Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Carr (1999)
Title Characterization of subtype A HIV-1 from Africa by full genome sequencing.
Citation AIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 7
NumPts 7
Subtype A, D

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
SE6594 SE6594 AZT, DDI None D67N, K70R, K219Q E138A K20R, V35T, V60I, K104N, D121H, K122E, I135T, K173S, Q174K, V179I, T200A, Q207S, R211S, D250E, A272P, K281R, T286A, E291D, V292I, I293V, P294E, E312D, G335D, M357K, G359S, A360V, T369A, A371M, I375V, A376V, A400T, T403M, E404D, K431E, E432D, E438D, Y441F, D443E, N447K, E449K, L452LR, G456W, T459A, D460E, S468P, T470A, D471K, Q480P, I482L, A485S, L491S, E492V, K512R, S519N, Q524K, I526V, K527G, E529D, A554S K424L, L425W, Q428L, T439S, R448E, K451L, K454T, A455G, Y457F, R461G, K465V, N474H, K476T, L484P, N494I, T497N, Y501S, L503G 
SE7108 SE7108 AZT, DDI None D67N, K70R, T215Y, K219Q  V35T, V60I, D121H, K122E, D123E, I135T, K173S, Q174K, D177E, I178L, V179I, T200I, Q207E, R211K, K238R, V245K, D250E, L282C, T286A, V292I, I293V, G335D, T338S, P345Q, F346Y, R356K, M357L, A360T, V365I, E370A, T377Q, S379C, K390R, A400T, E432D, V435A, A437V, V458I, H483N, L491P, K512R, S519N, Q524K, K527G, E529D, A534S, A554S  
SE7253 SE7253 None None   V35T, V60I, K122E, D123S, I135T, I142V, K173L, Q174K, D177E, V179I, Q207A, R211S, V245E, D250E, K281R, T286A, E291D, V292I, I293V, P294T, E312D, Q334L, G335D, M357K, G359S, K366R, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, V435A, D471E, Q480H, L491S, K512S, L517I, S519N, Q524K, K527G, E529D, A534S, A554S  
SE7535 SE7535 None None  E138A V35T, V60I, V111L, D121H, K122E, D123G, I135T, K173E, Q174R, D177E, I178V, V179I, Q207E, R211S, D250E, K277R, T286A, E291D, V292I, I293V, P294T, E312D, V317A, A327V, G335D, P345T, M357K, G359S, T369A, A371V, I375V, T377M, K388R, F389S, A400T, T403I, E404D, E432D, D460N, D471E, Q480H, H483L, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, A554S L234V 
SE8538 SE8538 AZT None K70R  V35T, V60I, T69N, K122E, D123S, I135T, A158S, K173S, Q174K, D177E, V179I, Q207A, R211S, F214L, V245N, D250E, T286A, E291D, V292I, I293V, P294T, E312A, G335D, M357K, G359S, T369A, A371V, I375V, A376V, T377M, A400T, T403M, E432D, V435A, D471E, L479V, Q480H, L491S, K512S, S519N, Q524K, K527G, E529D, A534S, A554S L391V 
SE8891 SE8891 None None   K11T, K20R, V21I, V35T, T39R, Q91X, L92X, G93X, I94X, D123N, T165I, K173V, D177E, V179I, T200A, I202V, Q207A, R211S, V245Q, E248N, D250E, S251N, A272V, T286A, E291D, V292I, I293V, P294T, E312D, G335D, M357K, G359S, K366R, T369V, A371V, I375V, A376V, T377M, A400T, T403M, E404D, E432D, S468T, T470A, D471E, Q480H, H483Y, L491S, K512R, S519N, Q524K, K527G, E529D, A534S, I556V, K558R, V559I V90VIL 
SE9488 SE9488 None None   K11T, V35T, E40D, I47L, K49R, V60I, I135T, E169A, K173S, D177E, V179I, Q207A, R211S, V245Q, E248D, A288S, E291D, I293V, P294T, K311R, E312D, G335D, R356K, M357K, G359S, K366R, T369A, A371V, I375V, A376V, T377M, V381I, A400T, T403M, E404D, E432D, V435I, D471E, Q480H, H483Q, L491S, K512R, L517I, S519N, Q524K, K527Q, E529D, A534S, A554S