Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Fitzgibbon (2001)
Title Emergence of drug resistance mutations in a group of HIV-infected children taking nelfinavir-containing regimens.
Citation ARHR
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 23
NumPts 12
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
JF-1 JF1-B AZT, 3TC, D4T, DDI NVP M41L, L74V, L210W, T215Y K103N, Y181C V35P, T39A, R83K, A98S, I178L, R211K, V245E  
  JF1-M4 AZT, 3TC, D4T, DDI, DDC NVP M41L, L74V, L210W, T215Y K103N, Y181C K22N, V35T, T39A, R83K, A98S, K122E, I178L, R211K, V245E  
JF-10 JF10-M8 AZT, 3TC, D4T None M41L, M184V, L210W, T215Y  K22N, K43N, K122E, D123E, A158S, R211K  
  JF10-M12 AZT, 3TC, D4T None M41L, M184V, L210W, T215Y  K122E, D123E, A158S, S162C, R211K Y146F 
JF-11 JF11-M5 NRTI, D4T, DDI None M41L, D67N, L210W, T215Y  V35I, E44D, K122E, D177E, I178M, G196E, T200K, K201R, H208Y, R211K, V245M P226A 
  JF11-M13 NRTI, D4T, DDI None M41L, D67N, L210W, T215Y  K22N, V35I, E44D, K122E, D177E, I178M, T200K, H208Y, R211K, V245M  
JF-12 JF12-B AZT, DDI None M41L, L210W, T215Y  E6D, T39A, V118I, S162C, Q207E, R211K  
  JF12-M9 AZT, DDI, 3TC, D4T None M41L, M184V, L210W, T215Y  T39A, V118I, S162C, Q207E, R211K  
JF-2 JF2-B AZT, 3TC None M41L, D67N, L210W, T215Y  V35I, K49R, P52A, R83K, K103R, I135T, S162C, R211K, V245E  
  JF2-M4 AZT, 3TC, D4T None M41L, M184V, L210W, T215Y  V35I, K49R, P52A, R83K, K103R, I135T, S162C, R211K, V245E  
JF-3 JF3-M6 D4T, DDI, AZT, 3TC, DDC NVP, DLV L210W, T215Y K103N, Y181C T27S, V35I, A98S, I142V, I178L, G196E, E248D  
JF-4 JF4-B DDI None   K22N, R83K, D123E, I135T, I178V, R211K, V245E  
  JF4-M7 DDI, 3TC, D4T NVP   R83K, D123E, I135T, I178V, R211K, V245E  
JF-5 JF5-B AZT, DDI None M41L, D67N, K70R, L210W, T215Y  K22N, V60I, E169D, G196E, H208Y, R211K  
  JF5-M9 AZT, DDI, 3TC, D4T None M41L, D67N, K70R, M184V, T215Y, K219Q  V60I, A158S, E169D, G196E, R211K  
JF-6 JF6-B AZT, DDI None D67N, K70R, T215F, K219Q  V35M, K103R, K122E, D123E, A158S, N175Y, T200E  
  JF6-M8 AZT, DDI, D4T NVP D67N, K70R, T215S, K219Q Y181C K20R, V35M, K103R, D123E, A158S, N175Y, T200E  
  JF6-M12 AZT, DDI, D4T NVP D67N, K70R, T215S, K219Q Y181C K20R, V35M, K103R, D123E, A158S, N175Y, T200E Q222E 
JF-7 JF7-M13 AZT, DDI, 3TC, D4T None M41L, D67N, M184V, L210W, T215Y  K43E, V118I, R211K  
JF-8 JF8-B9 AZT, DDI None K70R, T215F, K219Q  K22N, K103R, K122E, I135T, R211K, F214L  
  JF8-M10 AZT, DDI, 3TC, D4T None M41L, D67N, K70R, T215F, K219Q  V35M, T69N, K103R, V118I, K122E, I135T, K201I, H208Y, R211K, F214L, L228H Y56S 
  JF8-M14 AZT, DDI, 3TC, D4T None M41L, D67N, K70R, T215F, K219Q  K20R, V35M, T69N, K103R, V118I, K122E, I135T, K201I, H208Y, R211K, F214L, L228H  
JF-9 JF9-M6 NRTI, D4T None M41L, D67N, T69D, M184V, L210W, T215Y  E44D, V60I, V118I, D123E, R211K