Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Shulman (2000)
Title Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: Clinical and genotypic predictors of virologic response.
Citation JAIDS
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 84
NumPts 33
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
CA1121 CA2596 SQV, IDV, RTV 89 I54V, L90M K20T, G73S K14R, I15V, E35D, M36I, N37D, I62V, L63P, A71V  
CA1141 CA2591 IDV 48 I54V, V82A G73C L10I, I15V, M36I, N37D, K45R, I62V, L63P, I72E  
  CA9587 IDV, SQV, RTV 134 G48V, I54V, V82AT G73C L10I, I15V, K20R, M36I, N37D, I62V, L63P, I72E  
CA1145 CA2604 IDV, SQV, RTV, NFV 104 M46I, I84IV, L90M G73T L10I, V11VI, T12A, L19I, K20I, L63P, I64IV, A71V, I93L  
  CA9977 IDV, SQV, RTV, NFV 117 M46I, I84IV, L90M G73T L10I, V11VI, T12A, I15V, L19I, K20I, L63P, I64IV, A71IV, I93L  
  CA10016 IDV, SQV, RTV, NFV 127 M46I, I84IV, L90M G73T L10I, T12AP, I15V, L19I, K20I, L63P, I64IV, A71IV, P79PAS, I93L  
  CA8047 IDV, SQV, RTV, NFV 139 M46I, I84V, L90M G73T L10I, T12P, I15V, L19I, K20I, L63P, I64V, A71I, P79AS, I93L  
CA1158 CA2634 IDV, SQV, NFV 78 I54V, V82A, L90M F53FL L10I, E35D, M36V, R57K, D60E, I62V, L63P, A71V, I93L  
  CA10673 IDV, SQV, NFV, RTV 90 I54V, V82A, L90M F53L L10LI, E35D, M36V, R57K, D60E, I62V, L63P, A71V, I93L  
  CA8195 IDV, SQV, NFV, RTV 127 I54V, V82A  E35D, R57K, D60E, I62V, L63P, A71V  
  CA11021 IDV, SQV, NFV, RTV 127 I54V, V82A, L90M L23I, F53L L10I, E35D, M36V, R57K, D60E, I62V, L63P, A71V, I93L  
CA1173 CA9980 SQV, IDV, RTV 123 G48V, I54V, V82A, I84V  L10I, V77I  
CA1259 CA3027 IDV, SQV, RTV 65 M46L, G48V, I54V, V82A Q58E L10I, L63C, A71V, V77I, Q92K, I93L  
CA1271 CA4213 IDV, SQV, RTV 101 V32I, M46I, I47V, L90M G73GC E35D, M36I, N37E, R41K, L63P, K70T, V77I, I93L  
  CA3733 IDV, SQV, RTV 104 V32I, M46MI, I47V K20KT, G73GC I15ILV, G16GA, E35D, N37E, R41KN, L63P, K70T, V77I, I93L  
  CA9982 IDV, SQV, RTV 114 V32I, M46I, I47V, L90M G73S L10LI, K20R, E35D, M36I, N37E, R41K, L63P, K70KT, A71AV, V77I, I93L  
CA1274 CA3059 SQV, IDV, RTV, NFV 154 L90M Q58E, G73S L10I, I15V, K20M, M36I, I62V, L63P  
  CA4371 SQV, IDV, RTV, NFV 184 L90M Q58E, G73S L10I, I15V, K20I, M36I, I62V, L63P  
CA1277 CA4390 IDV, NFV 64  L23I K20KR, N37T, L63P, T74S, V77VI, V82I, I93L  
CA1337 CA3368 RTV, IDV, NFV, SQV 90 V32I, M46MI, I54V, V82A, L90M K20KT I13V, I15V, L19I, M36I, L63P, A71V  
  CA9981 RTV, IDV, NFV, SQV 104 V32I, M46I, I54V, V82A, L90M F53FL I13V, I15V, L19I, E35ED, M36I, L63P, A71V  
  CA9979 RTV, IDV, NFV, SQV 129 V32I, M46I, I54V, V82A, L90M F53FL I13V, I15V, L19I, E35D, M36I, L63P, A71IV  
CA1341 CA3376 IDV, SQV, RTV 110 I54V, V82A, L90M Q58E, G73T L10I, L19I, R41K, I62V, L63P, A71I, V77I, I93L  
  CA9585 IDV, SQV, RTV, NFV 163 I54V, V82A, L90M Q58E, G73T L10I, L19I, R41K, I62V, L63P, A71I, V77I, I93L  
CA1391 CA3643 IDV, SQV, RTV 64 I84V, L90M G73S R57K, L63P, A71V  
  CA9983 IDV, SQV, RTV 73 I84V, L90M G73GS R57K, L63P, A71V  
  CA7515 IDV, SQV, RTV, NFV 104 I84V, L90M  R57K, L63P, A71V  
CA1422 CA3809 SQV, NFV 24   I13V, L63P  
  CA10006 SQV, NFV 31   I13V, L63P  
  CA9486 SQV, NFV 57   I13V, L63P  
CA1433 CA3833 IDV, SQV, RTV 66 M46L, I54V, V82A, L90M  L10V, E35ED, M36I, R57K, L63P, A71V, I93L  
  CA10669 IDV, SQV, RTV, NFV 90 M46L, I54V, V82A, L90M  L10V, E35D, M36I, R57K, L63P, A71V, I93L  
  CA9555 IDV, SQV, RTV, NFV 104 M46L, I54V, V82A, L90M  L10V, E35D, M36MI, R57K, L63P, A71V, I93L  
CA1449 CA3872 Unknown    I15V, E35D, N37E, R57K, D60DE, L63P, I72IT  
  CA10674 Unknown    I15V, E35D, N37E, I62V, L63P  
  CA9793 Unknown, NFV, IDV 25 D30N N88D I15V, E35D, M36V, N37E, I62V, L63P  
CA1466 CA11103 NFV, RTV, IDV 101 M46I, L90M G73C K20V, N37S, R41K, I62IV, L63P, I64V, T74S, V77I  
CA1600 CA4555 SQV, IDV, RTV 77 G48V, I54T, V82A  L10I, R57K, L63P, I64L, A71V, I72V, V77VI  
  CA10020 SQV, IDV, RTV 77 G48V, I54T, V82A  L10I, R57K, L63P, I64L, A71V, I72V, V77VI  
  CA10013 SQV, IDV, RTV 92 G48V, I54T, V82A  L10I, R57K, L63P, I64L, A71V, I72V, I93M  
CA1802 CA4841 RTV, SQV 102 I54V, V82A, I84V L24I L63P, A71I, V77I  
CA4014 CA10671 IDV 28 V32I, M46L, V82A  I64V, A71AV  
  CA10684 IDV 34   I47IM  
  CA10685 IDV 34     
  CA9634 IDV 34   I64V  
CA4172 CA1190 SQV, IDV, RTV, NFV, Unknown 107 I84V, L90M G73S L10I, I13V, K20IM, M36I, I62IV, L63P, A71V, I72V  
  CA10019 SQV, IDV, RTV, NFV, Unknown 107 I84IV, L90LM G73GS L10LI, I13V, K20IM, M36I, L63P, A71AV, I72V  
  CA10014 SQV, IDV, RTV, NFV, Unknown 107 I84V, L90LM G73GS L10I, I13V, K20IM, M36I, L63P, A71AV, I72V  
CA606 CA10679 SQV, IDV, RTV 106 M46MI, I84V, L90M G73S L10I, K20I, D29DV, N37D, R41RK, I62V, L63P, K70R, A71AT, I72IT  
  CA9976 SQV, IDV, RTV, Unknown 119 I84V, L90M G73S L10I, K20I, N37D, I62V, L63P, K70R, A71AT, I72IT  
CA622 CA1184 IDV, SQV, RTV 78 M46I, I54IL, V82T, L90M G73S L10I, R41K, K45R, L63P, A71V, V77I, I85V, I93L  
  CA10676 IDV, SQV, RTV 120 M46I, V82T, I84V, L90M G73S L10I, N37ND, R41K, K45KR, L63P, A71LV, V77I, I85V, I93L  
  CA10677 IDV, SQV, RTV 124 M46I, V82T, I84V, L90M G73S L10I, N37ND, R41K, K45KR, L63P, A71V, V77I, I85V, I93L  
CA624 CA9984 NFV, SQV, RTV 58 D30N, I54V, L90M N88D I13V, K20R, L33LI, E35D, M36I, L63P, A71AT  
CA629 CA10008 SQV, IDV, NFV, RTV 464 M46I, L90M F53L, G73S L10I, L63P, C67F, H69HQ, A71V, I72IM, V77I  
  CA9975 SQV, IDV, NFV, RTV, Unknown 468 M46I, L90M F53L, G73ST L10I, L63P, C67F, H69HQ, A71V, I72IM, V77I  
  CA9583 SQV, IDV, NFV, RTV, Unknown 468 M46I, L90M F53L, G73ST L10I, L63P, C67F, H69HQ, A71V, I72IM, V77I  
CA632 CA9441 IDV, SQV, RTV 119 M46L, G48EV, I54IV, V82T, L90M F53FL L10R, G16A, L63P, A71V, I72IV, T74TS, V77I, I93L  
CA634 CA10670 SQV, IDV, RTV 106 M46I, G48V, I54T, V82A  L10I, K20R, L23F, E35D, M36I, N37D, I62V, L63P, A71V, I72ILV, V77I, I93L  
  CA10672 SQV, IDV, RTV, Unknown 113 M46I, G48V, I54T, V82A  L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, V77I, I93L  
  CA9579 SQV, IDV, RTV, Unknown 155 M46MI, G48V, I54T, V82A  L10I, I15IV, K20R, E35D, M36I, N37D, I62V, L63P, A71V, V77I, I93L  
CA637 CA9994 SQV, IDV, NFV, RTV 108 M46MI, I84V, L90M L10LF K20KIM, E35D, M36I, N37E, I62V, I64V, H69Y  
  CA9993 SQV, IDV, NFV, RTV 108 M46MI, I84V, L90M L10LFV K20KIM, E35D, M36I, N37E, I62V, I64V, H69Y  
  CA9628 SQV, IDV, NFV, RTV 108 I84V, L90M L10FY K20KIM, E35D, M36I, N37E, I62V, I64V, H69Y  
CA640 CA1220 SQV, IDV, RTV 136 G48V, I54V, V82A, I84V  L10I, G17E, N37D, L63P, C67S, A71V, I72IV, V77I, I93L  
  CA3365 SQV, IDV, RTV 158 G48V, I54V, V82A  L10I, G17E, N37D, L63P, C67S, A71V, V77I, I93L  
  CA10011 SQV, IDV, RTV 171 G48V, I54V, V82A, I84V K43T L10I, G17E, N37D, L63P, C67S, A71V, V77I, I93L  
  CA9974 SQV, IDV, RTV, Unknown 174 G48V, I54V, V82A, I84V K43T L10I, G17E, N37D, L63P, C67S, A71V, I72IV, V77I, I93L  
  CA9521 SQV, IDV, RTV, Unknown 205 G48V, I54V, V82A, I84V K43T L10I, G17E, N37D, L63P, C67S, A71V, I72V, V77I, I93L  
  CA9582 SQV, IDV, RTV, Unknown 212 G48V, I54V, V82A, I84V K43T R8RQ, L10I, G17E, N37D, L63P, C67S, A71V, I72IV, V77I, I93L  
CA790 CA3169 IDV, SQV, RTV 98 M46MIL L24LI, G73GS L10I, I13V, K14KR, K43KN, L63P, I72MV  
  CA9995 IDV, SQV, RTV 145 M46I, I84V L24I, G73S L10I, I13V, L63P, I72V, I93L  
  CA9744 IDV, SQV, RTV 167   I13V, L63P, I72IMV  
  CA10724 IDV, SQV, RTV 173 M46I L24I, G73S L10I, I13V, K14KR, L63P, A71T, I72V, I93L  
CA794 CA3075 IDV, SQV, RTV 88 M46L, I54V, V82A, L90M  L10I, I62V, L63P, A71V  
  CA10675 IDV, SQV, RTV 107 M46L, I54V, V82A, I84V, L90M  L10I, K20KI, D60E, I62V, L63P, A71V  
  CA5076 IDV, SQV, RTV 127 M46L, I54V, V82A, I84V, L90M K43T L10I, E35D, M36V, D60E, I62V, L63P, A71V  
  CA9584 IDV, SQV, RTV 148 M46L, I54V, V82A, I84V, L90M K43T L10I, E35D, M36V, D60E, I62V, L63P, A71V  
CA796 CA10007 SQV, NFV, IDV, RTV 111 M46I, L90M L24LF, F53L, G73S L10I, N37D, D60E, L63P, A71IV, V77I, I93L  
  CA9973 SQV, NFV, IDV, RTV, Unknown 111 M46I, L90M F53FL, G73S L10I, N37D, D60DE, L63P, A71V, V77I, I93IL  
CA799 CA9998 RTV, IDV, SQV, NFV 107 I54V, V82A, L90M G73S L10I, I15V, K20M, E35D, M36I, R57K, I62V, L63P, A71V  
  CA9581 RTV, IDV, SQV, NFV, Unknown 115 I54V, V82A, L90M G73S L10I, I15V, K20M, E35D, M36I, R57K, I62V, L63P, A71V  
WI004173 PCCSHV2688 SQV, IDV 133 I54V, V82A, L90M  L10I, K20R, A22AV, E35D, M36I, N37NS, P44X, I62V, L63P, A71T, I93L  
  41731906 SQV, IDV 169 I54V, V82A, L90M  L10I, K20R, E35D, M36I, R41K, I62V, L63P, A71T, I93L, C95F