Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Kempf (2001)
Title Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients.
Citation J Virol
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 177
NumPts 112
Subtype B

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 177 Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
DK-1014 DK-1014 IDV 85   K14R, I15V, E35D, M36I, R41K, L63SP, E65ED, A71AV, I72IT, I93L  
DK-1115 DK-1115 SQV, IDV 155 M46I, V82A, L90M Q58E, G73T L10I, Q61N, L63P, I64V, I93L  
DK-125 DK-125 IDV, NFV 172 M46I, I54V, V82F, L90M Q58E L10I, D60DE, I62IV, L63LP, I64V, I72IM, V77I, I93L  
DK-1324 DK-1324 NFV 45 L90M  L63P, H69Y, A71T, I72E, V77I  
DK-1543 DK-1543 NFV 72 M46I K20T, L24I I64V, V77VI  
DK-1584 DK-1584 RTV, NFV, IDV 76 D30N, M46MI  R41K, I62V, L63P, V75VI, V77I, I93L  
DK-1704 DK-1704 IDV 67 M46MI, V82F  E35D, M36I, N37D, R41K, R57K, L63P, V77I, I93L  
DK-1884 DK-1884 RTV, IDV, SQV, NFV 159   L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63P, H69QK, L89M  
DK-1894 DK-1894 RTV, SQV, IDV, NFV 171 M46MI, I54IV, V82VA, I84IV, L90M G73S L10I, I15V, K20M, E35ED, M36I, I62IV, L63P, A71AV, I85IV, I93IL  
DK-2105 DK-2105 SQV, RTV, IDV, NFV 179   I13V, I15IV, G16A, I62V, L63P, H69N, V77VI  
DK-2194 DK-2194 SQV, NFV, IDV 134   I13IV, K14KR, R57RK, V77VI  
DK-2304 DK-2304 SQV 67 G48V  L10I, R41K, I62V, L63S, I64V, T74S D30DG 
DK-2314 DK-2314 NFV 133 M46I, N88S, L90M  L10IM, I13V, Q18H, N37D, K55KR, Q61QH, L63P, A71T, I72T, V77I, I93L  
DK-2405 DK-2405 SQV, IDV 131 M46ML, V82VA  G68GE, H69X, A71V, I93L  
DK-2415 DK-2415 IDV, RTV 134 M46I, I54V, V82A  I13V, Q18H, K20I, E35G, M36I, N37S, R41K, K43R, L63P, H69K, A71T, P79PA, L89X, Q92QK  
DK-243 DK-243 NFV 29 D30N  E35D, M36I, N37E, D60E, I64V  
DK-2715 DK-2715 RTV, IDV 30 M46ML, I54V, V82A, N88S, L90M L33F, Q58E, G73TS L10I, I13V, K55KR, I62IV, L63P, A71V, V77I  
DK-2833 DK-2833 NFV 46   I13V, L63P, V77I  
DK-284 DK-284 NFV, IDV 62   I13V, N37NS, I62IV, L63X, I64X, E65ED, V77I, L89LM  
DK-294 DK-294 SQV, IDV, RTV 181   I15V, M36I, R41K, L63P, E65D, K70R  
DK-3015 DK-3015 RTV, IDV, SQV, NFV 123 I54V, V82A, L90M L10LF L33LI, E35D, M36I, L63P, A71V, I93L  
DK-3025 DK-3025 IDV, RTV, NFV 164 I54V, V82A, L90M K43T L10V, K20R, E35D, M36I, I62V, L63P, I64V, I93L  
DK-3083 DK-3083 SQV 31   E35D, N37D, R57K, A71T, I93L  
DK-3133 DK-3133 IDV 98 I54V, V82T F53L E35D, M36I, L63P, I64V, A71V  
DK-3143 DK-3143 NFV 68 D30N, L90M N88D I13V, L19V, L33I, E35D, M36I, P39Q, I62IV, L63P, I64V, A71T  
DK-3184 DK-3184 RTV, IDV, NFV 185 I54V, V82A L24I L10I, I15V, N37D, K45V, L63P, L89M  
DK-3443 DK-3443 NFV 57  N88ND P39PT, R57K, L63P  
DK-3484 DK-3484 SQV, RTV, NFV 147   L10I, I13IV, M36I, L63P, K70KQ, I93L  
DK-3494 DK-3494 SQV, RTV 165 G48V, I54V, V82A, L90M  L10I, L63P, A71V, I72M, V77I, I93L  
DK-354 DK-354 IDV 58   I13V, R57K, L63P  
DK-3604 DK-3604 SQV 80 I84V, L90M F53L L10I, N37NS, L63P, A71V, L89I  
DK-3705 DK-3705 SQV, RTV, IDV, NFV 139 I54V, V82T, L90M  L10I, L19R, N37NY, R41K, D60E, L63P, A71V, V77I, I93L  
DK-3794 DK-3794 IDV, SQV, RTV 148 I54V, V82A, I84V, L90M  L10I, I15V, L63P, A71V, I85V  
DK-3823 DK-3823 IDV 147 M46L, I54V, V82A F53L L10I, T12K, I15V, I62V, L63P, A71V, T74A  
DK-3914 DK-3914 NFV 19   I13V, I15V, E35D, R41K, I62V, L63P, A71T  
DK-404 DK-404 IDV 45 M46I, N88S  I62V, L63P, I93L  
DK-4094 DK-4094 IDV, SQV, RTV, NFV 151 M46I, I54V, V82A, L90M L10VF L63P, H69K, A71V, I93L  
DK-4214 DK-4214 RTV 80 M46L, V82L Q58E L63LP  
DK-4224 DK-4224 IDV 32 M46L, V82A F53L I13V, L63LP, I64V  
DK-4305 DK-4305 IDV, NFV, RTV 161 M46I, I54V, V82A L24I L10I, K14R, L63P, H69Q, A71V, V77I, I93M  
DK-4315 DK-4315 IDV, RTV, NFV 173 L90M G73S L10I, K20I, N37D, R57K, D60E, L63P, A71I, V77I, I93L  
DK-4433 DK-4433 RTV 54 I54V, V82A  L10I, T12P, K14R, I62V, L63H, I93L  
DK-4784 DK-4784 IDV, SQV, RTV 193 M46L, G48S, I54V, V82A L10IF, L24I, F53L K20R, L33I, E35D, M36I, N37D, R41K, K55R, R57K, L63P, I64V  
DK-4904 DK-4904 NFV 57 D30DN N88D N37ND, A71AT, V77VI  
DK-5043 DK-5043 IDV 56   E35D, M36I, N37D, L63P, C67S, A71T, I72V  
DK-505 DK-505 SQV, IDV 257 I54V, V82T L24I, F53FL L10I, M36I, R41K, D60E, I62V, L63P, I66F, K70R, A71V  
DK-5084 DK-5084 SQV, RTV, IDV, NFV 126 M46I, I84V, L90M G73GS L10I, T12A, L19LI, K20X, E35D, N37P, K55KR, R57K, I62IV, L63P, I64IV, I66IV, A71V, V77VI, I93IL  
DK-5204 DK-5204 SQV 57 I84V, L90M L10F, T74P E35D, L63P, A71V, I93L  
DK-5394 DK-5394 IDV, NFV 93 M46L  L10R, L63P, A71T, I72T, V77VI, I93IL  
DK-5454 DK-5454 NFV 51 D30N L10LF, N88D T31TP, P39PS, R41K, K45KQ, I64V, A71AV  
DK-5605 DK-5605 IDV, NFV 104 M46MI, L90M  L10R, L63P, I64V, V77I, I93L  
DK-5615 DK-5615 SQV, IDV 166 M46L, V82A L24I L10I, I15V, L19I, K55KR, I62V, L63PA, T74A, L89LM  
DK-5673 DK-5673 IDV 92 L90LM  L63P, I85IV, I93L  
DK-5723 DK-5723 NFV 46 L90LM  I13V, E35D, M36L, I62V, L63P, A71T  
DK-5814 DK-5814 NFV 69 I84V, L90M G73S L10I, I62IV, L63P, A71V, V77I, I93L  
DK-5915 DK-5915 RTV, SQV, NFV 134 I84V, L90M G73S L10I, I13V, L19I, L24LS, I62V, L63P, A71T, I72IT, V77I  
DK-594 DK-594 SQV, IDV, NFV, RTV 150 M46I, L90M G73S L10LI, K20X, I62IV, L63C, H69X, A71V, V77I, I93L  
DK-5973 DK-5973 IDV 83 I54V, V82A L10F E35D, M36V, R41K, D60E, Q61E, I62V, L63P, I64V  
DK-6033 DK-6033 SQV 130 L90M G73S R41RK, L63P, I64V, T74TS  
DK-6114 DK-6114 NFV 57   V77VI  
DK-6215 DK-6215 SQV, RTV 258 M46MI, L90M F53L, T74P K14R, L19T, K20M, E35EG, M36I, I62V, L63P, A71T, Q92K  
DK-6225 DK-6225 IDV, SQV, RTV 147 M46L, I54V, V82A, L90M G73GS L10I, T12TP, K14KR, I15IV, K20I, L33LV, L63P, A71V  
DK-623 DK-623 NFV 58 D30N N88ND T12K, I13V, L19I, A71V, I72IV  
DK-6273 DK-6273 NFV 47 N88S  E35D, N37D, K45KR, L63P, I64V, I72V  
DK-6333 DK-6333 IDV 97 V32I, M46L, V82A L10F E35D, M36I, K43KE, I64V, A71V  
DK-6384 DK-6384 SQV, NFV, RTV, IDV 94 M46MI, I84IV, L90M G73GS L10VI, I15IV, N37ND, I62IV, L63P, C67CY, A71AV, I72IR, V77VI, I93L  
DK-654 DK-654 RTV 107 I54V, V82A, L90M  L10I, I62V, L63P, A71V, V77I, I93L  
DK-6684 DK-6684 SQV, NFV 144 M46MI, L90M F53FL, G73S L10I, D60DE, L63P, A71AV, I72IL, V77I  
DK-6694 DK-6694 SQV, RTV 157 I84V, L90M G73S L10I, T12P, I13V, K14R, L63P, A71V, I72IL  
DK-6804 DK-6804 NFV 49 L90M  L10I, I13IV, E35D, M36I, R57RK, Q61QE, I62V, L63PA, C67DY, A71V, I93L  
DK-6905 DK-6905 SQV, IDV, RTV, NFV 150 M46VL, I54V, V82A, N88NS L24I, F53FL L10I, T12D, K14R, I15V, K20R, E35D, M36I, R41K, L63P, H69K, K70R, A71V  
DK-6994 DK-6994 SQV, IDV, NFV, RTV 145   R41K, L63LP, V77VI, I93L  
DK-714 DK-714 IDV 64 V32I, M46I, V82A L10F K14R, I15V, L63A, E65D, A71V  
DK-7205 DK-7205 IDV, NFV, SQV, RTV 146 M46I, I54V, I84V L24I, G73S L10I, T12P, K14R, Q18R, K20I, N37D, L63P, I66IV, A71V, V77I, I93L  
DK-7294 DK-7294 NFV, IDV 87   E35D, M36MI, R57K, D60E, Q61E, L63P  
DK-7354 DK-7354 SQV 33 L90LM  L10V, K14R, E35ED, M36L, N37NT, I62V, L63P  
DK-7414 DK-7414 NFV 61 D30N  I13V, E35D, M36I, L63P  
DK-7505 DK-7505 RTV, SQV, NFV 123 M46L, I54V, V82A, L90M Q58E L10I, K20R, M36I, I62V, L63P, A71V  
DK-7515 DK-7515 RTV, IDV 134   E35D, M36I, N37D, L63LQ, I64V  
DK-7623 DK-7623 IDV 111 I54V, V82A  L10I, E35D, L63A, A71V, I85V, I93L  
DK-7815 DK-7815 IDV, RTV, SQV, NFV 165 I54V, V82VA, I84IV, L90M L33F, F53L, G73GS L10VI, I13V, K14KR, K20KR, E35D, M36I, R41K, D60E, Q61G, I62V, L63P, A71V  
DK-7933 DK-7933 NFV 123 V32I K20T K14R, I15V, M36L, I66F, A71V, V82I, I85V T74TI 
DK-7974 DK-7974 RTV, SQV, NFV, IDV 129 I54V, I84V, L90M G73T L10I, L19T, K20R, E35D, M36V, N37S, L63P, C67CF, A71V, V77I, I93L  
DK-7984 DK-7984 SQV, IDV, RTV 103 I54L, I84V, L90M L33F, G73S L10LI, I13V, L19I, L63LP, H69Y, A71V, V77I, I93L  
DK-8125 DK-8125 IDV, NFV, SQV, RTV 163 M46I, I54V, V82VA, I84IV, L90M K43KT, F53L L10I, I15IV, L19V, K20M, M36I, D60E, L63P, C67E, H69Y, A71V, I72T, I93L  
DK-815 DK-815 RTV, IDV 72 I54V, V82A, L90M K43T, F53L L10I, K20R, E35D, M36I, R41RK, I62V, L63P, A71V  
DK-8284 DK-8284 SQV, IDV, NFV 149 M46I, I84IV, L90LM T74P L10I, I13V, L19I, E35D, M36I, R41K, I62V, I64V, H69K, L89M N88Y 
DK-8404 DK-8404 SQV 97 I84V, L90M  L10I, Q61E, L63P, C67S, A71T, V77I, I93L  
DK-8594 DK-8594 IDV 116 M46I, L90M G73A L10I, I13V, I15V, E35D, N37D, K55KR, R57K, I62IV, L63P, A71T, I72E, V77I, I93L  
DK-8654 DK-8654 SQV 25   N37NS, R57K, I64V  
DK-8704 DK-8704 NFV 54 D30N N88D I13V, L63P, A71AT, I72IV, V77I  
DK-8714 DK-8714 SQV 96 G48GV, I54IV  L10LI, R41K, I64V, E65D  
DK-873 DK-873 NFV 37 D30N  E35D, M36MI, K45KR, L63P, I64L  
DK-8805 DK-8805 IDV, SQV, RTV 169 M46L, G48V, I54T, V82A  L10I, R41K, L63P, A71L, I72IT, V77I, I93L  
DK-8873 DK-8873 NFV 76 D30N N88D L10I, L63T, I64V, E65D, A71V, V77VI  
DK-8923 DK-8923 IDV 198 I54V, V82A, L90M  T12S, L19I, L33I, M36MI, N37A, R57K, L63P, I64V, A71V, I93L  
DK-9014 DK-9014 IDV 147 V32VI, M46I, I47V  L10IV, L63P, V77I, Q92QKR, I93L, C95F  
DK-923 DK-923 IDV 197 M46I, L76V  L10I, K20I, E35D, M36I, N37D, D60E, I62V, L63P, I64V, A71V, I93L  
DK-933 DK-933 IDV 96 I54V, V82A L24I L10I, L63P, A71T  
DK-974 DK-974 IDV, SQV, RTV 180 M46ML, L90LM G73GS L10LI, I15V, R41RK, I62IV, L63LP, I93L