Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Walter (2000)
Title Phenotypic HIV-1 resistance correlates with treatment outcome of nelfinavir salvage therapy.
Citation Antivir Ther
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 19
NumPts 11
Subtype B, CRF01_AE

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
HW1 HW1_1 SQV, RTV, IDV  M46I, L90M G73T L10I, L19I, R41X, L63P, I64ILV, I72L, V77I, I93L  
  HW1_2 SQV, RTV, IDV, NFV 12 M46I, L90M G73T R8G, L10I, R41K, L63P, I72L, V77I, I93F  
HW10 HW10_1 IDV    T12S, I15V, R41K, L63S, I64V  
HW11 HW11_1 RTV    M36I, R57K, I62V, L63P, E65D  
HW2 HW2_1 SQV, RTV  I54V, V82A  L10I, K20R, E35D, M36I, N37D, D60E, L63P, A71V V77G 
  HW2_2 SQV, RTV, NFV 12 I54V, V82A, L90M  L10I, K20R, E35D, M36I, N37D, R41K, D60E, L63P, E65K, A71V, V77I, G78R, N83X, I85V, Q92H G48GRW 
HW3 HW3_1 SQV, IDV  M46L, I54L, V82A  L19X, L38W, P39X, L63P, I72T, V77I, L89I D29S, F53V, C67V, A71G, P79L, I93P, C95R 
  HW3_2 SQV, IDV, NFV 12 M46L, I54V, V82A L24I L10I, L63P, H69N, A71V, V77I, L89X  
HW4 HW4_1 RTV, IDV  V32I, M46I, V82A  A71V, I85X  
  HW4_2 RTV, IDV, SQV, NFV 16 V32I, M46I, V82A F53L, G73S L10I, I62M, E65K, A71V, I72L, V77I, Q92X  
HW5 HW5_1 RTV, IDV  I54V, V82A L24I I15V, E35D, N37E, R41K, I62V, L63P, A71T  
  HW5_2 RTV, IDV, NFV, SQV 28 I54V, V82A L24I, F53L I15V, E35D, M36I, N37D, R41K, L63P, A71T, R87K  
HW6 HW6_1 IDV    I13V, G16E, N37C, I62V, L63S, I64M  
  HW6_2 IDV, SQV, NFV 16   I13V, N37S, L63T, E65X, V77I, L89M  
HW7 HW7_1 RTV, IDV  M46I, I54V, V82A  L10I, I15V, R41K, Q61X, I62M, L63T, H69Y, I72T, I93L  
  HW7_2 RTV, IDV, SQV, NFV 36 M46L, I54V, V82A, L90M K43T, F53L L10I, I15V, R41K, L63P, A71V, I72T, I93L  
HW8 HW8_1 IDV, SQV    I13V, G16E, K20R, E35D, M36I, R41K, I62M, H69K, K70R, I72V, G73X, L89M, Q92X  
  HW8_2 IDV, SQV, NFV 24   L90X L33S, L89P 
HW9 HW9_1 RTV, IDV  M46I  I15V, L19I, E35D, R57K, L63P, A71T, I85X, I93L V82R