Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Coakley (2000)
Title Phenotypic and genotypic resistance patterns of HIV-1 isolates derived from individuals treated with didanosine and stavudine.
Citation AIDS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 76
NumPts 36
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
EC1 EC1B None None   S105SA, A158S, S162C, A272S, V292I, I293V, K311R, Q334L, A360V, A376T, T386A, V435A, G436E, S468P, Q524E, A554K, K558R Q373P 
  EC1F D4T, DDI None   K11N, K22N, S105A, A158S, S162H, V245M, E248D, A272S, V292I, I293V, K311R, Q334L, G359S, K366R, T369A, A371V, A376T, T377L, T386A, V435A, G436E, S468P, Q524E, A554K, K558R  
EC10 EC10B None None   K20R, T69S, D177E, R211K, V245K, E248D, D250E, A272P, K277R, T286A, I293V, S468P, S519N, K527N  
  EC10F D4T, DDI None   K20R, T69S, D177E, V245K, E248D, D250E, A272P, K277R, T286A, I293V, K347Q, S379G, T403I, E404D, S468P, S519N, K527N  
EC11 EC11B None None   V21I, K249Q, Q334Y, K390R, A400T, R461K, V467I, S468T, S519N, K558T  
  EC11F D4T, DDI None   V21I, V245E, Q334Y, K390R, A400T, R461K, V467I, S468T, S519N  
EC12 EC12B None None   K49R, I202V, K275Q, K277R, K281R, T286A, I329L, Q334H, Q367L, A400T, E404D, V435E, L452A, D460N, V467I, S519N, V559I  
  EC12F D4T, DDI None   K49R, I202V, F214L, K275Q, K277R, K281R, T286A, I329L, Q334H, Q367L, A400T, E404D, V435E, L452A, D460N, V467I  
EC13 EC13B None None   V10A, K22N, E204D, R211K, A272P, A327V, Q334L, M357T, A376P, T377P, E404D, V435L, L452S, V467I, S468P, T470P, Q480H, Q524E, E546A, K550N, A554S K366N, T369P 
  EC13F D4T, DDI None   E6D, E204D, R211K, A272P, A327V, Q334L, T338A, M357T, E404D, L452S, V467I, S468P, T470P, Q480H, Q524E V60A 
EC14 EC14B None None   D177E, Q207E, R211K, V245K, I293V, Q334E, R356K, K390R, A400S, E432D, F440Y, K454Q, R463K, V467I, A554N  
  EC14F D4T, DDI None   D177E, Q207E, R211K, V245VE, I293V, Q334E, R356K, K390R, A400S, V435I, F440Y, K454Q, R463K, V467I, A554N  
EC15 EC15B None None   Q207E, R211K, V245M, I293V, E312N, I326V, I329V, G333E, M357T, A376S, V381I, K390R, K395R, D460N, R461K, L491S, A554NT, K558R  
  EC15F D4T, DDI None   Q207E, R211K, V245M, I293V, E312N, I326V, I329V, G333E, M357T, A376S, V381I, K390R, K395R, D460N, R461K, V467I, L469I, L491S, A554T, K558R  
EC16 EC16B None None   E6D, K20Q, D123E, D177E, T200I, R211K, F214L, K277R, T286A, A360T, A376T, K390R, A400T, H483Y, H539P, E546A, K550P, K558T  
  EC16F D4T, DDI None   E6D, D123E, D177E, R211K, K277R, T286A, P345Q, A376T, K390R, A400T, H483Y  
EC17 EC17B None None   K122E, I135T, R211K, F214L, A272P, K277R, P294S, E297R, S322P, Q334C, K390R, Q394H, E396D, A400T, D460N, R461K, L491V, L503V, E523D, Q524E, A554T  
  EC17F D4T, DDI None   K20Q, K32N, K122E, I135T, R211K, F214L, V245M, A272P, K281R, T286A, E297K, K390R, Q394H, E396D, A400T, D460N, R461K, I482V, L491V, Q524E, A554T  
EC18 EC18B None None   L12F, P14A, Q23P, R83K, D123E, D177E, A272P, K277R, K347Q, A360T, K366R, A376T, A400T, V435I, D460N, T470TA  
  EC18F D4T, DDI None   R83K, D123E, D177E, I178IV, A272P, K277R, K347Q, A360T K70K*, I167N 
EC19 EC19B None None  E138A K101Q, K122E, I135AT, I202IV, Q207QH, R211K, K277R, Q278H, I293V, I329V, T377V, I382L, K390R, T403M, K451R, S468P, A554P  
  EC19F D4T, DDI None  E138A K101Q, K122E, I135T, I202V, R211K, K277R, Q278H, I293V, I329V, T377V, I382L, K390R, T403M, K451R, S468P  
EC2 EC2B None None   Q23P, K102Q, I135V, S162C, K173R, T200A, I257L, A272P, A288S, I293V, P321S, A376T, I382L, T450N, L452S, S468P, H483Q, L491S, L517I, S519N A371P 
  EC2F D4T, DDI None   K102Q, I135V, S162C, K173R, T200A, I257L, A272P, A288S, I293V, V317A, A376T, T450N, L452S, S468P, H483Q, L491S, L517I, S519N, K530R  
EC20 EC20B None None   R83K, S162C, Q207R, A272P, E344D, V381I, K390R, K395R, A400T, R461K, Q547H, A554T  
  EC20F D4T, DDI None   R83K, K104N, K122E, S162C, Q207R, A272P, E344D, V381I, K390R, K395R, A400T, R461K, Q547H  
EC21 EC21B None None   K43R, K173Q, D177E, R211K, D237E, V245M, A272P, I293V, Q334Y, T377Q, R463K F87S, L282P 
  EC21F D4T, DDI None   K43R, K173Q, D177E, R211K, D237E, V245M, W252R, A272P, I293V, Q334Y, S379G, T386I, K390R, E399D, A400L, V417T, A437T, T477A, V548I, A554S P9L, G155V 
EC22 EC22B None None M41L  V60I, R83K, D123E, S162C, D177E, T200A, E248D, K277R, T286A, I293V, E297K, G333D, E370D, T377K, V381I, K390R, V435I, D460N, L469I, L491S  
  EC22F D4T, DDI None   V60I, R83K, D123E, S162C, D177E, T200A, V245E, K277R, Q278H, T286A, I293V, E297K, G333D, E370D, T377K, V381I, K390R, V435I, D460N, L469I, L491S  
EC23 EC23B None None K70N  V35I, I50V, N57T, R83K, D123E, K166I, D177E, T200A, A272P, K281R, E297K, I329V, A371V, A376T, A400T, D460N K49H 
  EC23F D4T, DDI None   E6D, V35I, R83K, D123E, E169D, D177E, T200A, A272P, K281R, E297K, I329V, A371V, A376T I5F 
EC24 EC24B None None   K22E, E28D, S162C, Q207E, R211K, P226S, V245M, I293V, E312N, I326V, I329V, G333E, M357T, A376S, V381I, K390R, D460N, R461K, V467I, L491S, A554T, K558R  
  EC24F D4T, DDI None   S162C, Q207E, R211K, V245M, I293V, E312N, I329V, G333E, M357T, A376S, K390R, T397P, D460N, R461K, V467I, L491S, T497P, K512R, A554T, K558R T369P 
  EC24PF D4T, DDI None D67N  A158S, Q207E, V245M, E312N, I329V, G333E, E344G, M357T, A376P, V381I, K390R, P421S, L425I, D460DN, S468PT, H483HY, K512KQ, S519SN W266R 
EC25 EC25B None None   K122E, V179VI, R211RK, F214FL, A272AP, K277KR, E297EK, A327AV, Y342YF, M357MT, A376AT, T386TI, A400T, D460S, K512Q, S519N  
  EC25F D4T, DDI None T215I  K22N, V35I, R83K, K102Q, A158S, V245M, K277R, T286A, E297K, M357I, G359S, A371V, I375V, K390R, L452K, D460N, L491S, N494H, Q520P V8D, D324I, K353KN 
EC26 EC26B None None  V179D D123E, D177E, T200A, V245M, A272S, K277R, I293V, G333E, Q334Y, T338S, M357I, T377V, K390R, A400T, K512I  
  EC26F D4T, DDI None V75T V179D D123E, D177E, V245M, A272S, K277R, I293V, G333E, Q334H, T338S, M357I, T377L, A400T, T470N, K512I, E516K, V548I  
EC27 EC27B None None   I135V, I178M, Q207E, V276I, K281R, L283I, V292I, I293V, Q334E, D460N, S468P, S519N  
  EC27F D4T, DDI None T215Y  I135V, I178M, Q207E, V276I, K281R, L283I, V292I, I293V, Q334E, I375V, D460N, S468P, Q509H, S519N, K550T, V559I  
EC28 EC28B None None   R83K, D123E, D177E, I178V, A272P, K277R, K347Q, A360T, K366R, A376T, A400T, V435I, D460N, L491LS  
  EC28F D4T, DDI None V75T V179D I135R, S162C, Q207E, R211K, K277R, I293V, E297K, V317A, I326V, Q334L, R356K, M357V, T377M, T403M, T419A, E432D, A445T, A446P, R448M, K451P, G453V, A455P, S468P, L469I, L491S F440V 
EC29 EC29B None None   K20R, V35I, R83K, A98S, I135T, Q334R, G335D, M357T, G359S, A376T, V381I, T386I, A400T, D460N, H483Y, K512R, K527Q  
  EC29F D4T, DDI None T215Y  K20R, V35I, R83K, A98S, I135T, E203D, Q207E, Q334R, G335D, M357T, G359S, A376T, V381I, T386I, A400T, D460N, H483Y, K527Q  
EC3 EC3B None None   K20Q, T39A, S68N, S162A, G196E, A272P, G335E, R356K, A360T, K390R, A446S, L491S, Q520L  
  EC3F D4T, DDI None   T39A, S68N, S162A, A272P, G335E, R356K, A360T, K390R, A446S, L469I, L491S, L503F, E516V, L517I, Q520L, E546G, A554N  
EC30 EC30B None None   V60I, I142V, T286A, I293V, M357T, A400S, E404D, E432D, A446S, D460N, L491P  
  EC30F D4T, DDI None Q151M  V60I, I142V, P243R, T286A, I293V, M357T, A376T, A400S, E404D, E432D, A446S, D460N, L491P, S519N  
EC31 EC31B None None   S68G, K122E, S162C, D177N, V245E, K277R, I293V, E344D, P345Q, K390R, A400T, F416Y, S519N, I522V, A554T  
  EC31F D4T, DDI None Q151M  S68G, K122E, S162C, D177N, V245E, K277R, I293V, E344D, P345Q, K390R, A400T, F416Y, R461K, S519N, I522V, A554T  
EC32 EC32B None None   I135T, S162C, R211K, K277R, Q278H, T286TA, I293V, Q334L, T377I, K390R, T403I, S468P  
  EC32F D4T, DDI None T215Y  I135T, S162C, R211K, K277R, Q278H, T286A, I293V, Q334L, A360T, K390R, A400T, S468P  
EC33 EC33B None None   R83K, K275Q, V276T, K277R, L283I, E297K, I329L, A376T, A400T, E432D, V435A, E449D, D460N, R461K, L469I, I482V, H483L, E523D, I526V Q182P 
  EC33F D4T, DDI None M41L, T215Y  D17N, K22E, R83K, D123E, K275Q, V276T, K277R, T286A, E297K, I329L, T369A, A376T, A400T, N418H, P421S, V435A, E449D, D460N, R461K, L469I, H483L, I506L, Q509R, I526V  
EC34 EC34B None None   K122E, A158S, I178M, R211G, A272P, K277R, T286A, I293V, I329V, T377Q, K390R, D460N, R461K, V466I, S468T, S519N  
  EC3416w D4T, DDI None   T7P, K13N, K20R, K22N, K122E, A158S, I178M, R211G, A272P, K277R, T286A, I329V, G333E, M357I, H361R, T377P, K390R, D460N, R461K, V466I, S468T, S519N, K527E, E529Q, Y532L, H539L, E546A, K550T, K558T  
  EC3428w D4T, DDI None Q151M  K13N, K22N, K122E, A158S, I178M, R211G, A272P, T286A, I329V, T377Q, K390R, D460N, R461K, V466T, S468T  
  EC3452w D4T, DDI None F116Y, Q151M V108I V60I, K122E, A158S, I178M, R211G, A272P, T286A, I329V, T377Q, K390R, D460N, R461K, V466T, S468T, L486S, S519N Q367P 
  EC3480w D4T, DDI None A62V, V75I, F77L, F116Y, Q151M  K122E, A158S, I178M, R211G, A272P, T286A, I329V I142D, R143W 
EC35 EC35B None None   R83K, D123E, D177E, T200A, V245M, A272P, K281R, T286A, E297K, A376T, K390R, A400T, V435I, K454R, D460N, A554N  
  EC35F D4T, DDI None T215Y  R83K, D123E, D177E, T200A, L210V, V245M, A272P, K281R, T286A, E297K, A376T, K390R, A400T, V435I, K454R, D460N, A554N, K558R  
EC36 EC36B None None   R211K, V245M, A272P, K277R, I293V, E297K, G333D, R356K, T377A, S468P, H483N  
  EC36F D4T, DDI None M41L, T215F  I178M, V245M, A272P, K277R, I293V, E297K, G333D, R356K, S468P, H483Y, E492D, Q509H  
EC4 EC4B None None   E6D, V35I, S68G, I135T, T139S, K173Q, V245I, A272T, I293V, E297A, A304E, E308Q, Q334Y, T338S, M357T, A376P, T403V, V435I, S468P, H483N, L491S, K558R  
  EC4F D4T, DDI None   E6D, V35I, S68G, I135T, T139S, K173Q, V245I, A272T, I293V, E297A, A304E, E308Q, Q334Y, T338S, A376T, V381I, T403V, V435I, S468P, H483N, L491S, I556V, K558R  
EC5 EC5B None None   V35E, V60I, S68G, I135R, G196E, T200A, I257L, T286A, I293V, G335D, R356K, M357V, R358K, V365I, T377R, K388R, A400T, T403I, R461K, H483Y, A554S, K558R  
  EC5F D4T, DDI None   V35E, K49R, V60I, I135R, G196E, T200A, I257L, T286A, I293V, G335D, R356K, M357V, R358K, V365I, T377R, K388R, A400T, T403I, R461K, H483Y, A554S, K558R  
EC6 EC6B None None   K11R, Q23QH, K49R, K122E, K166I, V245M, K277R, I293V, P345Q, A360T, A400T, E404D, L452I, K512Q, A554T  
  EC6F D4T, DDI None   K11R, K49R, K122E, I142V, K166I, V245M, K277R, I293V  
EC7 EC7B None None   K122E, N175Y, I178M, G196E, T200A, Q207K, R211A, V245M, K249R, A272P, I293V, E297K, K311R, V317A, G333E, Q334L, R356K, K366R, A376S, T377M, K385R, S468P, K527R, V552VI  
  EC7F D4T, DDI None   K82R, V179I, R211K, E297K, A327V, Y342F, M357T, T377N, T386I, A400T, D460S, E529K  
EC8 EC8B None None   V35I, R83K, I178V, T200A, I202V, V245T, K277R, T286A, A360T, H361P, T369V, I375L, A376P, G384E, E399D, A400T, Y405H, N418S, D460N, R461K, S468T, Q524E  
  EC8F D4T, DDI None   V35I, R83K, I178V, T200A, I202V, P243A, V245T, K277R, T286A, A360T, T369V, A376T, E399D, A400T, Y405H, N418S, D460N, R461K, S468T, T470S, Q520L, Q524E  
EC9 EC9B None None   A98S, K122E, I293V, E297A, M357T, A376T, K390R, A400T, K431T, L517V  
  EC9F D4T, DDI None   A98S, K122E, I293V, E297A, M357T, A360T, A376T, K390R, A400T, K431T, L491S, G504E, L517V