Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Jorgensen (2000)
Title Genotypic and phenotypic nevirapine resistance correlates with virological failure during salvage therapy including abacavir and nevirapine.
Citation Antivir Ther
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 36
NumPts 16
Subtype B, D

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
LBJ1 LBJ1D_0 AZT, 3TC, D4T, DDI None M41L, L210W, T215NY L234I K20X, E79D, K122E, I135IT, S162C, Q174R, I178V, Q207E, R211K V118L 
  LBJ1R_8 AZT, 3TC, D4T, DDI, ABC NVP M41L, D67N, M184V, L210W, T215Y  I5T, V35I, K43E, E44D, K101Q, L109LV, V118I, K122E, S162C, S163G, Q174L, D177E, I178L, Q207E, R211K, D218E, E248K R72I, K73E, L168V, R172R*, H208P, K220Q 
  LBJ1D_16 AZT, 3TC, D4T, DDI, ABC NVP M41L, L210W, T215Y  M16L, K43E, K122E, S162C, Q174R, D177E, I178M, T200TA, Q207E, R211K, P236L K20N, G99W 
LBJ10 LBJ10D_0 AZT, 3TC, D4T, DDI None M41L, D67N, M184V, T215F, K219Q  V35T, E36Q, K49Q, V75L, K104N, V106L, K122E, I135K, S162Y, R199RT, T200A, E203D, V245L, E248K K32HQ, D76H, R78T, R83I 
  LBJ10D_8 AZT, 3TC, D4T, DDI, ABC NVP M41L, M184V, T215HY  D17G, V35T, D113DE, D121DN, K122AE, I135K, S162Y, I195IR, R199RT, T200A, Q207P, E248K R206T 
  LBJ10R_8 AZT, 3TC, D4T, DDI, ABC NVP D67N, K70R, M184V, T215F Y181C K20R, K32N, V35I, T69N, K122E, I135K, S162Y, Y188X, T200A, Q207E  
LBJ11 LBJ11D_0 DDC, AZT, 3TC, D4T None M41L, V75M, L210W, T215Y  V35T, K49R, V60I, D121Y, K122E, D177E, I178L, Q207E, R211K, P243S, V245K, A272P  
  LBJ11D_5 DDC, AZT, 3TC, D4T, ABC, DDI NVP M41ML, V75VM, L210W, T215SY  K11X, V35T, K49R, V60I, D121Y, K122E, K166KI, D177E, I178L, T200I, Q207E, R211K, P243PS  
  LBJ11R_5 DDC, AZT, 3TC, D4T, ABC, DDI NVP M41L, V75M, M184V, L210W, T215Y Y181C V35T, K49R, V60I, D121Y, K122E, S162G, K166I, D177E, I178L, Q207E, R211K, P243S, V245K, A272P, I274L  
LBJ12 LBJ12D_0 3TC, D4T, AZT, DDI NVP M41L, L74IV, L210W, T215Y Y181C E44D, V118I, D121H, K122E, I135V, S162C, E194D, E203D, K223T, E224G, L228R L205M, S251W, W252K, T253G, V254S 
  LBJ12D_8 3TC, D4T, AZT, DDI, ABC NVP M41L, A62V, L74V, L210W, T215Y A98G, Y181C, G190A E44D, V118I, K122E, I135V, S162C, R172K, E203D, K223T, L228R, E248EK, K259KR W252L, T253G, V254L, N255S, D256M, Q258Y, L260S 
  LBJ12R_8 3TC, D4T, AZT, DDI, ABC NVP M41L, L74V, L210W, T215Y K103N, Y181C E44D, V118I, K122E, I135V, I142V, S162C, E203D, K223Q, L228R, I293V R172T 
LBJ13 LBJ13D_0 AZT, 3TC, D4T, DDI None M41L, L74IV, L210W, T215Y Y181C E44D, V118I, D121H, K122E, I135V, S162C, E194D, E203D, K223T, E224G, L228R L205M, S251W, W252K, T253G, V254S 
  LBJ13D_8 AZT, 3TC, D4T, DDI, ABC NVP   T27TI, K32R, V35I, K43N, V60I, K101KR, R125RK, I135T, D177E, T200I, Q207E, R211K, E248K I63IR, G93G*, H96HR, K122EG 
  LBJ13R_8 AZT, 3TC, D4T, DDI, ABC NVP  Y181C K32R, V35I, T39TA, K43N, V60I, K122E, I135T, D177E, T200I, Q207E, R211K, D218X, V245K, D250E, A272P, L282C, R284K, T286A, I293V, E297A, K331N, Q332K  
LBJ15 LBJ15D_8 AZT, 3TC, D4T, DDI, ABC NVP K70KR K101E K11R, K20R, D123E, T200I, R211K  
LBJ16 LBJ16D_4 3TC, D4T, DDC, AZT, DDI, ABC NVP M41L, T215Y  V35I, T39A, K102R, I142V, Q207E, I244IV, V245M, S251R R206RT, D250R 
LBJ18 LBJ18D_0 3TC, D4T, AZT, DDI, ABC aAPA, NVP M41L, D67N, K70R, V75M, M184V, L210W, T215Y A98G, Y181C V35I, K43Q, E44D, K122E, I135V, G196E, T200I, Q207E, H208Y, R211K, E248K, D250N T253E 
LBJ2 LBJ2D_0 DDC, AZT, 3TC, D4T None M41L, D67N, M184V, L210W, T215Y, K219N A98G, Y181C K20R, K43E, E44A, V118I, K122E, S162C, E169D, T200A, H208Y, R211K, D218E  
  LBJ2R_8 DDC, AZT, 3TC, D4T, ABC NVP M41L, D67N, M184MIV, L210W, T215Y, K219N  K20R, K43E, E44A, V60I, K122E, S162C, E169D, Y188X, T200A, H208Y, R211K, D218E  
LBJ3 LBJ3D_0 AZT, 3TC, D4T, DDI None M41L, D67N, K70R, L74I, M184V, T215F, K219Q A98G T69N, K122E, I167V, G196R, Q197E, I202V, E203K, Q207E, H208Y, R211K, L228H, V245VLM  
  LBJ3D_8 AZT, 3TC, D4T, DDI, ABC NVP M41L, D67N, K70R, L74I, M184V, T215F, K219Q A98G, G190GA T69N, L109V, D121E, K122E, I167V, Q197E, I202V, E203K, Q207E, H208Y, R211K, K223Q, L228H, Q242H, V245M R143RT 
  LBJ3R_8 AZT, 3TC, D4T, DDI, ABC NVP M41L, D67N, K70R, L74I, M184V, T215F, K219Q A98G, G190A T69N, L109LI, K122E, I167V, Q197E, I202V, E203K, Q207E, H208Y, R211K, K223Q, L228H, Q242H  
LBJ4 LBJ4D_0 AZT, 3TC None M41L, D67N, K70R, M184MV, L210W, T215F, K219Q  T39A, E53ED, K104N, K122E, T139TM, A158P, S162Y, T200A, R211S  
  LBJ4D_8 AZT, 3TC, ABC, D4T NVP M41L, D67N, K70R, V75IM, M184V, L210W, T215F, K219Q  T39A, E53D, K122E, T139M, A158AP, S162Y, T200A, R211S E29EQ, E36E* 
  LBJ4R_8 AZT, 3TC, ABC, D4T NVP M41L, D67N, K70R, V75M, M184V, L210LW, T215F, K219Q G190S T39A, K122E, T139M, S162Y, T200A, E203ED, R211S  
LBJ5 LBJ5D_0 3TC, D4T, AZT, DDI NVP, aAPA M41L, D67DN, T69D, V75A, M184MV, L210W, T215Y, K219N G190GA K20R, K43E, E44A, V118I, D123E, A158P, Q161H, S162C, S163C, I178L, E203K, E204EG, Q207EG, H208Y, R211K, I244K  
  LBJ5D_8 3TC, D4T, AZT, DDI, ABC NVP, aAPA M41L, D67N, T69D, L210W, T215Y, K219N  K43E, E44A, V75VL, D121N, D123E, Q145H, A158P, S162C, I178L, V179I, R199T, E203K, Q207E, R211K D76DH, I94IM, V118L, R206RT 
LBJ6 LBJ6D_0 3TC, D4T, AZT, DDI NVP M41L, L210W, T215Y A98G K43E, T69N, A158P, S162C, K173E, R199T, Q207E, H208L V118IL 
  LBJ6D_8 3TC, D4T, AZT, DDI, ABC NVP M41L, L210W, T215Y A98G E29EG, K43E, T69TN, V118I, S162C, K173E, R199RT, Q207G D76DH 
LBJ7 LBJ7D_0 DDC, AZT, 3TC None M41ML, T215SY  E44EA, N175NH, Q207S, R211K, Q278H  
  LBJ7R_8 DDC, AZT, 3TC, ABC NVP M41L, A62V, M184V, L210W, T215Y, K219N Y181C K11T, K43E, E44A, V118I, Q207A, R211K, L228R  
LBJ8 LBJ8D_0 AZT, 3TC, D4T, DDI None M41L, D67N, V75M, M184V, L210W, T215Y  I5M, E29G, V35L, E36G, T39A, K43E, K122E, K173R, Q174K, R211N, E248K  
  LBJ8D_8 AZT, 3TC, D4T, DDI, ABC NVP M41L, D67N, V75M, M184V, L210W, T215Y L234I M16ML, V35L, T39A, K43E, F116FS, K122E, K166KE, K173KR, Q174EK, R199RT, H208HL, R211N, P236L  
LBJ9 LBJ9D_0 AZT, 3TC, DDI None D67N, K70R, T215FS, K219Q  K20R, E36EQ, K46Q, T69N, K104KN, D121DN, K122E, A158AP, T200D, H208HL, R211RK, D218E, E248K  
  LBJ9D_8 AZT, 3TC, DDI, ABC, D4T NVP D67S, K70R, T215F, K219Q  K20R, K46Q, K49R, T69N, K104N, S117SP, D121DN, K122E, D123N, R143K, T200D, H208Y, R211K, D218E, V245A I244D