Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Vergne (2002)
Title Resistance to antiretroviral treatment in Gabon: need for implementation of guidelines on antiretroviral therapy use and HIV-1 drug resistance monitoring in developing countries.
Citation JAIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 32
NumPts 32
Subtype CRF02_AG, A, D, G, CRF11_cpx, A + CRF02_AG, K, B, H, A + J

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
LV01B LV01B D4T, DDI None K70N, V75T  V35T, T39N, T69N, K122E, D123S, I135T, S162C, K173S, Q174R, D177E, T200E, Q207A, R211S, V245Q, A272P, K275R, T286A, V292I, I293V, P294T, L295M, I326V, G335D, R356K, M357K, R358K, G359S, T369A, I375V, K390R, A400T, T403M, E404D, E432D  
LV02B LV02B D4T, DDI None   V35T, K49R, V60I, V118I, K122E, T165I, D177E, I178L, T200A, E204K, Q207E, F214L, V245I, D250E, A272P, K275R, Q278E, T286A, E328D, I329V, Y339W, A360T, V381I, K390R, E399D  
LV03 LV03 Unknown Unknown   K11T, I31V, V35T, T39K, V60I, K64R, K104R, D121Y, K122E, D123G, K173E, Q174R, D177E, T200A, Q207A, R211N, V245Q, E248D, A272S, K281R, E291D, V292I, I293V, E312T, Y319L, D320E, I326V, G335D, M357K, G359S, K366R, T369A, I375V, T377Q, K395R, A400T, E432D, V435L D324H 
LV04B LV04B AZT, D4T None K65R, K70R, V75I, F77L, F116Y, Q151M  K11T, V35T, T39K, K43E, S68G, D121Y, K122E, D123G, K173S, Q174K, I180V, Q207A, R211S, V245Q, E248D, K277R, K281R, T286A, E291D, V292I, I293V, P294T, S322T, G335D, M357K, G359S, K366R, I375V, T377Q, S379C, K390R, T403M, K431T, E432D, V435A  
LV05D LV05D AZT, 3TC None   P4T, V35T, E36D, A98S, K122E, D123N, I135V, S162A, K173I, Q174K, D177E, I178M, T200A, Q207E, R211K, F214L, V245E, A272P, K277R, T286A, E291D, V292I, I293V, N306D, S322A, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376T, A400T, T403M, E432D, V435G  
LV06G LV06G Unknown Unknown M41L, T215F  V35T, K122E, D123N, I135V, S162A, K173T, Q174E, D177E, I178M, T200A, Q207E, R211K, V245K, T286A, A288S, E291D, V292I, I293V, P294V, E297D, S322A, I326V, G335D, R356K, M357K, G359S, A371V, I375V, A376T, K388R, K390R, A400T, E432D, V435A  
LV07G LV07G D4T, DDI None   V35T, E36D, K122E, D123N, S162A, K173T, Q174K, D177E, T200A, I202V, Q207E, V245Q, A272P, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357R, R358K, G359S, A371V, I375A, T377I, K390R, K395R, T403M, E432D, V435I  
LV08I LV08I Unknown Unknown D67N  E6A, K11T, V35T, T39L, V60I, T107S, V118A, D121H, K122E, D123G, Q174G, D177E, T200A, Q207A, R211K, P243S, I244V, V245K, K249Q, A272P, K277R, T286A, E291D, V292I, I293V, E297K, K311R, G335D, R356K, G359T, I375V, T386I, K388R, K390R, A400T, P421H, K431T, V435A F440A 
LV09I LV09I D4T, DDI None M41L, T215Y  E6D, V35T, T39A, K122E, D123S, I135T, D177E, R199T, T200E, I202V, Q207E, R211K, P243A, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, I329V, Q334L, G335D, R356K, M357R, G359T, A360T, K366R, T369V, A371L, V372T, I375V, A376C, T377M, T386I, K395R, A400T, T403A, E404D, F416Y, V435M  
LV10K LV10K Unknown Unknown K70R, M184V  E6D, V21I, V35T, E40D, K49R, V60I, K102Q, K122E, D123N, K173T, Q174K, D177E, I178M, T200A, Q207D, R211K, V245Q, E248D, D250E, S251A, A272P, L283I, E291D, V292I, I293V, E297A, D324E, I329V, Q334L, G335D, F346Y, R356K, M357R, R358G, G359S, A360V, A371V, A376S, T386I, K390R, Q394R, E399D, A400V, E413D, Q428R, K431T, V435P  
LV11L LV11L D4T, DDI None T215Y  V35T, E36D, K49R, V60I, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, R211K, V245Q, E248N, A272P, Q278H, T286A, E291D, V292I, I293V, P294T, K311R, S322G, I326V, G335D, R356K, M357R, G359T, A371V, I375V, A400T, T403Q, K431Q  
LV12M LV12M Unknown Unknown M41L, T215Y  K20R, V35T, V60I, D123E, I135V, A158S, S162A, F171Y, K173A, Q174K, D177E, I178L, T200A, Q207E, R211K, V245E, D250E, A272P, K275R, K277R, Q278H, T286A, E291D, V292I, I293V, P294T, L295M, S322T, I326V, G335D, R356K, M357K, G359S, A371V, I375V, K390R, A400T, T403M, E432D, V435M  
LV14M LV14M Unknown Unknown M41L, D67N, T215Y  V21I, V35T, T39E, V60I, K122E, D123N, I142V, K173T, Q174K, D177E, I178M, G196E, T200V, V245Q, S251D, A272P, K275R, Q278N, L283I, V292I, I293V, L295M, E297K, I326V, G335D, R356K, M357K, G359S, K366R, E370Q, A371V, I375V, A376C, T377L, K395R, T403M, W410Y, Y427C T107V 
LV15M LV15M Unknown Unknown   V35M, R83K, E204D, Q207A, R211K, I244V, V245M, D250E, S251N, A272P, V292I, I329L, V365I, A376S, T386I, K390R, A400T, V417I, V435I  
LV16M LV16M AZT, 3TC None M184V  E6D, V35T, T39E, K122E, D123S, I135T, K173A, Q174K, D177E, Q207A, R211N, K238R, V245Q, E248N, D250E, S251D, A272P, A288T, E291D, V292I, I293V, P294V, E312N, G335D, M357K, G359S, K366R, I375V, T377V, K395R, A400T, E432D V8K 
LV18N LV18N Unknown Unknown   V35T, K122E, K173A, Q174K, D177E, V179I, T200A, Q207A, V245Q, E248D, A272S, K281R, E291D, I293V, E312N, I326V, G335D, R356K, M357K, G359S, K366R, T369V, A371V, I375V, A376T, T377Q, K390R, A400T, E432D, V435I  
LV19 LV19 D4T, DDI None  V106I E6D, V35T, E40A, K43E, V60I, V118I, D121C, K122E, T165I, D177E, I178V, T200E, E204K, F214L, V245T, E248D, D250E, A272P, K281R, R284K, I293V, I329L, G335S, A360T, K366R, A376S, T386I, K390R, E404D  
LV20N LV20N Unknown Unknown   V35T, T39Q, K122E, S162C, Q174R, D177E, I178M, T200A, Q207E, R211K, V245Q, E248D, A272P, E291D, V292I, I293V, E297A, Q334N, F346Y, M357L, G359S, T377I, K390R, A400T  
LV22S LV22S D4T, DDI None K70E, V75A Y181C, H221Y V21I, V35T, V60I, I142M, S163A, D177E, I178L, Q207D, R211K, V245Q, E248D, D250E, A272S, K281R, R284K, T286A, I293V, I329L, A360T, A376S, T386I, K390R, E404N, K431Q K73L 
LVLBV02_02 LVLBV02_02 None None   E6D, V35T, T39A, E40D, T69P, D123S, K173T, T200E, I202V, Q207K, R211K, P243A, V245Q, E248D, D250E, A272P, E291D, V292I, I293V, P294T, E297A, K311R, I329V, Q334L, G335D, R356K, M357R, G359T, K366R, T369A, A371V, V372T, A376S, T377M, T386I, K390R, K395R, A400T, E404D, V435M  
LVLBV02_08 LVLBV02_08 None None   E6D, K11T, V35T, T39K, D121Y, K122E, D123G, K173L, Q174K, D177E, V179I, Q207A, R211S, V245Q, E248D, A272P, K281R, E291D, V292I, I293V, E312N, K323R, G335D, M357K, G359T, K366R, T369A, I375V, T377L, K395R, E432D  
LVLBV03_09 LVLBV03_09 None None   V35T, E36D, T39S, K101Q, K122E, S162A, K173T, Q174K, D177E, I178M, T200A, Q207E, P243H, V245Q, T286A, E291D, I293V, P294T, S322T, I326V, G335D, R356K, M357R, G359S, A371V, I375V, T377V, K390R, K395R, E432D  
LVLBV06_12 LVLBV06_12 None None   I5V, V35T, K49R, K102Q, K122E, D123S, K173T, D177E, T200A, Q207E, V245Q, E248D, D250E, S251N, A272P, E291D, V292I, I293V, P294A, E297A, I329V, Q334L, G335D, R356K, M357R, G359T, A371V, V372T, K374I, T377M, P387L, K390R, A400T, E404D E413Q 
LVLBV11_05 LVLBV11_05 None None   I5V, E6D, V35T, E40D, K122P, D123S, S162A, K173A, Q174K, D177E, Q197K, T200A, Q207E, R211K, V245K, A272P, E291D, V292I, I293V, K311R, I329V, Q334V, G335D, R356K, M357R, G359T, K366R, A371V, A376C, T377L, T386I, K390R, K395R, A400T  
LVLBV14_06 LVLBV14_06 None None   V35T, E36D, D123N, I135V, S162A, K173A, Q174K, I178M, T200A, Q207E, V245T, E248D, T286A, I293V, E312D, G335D, M357K, G359S, A371V, I375V, S379G, K390R, T403M N418K 
LVLBV14_09 LVLBV14_09 None None   K20R, V35T, K122E, D123N, S162A, Q174N, D177E, T200A, Q207E, R211K, P243S, V245Q, A272P, V276I, T286A, E291D, I293V, S322A, I329V, G335D, R356K, M357K, G359S, T369V, A371V, I375A, K390R, T403M, A408D R199I 
LVLBV15_01 LVLBV15_01 None None   V35T, D123N, I135V, S162A, K173T, Q174K, D177E, I178M, T200A, Q207K, R211T, V245K, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357R, G359S, A371V, I375A, T377M, K390R, T403M, E432D, V435A  
LVLBV18_08 LVLBV18_08 None None   P4S, K11T, T27S, V35T, T39K, K43E, D123S, K173S, Q174K, D177E, Q207A, R211S, V245Q, E248D, V261I, A272S, K281R, E291D, V292I, I293V, E312N, G335D, R356K, M357K, G359S, K366R, T369A, I375V, T377Q, K390R, K395R, T403M, E432D  
LVLBV23_11 LVLBV23_11 None None   V35T, E36D, T39L, I135V, S162A, F171Y, K173A, Q174K, D177E, T200A, Q207E, P243H, V245Q, A272P, V276I, T286A, E291D, V292T, I293V, P294I, P321S, S322T, I326V, G335D, R356K, M357K, G359S, T369A, A371V, I375V, A376V, T386P, K390R, K395R, A400T, T403M, E432D, V435E  
LVLBV24_09 LVLBV24_09 None None   V35T, K122E, I135V, S162A, K173T, Q174R, D177E, I178M, T200A, Q207E, R211K, V245Q, A272P, T286A, V292I, I293V, P294T, T296P, S322T, I326V, G335D, Q343R, R356K, M357K, G359S, A371V, I375V, K388I, K390R, T403M, E432D L422V 
LVLBV26_05 LVLBV26_05 None None  A98G, V106I K20R, V35T, T39E, E40D, V60I, K104R, V118I, D123S, I135V, K173A, Q174K, D177E, T200A, Q207E, R211K, F214L, V245Q, E248D, D250E, S251I, A272P, Q278H, K281R, T286A, E291D, V292I, I293V, P294T, E297T, L301M, P321Q, D324E, I329V, Q334L, G335D, F346Y, R356K, M357K, R358G, G359S, A371V, S379G, T386V, K390R, Q394R, A400V  
LVLBV30_10 LVLBV30_10 None None   V35T, E40D, K122E, D123N, I135V, S162A, K173T, Q174K, D177E, T200A, Q207E, R211K, V245Q, E248N, T286A, E291D, V292I, I293V, P294T, S322T, I326V, G335D, R356K, M357K, R358K, G359S, A371V, I375V, T377L, K390R, E396D, T403M, E432D, V435M, A437V