BC (5), CRF43_02G (5), B + C (5), CRF17_BF (5), CRF36_cpx (4), CRF69_01B (4), CRF56_cpx (4), CRF24_BG (4), Unknown (4), CRF07_BC (3), A + B (3), CRF27_cpx (3), CRF38_BF (3), CRF22_01A1 (3), A + D (3), A + J (3), CRF37_cpx (3), CRF10_CD (2), CRF44_BF (2), CRF29_BF (2), HIV-2 Group H (2), B + CRF01_AE (2), G + Unknown (2), CRF14_BG (1), G + H + J (1), CRF08_BC (1), CRF48_01B (1), G + CRF02_AG (1), CRF52_01B (1), CRF28_BF (1), CRF31_BC (1), CRF74_01B (1)
North America
(n = 57,354)		U.S. (51,325), Canada (6,029)B (54,437), C (1,117), CRF02_AG (473), A (455), CRF01_AE (282), D (196), G (126), NA (61), F (50), CRF05_DF (21), CRF12_BF (20), CRF45_cpx (17), CRF06_cpx (12), H (12), J (10), CRF18_cpx (10), CRF24_BG (7), CRF07_BC (6), G + J (6), CRF09_cpx (5), U (4), A + D (3), CRF20_BG (3), CRF35_AD (2), B + C (2), G + CRF02_AG (2), CRF28_BF (2), B + F (2), CRF13_cpx (2), Unknown (2), CRF25_cpx (1), CRF03_AB (1), HIV-2 Group E (1), CRF74_01B (1), HIV-2 CRF01_AB (1), CRF52_01B (1), CRF11_cpx (1)
Oceania
(n = 6,941)		Australia (6,819), Papua New Guinea (122)B (4,920), C (836), CRF01_AE (706), Unknown (133), CRF02_AG (130), A (106), D (34), G (25), CRF12_BF (8), CRF07_BC (7), B + F (7), B + CRF01_AE (5), B + C (5), F (4), CRF50_A1D (3), CRF35_AD (3), CRF60_BC (2), CRF05_DF (1), CRF59_01B (1), CRF33_01B (1), CRF08_BC (1), CRF06_cpx (1), CRF24_BG (1), CRF74_01B (1)
South America
(n = 24,070)		Brazil (18,355), Argentina (3,732), Peru (1,027), French Guiana (304), Venezuela (281), Chile (149), Suriname (105), Ecuador (56), Colombia (37), Uruguay (13), Guyana (6), Bolivia (3), Paraguay (2)B (16,713), F (2,474), C (2,127), CRF12_BF (1,672), B + F (610), D (133), B + C (47), CRF02_AG (45), CRF05_DF (34), CRF31_BC (33), A (30), CRF45_cpx (25), CRF29_BF (20), CRF38_BF (16), CRF17_BF (13), CRF40_BF (10), CRF01_AE (10), CRF44_BF (9), CRF69_01B (8), K (8), G (5), CRF28_BF (5), CRF39_BF (3), CRF47_BF (3), CRF07_BC (3), J (2), CRF09_cpx (2), CRF60_BC (2), CRF42_BF (1), HIV-2 Group A (1), Unknown (1), CRF71_BF (1), CRF19_cpx (1), H (1), CRF18_cpx (1), CRF04_cpx (1)

Mapping CRF subtypes from viruses to each genes
CRFsNo. virusesMapped subtype
proteaseRTintegrase
CRF01_AE14,277CRF01_AE (11,220)CRF01_AE (13,152)CRF01_AE (996)
CRF02_AG7,172CRF02_AG (5,893)CRF02_AG (5,663)CRF02_AG (690)
CRF03_AB16A (15)B (15)B (3)
CRF04_cpx25CRF04_cpx (15)CRF04_cpx (16)CRF04_cpx (5)
CRF05_DF23CRF05_DF (23)CRF05_DF (21)CRF05_DF (3)
CRF06_cpx821CRF06_cpx (648)CRF06_cpx (586)CRF06_cpx (115)
CRF07_BC1,146B (1,138)CRF07_BC (1,146)C (49)
CRF08_BC411C (408)CRF08_BC (411)C (21)
CRF09_cpx74CRF09_cpx (59)CRF09_cpx (59)CRF09_cpx (11)
CRF10_CD88D (55)CRF10_CD (87)CRF10_CD (5)
CRF11_cpx212CRF11_cpx (191)CRF11_cpx (169)CRF11_cpx (24)
CRF12_BF506F (489)CRF12_BF (486)F (32)
CRF13_cpx61CRF13_cpx (56)CRF13_cpx (50)CRF13_cpx (10)
CRF14_BG25G (22)G (24)G (5)
CRF16_A2D5A (5)A (5)A (1)
CRF17_BF16CRF17_BF (16)CRF17_BF (16)F (7)
CRF18_cpx67CRF18_cpx (63)CRF18_cpx (59)CRF18_cpx (6)
CRF19_cpx84D (83)D (83)CRF19_cpx (4)
CRF20_BG27CRF20_BG (27)CRF20_BG (27)G (4)
CRF21_A2D3D (3)CRF21_A2D (3)A (3)
CRF22_01A125A (18)A (17)A (14)
CRF23_BG11CRF23_BG (11)CRF23_BG (11)G (2)
CRF24_BG25CRF24_BG (25)CRF24_BG (25)G (5)
CRF25_cpx9F (7)B (7)B (8)
CRF26_AU10F (10)CRF29_BF (10)F (4)
CRF27_cpx5CRF27_cpx (4)CRF27_cpx (5)CRF27_cpx (3)
CRF28_BF14F (14)B (14)B (2)
CRF29_BF11F (11)CRF29_BF (11)F (4)
CRF30_02061CRF30_0206 (1)CRF30_0206 (0)CRF30_0206 (0)
CRF31_BC39C (38)CRF31_BC (39)C (5)
CRF33_01B76CRF33_01B (75)CRF33_01B (74)CRF01_AE (3)
CRF34_01B8B (8)CRF01_AE (8)CRF01_AE (4)
CRF35_AD53CRF35_AD (52)CRF35_AD (44)A (13)
CRF36_cpx2CRF36_cpx (2)CRF36_cpx (2)CRF36_cpx (2)
CRF37_cpx16G (14)CRF37_cpx (5)CRF37_cpx (4)
CRF38_BF14CRF38_BF1 (4)CRF38_BF1 (4)CRF38_BF1 (4)
CRF42_BF17CRF42_BF (17)CRF42_BF (17)CRF42_BF (17)
CRF43_02G20CRF43_02G (19)CRF43_02G (18)CRF43_02G (5)
CRF44_BF1CRF44_BF (1)CRF44_BF (1)CRF44_BF (1)
CRF45_cpx20CRF45_cpx (19)CRF45_cpx (18)CRF45_cpx (9)
CRF47_BF8CRF47_BF (8)CRF47_BF (8)CRF47_BF (5)
CRF49_cpx7CRF49_cpx (5)CRF49_cpx (5)CRF49_cpx (4)
CRF50_A1D1D (1)A (0)A (0)
CRF52_01B1CRF01_AE (1)CRF01_AE/B (1)CRF01_AE (0)
CRF54_01B10B (10)CRF53_01B (10)B (0)
CRF55_01B75CRF01_AE (74)CRF01_AE/B (75)CRF01_AE/B (1)
CRF56_cpx5CRF01_AE (5)CRF02_AG/B (5)CRF02_AG/B (1)
CRF58_01B4CRF01_AE (2)CRF01_AE/B (4)CRF01_AE/B (1)
CRF59_01B5CRF01_AE (5)CRF01_AE/B (5)CRF01_AE (1)
CRF60_BC1C (1)B/C (1)C (0)
CRF61_BC1C (1)B/C (1)C (1)
CRF62_BC1C (1)B/C (1)C (0)
CRF63_02A141CRF02_AG (41)CRF02_AG/A (41)CRF02_AG/A (37)
CRF64_BC1B/C (1)B/C (1)C (0)

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Resources

Team