Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Romano (2002)
Title Treatment with lopinavir/ritonavir in heavily pretreated subjects failing multiple antiretroviral regimens in clinical practice.
Citation JAIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 80
NumPts 41
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
MZ-pt1 pt1-t0 AZT, DDC, D4T, 3TC, DDI, ADV, ABC EFV M41L, D67N, T69D, K70R, L74V, T215F, K219Q L100I, K103N P4PS, T39A, V60I, A98S, K122E, I135V, I167V, V179I, G196E, H208Y, R211K, L228H D218V 
  pt1-t1 AZT, DDC, D4T, 3TC, DDI, ADV, ABC EFV M41L, D67N, T69D, K70R, L74V, M184MV, T215F, K219W L100I, K103N P4S, K20R, V35I, T39A, K43E, V60I, A98S, K122E, I135V, I167V, V179I, G196E, H208Y, R211K, D218E, L228H  
MZ-pt10 pt10-t0 AZT, DDI, 3TC, D4T, ABC EFV, NVP M41L, L74V, M184V, T215Y K101P, K103N P4S, K20R, R83K, D123E, V189I  
  pt10-t1 AZT, DDI, 3TC, D4T, ABC EFV, NVP M41ML, M184MV K103KN, G190GA K20KR, R83K, D123E, T215X  
MZ-pt11 pt11-t0 AZT, DDI, 3TC, D4T, DDC NVP, EFV K65KR, D67N, T69D, K70R, F116FY, T215F, K219KE K101E, K103KN, Y181YC, G190A V90I, A98S, K102R, K122KE, Q151X, E169D, E194ED, G196E, Q207AE  
MZ-pt12 pt12-t0 AZT, DDC, 3TC, D4T, DDI EFV D67G, T69D, K70R, K219Q K103N P4S, K20R, T39A, S68G, D123E, I135T  
  pt12-t1 AZT, DDC, 3TC, D4T, DDI EFV D67G, T69D, K70R, K219Q K103KN P4S, K20R, T39A, S68G, D123E, I135T R83RS, V148VE 
MZ-pt13 pt13-t0 DDC, AZT, 3TC, D4T, DDI EFV M41L, D67N, K70R, L74I, M184I, T215F, K219Q  V35I, S117A, V118I, Q174E, F214L, D218E  
  pt13-t1 DDC, AZT, 3TC, D4T, DDI EFV M41ML, D67DN, K70KR, L74LI, M184MI, K219KE Y181YC K20KR, V35I, V118VI, K122KQ, S134SG, Q174E, F214L, T215X N137ND 
MZ-pt14 pt14-t0 AZT, DDI, DDC, 3TC, D4T, ABC EFV M41L, D67N, M184I, L210W, T215Y, K219R  K20R, V35T, T39A, E44D, K102Q, V118I, D123E, S162D, K166R, D177G, E203K, E204D, Q207D, H208Y, R211K, K223E, E224D  
  pt14-t1 AZT, DDI, DDC, 3TC, D4T, ABC EFV M41L, D67N, M184I, L210W, T215Y, K219R  K20R, V35T, T39A, E44D, V118I, D123E, S162D, K166R, D177G, E203K, Q207D, H208Y, R211K, K223E, E224D  
MZ-pt15 pt15-t0 DDC, AZT, 3TC, D4T, DDI, ABC NVP, EFV   K20R, T69S, I135T, R211K, F214L  
  pt15-t1 DDC, AZT, 3TC, D4T, DDI, ABC NVP, EFV   K20R, T69S, I135T, R206K, R211K, F214L R83RS 
MZ-pt16 pt16-t0 DDC, AZT, 3TC, D4T, DDI, ABC EFV M41L, D67N, L74V, L210W, T215Y, K219N V179D, Y181C, Y188L K43Q, K49R, V60VI, K103R, I135T, I202V, R211K  
  pt16-t1 DDC, AZT, 3TC, D4T, DDI, ABC EFV M41L, D67DN, L210W, T215Y Y188YF K43Q, K49R, K103KR, I135T, I202IV, R211RK  
MZ-pt17 pt17-t0 AZT, DDI, DDC, 3TC, D4T EFV M41L, D67E, V75M, L210W, T215Y K103N, Y181YC, G190A V35T, T39A, E44D, S68G, K122E, D123E, I135T, I142M, D177E, I178L, G196E, E204N, R211N  
  pt17-t1 AZT, DDI, DDC, 3TC, D4T EFV M41L, D67E, V75M, L210W, T215Y K103N, Y181C, G190A V35T, T39A, E44D, S68G, K82R, K101N, V118I, K122E, D123E, I135T, I142V, D177E, I178L, G196E, E204N, R211N  
MZ-pt18 pt18-t0 AZT, DDC, 3TC, D4T, DDI EFV M41L, L210W, T215Y, K219R V106VI, V179VD, Y188L K43Q, E44D, V118I, K122P, D123E, S162C, D177E, I178L, T200K, Q207E, H208Y, R211K, K223Q, L228H  
  pt18-t1 AZT, DDC, 3TC, D4T, DDI EFV M41L, L210W, T215Y, K219R V106I, Y188L K43Q, E44D, V118I, K122P, D123E, P133PL, S162C, D177E, I178L, T200K, Q207E, H208Y, R211K, K223Q, L228H  
MZ-pt19 pt19-t0 AZT, D4T, DDI, DDC, 3TC DLV M41L, D67N, L74IV, L210W, T215Y, K219R K103N, Y181YC K20R, V35I, K43Q, E44D, V111I, V118I, D123E, I178F, G196E, H208Y, R211K, K223Q  
MZ-pt2 pt2-t0 DDC, AZT, 3TC, D4T, DDI, ABC NVP M41L, D67N, K70R, V75T, L210W, T215Y K101KE, Y181C, G190A, F227L V118VI, K122E, D123E, I135T, Q151X, S162C, D177E, D218E, K219D, L228H Q222K 
  pt2-t1 DDC, AZT, 3TC, D4T, DDI, ABC NVP M41L, D67N, K70KR, L210W, T215Y Y181C, G190A V75X, K122E, D123E, I135T, Q151X, S162C, D177E, D218E, K219DH, F227FS  
MZ-pt20 pt20-t0 AZT, DDI, DDC, 3TC, D4T EFV D67N, L210W, T215Y, K219R K103N, V108I S48T, V118VI, K122E, I135T, S162C, I178M, G196E, T200I, E203K, R211K, K223E  
  pt20-t1 AZT, DDI, DDC, 3TC, D4T EFV D67N, L210W, T215Y, K219R K103N, V108I S48T, V118I, K122E, I135T, S162C, I178M, G196E, T200I, E203K, R211K, K223E  
MZ-pt21 pt21-t0 AZT, 3TC, D4T, DDI EFV D67N, K70R, Q151M, T215I, K219E Y188L T39TA, K64R, K122E, I135T, S162C, R172K  
  pt21-t1 AZT, 3TC, D4T, DDI EFV D67DN, K70KR, T215TI, K219KE  K64R, K122KE, I135T, Q151X, S162CY, R211RK  
MZ-pt22 pt22-t0 AZT, DDI, 3TC, D4T NVP T215Y K103N, Y181C K122E, I135L, T200K  
  pt22-t1 AZT, DDI, 3TC, D4T NVP T215Y K103N, Y181C L26LF, K122E, I135L, Q174QR, T200K  
MZ-pt23 pt23-t0 AZT, DDI, DDC, D4T, 3TC, ABC NVP M41L, T215Y Y188L V35VL, D123E, I142T, D177G, R211K  
  pt23-t1 AZT, DDI, DDC, D4T, 3TC, ABC NVP M41L, T215Y  D123E, I142T, D177G, R211K  
MZ-pt24 pt24-t0 AZT, 3TC, D4T, DDI EFV M41L, M184V, T215Y  D123E R199S 
  pt24-t1 AZT, 3TC, D4T, DDI EFV M41L, M184MV, T215Y K101P, K103KN K43KN, D123E, F214FL R83RS 
MZ-pt25 pt25-t0 AZT, 3TC, D4T None   V35I, K122E, D123E, I135T, T165I, D177E, G196E, T200A  
  pt25-t1 AZT, 3TC, D4T None   V35VI, K122KE, D123E, I135T, T165I, P170PL, D177E, G196E, T200A, I202IV  
MZ-pt26 pt26-t0 AZT, DDI, DDC, 3TC, D4T EFV D67DN, K70KR K103KN, V108VI V8I, T69X, R83RK, K122KE, Q207E, H208Y, T215X  
  pt26-t1 AZT, DDI, DDC, 3TC, D4T, ABC EFV D67N, T69D, K70R, M184V, T215F, K219Q  K122E, G196E, E203K, Q207E, H208Y, K223Q  
MZ-pt27 pt27-t0 AZT, DDC, 3TC, D4T, ABC, DDI EFV M41L, D67N, V75M, F77L, M184V, L210W, T215Y  V21I, V35I, T39A, K43E, E44D, K49R, K101Q, V118I, K122E, E169D, G196E, D218E E53DH 
  pt27-t1 AZT, DDC, 3TC, D4T, ABC, DDI EFV M41L, D67N, T69D, V75M, F77L, Y115YF, M184MV, L210W, T215Y  V21I, V35I, T39A, K43E, E44D, K49R, E53D, K101Q, V118I, K122E, E169D, G196E, D218E  
MZ-pt28 pt28-t0 AZT, DDI, DDC, 3TC, D4T EFV M41L, D67N, T69D, L74LV, L210W, T215Y A98G, L100LI, K103N T27S, V35VI, E40F, K43E, D123E, I135T, H208F, R211EK D185DG 
  pt28-t1 AZT, DDI, DDC, 3TC, D4T EFV M41L, D67N, T69D, L210W, T215Y A98G, K103N T27S, V35VI, K43KE, V118VI, D123E, I135T, H208FY, R211K  
MZ-pt29 pt29-t0 DDC, AZT, 3TC, D4T, ABC, DDI EFV M41L, M184V, T215Y  E6ED, K49R, Q207E, R211K D17DV, E79EA 
  pt29-t1 DDC, AZT, 3TC, D4T, ABC, DDI EFV M41L, T215Y  K49R, Q207E, R211K R83RS, P150PQ 
MZ-pt3 pt3-t0 AZT, DDI, DDC, 3TC, D4T EFV, NVP M41L, D67N, L210W, T215Y K103N, Y181C V35I, K43Q, K122E, A158S, E169D, G196E, I202V, R211K  
  pt3-t1 AZT, DDI, DDC, 3TC, D4T EFV, NVP M41L, D67N, L210W, T215Y  K32KE, V35IM, K43X, E44ED, K122E, A158S, E169D, G196E, I202V, R211K  
MZ-pt30 pt30-t0 DDC, AZT, 3TC, DDI, ABC NVP M41L, D67N, K70R, M184V, K219Q K103KN K49R, I50V, A98AS, K101KQ, K122E, I135T, D177G, R211RK, D218E  
  pt30-t1 DDC, AZT, 3TC, DDI, ABC NVP D67N, K70R, K219Q  K49R, I50V, A98S, K122E, I135T, D177G  
MZ-pt31 pt31-t0 DDC, AZT, 3TC, D4T, DDI NVP L210W, T215Y, K219E V179L, Y181C V35I, T39A, E40K, K43E, V60I, R83K, K101N, V118I, R211K, D218E  
  pt31-t1 DDC, AZT, 3TC, D4T, DDI NVP M41L, D67N, L74V, L210W, T215C, K219E V179L, Y181C V35I, T39A, E40K, K43E, V60I, R83K, K101N, V118I, R211K, D218E  
MZ-pt32 pt32-t0 AZT, DDC, 3TC, D4T, ABC, DDI NVP M41L, D67E, V75M, L210W, T215Y Y181C, G190A V35I, K43E, E44D, S68G, V118I, K122P, I135T, A158S, D177E, V179I, T200E, I202V, E203K, Q207E, R211K  
  pt32-t1 AZT, DDC, 3TC, D4T, ABC, DDI NVP M41L, D67E, V75M, M184MI, L210W, T215Y Y181C, G190A V35I, K43E, E44D, S68G, V118I, K122P, I135T, A158S, D177E, V179I, T200E, I202V, E203K, Q207E, R211K  
MZ-pt33 pt33-t0 D4T, AZT, DDI, 3TC EFV, NVP M41L, L210W, T215Y K103N K20R, T39A, S48E, V60I, V118I, K122P, D123E, I135IV, D177E, Q207E, R211K, L228H  
  pt33-t1 D4T, AZT, DDI, 3TC, ABC EFV, NVP M41L, M184V, L210W, T215Y K103KN P4S, K20R, T39A, S48E, V60I, V118I, K122P, D123E, I135V, D177E, Q207E, R211K K220I 
MZ-pt34 pt34-t0 AZT, DDC, 3TC, D4T, DDI EFV M41L, T215Y K103N, V106IM K20R, A98S, K102R, K122E, V179I, G190GR, T200TA, E203ED, R211E  
  pt34-t1 AZT, DDC, 3TC, D4T, DDI EFV M41L, T215Y K103N, Y188L K20R, A98S, K102R, K122E, T200A, E203D, R211E  
MZ-pt35 pt35-t0 AZT, DDI, 3TC, D4T EFV M41L, L210W, T215Y L100I, K103N K20R, K43Q, V118I, K122E, D123DN, I135T, I202V, R211RK, L228R  
  pt35-t1 AZT, DDI, 3TC, D4T EFV M41L, L210W, T215Y L100LI, K103KN K20R, K43Q, V118I, K122E, D123DN, I135T, I202V  
MZ-pt36 pt36-t0 DDC, AZT, 3TC, D4T, DDI, ABC EFV D67H, K70R, L74I, T215F, K219Q G190A K20R, A62AP, T69N, D123E, I142IT, S162C, E169D, I178L, H208Y, R211K, D218E F160FS 
  pt36-t1 DDC, AZT, 3TC, D4T, DDI, ABC EFV M41L, D67H, K70R, L74I, M184V, T215F, K219Q  K20R, T69N, K101KQ, L109V, K122KE, D123DE, I142T, S162C, E169D, I178L, H208Y, R211K, D218E  
MZ-pt37 pt37-t0 AZT, DDI, DDC, 3TC, D4T NVP, EFV M41L, T69S_SS, L74V, L210W, T215Y K103N, V108VI, Y181C, G190A, H221Y V35I, W88C, V118I, K122E, T139K, F171Y, R211K  
  pt37-t1 AZT, DDI, DDC, 3TC, D4T NVP, EFV M41L, T69S_SS, L74V, L210W, T215Y K103N, V108VI, Y181C, G190A, H221Y V35I, W88C, V118I, K122E, T139K, F171Y, R211K  
MZ-pt38 pt38-t0 AZT, DDI, D4T, 3TC, ABC None K65R, V75I, F77L, F116Y, Q151M  S68G, T69I, E79D, V118VI, D121Y, K122E, S162C, I178M, Q197E, T200A, E204D, R211T, F214L  
  pt38-t1 AZT, DDI, D4T, 3TC, ABC NVP K65R, V75I, F77L, F116Y, Q151M Y181CF V35I, S68G, E79D, R83K, V118I, D121Y, K122E, S162C, S163A, I178M, Q197E, T200A, R211AT, F214L  
MZ-pt39 pt39-t0 AZT, DDC, 3TC, D4T EFV  K101P, K103N V35I, D123E, D177E, T200A  
  pt39-t1 AZT, DDC, 3TC, D4T, DDI EFV M41ML, L74LV, L210W, T215CY K101PQ, K103N V35I, K102KR, D123E, D177E, T200A, I202IV  
MZ-pt4 pt4-t0 DDI, AZT, DDC, 3TC, D4T EFV M41L, D67DN, M184MI, L210LW, T215Y  K43N, V118I, D123E, I135IV, Q207E, H208Y, R211K, K223E  
  pt4-t1 DDI, AZT, DDC, 3TC, D4T EFV M41L, T215Y  K43KN, V118I, D123E, Q197QR, I202V, R211K R83RS 
MZ-pt40 pt40-t0 AZT, DDC, 3TC, D4T, DDI, ABC NVP M41L, D67N, V75M, F77FL, L210W, T215Y, K219KR  V35L, K43Q, E44D, K101X, L109I, V118I, K122E, D123E, I135T, G196E, H208Y, D218E  
  pt40-t1 AZT, DDC, 3TC, D4T, DDI, ABC NVP M41L, D67N, V75M, F77L, L210W, T215Y, K219R G190GA V35L, K43Q, E44D, K101X, L109I, V118I, K122E, D123E, I135T, G196E, H208Y, R211K, D218E  
MZ-pt41 pt41-t0 AZT, DDI, 3TC, D4T EFV M41L, D67N, T69D, L210W, T215C K101P, K103NS, G190GRS V35I, E44D, A98S, K122E, D123E, D177G, G196E, R211KT  
  pt41-t1 AZT, DDI, 3TC, D4T EFV M41L, D67N, T69D, M184V, L210W, T215Y  V35I, E44D, A98S, K101Q, K122E, D123E, N175NY, D177DG, G196GE, R211K  
MZ-pt5 pt5-t0 AZT, DDC, 3TC, D4T EFV M41L, D67DN, V75M, L210W, T215Y K103N P19PQ, K43N, K122E, T139M, S162Y, E169ED, D177E, Q207E  
  pt5-t1 AZT, DDC, 3TC, D4T, DDI EFV M41L, D67N, V75M, L210W, T215Y K103N K43N, K122E, T139M, S162Y, D177E, Q207E, R211K  
MZ-pt6 pt6-t0 AZT, DDI, DDC, 3TC, D4T, ABC NVP, EFV M41L, L74LI, V75M, L210W, T215Y, K219N K103KN, Y181C, G190E K43E, E44A, V118I, K122E, V179G, T200K, R211K, L228H  
  pt6-t1 AZT, DDI, DDC, 3TC, D4T, ABC NVP, EFV M41L, V75M, M184V, L210W, T215Y, K219KR G190S K20R, K43E, E44A, V118I, K122E, D177DN, T200K, H208HY, L228I  
MZ-pt7 pt7-t0 AZT, DDI, DDC, 3TC, D4T EFV M41L, L74V, L210W, T215Y, K219N G190E E44D, A98S, V118I, K122E, K166R, D177E, R211K, L228H  
  pt7-t1 AZT, DDI, DDC, 3TC, D4T EFV M41L, M184V, L210W, T215Y  E44D, A98S, V118I, K122E, K166KR, D177G, E203K, R211K, K223Q, L228H  
MZ-pt8 pt8-t0 AZT, DDC, 3TC, D4T, DDI, ABC EFV M41L, D67N, L74V, L210W, T215Y, K219N L100I, K103N K20R, V35I, K43N, E44D, V118I, K122E, D177G, H208Y, R211K, D218E, F227Y  
  pt8-t1 AZT, DDC, 3TC, D4T, DDI, ABC EFV M41L, D67N, L74V, L210W, T215Y, K219N L100I, K103N K20R, V35I, K43N, E44D, V118I, K122E, D177G, H208Y, R211K, D218E  
MZ-pt9 pt9-t0 AZT, DDI, DDC, 3TC, D4T, ABC EFV, NVP M41L, D67N, M184MV, L210W, T215Y, K219Q K101HQ, V106I, G190GRS V35L, T39TA, E44D, K104KR, V118VI, K122E, D123DN, I135IT, S162D, Q174QK, D177DE, Q197K, T200A, I202V, Q207DE, H208HY, R211RK D86Y 
  pt9-t1 AZT, DDI, DDC, 3TC, D4T, ABC EFV, NVP M41L, D67N, M184V, L210W, T215Y, K219R K101H, V106I, G190GS, H221Y V35L, T39A, E44D, V118I, K122E, D123N, I135T, S162D, Q174K, Q197K, T200A, I202V, Q207D, H208Y