Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Falloon (2000)
Title Combination therapy with amprenavir, abacavir, and efavirenz in human immunodeficiency virus (HIV)-infected patients failing a protease-inhibitor regimen: pharmacokinetic drug interactions and antiviral activity.
Citation Clin Infect Dis
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 20
NumPts 10
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
JF01 JF01-(-)1w IDV, SQV 156 V32I, M46L, I54IV, V82A L89V L10I, L63LP, A71V  
  JF01-8w IDV, SQV, APV 164 V32I, M46L, I54V, V82A Q58QE, L89V L10I, L63LP, A71V, C95X  
JF02 JF02-0w IDV, RTV, SQV 124 M46I, I54V, V82A, L90M G73S L10I, K14R, L33I, E35D, M36I, I62V, L63P, A71V, I93L  
  JF02-8w IDV, RTV, SQV, APV 132 M46MI, V82A, L90M L24LF, G73S L10I, K14KR, L33I, M36I, I62V, L63P, A71V, I93L  
JF03 JF03-(-)4w IDV, SQV 136 M46L, I54V, V82A L24I L10I, I15V, K20R, M36I, I62V, L63P, K70Q, L89M  
  JF03-8w IDV, SQV, APV 144 M46L, I54V, V82A L24I L10I, I15V, K20R, M36I, I62V, L63P, K70Q, L89M  
JF05 JF05-0w IDV, RTV, SQV 140 M46L, I54V, V82A L24I, G73S L10I, E35D, M36I, N37S, R57K, I62V, L63P, A71V  
  JF05-8w IDV, RTV, SQV, APV 148 M46L, I54V, V82A L24I, G73S L10I, E35D, M36I, N37S, R57K, I62V, L63P, A71V  
JF06 JF06-0w IDV, SQV 116 M46L, I54V, V82A, L90M  L10I, L63P, A71V  
  JF06-8w IDV, SQV, APV 124 M46L, I54V, V82A, L90M  L10I, L63P, A71V  
JF07 JF07-0w IDV, SQV 100 M46L, I54V, V82A, L90M  L10I, K14R, R41K, L63P, A71V, I93L  
  JF07-8w IDV, SQV, APV 108 M46L, I54V, V82A, L90M  L10I, K14R, R41K, L63P, A71V, I93L  
JF08 JF08-(-)6w IDV, SQV 96 I54V, V82T, L90M  L10I, I15V, E35D, N37E, K45R, L63P, A71V, I93L, C95F  
  JF08-12w IDV, SQV, APV 102 I54V, V82T, L90M  L10I, I15V, E35D, N37E, K45R, L63P, A71V, I93L, C95F  
JF09 JF09-0w IDV, SQV 116 M46L, V82A, L90M  L10I, V11VI, T12E, I15V, L19I, R41K, L63P, A71T  
  JF09-9w IDV, SQV, APV 125 M46L, V82A, L90M  L10I, V11VI, T12E, I15V, L19I, R41K, L63P, A71T  
JF10 JF10-(-)1w IDV, SQV 68 M46I, V82T, L90M G73S L10R, N37D, I62V, L63P, A71V, V77I, I93L  
  JF10-12w IDV, SQV, APV 80 M46I, V82T, L90M G73S L10R, N37D, I62V, L63P, A71V, V77I, I93L  
JF11 JF11-(-)1w IDV, SQV 96   L10I, V11VI, I64V, I93L  
  JF11-8w IDV, SQV, APV 96   L10I, I64V, I93L