Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Bacheler (2001)
Title Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse transcriptase inhibitor therapy.
Citation J Virol
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 67
NumPts 34
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
DMP003-01 03-01000 NRTI None M41L, D67N, M184V, L210W, T215Y  K43E, V118I, G196E, T200I, Q207E, R211K  
  03-01126 NRTI EFV M41ML, D67DN, V75VIM, M184MI, L210LW  E28G, K102KQ, V118VI, K122KE, G196E, T200TA, K201I, R211K, T215X  
DMP003-03 03-03000A NRTI None M41L, T215Y  V118VI, Q207E, L210LF, I326V, I329LV, F346Y, A400T  
  03-03134 NRTI EFV M41L K103N Q207E, R211RG  
  03-03273 NRTI EFV   P55S, Q161QH  
DMP003-04 03-04186 NRTI EFV   A98S, K122P, S162C, D177E, T200A, E204EG, E224D  
DMP003-07 03-07000 NRTI None   V35M, T39TA, R83K, K122E, I135V, S162C, T200A, D256DE, A272P, T286A, I293V, E297Q, V314VI, D324E, F346Y, I375V, A400T K22KT 
  03-07502 NRTI EFV D67DG, L74LV G190E V35M, R83K, K122E, I135V, S162C, T200A, A272P, T286A, I293V, E297Q, D324E, F346Y, M357R, I375V, A400T  
DMP003-20 03-20000 NRTI None   S162C, I178M, Q207E, R211K  
  03-20206 NRTI EFV   S162C, Q207E, R211K  
DMP003-21 03-21000 NRTI None   K82KR, R83K, K122KE, S162C, R211K, V245E, I293V, D324E, I329L, K390R, A400T  
  03-21503 NRTI EFV M184V V106I, Y188L V60I, R83K, K122E, I135V, S162C, T200I, V245E, T286A, I293V, E297K, I329L, A400T  
DMP003-24 03-24328 NRTI, D4T EFV  K103N K122E, E169D, T200E, Q207E  
DMP003-26 03-26000 NRTI None M41ML, D67DN, K70KR, T215Y E138EA R83RK, D121Y, K122E, S162C, R211K, A272P, K281R, T286AP, E291ED, T296TS, E297EK, K311R, Q334E, E344ED, R358K, G359X, A371AT, K390KR, A400T  
  03-26014 NRTI EFV D67N, K70R, T215Y K103KN, G190GRS K20KR, D121Y, K122E, S162C, R211K, A272P, K281R, T286P, E297K, K311R, Q334E, E344D, R358K, G359S, A371AT, K390KR, A400T  
  03-26125 NRTI EFV K70R K103N, E138A, Y188L K20KR, D121Y, K122E, S162C, T200A  
DMP003-28 03-28000 NRTI None M184V  E28EG, K122E, D123E, S162C, D177E, T200TA, Q207E, R211K, V245VI, A272P, K277R, Q278N, T286A, I293V, D324E, G333E, R358K, G359S, K390R, A400AST  
  03-28321A NRTI EFV  K103N, P225H K122E, D123E, I135L, S162C, D177E, T200A, Q207E, A272P, K277R, Q278N, T286A, I293V, D324E, G333E, M357MT, R358K, G359S, K390R  
  03-28419 NRTI EFV   T107TP, K122E, D123E, S162C, D177E, Q207E, R211K Y56YS 
DMP003-32 03-32000 NRTI None   V60VI, I135T, I202V, R211K, K249KQ, A272P, K277R, T286A, I293V, P294T, S322T, M357MT, S379G  
  03-32490 NRTI EFV  K103N, N348I S68SN, V90VI, I135T, G196GR, I202V, R211K, A272P, K277R, T286A, I293V, P294T, S322T, S379G  
DMP003-44 03-44000B NRTI None   T27A, V35I, A98S, Q207E, R211K, K249Q, S251N, I293V, P294Q, E297K, Q334E, R356K, T369A, K374R, I375V, A376T, K390R, A400T  
  03-44259B NRTI EFV  K103N E6K, A98S, K101Q, K122E, Q207E, R211K, K249Q, S251N, I293V, P294Q, E297K, Q334E, T369A, K374R, I375V, A376T, K390R, A400T  
DMP003-47 03-47000 NRTI None D67DN, K70KR  K122E, I142IV, G196GE, T200A, R211AT, T215X, V245E, I293V, M357T, A376T, K390R, A400S  
  03-47497 NRTI, D4T EFV K70R K103N, P225H K122E, D123N, I142V, T200A, R211RT, V245E, I293V, N348NT, M357T, A376ST, K390R, A400S  
DMP003-50 03-50139 NRTI EFV T215TS K103N V35I, R83K, R211K, Y232H, A272P, I274V, T286P, I293V, E297K, A304E, Q334L, T338S, M357R, G359S, K366R, T369V, A371V, I375V, A376T, T377Q, A400T  
  03-50182 NRTI EFV  K103N V35I, R83K, R211K  
DMP003-55 03-55000 NRTI None   K122KE, D123DE, K173Q, D177DE, I178IM, R211T, T215X, V245M, A272P, G333GE, Q334X, T338S, M357AV, I375V, T377TI, T386TA, K390R, A400T  
  03-55126 NRTI EFV   K122E, K173Q, D177E, R211RT  
  03-55504 NRTI EFV  K103N, P225H K122E, I135T, K173Q, D177E, V245M, A272P, Q334C, T338S, M357A, I375V, T386TA, K390R, A400T  
DMP003-57 03-57000 NRTI None   Q197E, Q207H, R211K  
DMP003-63 03-63000 NRTI None   D123E, I135T, D177E, I178V, F214L  
DMP003-69 03-69000A NRTI None D67DN, K70R, K219Q  K122E, I178M, G196E, R211K, A272P, K277R, I293V, G333D, R358K, K390R, A400T  
  03-69183C NRTI EFV K70R V108I K122E, D123N, I178M, G196E, Q207QE, R211RK, A272P, V276VI, K277R, I293IV, G333D, R358K, K390R, A400T T216TI 
DMP003-70 03-70290B NRTI None   V21VI, S162C, E169ED, D177E, G196E, V245M, A272P, K275Q, V276I, T286TA, P294PS, S322T, Q334H K122NS 
  03-70290A NRTI, D4T EFV  K103N, P225H V21I, I135L, S162C, E169D, D177E, G196E K122S 
DMP003-72 03-72183 NRTI EFV K219KR K103N, P225H V21I, I135L, S162C, E169D, D177E, G196E, V245M, A272P, K275Q, V276I, T286A, S322T, Q334H, A400T K122S 
DMP003-73 03-73000 NRTI EFV  K103N, V108I K173N, Q197E, R211G  
DMP003-77 03-77000 NRTI None   K173N, Q197E, R211G, K277R, V292I, I293V, K311R, S322T, D324E, Q334N, K366R, A376T, A400T  
DMP003-89 03-89000 NRTI EFV  K103N, G190GS, P225PH K122P, D123E, S162C, A272P, K277R, I293V, K311R, G333E, R356K, M357ML, K366R, A400T R358RW 
  03-89503 NRTI EFV   E53D, K101R, K166T, R211K  
DMP003-94 03-94242B NRTI None M41L, T215D  V60I, R83K, R211K, A272P, I293V, G333E, Q334Y, M357T, K390R, A400L  
  03-94000B NRTI EFV M41L, T215D K103N, V108I, N348I V60I, R83K, R211K, A272P, I293V, G333E, Q334Y, M357T, K390R, A400L  
DMP003-99 03-99114 NRTI None M184V  K102Q, I142V, S162A  
  03-99000B NRTI EFV M184V K103N K102Q, I142V, S162A  
DMP004-100 04-100000B AZT, 3TC None M184V N348I V21I, R83K, R211K, E248N, T286A, Q334H, A376T, T386A, K390R, A400T  
  04-100139B AZT, 3TC EFV D67N, K70R, M184V, K219E K103N K20R, E42ED, I135T, T200A, R211K, E248D, D250N, T286A, G333E, Q334H, A371V, A376T, T386A, K390R, I393M, A400T  
DMP004-107 04-107230A AZT, 3TC None M41L, M184V, T215Y  R83K, D123E, I135IV, K166R, D177E  
  04-107149 AZT, 3TC EFV M41L, M184V, T215FS Y188L K20KR, K22KN, D123E, K166KR, D177DE T7LP 
  04-107230B AZT, 3TC EFV M41L, M184V, T215F Y188L T7A, K20R, R83K, D123E, K166R, D177E, T200P  
DMP004-121 04-121000A AZT, 3TC None M41ML, M184V, T215Y  K102Q, K122E, I135V, I142V, S162C, E169D, V245E, A272P, Q334QE, A355AS, A360V, K366R, A376V, T386A  
  04-121167 AZT, 3TC EFV M41L, M184V, T215Y K103N K22KN, K102Q, I135V, I142V, S162C, E169D  
  04-121251 AZT, 3TC EFV M41L, M184V, T215Y K103N, V108I K102Q, K122E, I135V, I142V, S162C, E169D, I202IM  
DMP004-126 04-126112 AZT, 3TC EFV D67N, K70R, M184MV, K219Q K103N, G190A K32R, V35M, D123E, F214L, T286A, I293V, M357V, I375V, A376T, T386A, A400T  
DMP004-132 04-132000 AZT, 3TC None M41L, D67N, T69D, K70R, M184V, T215F, K219Q  V90VI, K104KR, K122E, D123E, I135T, K154KE, G196E, L228H, T286TA, V317VA, I326V, Q334IV, R356K, G359S, A360T, T377Q, K390R, A400T  
  04-132162 AZT, 3TC EFV M41ML, D67N, T69D, K70R, M184V, T215F, K219Q L100I, K103N K20R, K102R, K122E, D123E, I135T, G196E, L228H, R284RK, T286A, K311KR, I326V, Q334IV, R356K, G359S, A360T, T377LQ, K390R, A400T  
  04-132041 AZT, 3TC EFV D67N, T69D, K70R, M184V, T215F, K219Q K101KE, K103N, V108VI, G190GA K20KR, E28EK, K102KR, K122X, D123E, I132IV, I135T, G196E, R284K, T286A, I326V, Q334I, R356K, G359S, A360T, T377Q, K390R, A400AT Q367QP 
DMP004-135 04-135000 AZT, 3TC None K70R, M184V N348I E169D, K173Q, T200TA, F214L, V245M, D250E, A272P, K277R, I293V, G335D, T338S, G352GR, R356K, M357IT, A360AV, A376T, I393ILM, E396EG, T397TP, A400T  
  04-135055 AZT, 3TC EFV K70R, M184V K103N, N348I T27TI, E169D, K173Q, T200A, F214L, V245T, D250E, A272P, K277R, I293V, G335D, T338S, R356K, M357T, A360AV, A376T, A400T  
DMP004-141 04-141000C AZT, 3TC None M41L, M184V, L210W, T215Y  I135T, R211K, A272S, T286A, I293V, E312Q, M357T, A360AT, K366KR, S379G, T386I, A400T  
  04-141041 AZT, 3TC EFV M41L, M184V, L210W, T215Y K103N K122E, I135T, R211RK, A272S, I293V, E312Q, M357ST, R358K, K366R, T369TI, S379G, T386I, A400T  
  04-141116B AZT, 3TC EFV M41L, M184V, L210W, T215Y K103N, K238T, N348I K122E, I135T, E204ED, R211K, A272S, I293V, M357T, S379G, T386I, A400T  
DMP004-143 04-143000B AZT, 3TC None M184V  V35R, K49R, V60I, K166I, D177E, I178M, T200A, Q207E, A272P, T286A, E297K, G333E, Q334Y, M357T, G359GS, E370D, K390R, A400T  
  04-143113 AZT, 3TC EFV M184V K103N K49R, V60I, I142V, T165L, K166T, Q207A  
DMP004-146 04-146000 AZT, 3TC None M41L, V75VIM, M184V, L210LW, T215Y  V35IT, K43KQ, E44ED, V118VI, D123E, K166R, I178M, Q207A, R211K, L228LH, V245KT, K277T, I293V, E298A, Q336QH, A360T, T377R, K390R  
  04-146043 AZT, 3TC EFV M41L, V75M, M184V, L210W, T215Y, K219KR K103N V35IMT, K43X, E44D, T69X, V118I, D123E, I135IT, K166R, I178M, E203K, Q207A, R211K, K223E, L228R, V241VM, V245K, K277T, R284RK, I293V, E298A, A360T, T369TI, T377R, K390R  
DMP004-147 04-147295 AZT, 3TC EFV T69DN, K70R K103N K20R, V60VI, R83K, D177DE, I178IM, Q197QE, R211K, A272P, K277R, E291ED, I293IV, S322T, Q334QE, R356K, M357IT, G359S, T369S, A371V, S379G, A400T