HIV Drug Resistance Database

References

Author	Maguire (2002)
Title	Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: Selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors.
Citation	AAC

Isolate	PIMajorDRMs	PIMinorDRMs	Method	Drug	Fold Res.
MM-L1	I54V, V82A		Antivirogram	FPV	0.5
MM-L10			Antivirogram	FPV	1.4
MM-L11	I84V		Antivirogram	FPV	1.7
MM-L12	I47V		Antivirogram	FPV	1.9
MM-L13			Antivirogram	FPV	1.9
MM-L14	I47V		Antivirogram	FPV	2.2
MM-L15	I54L	L33F	Antivirogram	FPV	2.4
MM-L16	I84V		Antivirogram	FPV	2.4
MM-L17	M46L, I50V		Antivirogram	FPV	2.5
MM-L18	M46L		Antivirogram	FPV	2.6
MM-L19	V32I		Antivirogram	FPV	2.8
MM-L2	I54V		Antivirogram	FPV	0.7
MM-L20	I54L		Antivirogram	FPV	3.4
MM-L21	I50V		Antivirogram	FPV	3.5
MM-L22	I54L	L33F	Antivirogram	FPV	4.4
MM-L23	I50V	L33F	Antivirogram	FPV	4.4
MM-L24	V32I, I47V		Antivirogram	FPV	4.7
MM-L25	I54M		Antivirogram	FPV	5.4
MM-L26	V32I, I47V		Antivirogram	FPV	5.8
MM-L27	I54M	L33F	Antivirogram	FPV	6.5
MM-L28	M46I, I50V		Antivirogram	FPV	12
MM-L3			Antivirogram	FPV	0.8
MM-L4	I54V	L33F	Antivirogram	FPV	0.8
MM-L5		L33F	Antivirogram	FPV	0.9
MM-L6	I54V	L33F	Antivirogram	FPV	0.9
MM-L7	L90M		Antivirogram	FPV	1.1
MM-L8	V82A		Antivirogram	FPV	1.1
MM-L9		L33F	Antivirogram	FPV	1.4