Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.


Author Kempf (2001)
Title Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 176
NumPts 112
Subtype B


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Page 1   listing Isolate 1 to Isolate 100 from Total 176 Clinical RT Isolates

SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
DK-1014 DK-1014 RTI RTI M184V  D123E, I135T, K173N, T200A, V245M, T286TA, I293IV, E297A, T377Q K126KE 
DK-1115 DK-1115 RTI RTI M41L, D67N, T69D, M184V, L210W, T215Y  K20R, E44D, V60I, K102KE, V118VI, D121H, K122E, I135T, S162YD, K166KR, D177E, G196GE, E203EK, Q207E, A272P, T286A, E297K  
DK-125 DK-125 RTI RTI M41L, D67N, T69D, M184V, L210W, T215Y  K20KR, V35L, T39A, E40F, K43E, V118I, K122P, D177E, I178IM, G196E, H208YF, R211K, V245T, Q278E, T296S, E297K M230MV 
DK-1324 DK-1324 RTI RTI M184V E138EQ E6ED, K32KR, V35T, I135IM, S162X, E169ED, I202V, Q207E, Q278H, K281R, V292VI, I293V, P294T, D324DE, K366R  
DK-1543 DK-1543 RTI RTI M184V  K102E, I135T, S162C, R211K, I293V, Q334L, M357S, T369V  
DK-1584 DK-1584 RTI RTI K65R V106VI V35M, S68G, K82R, K122E, I135T, G196E, R211G, V245Q, A272P, V292I, I293IV  
DK-1704 DK-1704 RTI RTI M41ML, D67N, K70R, M184V, T215VF, K219Q  K20R, K104N, I167V, I202V, R211K, V245K, A288K, V292I, I293V, D324E, M357T, A400IV  
DK-1884 DK-1884 RTI RTI D67DN, K219KQ  K11KT, V35T, K49R, V60I, K122E, D123S, I135T, I142V, K173L, Q174K, D177E, V179I, Q207A, R211T, T215X, D218DE, V245Q, A272P, L283I, P294T, L295M N147NT 
DK-1894 DK-1894 RTI RTI D67N, T69ND, K70R, M184V, T215F, K219Q  K20KR, K43KQ, K122E, D123X, T200A, I202V, H208HY, A272P, I293IV  
DK-2105 DK-2105 RTI RTI   V8VI, V35VI, R83K, K104KR, D123E, I135T, A272P, K281R, E297K  
DK-2194 DK-2194 RTI RTI   R83K, T200TA, V245E, K281R, E297EA  
DK-2304 DK-2304 RTI RTI M41L, M184V N348NI D123E, S162SG, I178L, T215X, V245T, T286A, I293V, E297K, G333E, G335C, R356K, Q367L, A376V, S379C, T386I, A400AT  
DK-2314 DK-2314 RTI RTI L74LV, V75A, M184V, T215Y K103N, G190GC K73M, R83K, L100X, K101KQ, V118I, D123G, I135IM, S162X, I178L, T286A, I293V, E297A, D324E, R358K  
DK-2405 DK-2405 RTI RTI M184V  V21VI, K102KE, D123E, D177E, I178IL, V179VI, T200TA, A272P, K277KR, T286A, E297K A304AS 
DK-2415 DK-2415 RTI RTI M41L, D67N, M184V, L210W, T215Y, K219KE  V35T, V60I, V118I, K122E, I135V, S162SN, T200A, E203ED, Q207E, R211K, V245Q, A272P, L283I, T286A, E291D, V292I, A304E  
DK-243 DK-243 RTI RTI M184V  V60I, V90I, K122Q, D123E, I178L, R211K, D237DN, I293V, I326V, Q334L, R356K, M357T, T397TI  
DK-2715 DK-2715 RTI RTI M41L, D67N, V75M, L210W, T215Y A98G T39E, K43KE, E44D, E79D, K103R, V118I, K122E, I142V, K173E, G196GE, H208Y, R211K, Q278H, T286A  
DK-2833 DK-2833 RTI RTI A62V, M184I  K102Q, D123N, I135V, S162C, R211K, E248D, T286A, E297K, A327V, F346C, M357T, K366R, T386I  
DK-284 DK-284 RTI RTI   K20R, V35VI, T69TN, D121H, K122E, I135T, D177E, R211TK, A272P, T286A, E297K, L301I  
DK-294 DK-294 RTI RTI M41L, A62AV, K70KT, V75I, M184V  K20KR, V21VI, K43KN, W88S, D123E, D177E, I178L, G196E, V245VE, D250E, A272P, K281R, A288S, I293IV, P294S, E297K  
DK-3015 DK-3015 RTI RTI D67N, K70R, M184V  T27S, T39A, K102KR, D123E, I142T, D177E, G196E, Q207QE, V245K, A272AP  
DK-3025 DK-3025 RTI RTI M41L, A62AV, M184V, T215Y  I135IV, Q207E, R211K L205LV 
DK-3083 DK-3083 RTI RTI M184V  K20KR, V35VA, T139X, I142X, G196GE, R211K, V245K, V292I, I293V, S322T, Y342YF, F346FS, M357V, T369TI, K390R, A400S  
DK-3133 DK-3133 RTI RTI D67N, K70R, M184V N348I R83K, D123E, Q197E, R211K, I329L, R356K, G359S, V365I, A376S, K390R  
DK-3143 DK-3143 RTI RTI K70KR, M184V  K43KE, I135T, R211K, S251T, S322T  
DK-3184 DK-3184 RTI RTI M41L, L210W, T215Y  P4PT, K20KR, V35I, T39S, E44D, S68SG, V118I, I135T, E194K, G196E, Q207E, R211K, L228H, V245K  
DK-3443 DK-3443 RTI RTI M184V  V21I, D123E, S162A, D177E, V245K, A272AP, T286A, A288S, I293V, K311R, G333D, Q334QH, T338TS, Q343QH, M357T, A360AT, T377L, S379C, K390R, E399D  
DK-3484 DK-3484 RTI RTI K70KR, M184V  K32E, V35I, T69A, D121Y, K122E, I135K, I142V, A158AS, D177E, G196GR, T200TI, Q207E, V245VI, A272P, T286A L209LM 
DK-3494 DK-3494 RTI RTI M184V, T215Y M230L A98AS, V118VI, K122KE, D177E, Q207E, R211K, D250E, A272P, I274V  
DK-354 DK-354 RTI RTI M184V  A98S, I135IL, S162X, T200EA, V245E, E297K, S379G, K390R  
DK-3604 DK-3604 RTI RTI M41L, L210W, T215Y  K104KR, V118I, I135T, Q207E, V245M, Q278H, A288S, I293V, I329V, A360AT, A371AV, A376S, T386I, K390R W401A 
DK-3705 DK-3705 RTI RTI M41L, D67N, T215Y E138EK, V179ED K122E, I135V, I142X, S162SC, R211S, S251H, T286A  
DK-3794 DK-3794 RTI RTI M41L, D67N, M184MV, L210W, T215Y  K20R, E44D, K49R, R83K, K102KQ, D121DA, K122E, I135V, G196E, R211K, E297A  
DK-3823 DK-3823 RTI RTI     
DK-3914 DK-3914 RTI RTI M184V  V35I, E40ED, I135T, R211K, V245K, T286A, E297K, V317VA, I326IV, Q334L, T377Q, K390R  
DK-404 DK-404 RTI RTI M41L, L210W, T215Y N348I D121Y, S162A, K173N, E203K, Q207E, E297Q, Q334L, A360V, K390R  
DK-4094 DK-4094 RTI RTI M41L, D67N, K70R, T215F, K219E  V60VI, V75X, D123E, S162SN, G196E, Q207H, A272P, Q278H, E297K  
DK-4214 DK-4214 RTI RTI M184V, L210W, T215Y  V35M, R83K, A158S, E169D, T200I, R211K, I293V, G333E, Q334QH, M357T, K390R, K395R, A400L  
DK-4224 DK-4224 RTI RTI M41L, M184V, L210W, T215Y  K11R, I178M, T200A, Q278H, I293V, F346L, G359S, A371V, A376S  
DK-4305 DK-4305 RTI RTI M41L, D67N, T69D, M184V, T215Y  K30KR, V35T, V60VI, V111X, K122P, I135T, I178M, A272P, E297A N147NT, W252WC, I274IT 
DK-4315 DK-4315 RTI RTI M41L, M184V, L210W, T215Y A98G T39A, E44ED, S68G, D123E, I142IV, Q174H, G196E, E203K, Q207E, R211K, A272P, K281R, T286P, E297RK  
DK-4433 DK-4433 RTI RTI D67N, K70R  V35I, K122P, I135R, D177E, T200R, P294T, E297K  
DK-4784 DK-4784 RTI RTI M41L, L74LI, M184MV, L210W, T215Y  K122E, R172RK, Q174R, G196E, R211K, A272P, E297R  
DK-4904 DK-4904 RTI RTI D67DN, K70R, M184V, K219Q  V21VI, T39A, K102KR, D123E, I135V, N175NY, D177DE, V179VI, G196ED, T200TA, A272AP, N348NT, M357T, K390R, K395R, E399D  
DK-5043 DK-5043 RTI RTI D67N, M184V, T215C, K219Q  E6D, I31IT, V35I, K102R, K104N, D121H, I132IV, I135IV, D177E, T200I, R211K, D218E, L260LV, V276I, A288S, I293V, Q334P, T338TA, R356K, M357T, I375IV  
DK-505 DK-505 RTI RTI M41L, T69D, M184V, L210W, T215Y, K219R F227FL K20R, T39TA, K43E, E44D, S48X, V118I, K122E, D123N, I142IV, T200A, E203K, H208Y, R211KE, F214FL, K223E, L228R, D250E, Q278H, T286A F130FC, M230K 
DK-5084 DK-5084 RTI RTI M41L, D67N, M184MV, L210W, T215Y, K219N  K43E, E44A, V118I, K122E, I135V, I142V, S162YC, G196GE, E203D, Q207QE, H208YF, R211K, Q278H  
DK-5204 DK-5204 RTI RTI M184V  E6D, R83K, D177E, T200A, E203K, Q207E, R211K, K277KR, E297K, K311R, I329V, G333E, R356K, A371V, K390R  
DK-5394 DK-5394 RTI RTI M41L, M184V, T215Y  E28ED, T39A, K49R, K122E, D123N, I135T, I142V, S251I, I257L, A272P, Q278QH, T286TA, E297A F130FC, R143RI, N147NT 
DK-5454 DK-5454 RTI RTI M41L, M184V, T215Y  T39TA, I142V, F171FY, V245K, R358RK, G359GS, A360AT, A376AT  
DK-5605 DK-5605 RTI RTI M41L, D67DN, K70R, M184V, T215Y  K22N, S48T, K122P, E204ED, R211K, A272P Q23N 
DK-5615 DK-5615 NRTI None M41L, D67N, T69ED, K70R, L210LW, T215F, K219Q  K11Q, T39TA, V60VI, V118VI, D121DH, K122KE, D123SN, I135IT, I180V, G196E, T200MI, D218E, L228LH, A272P  
DK-5673 DK-5673 RTI RTI M184V  T39A, I142V, I178M, Q207H, R211K, V245MT, I293V, E297EK, V317A, I329L, R356K, A360V  
DK-5723 DK-5723 RTI RTI D67N, T69D, K70R, M184V, T215F, K219Q  P14PL, D123E, A158S, S162A, I178L, R211K, R284K, T286A, E297K, S322T, Q334E, M357T, A360T, A376S, T377M  
DK-5814 DK-5814 RTI RTI M41L, M184V, T215Y N348I R83K, Q207R, V245E, I293V, M357T, K366KR  
DK-5915 DK-5915 RTI RTI M41L, M184MV, L210LW, T215Y  K43KE, A98S, K122E, Q174QE, R211RK, V245E, S251I, T286TA  
DK-594 DK-594 RTI RTI D67N, K70R, T215I, K219Q  K43KE, K103R, K122E, F214FL, T286A, A288S, E297A  
DK-5973 DK-5973 RTI RTI M184V  K43QE, A98S, I142V, E203K, R211S, V245T, E297K, I329L, M357MV, K366KR, A376S, K390R, K395R  
DK-6033 DK-6033 RTI RTI M41ML, M184V, T215Y N348I K22KN, I31IL, T39TP, E42EK, R83K, D86DN, K173KR, E194Q, G196GE, T200TI, R211K, V245K, R284RK, I293V, Q334N, I375V, T377R, K390R  
DK-6114 DK-6114 RTI RTI D67N, K70R, M184V, K219Q  K20R, T69TN, I135T, I195T, T200A, V245K, T286A, I293V, Y339F, R356K, G359GS  
DK-6215 DK-6215 RTI RTI M41ML, D67N, K70R, T215Y  V35I, K49R, V60I, R83K, V90I, A98S, I135V, R211TA, D218DE, V245S  
DK-6225 DK-6225 RTI RTI M41L, D67N, K70R, M184V, T215F, K219Q  V118I, K122E, I135T, S162D, D177E, T200E, E203D, F214L, V245K, E297A  
DK-623 DK-623 RTI RTI A62AV, M184V N348I K49R, A98S, T165I, G196E, I293V, T296S, E297K, K390R  
DK-6273 DK-6273 NRTI None M41L, D67N, K70R, L210W, T215Y  I5V, E6D, K20R, E44D, V60I, V118I, D123E, D177E, G196E, T200I, E203D, Q207E, H208Y, R211K, K219H, L228H, T286A, I293V, E297K, I329V, G333E, Q334Y, M357T, E399D  
DK-6333 DK-6333 RTI RTI M41L, M184V, L210W, T215Y  D123G, I135T, E203K, Q207E, R211K, T286A, I329V, M357MR, G359GS, A360T, A371V  
DK-6384 DK-6384 RTI RTI M41L, T215Y, K219KQ  V60VI, R83K, V90VI, K122E, I135IT, S162Y, E169ED, T200TI, E203ED, Q207X, R211RK, A272P  
DK-654 DK-654 RTI RTI M41L, D67DN, M184V, T215Y N348I K20R, I135V, S162C, Q207E, H208HY, R211RK, I293V, Q334L, A360T, K366R, E370D, T386TI  
DK-6684 DK-6684 RTI RTI M41L, D67N, K70R, M184V, L210W, T215Y, K219E  T39A, K43KN, E44ED, D123E, E169D, D177E, V179VI, T200A, H208Y, R211K, L228H, V245K, A272P, A288S, E297A  
DK-6694 DK-6694 RTI RTI D67N, K70R, T215IF, K219E  V35T, V60I, A98S, K122E, I135T, K166R, I202V, L210LF, A272P, L283I  
DK-6804 DK-6804 RTI RTI D67G, K70R, T215F, K219Q  K20R, S68G, R211S, E224ED, K281R, I293V, E297K, I329IL, Q334P, R356RK, G359GS, T369X, A371AV, I375V  
DK-6905 DK-6905 RTI RTI M41L, D67N, K70R, M184V, T215F, K219E  V35T, T39K, K43Q, V60I, V118I, D121H, K122E, I135V, K173T, Q174K, D177E, T200A, Q207E, R211RK, F214L, V245Q, E248D, D250E, A272P, K275R, Q278N, T286A, A288V, V292I, E297A  
DK-6994 DK-6994 RTI RTI L210LW  V60I, I142V, K173KR, R211RG, V245M, P247PA, Q278E, A288AS, I293IV, E297R  
DK-714 DK-714 RTI RTI M41L, M184V, T215Y V108I, N348I T27S, D123E, Q174K, D177E, D250E, A272T, R284K, T286A, Q334N, T338S, K385R, K390R, E399G  
DK-7205 DK-7205 RTI RTI M41L, D67N, V75VA, M184V, L210W, T215Y  K20R, K32N, V35I, K43E, E44D, V118I, K122E, D123DE, I135K, S162YC, K173KE, P176PS, I178IL, G196E, Q197KE, I202IV, R211K, K238KR, A272P, E291D, I293IV, P294Q  
DK-7294 DK-7294 RTI RTI M184V  D121DY, K122E, E203D, R211K, L283I, E297A N136ND 
DK-7354 DK-7354 RTI RTI T215Y K101E K20R, V35VI, S162C, I195IV, T200EA, E203D, T286A, I293V, T296S, E297K, P313Q, V317A, D324DE, G333D, G335GS, R356K, A360T, K395KR, E399D  
DK-7414 DK-7414 RTI RTI K70R, M184V N348I V35VA, V60I, I135T, R211K, P345Q, R356K, A360T, K390R Y339V 
DK-7505 DK-7505 RTI RTI M41L, D67N, M184V, T215Y  V35I, K43KE, R83K, D123E, T139K, I202V, D250E, A272P, E297A, E300Q  
DK-7515 DK-7515 RTI RTI  E138A A98S, D123DE, I202V, R211K, A272P, K281R, T286A, E297K N147NT 
DK-7623 DK-7623 RTI RTI D67N, M184V  V35T, A158S, Q207K, R211K, V245T, T286A, A288S, E297K, K311R, V317A, I329V, G333E, Q334N, Q367L, E399D  
DK-7815 DK-7815 RTI RTI D67N, K70G, F116Y, Q151M, L210LW, T215Y  P1PL, K11KT, K20R, V35VI, K122E, D123X, I135T, I167IV, P170PL, V179I, I202V, E204EK, H208HY, R211K, T286A, E297K  
DK-7933 DK-7933 RTI RTI K70R, M184V  Q197L, V245E, A288T, E297A, I326V, A400V  
DK-7974 DK-7974 RTI RTI M41L, D67N, L210W, T215Y  K20R, K43N, E44D, V118I, K122E, S162X, K166R, V179VI, T200I, R211K  
DK-7984 DK-7984 RTI RTI M41L, L210W, T215Y  V35M, K43Q, D67DA, V118VI, D121DH, K122KE, D123DE, I135V, D177E, Q207E, R211K, L228H, A272AP, T286A, E297EK  
DK-8125 DK-8125 RTI RTI M41L, M184V, L210W, T215Y  K20KR, V35VI, K43E, E44EA, K122P, D123E, I142V, E169D, G196E, T200K, H208Y, R211K, V245K, A272P, A288AS, E297K  
DK-815 DK-815 RTI RTI M41L, D67N, V75M, L210W, T215Y A98G, K103N V35M, T39A, K43E, E44D, V118I, K122E, I178L, H208HY, R211K, A272P, T286A, V292I, E297EA  
DK-8284 DK-8284 RTI RTI D67N, K70R, K219Q  V35T, T39L, I50V, V60I, K122E, D123S, I135T, K173S, Q174K, D177E, V179I, T200K, Q207A, R211S, F214L, V245Q, T286A, E291D  
DK-8404 DK-8404 RTI RTI D67N, K70R, M184V, K219Q  K102KR, D123E, I135IV, D218E, Q278H, E297KR, E312EQ, I329L, G359GS, V365VI, K390R  
DK-8594 DK-8594 RTI RTI D67G, M184V, K219Q  K20KR, V35I, K64N, I135T, K166R, H208Y, R211K, D218E, A272P  
DK-8654 DK-8654 RTI RTI D67DN, K70R, K219Q  V35VI, T69S, A98S, K102KR, G196E, F214FL, L228HR, A272S, K281R, I293V, E297K, D324DE, I329IV, A360T  
DK-8704 DK-8704 RTI RTI M41L, D67N, T69D, M184V, L210W, T215Y A98G K32KR, V60I, I135IT, R211K, K238R, T286A, V292I, I293IV, A360AT, K390R  
DK-8714 DK-8714 RTI RTI K70KR, M184V N348I V8I, V118I, S162C, D177E, Y318YD, D324E, M357V, S379G, V381I, K390R  
DK-873 DK-873 RTI RTI M41L, D67N, K70R, T215F, K219E  I178M, T200A, E204D, S251T, R284K, T286A, I293V, S322T, Q334E, A355AT, M357S, A360T, K390R  
DK-8805 DK-8805 RTI RTI M41L, D67N, T69D, M184V, L210W, T215Y  T39A, K43KQ, E44D, R83RK, V118VI, K122E, I135T, E169D, D177DG, T200E, E203K, Q207QE, H208Y, R211K, A272P, V276T, K277KR  
DK-8873 DK-8873 RTI RTI M184V  K11KT, R83K, R211K, T286A, E297K, I329L, Q334H, F346Y, V365VI, L368LV, T369IV, K390R  
DK-8923 DK-8923 RTI RTI K70R, M184V V179D D123N, I135L, R211KT, A272S, E291D, E297K, H315Y, I326V, Q334L, G359S, A360V, A376S, T386I, A400AT  
DK-9014 DK-9014 RTI RTI   K104KN, D177DE, Q207X, R211K, V245M, I293V, K311R, V317A, Q334L, R358K, G359S  
DK-923 DK-923 RTI RTI K70KR, M184V  A98S, T139TK, S162SC, Q207E, F214FL, R284RK, T286A, V292VI, I329L, M357T, A360T  
DK-933 DK-933 RTI RTI M41L, A62V, M184V, T215Y V106I K166R, G196E, T200I, D250E, T286A, E297A, L301M, D324E, Y342F, A360T, K366R, A371V  
DK-974 DK-974 RTI RTI M41ML, D67DN, K70KR, M184MV, L210LW  T39TA, E44ED, T69X, V118VI, K122KE, I135T, S162YC, E203EK, H208HY, R211ED, T215X, K223KE, L228LH, R284K, T286TA, E297EK