Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Cabana (1999)
Title Emergence and genetic evolution of HIV-1 variants with mutations conferring resistance to multiple reverse transcriptase and protease inhibitors.
Citation J Med Virol
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 54
NumPts 12
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
Cab-a A0 SQV  L90M G73S M36I, L63P, H69K, A71V, I72V  
  A11 SQV, IDV 34 V82A, L90M G73S L10I, M36I, D60E, I62V, L63P, H69K, A71V, I72V  
  A18 SQV, IDV, RTV 65 V82A, L90M G73S L10I, K20R, E35D, M36I, D60E, I62V, L63P, H69K, A71V, I72V  
Cab-b B0 None    K14R, E35D, N37D, L63P, V82I G52R 
  B41 IDV 40 M46I, L76V, V82A, I84V  L10I, I13V, Q18H, L63P, L89I  
  B44 IDV, SQV, RTV 74 L76V  L10I, I13V, L63P, L89I  
  B47 IDV, SQV, RTV 122 M46I, L76V, V82A  L10I, I13V, Q18H, I62V, L63P, L89I  
  B58 IDV, SQV, RTV 136 M46I, L76V, I84V  L10I, I13V, K14R, L63P, L89I  
Cab-c C0 None    N37S, R41K, L63P, I93L  
  C17 IDV 28   N37S, R41K, L63P, I93L  
  C28 IDV 28  L10F N37S, R41K, L63P, K70R, I93L  
Cab-d D0 None    R41K, I62V, L63P, I93L  
  D29 RTV 24 M46I, V82S  R41K, I62V, L63P, I93L  
  D35 RTV, IDV 48 M46I, V82T, I84V  L10I, R41K, I62V, L63P, I93L, C95F  
  D39 RTV, IDV, SQV 64 M46I, V82T, I84V  L10I, R41K, I62V, L63P, I93L I66S, C95Y 
  D42 RTV, IDV, SQV 76 M46I, V82T, I84V, L90M  L10I, R41K, I62V, L63P, I93L, C95F  
Cab-e E0 None    R41K, K43R, I62V, L63P, V77I, I93L  
  E35 IDV, RTV 36  G73S L10I, R41K, K43R, I62V, L63P, V77I, I93L  
  E37 IDV, RTV, SQV 44  G73S L10I, R41K, K43R, I62V, L63P, V77I, I93L R87I 
Cab-f F0 None    E35D, N37S, L63P, G68E, V77I  
  F16 IDV 36   E35D, L63P, V77I, I93L  
  F19 IDV, SQV, RTV 48 G48V, I54V, V82A, L90M  L10I, E35D, L63P, A71V, V77I, I93L  
  F22 IDV, SQV, RTV 60 G48V, I54V, V82A, L90M F53L L10I, E35D, L63P, A71V, V77I, I93L Q7S 
  F28 IDV, SQV, RTV 84 G48V, I54V, V82A, L90M  L10I, E35D, L63P, A71V, V77I, I93L  
  F34 IDV, SQV, RTV 108 G48V, I54V, V82A, L90M  L10I, E35D, N37D, L63P, A71V, V77I, I93L  
Cab-g G0 None    L63P, E65D I13T 
  G47 RTV, SQV 104 I54V, V82A, I84V, L90M L33F, G73S L10I, I13V, L63P, A71V, V77I  
  G51 RTV, SQV 112 I54V, V82A, I84V, L90M L33F, G73S L10I, I13V, L63P, A71V, V77I  
  G53 RTV, SQV, IDV 116 I54V, V82A, I84V, L90M L33F, G73S L10I, I13V, L63P, C67F, A71V, I72M, V77I  
  G56 RTV, SQV, IDV 128 I54V, V82A, I84V, L90M L33F, G73S L10I, I13V, L63P, E65D, A71V, I72M, V77I D25G, D29H 
Cab-h H0 None    L10I, R41K, I93L  
  H38 None    L10I, M36I, R41K, I64V  
  H41 IDV 12 M46L, I54V, V82A  L10I, M36I, R41K, I64V, A71V, I93L  
  H44 IDV 36 M46L, I54V, V82A  L10I, M36I, R41K, I64V, A71V, I93L  
  H51 IDV 52 M46L, I54V, V82A L24I, F53L L10I, M36I, R41K, I64V, A71V, I93L  
  H58 IDV, SQV, RTV 80 M46L, G48A, I54V, V82A L24I, F53L L10I, E35D, M36I, R41K, I64V, A71V, I93L  
  H60 IDV, SQV, RTV 88 M46L, G48T, I54V, V82A L24I L10I, E35D, M36I, N37D, R41K, I64V, A71V, I72V, I93L  
Cab-I I0 None    Q18H, L63P, V77I, I93L  
  I33 IDV 24 M46I, I84V, L90M G73S L10I, Q18H, L63P, V77I, I93L, C95F  
  I35 IDV, SQV, RTV 32 M46I, I84V, L90M G73S L10I, Q18H, L63P, V77I, I93L, C95F  
  I37 IDV, SQV, RTV 48 M46I, I84V, L90M G73S L10I, Q18H, L63P, V77I, I93L, C95V  
  I40 IDV, SQV, RTV 52 M46I, I84V, L90M G73T L10I, Q18H, F53Y, L63P, V77I, I93L, C95F  
Cab-j J0 SQV, RTV V82A, I84V, L90M  L10V, I15V, K20R, E35D, M36I, L63P, A71V  
  J4 SQV, RTV, NFV 16 V82T, I84V, L90M  L10V, I15V, K20R, E35D, M36I, L63P, A71V  
  J8 SQV, RTV, NFV 32 V82T, I84V, L90M  L10V, I15V, K20R, E35D, M36I, R41K, L63P, A71V  
  J12 SQV, RTV, NFV 48 I54V, V82T, L90M  L10V, I15V, K20R, E35D, M36I, L63P, A71V  
Cab-k K0 IDV 36   T12E, I15V, M36I, L63A, I64V  
  K18 IDV, SQV, RTV 72   T12E, I15V, M36I, L63A, I64V  
  K21 IDV, SQV, RTV 84 G48V, I54T, V82A  L10I, T12E, I15V, L19I, K20R, M36I, I62V, L63S, I64V, A71V, I93F  
  K24 IDV, SQV, RTV 96 G48V, I54T, V82A  L10I, T12E, I15V, L19I, K20R, M36I, I62V, L63S, I64V, A71V  
  K35 IDV, SQV, RTV 140 G48V, I54T, V82A  L10I, T12E, I15V, L19I, K20R, M36I, F53Y, I62V, L63S, A71V  
Cab-l L0 None    N37H, R41K, I62V, L63P  
  L39 RTV, SQV 52 V82A, I84V K43T E34K, N37H, R41K, I62V, L63P, I72L  
  L47 RTV, SQV 92 M46I, I84V, L90M L33F, F53L, G73V, T74P E34Q, N37H, R41K, I62V, L63P, I72L, V77I