Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Deeks (1999)
Title Novel four-drug salvage treatment regimens after failure of a human immunodeficiency virus type 1 protease inhibitor-containing regimen: antiviral activity and correlation of baseline phenotypic drug susceptibility with virologic outcome.
Citation J Infect Dis
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 15
NumPts 15
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
SD-10 SD-10 NRTI, AZT, 3TC None M184V  K102Q, D123E, S162C, T200A, Q207E, A272P, K277R, I293V  
SD-12 SD-12 NRTI, 3TC, DDI None D67N, T69D, K70R, M184V, T215F, K219Q  K122E, I142V, S162C, D177E, I178L, V179I, Q207E, E224D, A272P, I293V  
SD-13 SD-13 NRTI, 3TC, D4T None M41L, M184V, L210W, T215Y  K43Q, V60I, S68SG, T139M, R211K, V245Q, A272P, K277R, I293V, E297A  
SD-14 SD-14 NRTI, 3TC, DDI None M41L, L74I, M184V, L210W, T215Y  D177E, H208Y, R211K, L228R, T286A, T296S, E297EK  
SD-15 SD-15 AZT, 3TC, D4T, DDI None M41L, M184V, L210W, T215Y  K43Q, S68G, V118I, G196X, Q207E, R211K, L228H, K277R, T286A, I293V, E297KR  
SD-16 SD-16 NRTI, D4T, DDI None K70R  D177N, I178L, Q197E, R211K, V245T, D250E, T286A, I293V  
SD-17 SD-17 NRTI, AZT, 3TC None M41L, M184V, L210LW  K13KN, T39TA, K43Q, V60VI, S68SG, T139M, R211RK, T215X, V245LQ, A272PS, K277R, I293V, E297A  
SD-18 SD-18 AZT, 3TC None D67N, K70R, M184V, K219Q  E6D, T27TS, V118I, K122E, I135T, S162Y, R211K, F214L, I293V  
SD-19 SD-19 NRTI, AZT, 3TC None M41L, M184V, T215Y  D123E, Q174K, T200A, R211K, V245VM, A272P, I293V, E297KR  
SD-2 SD-2 NRTI, AZT, 3TC None M41L, M184V, L210W, T215Y  T39DN, E40D, K43E, T69A, A98AS, V118VI, I135V, S162C, R211K, L228H, V245E, A272P, K277R, V292I K32K* 
SD-20 SD-20 NRTI, 3TC, D4T None M41L, M184V, T215Y  I135V, K166R, A272P, K277R, E297KR P140Q 
SD-21 SD-21 D4T EFV  K103N, P225H K122E, D123E, I135M, S162C, T200A, Q207A, R211K, V245Q, K277R, I293V  
SD-5 SD-5 NRTI, AZT, 3TC None M184V  K20R, K122E, I142V, T165I, K277R, A288S, I293V  
SD-6 SD-6 NRTI, 3TC, D4T None D67G, K70R, M184V, K219Q  K20R, S68G, K122E, Q207AE, R211K, T286A  
SD-7 SD-7 NRTI, 3TC, DDI None L74V, M184V  K122E, K173R, Q174K, I178M, Q207E, A272P, T286A