Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Belec (2000)
Title High levels of drug resistance human immunodeficiency virus variants in patients exhibiting increasing CD4 + t cell counts despite virologic failure of protease inhibitors containing antiretroviral combination therapy.
Citation J Infect Dis
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 100
NumPts 59
Subtype B, F, B + F

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
nr11 nr11_m0 None    L10I, E35D, M36I, I64V, I93L  
  nr11_m12 IDV 52 M46I, I84A  L10I, L63P, I64V, A71T, V77I, I93L  
nr36 nr36_m0 None    E35D, N37D, R57K, L63P, A71T, V77I, I93L  
  nr36_m12 IDV 52 M46L, L90M G73S L10I, E35D, N37D, R57K, L63P, A71T, V77I, I93L  
nr45 nr45_m0 None    K14R, E35D, N37D, L63P, I72V  
  nr45_m12 IDV 52 V32I, M46I  L10I, K14R, K20R, E35D, N37D, L63P, I72V, V77I  
nr48 nr48_m0 None    L19I, E35D, N37H, R41K, L63P, I66F  
  nr48_m12 IDV 52 V32I, M46I, V82A, L90M  L10V, L19I, E35D, N37H, R41K, L63P, I66F, A71V  
nr49 nr49_m0 None    L10I, E35D, N37D, L63A, A71T, V77I, I93L  
  nr49_m12 IDV 52 G48V, I54V, V82A, I84V  L10I, E35D, N37D, L63P, A71T, I72V, V77I, I93L  
nr50 nr50_m0 None    I64V  
  nr50_m12 IDV 52 M46I, V82A L24I I64V, A71V  
nr51 nr51_m0 None    L10I, K43R, L63P, V77I, I93L  
  nr51_m12 IDV 52 M46L  L10I, K43R, L63P, V77I, I93L  
nr72 nr72_m0 None    E35D, N37H, R41K, R57K, L63P, V77I, I93L  
  nr72_m12 IDV 52 M46I, I84V, N88S T74P L10I, E35D, N37H, R41K, R57K, Y59F, L63P, A71V, I72V, V77I, I93L  
par1 par1_m0 None    L63P, V77I, I93L  
  par1_m12 IDV 52 M46I L24I, G73C L10I, K45R, L63P, I72V, V77I, I93L  
par10 par10_m0 None    L10I, R57K, L63P, I64V, I93L  
  par10_m12 IDV 52 M46I, L76V, V82F, L90M  L10I, N37D, L63P, I64V, I93L  
par12 par12_m0 None    I13V, P39T, R57K, L63P, H69K, A71T  
  par12_m12 IDV 52 M46I L10F, L24I, L89V I13V, P39T, R57K, I62V, L63P, H69K, A71T, I72M  
par13 par13_m0 None    T12A, L63P, I93L  
  par13_m12 IDV 52 I47V, V82A  L10I, L63P, I93L  
par14 par14_m0 None    T12P, K14R, N37S, R41K, I62V, L63H, I72V, V77I, I93L  
  par14_m12 IDV 52   T12P, K14R, N37D, L38M, R41K, I62V, L63H, V77I, I93L  
par15 par15_m0 None    I13V, K20R, M36I, N37T, I62V, I64V, I72V  
  par15_m12 IDV 52 I47V, I54V, V82A  L10I, I13V, K20R, M36I, N37T, I62V, L63P, I64V, I72V  
par16 par16_m0 None    L10I, M36I, P39Q, I62V, L63P, I64V, C67Y, I72V  
  par16_m12 IDV 52 M46I L24I, Q58E L10I, L19I, P39Q, I62V, L63P, I64V, C67Y, I72V, I93L  
par17 par17_m0 None    V77I  
  par17_m12 IDV 52 V32I, M46L, V82A  L63P, A71V, V77I  
par18 par18_m0 None    I13V, D60E, L63P, V77I  
  par18_m12 IDV 52 I84V, L90M G73S L10I, I13V, D60E, L63P, A71V, V77I  
par19 par19_m0 None    T12N, L19I, L63S, I64V  
  par19_m12 IDV 52 G48V, V82A L33F L10I, T12N, L19I, F53I, L63P  
par21 par21_m0 None    K20R, M36I, R41K, R57K, L63P, I72V, I93L  
  par21_m12 IDV 52   K20R, M36I, R41K, R57K, L63P, I72V, I93L  
par22 par22_m0 None    E35D, R41K, L63P, H69Y, V77I  
  par22_m12 IDV 52 I54V, V82A  L10I, E35D, R41K, R57K, L63P, H69Y, V77I  
par23 par23_m0 None    L10I, K14R, E35D, N37S, R41K, I64V  
  par23_m12 IDV 52 M46I, I84V L24I L10I, K14R, E35D, R41K, I64V, T74S  
par25 par25_m0 None  M46I  I13V, L63P, I72V, V77I, I85V, Q92K, C95F  
  par25_m12 IDV 52 M46I, L90M  L10V, I13V, L63P, I72V, V77I, I85V, Q92K, C95F  
par26 par26_m0 None    T12A, I13V, K14R, I15V, M36I, N37D, L63P  
  par26_m12 IDV 52   I13V, K14R, M36I, N37D, L63P  
par27 par27_m0 None    I15V, N37S  
  par27_m12 IDV 52 M46I, V82A  L10I, I15V, N37S, G51A, A71V  
par28 par28_m0 None    E35D, N37S, R41K, L63P  
  par28_m12 IDV 52   E35D, N37S, R41K, L63P  
par29 par29_m0 None    N37T, L63A, V77I  
  par29_m12 IDV 52 M46L, V82A  L10I, K14R, L63A, V77I  
par30 par30_m0 None    I15V, N37S, R41K, I62V, E65Q  
  par30_m12 IDV 52   I15V, N37S, I62V, V77I  
par4 par4_m0 None    L10I, L63P, H69N, V77I  
par5 par5_m0 None    N37T, L63P, I64V, V77I, I93L  
  par5_m12 IDV 52 M46I, I54V G73T L10V, N37T, L63P, I64V, V77I, I93L  
par53 par53_m0 None    I15V, N37S, R41K  
  par53_m12 IDV 52 V32I, M46I, I84V  L10I, I15V, M36I, N37S, R41K, A71V  
par6 par6_m0 None    K14R, R57K, L63P  
  par6_m12 IDV 52 M46I, V82A L10F K14R, I15V, N37D, R57K, L63P  
par7 par7_m0 None    L10V, K14R, I62V, L63P, I72V  
  par7_m12 IDV 52 M46L  L10V, I13V, K14R, R57K, L63P, I72V, I93L  
par71 par71_m0 None    P39S, L63P  
par8 par8_m0 None    E35D, N37D, A71V, I72T, V77I, I93L  
  par8_m12 IDV 52  G73S E35D, N37D, A71V, I72T, V77I, I93L  
par9 par9_m0 None    E35D, N37A, L63P  
  par9_m12 IDV 52 M46L  K20I, E35D, N37A, L63P  
r2 r2_m0 None    E35D, M36I, I62V, L63P, H69N  
  r2_m12 IDV 52   E35D, I62V, L63P  
r20 r20_m0 None    K14R, I15V  
r24 r24_m0 None    I15V, E35D, M36I, R41K  
r3 r3_m0 None    L10I, I15V, M36I, I64V, I93L  
r31 r31_m0 None    I15V, Q18E, E35D, M36I, R41K, K43R, R57K  
  r31_m12 IDV 52 G48V  L10V, I15V, Q18E, E35D, M36I, R41K, K43R, R57K, I62V, L63A  
r39 r39_m0 None    T12A, L63P, V77I, I93L  
  r39_m12 IDV 52   T12A, L19I, L63P, V77I, I93L  
r54 r54_m0 None    M36I, I64V  
r55 r55_m0 None    L10I, K14R, I62V, L63Q, C67S, V77I  
r56 r56_m0 None    N37D, K43R, L63P, A71T, V77I  
  r56_m12 IDV 52   N37D, K43R, A71T  
r57 r57_m0 None    M36I, L63P, I64V  
r58 r58_m0 None    L10V, I13V, L33V, I64V  
  r58_m12 IDV 58 M46I  L10V, I13V, L33I, M36I, R57K, L63P, I64V, I93L  
r59 r59_m0 None    E35D, R41K, D60E, L63P  
r60 r60_m0 None    T12S, K14R, L19T, L63P, I72T  
r61 r61_m0 None    T12S, I15V, L19I, K20M, E35Q, M36V, N37E, L63C, H69Y, I72V  
r62 r62_m0 None    I13V, K14R, G16E, M36I, L63C  
  r62_m12 IDV 52   L10V, T12S, L63P  
r63 r63_m0 None    L63P  
r64 r64_m0 None    M36I, L63P  
r65 r65_m0 None    R41K, R57K, L63P, V77I, I93L  
  r65_m12 IDV 52   R41K, R57K, L63P, V77I, I93L  
r66 r66_m0 None    T12A, L19V, L63P  
r67 r67_m0 None    L63P, V77I, I93L  
r68 r68_m0 None    E35D, N37D, D60E, Q61E, L63P, V77I  
r69 r69_m0 None    I13V, K14R, L63P  
r70 r70_m0 None    L10I, I15V, E35D, N37S, L63P, H69N  
  r70_m12 IDV 52   L63P  
r73 r73_m0 None    L33V, N37S, R41K, I62V, L63P, V82I, I93L