Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Parkin (2000)
Title Loss of antiretroviral drug susceptibility at low viral load during early virological failure in treatment-experienced patients.
Citation AIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 50
NumPts 16
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
SD-1 SD-1_0 NRTI, AZT, 3TC, ABC, D4T None D67N, T69D, K70R, M184V, T215F, K219Q H221Y V35I, L109I, K122E, T200A, I202T, H208Y, R211K, D218E, L228H, L283I, R284K, T286TA, E297K V189L 
  SD-1_4 NRTI, AZT, 3TC, ABC, D4T NVP D67N, T69D, K70R, M184V, T215F, K219Q H221Y V35I, L109LIM, K122E, T200A, I202T, H208Y, R211K, D218E, L228H, L283I, R284K, T286TA, E297K V189VL 
  SD-1_5 NRTI, AZT, 3TC, ABC, D4T NVP D67N, T69D, K70R, M184MV, T215F, K219Q Y181YC, H221Y, F227FL V35I, L109LIM, K122E, V179VI, T200A, I202T, H208Y, R211K, D218E, L228H, L283I, R284K, T286TA, E297K V189L 
  SD-1_11 NRTI, AZT, 3TC, ABC, D4T NVP D67N, T69D, K70R, T215F, K219Q V106A, H221Y, F227L V35I, K122E, R125RK, T200A, I202T, H208Y, R211K, D218E, L228H, L283I, R284K, T286A, E297K V189L 
SD-10 SD-10_13 NRTI, AZT, 3TC, ABC, D4T None M184V  K102Q, D123E, S162C, I178IL, V179VI, T200A, Q207E, A272P, K277R, I293V  
  SD-10_17 NRTI, AZT, 3TC, ABC, D4T None M184V  K102Q, D123E, S162C, T200A, Q207E, T215X, A272P, K277R, I293V  
  SD-10_26 NRTI, AZT, 3TC, ABC, D4T None M184V, T215Y  K102Q, D123E, T200A, Q207E, A272P, K277R, I293V  
  SD-10_33 NRTI, AZT, 3TC, ABC, D4T None M184V, T215Y  K102Q, D123E, I135ILV, S162SC, T200A, Q207E, A272P, K277R, I293V  
SD-12 SD-12_36 NRTI, 3TC, DDI, ABC NVP D67N, T69D, M184MV, T215F, K219Q Y181C K122E, I142V, S162C, D177E, I178L, V179I, Q207E, E224D, A272P, I293V  
  SD-12_48 NRTI, 3TC, DDI, ABC NVP D67N, T69D, K70KR, M184MV, T215F, K219Q Y181C, H221Y K122E, I142V, S162C, D177E, I178L, V179I, Q207E, E224D, A272P, I293V  
SD-13 SD-13_2 NRTI, 3TC, D4T, ABC NVP M41L, M184V, L210W, T215Y  K43Q, V60I, S68SG, V118VI, T139M, R211K, V245Q, A272P, K277R, I293V, E297A  
  SD-13_4 NRTI, 3TC, D4T, ABC NVP M41L, M184V, L210W, T215Y  K43KQ, V60I, S68SG, V118VI, T139M, R211RK, V245Q, A272P, K277R, I293V, E297A  
  SD-13_8 NRTI, 3TC, D4T, ABC NVP M41L, M184V, L210W, T215Y  K43Q, V60I, S68SG, V118VI, T139M, R211RK, V245Q, A272P, K277R, I293V, E297A  
SD-14 SD-14_4 NRTI, 3TC, DDI, ABC NVP M41L, A62AV, L74I, M184V, L210W, T215Y Y181YC, M230ML K122KE, D177E, H208Y, R211K, L228R, T286A, T296S, E297EK  
  SD-14_8 NRTI, 3TC, DDI, ABC NVP M41L, L74I, M184V, L210W, T215Y Y181C, M230L D177E, H208Y, R211K, L228R, T286A, T296S, E297K  
  SD-14_16 NRTI, 3TC, DDI, ABC NVP M41L, L74I, M184V, L210W, T215Y Y181C, M230L D177E, H208Y, R211K, L228R, T286A, T296S, E297K  
SD-15 SD-15_1 AZT, 3TC, D4T, DDI, ABC NVP M41L, M184V, L210W, T215Y  K43Q, S68G, V118I, Q207E, R211K, L228H, K277R, T286A, I293V, E297K  
  SD-15_2 AZT, 3TC, D4T, DDI, ABC NVP M41L, M184V, L210W, T215Y  K43Q, S68G, T69TA, V118I, G196GE, Q207E, R211K, L228H, K277R, T286A, I293V, E297K  
  SD-15_4 AZT, 3TC, D4T, DDI, ABC NVP M41L, M184V, L210W, T215Y  K43Q, S68G, K102KR, V118I, E194EQ, G196GE, E203EK, Q207E, R211K, L228H, K277R, R284RK, T286A, I293V, E297KR  
  SD-15_12 AZT, 3TC, D4T, DDI, ABC NVP M41L, A62AV, M184V, L210GW, T215Y  K43Q, S68G, K102KR, V118I, G196GE, Q207E, R211K, L228H, K277R, R284RK, T286A, I293V, E297KR  
SD-16 SD-16_4 NRTI, D4T, DDI, ABC NVP K70R  D177N, I178L, Q197E, R211K, V245T, D250E, T286A, I293V  
SD-17 SD-17_2 NRTI, AZT, 3TC, ABC NVP M184V  K13N, V35T, T39A, K122E, T200A, L228LR, A272S, T286A  
  SD-17_8 NRTI, AZT, 3TC, ABC NVP M184V  K13N, V35T, T39A, K122E, I135IV, T200A, A272S, T286A  
SD-18 SD-18_8 AZT, 3TC, ABC NVP D67N, K70R, M184V, K219Q  E6D, T27TS, E53ED, V118I, K122E, I135T, S162Y, R211K, F214L, I293V  
  SD-18_12 AZT, 3TC, ABC NVP D67N, K70R, M184V, K219Q  E6D, T27TS, E53ED, V118I, K122E, I135T, S162Y, R211K, F214L, I293V L100LS 
  SD-18_16 AZT, 3TC, ABC NVP D67N, K70R, M184V, K219Q  E6D, T27S, E53ED, V118I, K122E, I135T, S162Y, R211K, F214L, I293V  
SD-19 SD-19_2 NRTI, AZT, 3TC, ABC NVP M41L, M184V, T215Y  D123E, Q174K, D177DE, T200A, R211KT, V245VM, A272P, I293V, E297KR  
  SD-19_4 NRTI, AZT, 3TC, ABC NVP M41L, L74V, M184V, T215Y K103N, Y181C D123E, Q174K, T200A, R211T, V245M, A272P, I293V, E297K  
  SD-19_8 NRTI, AZT, 3TC, ABC NVP M41L, L74V, M184V, T215Y K103N, Y181C D123E, Q174K, T200A, R211T, V245M, A272P, I293V, E297K  
  SD-19_12 NRTI, AZT, 3TC, ABC NVP M41L, L74V, M184V, T215Y K103N, Y181C D123E, Q174K, T200A, R211T, V245VM, A272P, I293V, E297K  
SD-2 SD-2_10 NRTI, AZT, 3TC, ABC, D4T None M41L, M184V, L210W, T215Y A98G T39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, T286TA, V292I, I293IV  
  SD-2_18 NRTI, AZT, 3TC, ABC, D4T None M41L, M184V, L210W, T215Y A98G T39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, V292I, I293IV  
  SD-2_22 NRTI, AZT, 3TC, ABC, D4T None M41L, M184MV, L210W, T215Y A98G T39K, K43E, S68G, I135V, S162C, R211K, L228H, V245E, A272P, K277R, T286TA, V292I  
SD-20 SD-20_12 NRTI, 3TC, D4T, ABC NVP M41L, M184V, T215Y  V21VI, I135V, K166R, V189VI, A272P, K277R, E297KR  
  SD-20_16 NRTI, 3TC, D4T, ABC NVP M41L, M184V, T215Y  I135V, K166R, V189VI, A272P, K277R, E297K  
  SD-20_24 NRTI, 3TC, D4T, ABC NVP M41L, D67N, M184MV, T215Y K103N I135V, K166R, V245M, A272P, K277R, E297K  
  SD-20_28 NRTI, 3TC, D4T, ABC NVP M41L, D67N, M184V, T215Y K103N I135V, K166R, V245M, A272P, K277R, E297K  
  SD-20_36 NRTI, 3TC, D4T, ABC NVP M41L, D67N, M184MV, T215Y K103N I135V, K166R, V245M, A272P, K277R, E297K  
SD-21 SD-21_12 D4T, ABC, 3TC EFV D67DG, M184MI K103N, P225H K122E, D123E, I135IM, S162CY, T200A, Q207A, R211K, L228LQ, V245Q, K277R, I293V  
  SD-21_16 D4T, ABC, 3TC EFV  K103N, P225H K122E, D123E, S162C, T200A, Q207A, V245Q, K277R, I293V  
  SD-21_20 D4T, ABC, 3TC EFV D67DG, M184I K103N, P225H K122E, D123E, S162C, T200A, Q207A, R211K, L228LQ, V245Q, K277R, I293V  
  SD-21_24 D4T, ABC, 3TC EFV D67DG, M184IV K103N, P225H K122E, D123E, S162C, T200A, Q207A, R211K, L228LQ, V245Q, K277R, I293V  
SD-5 SD-5_16 NRTI, AZT, 3TC, ABC, D4T None M184V  K20R, K122E, I142V, T165I, K277R, A288S, I293V  
  SD-5_44 NRTI, AZT, 3TC, ABC, D4T None M184V  K20R, K101Q, K122E, I142V, T165I, K277R, A288S, I293V  
SD-6 SD-6_5 NRTI, 3TC, D4T, ABC None D67G, K70R, M184V, T215TA, K219Q  K20R, S68G, K122E, I135IT, I202IV, Q207AE, R211KQ, T286A  
  SD-6_9 NRTI, 3TC, D4T, ABC None D67G, K70R, M184V, K219Q  K20R, S68G, K122E, I202IV, E203ED, Q207AE, R211KQ, F214FL, T215X, T286A  
  SD-6_18 NRTI, 3TC, D4T, ABC None D67G, K70R, M184V, K219Q  K20R, S68G, K122E, I135IT, I202IV, Q207AE, R211KQ, T215X, T286A  
SD-7 SD-7_8 NRTI, 3TC, DDI, DDC, ABC None L74V, M184V  P4PS, K122E, Q174K, I178M, Q207E, R211A, Q222QR, T240S, A272P, T286A  
  SD-7_16 NRTI, 3TC, DDI, DDC, ABC None L74V, M184V  P4PS, I5IV, K122E, Q174K, I178M, Q207E, R211RG, T240TS, A272P, T286A  
  SD-7_36 NRTI, 3TC, DDI, DDC, ABC None L74V, M184V  P4S, K20KR, K122E, Q174K, I178M, Q207E, R211A, T240TS, A272P, T286A  

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