Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Rousseau (2000)
Title Patterns of resistance mutations to antiretroviral drugs in extensively treated HIV-1-infected patients with failure of highly active antiretroviral therapy.
Citation JAIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 22
NumPts 22
Subtype B, D

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
MNR1 MNR1 AZT, DDI, D4T, 3TC None M41L, D67N, M184V, L210W, T215Y, K219R V106I K32N, V35I, E44D, V118I, K122P, I135K, H208Y, R211K, K277R, T286A, I293V, E297K, Q334E, M357T, T369V, A371V, I375V, A376T, K390R, A400T, Y405H, V435I, A445Q, A446L, N447T, K454R  
MNR10 MNR4415 AZT, DDI, 3TC, D4T, ABC, Unknown Unknown M41L, D67N, M184V, L210W, T215Y  T39A, E44D, V118I, D121Y, K122E, I135T, T200I, H208Y, R211K, K219T, I293V, S322T, R356K, M357T, G359S, A376S, T386I, K390R, A400T, T403V  
MNR11 MNR4555 AZT, D4T, DDI, 3TC NVP, EFV M41L, D67N, L210W, T215Y K101P, G190A V35M, T39K, K43E, V118I, D121H, K122E, K166R, F171Y, Q207E, R211K, A272P, I293V, E297K, I329L, F346G, A360T, K366R, A376T, T386A, I393M, A400T  
MNR12 MNR4575 AZT, DDI, 3TC, D4T None M41L, D67N, L210W, T215Y V179D P4S, E28K, K32E, E44D, K49R, D123E, I135T, I178M, T200K, E203D, R211K, A272P, V276I, L283I, V292I, I293V, R356K, A376V, T386I, K395R, E399D, T403L, W410V  
MNR13 MNR4705 AZT, DDI, 3TC, D4T NVP M41L, A62V, D67N, T69Q_G, L210W, T215Y Y181C, G190A T39A, E44D, S68G, V111I, V118I, K122E, I135T, Q174R, D177E, E194K, R199T, H208Y, R211K, K223Q, L228R, K277R, I293V, E297K, M357T, G359S, T386I, A400T, G436E, A437Q, F440L, Y441C, V442R, D443W, G444A K70V, E438N, T439F 
MNR14 MNR4710 DDC, D4T, DDI, AZT, ABC, 3TC NVP, EFV M41L, D67N, K70R, L74I, L210W, T215Y, K219Q Y188H, G190Q G15R, V35L, K43N, E44D, D121H, K122E, D177E, G196E, R199T, E203Q, Q207D, H208Y, R211K, V245I, L283I, I293V, E297A, L303W, N306S, I329V, G333E, R356K, A360T, A371V, T386I, K390R, A400T C38W, V189G, E302V, G335V 
MNR15 MNR724HUG DDI, DDC, AZT, 3TC, D4T, ABC EFV M41L, T69S_SS, L74I, V75A, T215Y A98G, K103N, Y181C, G190A V35L, R83K, K122E, D123E, L210F, R211K, A272P, I293V, E297K, A371V, K390R, A400T  
MNR16 MNRMP1305 AZT, DDC, 3TC, ABC EFV M41L, A62V, T69S_SV, T215Y Y188L D123E, S162Y, D177E, V179I, T200A, Q207E, L228H, V245E, A272P, E297K, A371V, A400I, V435I, D460N, L491S, S519N  
MNR17 MNR714mal 3TC, DDI, AZT, ABC EFV M41L, D67N, T69D, L74I, L210W, T215Y L100I, K103N V35M, K43E, E44D, V118I, K122E, R211K, V245E, A272P, I293V, Q334H, G335S, M357A, G359S, T369V, A371V, I375V, A400T  
MNR18 MNRMP1263 DDC, AZT, 3TC, D4T, DDI None M41L, D67N, L210W, T215Y  V35T, T39D, K49R, V60I, V118I, K122E, I135T, E169D, D177E, G196E, I202V, Q207E, R211K, V245N, D250E, A272P, K277R, T286A, I293V, E297R, G335D, R356K, G359S, T377M, T386I, K390R, A400T, E404D, V435I  
MNR19 MNR718ryn AZT, DDI, 3TC, D4T, ABC NVP M41L, D67N, T69D, L210W, T215Y A98G, Y181C, H221Y K20R, V35M, K43Q, E44D, V111I, V118I, K122E, M164I, E169D, V179I, G196E, T200R, E203V, Q207E, H208Y, R211K, K277R, I293V, E297K, D324E, G333E, Q334P, R356K, G359S, K366R, A371V, V435M  
MNR2 MNR2 AZT, DDI, DDC, 3TC, D4T NVP M41L, D67N, V75M, L210W, T215Y, K219N V106A K43E, E44A, V60I, V118I, K122E, I132V, I178M, V179I, I180V, T200A, H208Y, R211K, D218E, V245K, T286A, E297K, D324E, Q334E, R358K, T377N, K390R, K395R, E396D, E399D, A400T  
MNR20 MNRBRI AZT, DDI, DDC, 3TC, D4T NVP M41L, D67S, K70R, L74I, V75A, M184V, T215F, K219E  K20R, T39A, T69N, K101Q, I135M, S162N, D177E, I178M, V179I, D218E, T240A V241D 
MNR21 MNRURE DDC, AZT, DDI, 3TC, D4T, ABC NVP M41L, D67N, L74V, L210W, T215Y K103N, Y181C K43Q, D177E, I178M, R211K  
MNR22 MNRSEN DDC, AZT, DDI, 3TC, D4T, ABC NVP, EFV M41L, D67N, K70R, L74I, V75T, T215Y, K219Q K101E, Y181C, G190A K32Q, E44D, K102Q, V118I, K122E, L210S, D218E, W229G M230W, Y232S, D237G, K238G 
MNR3 MNR657 AZT, DDI, 3TC, D4T NVP M41L, D67N, T69D, L210W, T215Y Y188L E28K, K32E, T39A, K43E, E44A, V60I, V118I, K122E, I142V, R172K, Q207E, H208Y, R211K, A272P, K277R, V292I, I293V, R358K, E370D, S379C, K390R, A400T  
MNR4 MNR3994 AZT, RTI, DDI, D4T, ABC, 3TC RTI M41L, D67N, M184I, L210W, T215Y, K219R A98G, K103N E44D, V118I, K122E, D123N, I178M, G196E, E203K, E204D, Q207E, H208Y, R211K, K223Q, A272P, L283I, I326V, Q334L, G359S, A371V, K390R, E399D, A400S, T403M, E449D  
MNR5 MNR4062 AZT, DDI, DDC, D4T, 3TC None M41L, D67N, T69D, L210W, T215Y E138A K20R, K43E, E44A, V60I, K102R, V118I, K122E, D123S, Q197L, R211K, A272P, E297A, D324E, Q334E, A360T, I375V, A376S, K385R, K390R, A400T, E432G, G436E  
MNR6 MNR4178 AZT, D4T, DDI, 3TC NVP M41L, D67N, K70E, L210W, T215Y, K219N  E44D, V118I, K122E, I135T, G196E, H198P, H208Y, R211K, V245M, A272P, I293V, S322T, D324E, P345Q, M357T, T386I, E404D, T419I  
MNR7 MNR4292 AZT, DDI, DDC, 3TC, D4T None M41L, D67N, T69D, M184V, L210W, T215Y V179D K43Q, E44D, V111I, K122E, D123E, I142V, T165I, I178M, G196E, T200K, Q207A, R211K, A272P, V276I, L283I, A288T, V292I, I293V, T338S, R356K, A360T, T369A, A376I, T386M, K390R, K395R, E399D, T403M, W410V, V435I  
MNR8 MNR4336 AZT, 3TC, D4T, DDI EFV M41L, D67N, T69D, L210W, T215Y Y181C V35M, K43E, E44A, V118I, D121H, K122E, S162D, E169D, I178L, T200A, H208Y, R211K, L228H, A272P, K277R, L283I, I293V, R356K, G359S, A371V, K390R, A400T, V435A, K451R  
MNR9 MNR4403 AZT, 3TC, DDI, ABC NVP, EFV A62V, D67N, T69D, K70R, V75I, F77L, F116Y, Q151M, M184V, T215F, K219Q K103N K20R, V35L, V118I, K122E, I135T, A158S, E169D, D177E, I202V, F214L, D218E, Q278H, E291D, I293V, K311R, M357T, R358K, A376T, K390R, E399D, A400T, E404D