<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Database Statistics

as of 6/2018

Genotype-Treatment
Number of individuals according to subtype and drug-class experienced1
Subtype 2proteaseRTintegrase
PI-NaivePI-TreatedRTI-NaiveRTI-TreatedINI-NaiveINI-Treated
B47,34717,56041,31736,1087,2511,013
A6,7864226,3534,1641,07330
C17,4123,32911,29019,6252,55724
D2,2562911,8191,38034420
F1,4301,5531,30684826311
G3,1623901,4472,5732281
CRF01_AE12,81767411,0816,0211,8421
CRF02_AG5,7702664,1143,1059126
Other2,7411,9936,7563,149549 
Total99,72126,47885,48376,97315,0191,106
1 Well-characterized treatment history is available for 151,483 individuals from whom 133,472 protease, 141,917 RT and 16,891 integrase isolates have been sequenced and published; "Mutation Prevalence According to Subtype and Treatment" page analyzes sequences obtained from the individuals for each subtype and summarizes the frequency of each mutation from treated individuals in comparison to the frequency of that mutation from untreated individuals.
2 "Other" subtypes include CRFs other than "CRF01_AE" and "CRF02_AG". Appendix II lists the CRFs available in HIVdb and how each CRF was mapped to a subtype for each gene for analysis.

Number of individuals according to regimen received
NRTI componentNNRTI component PI componentNRTI + PI or NNRTI regimen
AZT (2,126)
DDI (769)
D4T (745)
3TC (283)
ABC (224)
DDC (220)
TDF (37)
FTC (3)

D4T/3TC (6,845)
AZT/3TC (6,311)
3TC/TDF (2,974)
AZT/DDI (1,880)
DDI/D4T (1,709)
FTC/TDF (1,497)
3TC/ABC (933)
AZT/DDC (808)
DDI/3TC (283)
D4T/ABC (195)
DDI/ABC (151)
AZT/ABC (90)
AZT/D4T (86)
DDI/TDF (84)
DDC/D4T (75)
DDC/3TC (61)
D4T/TDF (33)
AZT/TDF (31)
ABC/TDF (22)
DDI/DDC (12)
3TC/FTC (11)
DDC/ABC (10)
DDC/TDF (5)
DDI/FTC (3)


AZT/3TC/ABC (576)
AZT/DDI/3TC (300)
AZT/D4T/3TC (143)
D4T/3TC/ABC (130)
DDI/D4T/3TC (110)
3TC/ABC/TDF (93)
DDI/D4T/ABC (90)
AZT/3TC/TDF (88)
AZT/DDC/3TC (72)
DDI/3TC/TDF (50)
D4T/3TC/TDF (39)
AZT/DDI/DDC (31)
DDI/3TC/ABC (29)
AZT/DDI/D4T (18)
DDI/ABC/TDF (16)
DDI/D4T/TDF (15)
AZT/DDI/ABC (11)
DDC/D4T/3TC (9)
DDI/FTC/TDF (8)
AZT/DDC/D4T (6)
DDI/DDC/3TC (3)
AZT/DDC/ABC (3)
AZT/ABC/TDF (2)
DDI/DDC/D4T (2)
ABC/FTC/TDF (2)
D4T/FTC/TDF (2)
AZT/FTC/TDF (2)
3TC/FTC/TDF (2)
DDC/D4T/ABC (2)
AZT/DDI/TDF (2)
D4T/ABC/TDF (2)


AZT/DDI/D4T/3TC (31)
AZT/3TC/ABC/TDF (31)
DDI/3TC/ABC/TDF (13)
DDI/D4T/3TC/ABC (13)
AZT/DDI/3TC/ABC (7)
DDI/D4T/3TC/TDF (6)
AZT/DDC/D4T/3TC (6)
AZT/DDI/DDC/3TC (4)
D4T/3TC/ABC/TDF (4)
AZT/D4T/3TC/ABC (4)
AZT/DDI/3TC/TDF (4)
AZT/DDC/3TC/ABC (2)


AZT/DDI/DDC/D4T/3TC (7)
DDI/D4T/3TC/ABC/TDF (3)
AZT/DDI/D4T/3TC/ABC (2)

EFV (8,510)
NVP (6,455)
DLV (193)
ETR (29)
RPV (18)		LPVr (2,517)
NFV (2,361)
IDV (2,263)
SQV (937)
SQVr (746)
RTV (616)
IDVr (372)
ATVr (265)
APV (229)
APVr (141)
ATV (131)
DRVr (69)
TPVr (18)
DRV (5)

NFV/SQV (212)
APV/LPVr (58)
IDV/SQV (51)
NFV/IDV (46)
NFV/RTV (27)
LPVr/SQV (25)
NFV/APV (14)
IDV/LPVr (13)
APV/SQV (12)
NFV/LPVr (8)
APV/IDV (7)
LPVr/ATV (3)
IDV/ATV (2)
LPVr/TPV (2)


NFV/RTV/SQV (19)
RTV/APV/SQV (16)
RTV/IDV/SQV (12)
NFV/RTV/IDV (11)
RTV/APV/LPVr (5)
NFV/IDV/SQV (5)
RTV/APV/ATV (4)
RTV/APV/IDV (2)
RTV/LPVr/SQV (2)
RTV/IDV/LPVr (2)


NFV/RTV/IDV/SQV (4)

D4T/3TC/EFV (2,477)
D4T/3TC/NVP (2,122)
3TC/TDF/EFV (1,965)
AZT/3TC/EFV (1,464)
AZT/3TC/NVP (1,455)
FTC/TDF/EFV (1,103)
AZT/3TC/IDV (993)
D4T/3TC/IDV (699)
AZT/3TC/NFV (638)
3TC/TDF/NVP (621)
D4T/3TC/NFV (620)
AZT/3TC/LPVr (551)
D4T/3TC/LPVr (465)
3TC/ABC/EFV (443)
AZT/3TC/SQV (348)
DDI/D4T/NFV (343)
DDI/D4T/EFV (298)
3TC/TDF/LPVr (288)
3TC/ABC/LPVr (253)
DDI/D4T/NVP (222)
AZT/DDI/LPVr (219)
FTC/TDF/NVP (201)
D4T/3TC/SQV (199)
AZT/3TC/RTV (193)
D4T/3TC/RTV (173)
D4T/3TC/SQVr (170)
DDI/D4T/IDV (138)
AZT/DDI/NVP (137)
AZT/3TC/SQVr (123)
DDI/D4T/SQVr (120)
AZT/DDC/SQV (113)
D4T/NFV/NVP (104)
AZT/3TC/ABC/EFV (103)
AZT/3TC/IDVr (95)
3TC/ABC/ATVr (87)
FTC/TDF/LPVr (80)
AZT/D4T/3TC/NVP/EFV (78)
FTC/TDF/ATVr (77)
D4T/3TC/IDVr (73)
D4T/3TC/NFV/NVP (69)
DDI/D4T/LPVr (69)
DDI/D4T/NFV/EFV (69)
AZT/DDI/EFV (67)
AZT/DDI/NFV (61)
3TC/TDF/ATVr (60)
AZT/DDI/IDV (56)
AZT/DDI/3TC/LPVr (55)
AZT/DDI/SQV (53)
3TC/ABC/NVP (52)
DDI/D4T/SQV (51)
DDI/D4T/NFV/NVP (49)
D4T/SQVr (48)
AZT/3TC/NFV/EFV (47)
DDI/D4T/RTV (46)
AZT/DDC/IDV (46)
DDI/3TC/IDV (46)
DDI/3TC/EFV (44)
AZT/3TC/TDF/LPVr (41)
AZT/3TC/ABC/LPVr (41)
DDI/D4T/IDVr (41)
D4T/IDV (39)
AZT/DDI/RTV (39)
DDI/3TC/LPVr (38)
DDI/TDF/EFV (38)
D4T/ABC/EFV (37)
DDI/NFV/NVP (36)
AZT/3TC/NFV/NVP (36)
3TC/TDF/ATV (35)
DDI/ABC/LPVr (35)
D4T/3TC/NFV/SQV (33)
AZT/SQV (33)
DDI/3TC/NFV (33)
D4T/NFV (32)
AZT/3TC/APV (32)
Genotype-Phenotype
Number of isolates according to phenotype method and drug resistance mutation1
Method2NRTINNRTIPIINI
WTMTTotalWTMTTotalWTMTTotalWTMTTotal
PhenoSense4351,5031,9389771,0802,0577791,3662,145589325914
Antivirogram1779501,1276459501,5952891,1391,42812285207
Others382032411031042076524731270259329
1 Phenotypic resistance test results are available for 12,500 isolates including 10,870 clinical isolates and 1,630 lab isolates; for each ARV drug class, the number of isolates are shown in WT (wildtype) and MT (mutants) isolates; WT genotypes are defined as lacking any of major drug resistance mutations (DRMs) listed here: PI-associated DRMs for PI, NRTI-associated for NRTI, NNRTI-associated for NNRTI and INI-associated DRMs for INI.
2 PhenoSense - Monogram, South San Francisco; Antivirogram - Virco, Belgium;
Appendixes: HIV-1 Group M virus
Number of virus samples according to geographical region and subtype
ContinentRegionsSubtypes
Africa
(n = 36,882)		South Africa (11,210), Uganda (4,793), Cameroon (3,264), Kenya (2,760), Nigeria (1,815), Zambia (1,176), Botswana (1,023), Zimbabwe (1,005), Tanzania (989), Mozambique (799), Cote d'Ivoire (557), Ethiopia (547), Angola (480), DRC (463), Malawi (460), Senegal (457), Ghana (453), Algeria (447), Burkina Faso (438), Togo (435), Burundi (416), Rwanda (415), Morocco (366), Mali (352), Central African Republic (255), Gabon (222), Liberia (215), Tunisia (196), Benin (128), Niger (99), Guinea (91), Equatorial Guinea (86), Chad (77), Swaziland (68), Congo-Brazzaville (67), Cape Verde (48), Seychelles (42), Africa (41), Libya (36), Madagascar (31), Sudan (30), Guinea-Bissau (13), Zaire (6), Dijibouti (4), Gambia (4), Somalia (3)C (17,476), CRF02_AG (5,983), A (5,765), D (2,532), G (1,714), B (1,083), CRF01_AE (439), CRF45_cpx (275), F (264), J (247), CRF35_AD (196), CRF06_cpx (194), CRF18_cpx (168), CRF09_cpx (118), H (86), CRF05_DF (76), CRF13_cpx (41), CRF11_cpx (40), A + G (36), CRF10_CD (23), G + J (20), K (18), Unknown (17), CRF49_cpx (16), A + D (7), CRF04_cpx (6), CRF26_AU (6), CRF25_cpx (6), CRF37_cpx (5), A + J (5), C + D (4), A + CRF02_AG (4), G + Unknown (3), CRF12_BF (2), CRF27_cpx (2), CRF63_02A1 (2), CRF56_cpx (1), CRF47_BF (1), B + CRF01_AE (1)
Asia
(n = 40,123)		China (12,909), Japan (8,518), Thailand (4,297), India (3,673), Vietnam (2,314), Taiwan (1,724), Cambodia (1,325), Malaysia (997), Israel (897), Korea (859), Philippines (401), Singapore (388), Hong Kong (325), Kazakhstan (259), Iran (246), Indonesia (227), Republic Of Georgia (201), Uzbekistan (148), Myanmar (91), Kuwait (83), Armenia (78), Saudi Arabia (60), Pakistan (36), Lebanon (25), Yemen (19), Afghanistan (15), Nepal (6), Turkey (2)B (17,102), CRF01_AE (15,173), C (5,325), A (1,177), CRF35_AD (215), CRF02_AG (194), CRF33_01B (161), B + CRF01_AE (144), B + C (136), CRF07_BC (107), G (90), CRF08_BC (72), A + CRF02_AG (41), D (34), CRF74_01B (28), Unknown (22), F (22), CRF45_cpx (17), CRF63_02A1 (9), CRF55_01B (8), CRF12_BF (8), CRF06_cpx (8), CRF05_DF (5), CRF64_BC (4), CRF09_cpx (4), CRF68_01B (3), CRF18_cpx (2), B + F (2), A + D (2), K (1), G + J (1), CRF24_BG (1), J (1), CRF69_01B (1), CRF16_A2D (1), CRF53_01B (1), CRF43_02G (1)
Europe
(n = 41,992)		Spain (5,977), Germany (5,636), Italy (4,216), France (4,024), U.K. (2,818), Portugal (2,502), Greece (2,480), Belgium (1,929), Russia (1,625), Poland (1,218), Sweden (1,179), Denmark (978), Ireland (923), Romania (868), Switzerland (778), Estonia (640), Ukraine (604), Austria (400), Bulgaria (388), Luxembourg (377), Europe (324), Slovenia (321), Netherlands (253), Cyprus (221), Serbia (187), Czech Republic (182), Croatia (134), Norway (119), Republic of Latvia (117), Hungary (112), Finland (97), Greenland (75), Latvia (72), Albania (66), Azerbaijan (41), Lithuania (38), Yugoslavia (33), Slovakia (26), Belarus (8), Moldova (6)B (27,221), A (3,771), CRF02_AG (2,742), G (2,359), C (2,286), F (1,362), CRF01_AE (835), D (388), CRF06_cpx (382), CRF12_BF (72), CRF45_cpx (68), CRF11_cpx (60), J (50), CRF09_cpx (49), H (43), CRF05_DF (40), CRF18_cpx (40), B + F (28), CRF04_cpx (25), CRF35_AD (20), CRF47_BF (14), U (12), A + G (12), CRF63_02A1 (11), CRF49_cpx (10), G + J (9), K (8), CRF50_A1D (8), CRF13_cpx (7), A + CRF02_AG (6), CRF25_cpx (6), B + CRF02_AG (5), B + C (5), CRF03_AB (4), CRF60_BC (3), CRF27_cpx (3), CRF19_cpx (3), A + D (3), A + B (2), CRF56_cpx (2), CRF24_BG (2), A + J (2), Unknown (2), CRF20_BG (2), B + CRF01_AE (2), CRF38_BF (2), CRF10_CD (2), G + Unknown (1), CRF74_01B (1), CRF31_BC (1), G + H + J (1)
North America
(n = 56,064)		U.S. (45,337), Canada (5,696), Mexico (1,964), Puerto Rico (1,134), Cuba (1,120), Honduras (336), El Salvador (207), Jamaica (118), Trinidad (63), Barbados (27), Dominican Republic (18), Haiti (16), Antigua (8), Saint Vincent (6), Saint Lucia (5), Grenada (4), Dominica (3), Montserrat (1), Panama (1)B (52,739), C (1,067), CRF02_AG (447), A (428), D (412), G (344), CRF01_AE (250), CRF18_cpx (107), F (62), NA (47), H (27), CRF45_cpx (25), CRF12_BF (22), CRF05_DF (21), CRF06_cpx (13), J (12), G + J (6), CRF09_cpx (5), U (4), CRF35_AD (3), CRF07_BC (3), B + F (3), A + D (3), CRF13_cpx (2), Unknown (2), CRF19_cpx (2), CRF23_BG (1), G + CRF02_AG (1), K (1), CRF04_cpx (1), CRF74_01B (1), A + G (1), CRF20_BG (1), CRF25_cpx (1)
Oceania
(n = 6,907)		Australia (6,785), Papua New Guinea (122)B (4,894), C (833), CRF01_AE (702), Unknown (133), CRF02_AG (130), A (105), D (34), G (25), CRF12_BF (8), CRF07_BC (7), B + F (7), B + CRF01_AE (5), B + C (5), F (4), CRF35_AD (3), CRF50_A1D (3), CRF60_BC (2), CRF05_DF (1), CRF24_BG (1), CRF08_BC (1), CRF33_01B (1), CRF59_01B (1), CRF74_01B (1), CRF06_cpx (1)
South America
(n = 21,257)		Brazil (16,135), Argentina (3,548), Peru (615), French Guiana (304), Venezuela (281), Chile (152), Suriname (105), Ecuador (56), Colombia (37), Uruguay (13), Guyana (6), Bolivia (3), Paraguay (2)B (14,592), F (2,270), C (1,833), CRF12_BF (1,555), B + F (622), D (130), B + C (43), CRF02_AG (39), CRF05_DF (34), CRF31_BC (27), CRF45_cpx (25), A (24), CRF44_BF (10), CRF01_AE (10), CRF38_BF (9), K (8), CRF40_BF (7), G (4), CRF17_BF (3), CRF47_BF (3), CRF09_cpx (2), J (2), CRF04_cpx (1), CRF60_BC (1), CRF71_BF (1), CRF18_cpx (1), Unknown (1)

Mapping CRF subtypes from viruses to each genes
CRFsNo. virusesMapped subtype
proteaseRTintegrase
CRF01_AE14,277CRF01_AE (11,220)CRF01_AE (13,152)CRF01_AE (996)
CRF02_AG7,172CRF02_AG (5,894)CRF02_AG (5,664)CRF02_AG (690)
CRF03_AB16A (15)B (15)B (3)
CRF04_cpx25CRF04_cpx (15)CRF04_cpx (16)CRF04_cpx (5)
CRF05_DF23CRF05_DF (23)CRF05_DF (21)CRF05_DF (3)
CRF06_cpx821CRF06_cpx (648)CRF06_cpx (586)CRF06_cpx (115)
CRF07_BC1,146B (1,138)CRF07_BC (1,146)C (49)
CRF08_BC411C (408)CRF08_BC (411)C (21)
CRF09_cpx74CRF09_cpx (59)CRF09_cpx (59)CRF09_cpx (11)
CRF10_CD88D (55)CRF10_CD (87)CRF10_CD (5)
CRF11_cpx212CRF11_cpx (191)CRF11_cpx (169)CRF11_cpx (24)
CRF12_BF506F (489)CRF12_BF (486)F (32)
CRF13_cpx61CRF13_cpx (56)CRF13_cpx (50)CRF13_cpx (10)
CRF14_BG25G (22)G (24)G (5)
CRF16_A2D5A (5)A (5)A (1)
CRF17_BF16CRF17_BF (16)CRF17_BF (16)F (7)
CRF18_cpx67CRF18_cpx (63)CRF18_cpx (59)CRF18_cpx (6)
CRF19_cpx84D (83)D (83)CRF19_cpx (4)
CRF20_BG27CRF20_BG (27)CRF20_BG (27)G (4)
CRF21_A2D3D (3)CRF21_A2D (3)A (3)
CRF22_01A125A (18)A (17)A (14)
CRF23_BG11CRF23_BG (11)CRF23_BG (11)G (2)
CRF24_BG25CRF24_BG (25)CRF24_BG (25)G (5)
CRF25_cpx9F (7)B (7)B (8)
CRF26_AU10F (10)CRF29_BF (10)F (4)
CRF27_cpx5CRF27_cpx (4)CRF27_cpx (5)CRF27_cpx (3)
CRF28_BF14F (14)B (14)B (2)
CRF29_BF11F (11)CRF29_BF (11)F (4)
CRF30_02061CRF30_0206 (1)CRF30_0206 (0)CRF30_0206 (0)
CRF31_BC39C (38)CRF31_BC (39)C (5)
CRF33_01B76CRF33_01B (75)CRF33_01B (74)CRF01_AE (3)
CRF34_01B8B (8)CRF01_AE (8)CRF01_AE (4)
CRF35_AD53CRF35_AD (52)CRF35_AD (44)A (13)
CRF36_cpx2CRF36_cpx (2)CRF36_cpx (2)CRF36_cpx (2)
CRF37_cpx16G (14)CRF37_cpx (5)CRF37_cpx (4)
CRF38_BF14CRF38_BF1 (4)CRF38_BF1 (4)CRF38_BF1 (4)
CRF42_BF17CRF42_BF (17)CRF42_BF (17)CRF42_BF (17)
CRF43_02G20CRF43_02G (19)CRF43_02G (18)CRF43_02G (5)
CRF44_BF1CRF44_BF (1)CRF44_BF (1)CRF44_BF (1)
CRF45_cpx20CRF45_cpx (19)CRF45_cpx (18)CRF45_cpx (9)
CRF47_BF8CRF47_BF (8)CRF47_BF (8)CRF47_BF (5)
CRF49_cpx7CRF49_cpx (5)CRF49_cpx (5)CRF49_cpx (4)
CRF50_A1D1D (1)A (0)A (0)
CRF52_01B1CRF01_AE (1)CRF01_AE/B (1)CRF01_AE (0)
CRF54_01B10B (10)CRF53_01B (10)B (0)
CRF55_01B75CRF01_AE (74)CRF01_AE/B (75)CRF01_AE/B (1)
CRF56_cpx5CRF01_AE (5)CRF02_AG/B (5)CRF02_AG/B (1)
CRF58_01B4CRF01_AE (2)CRF01_AE/B (4)CRF01_AE/B (1)
CRF59_01B5CRF01_AE (5)CRF01_AE/B (5)CRF01_AE (1)
CRF60_BC1C (1)B/C (1)C (0)
CRF61_BC1C (1)B/C (1)C (1)
CRF62_BC1C (1)B/C (1)C (0)
CRF63_02A141CRF02_AG (41)CRF02_AG/A (41)CRF02_AG/A (37)
CRF64_BC1B/C (1)B/C (1)C (0)

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