Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Lawrence (1999)
Title Clinical resistance patterns and responses to two sequential protease inhibitor regimens in saquinavir and reverse transcriptase inhibitor-experienced persons.
Citation J Infect Dis
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 24
NumPts 10
Subtype B

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
CA1149 CA10384 AZT, DDI, 3TC None M184V, T215Y  D121Y, K122E, I135L, S162C, V245T, K277R, Q278H, T286A  
  CA10386 AZT, DDI, 3TC, D4T None M41L, M184V, T215Y  K122E, S162C, V245KT, K277R, Q278H, T286A  
  CA2611 AZT, DDI, 3TC, D4T NVP M41L, M184V, T215Y K103KN, Y181YC K122E, S162C, V245E  
CA1165 CA10420 AZT, DDC, D4T, 3TC None M41L, D67DN, T69D, M184V, T215Y, K219KR  K20R, V60I, V118I, K122E, I135M, G196E, F214FL, L228H N255NH 
  CA10423 AZT, DDC, D4T, 3TC None M41L, D67DN, T69D, M184V, T215Y, K219R  K20R, V60I, V118I, K122E, I135M, G196E, F214FL, L228H  
  CA3102 AZT, DDC, D4T, 3TC NVP M41L, D67N, T69D, M184V, T215Y K103N K20R, V60I, V118VI, K122E, I135M, G196E, F214FL, L228H, I293V, E297R  
CA1313 CA10392 AZT, 3TC, DDI None M41L, D67N, T69D, M184V, L210W, T215Y  M16MV, K20R, T39TA, V60I, R83K, V90I, V118I, K122E, I135T, S162FY, E169D, G196E, Q207E, R211K  
  CA10394 AZT, 3TC, DDI, D4T None M41L, D67N, T69D, M184V, L210W, T215Y  M16V, K20R, T39A, K49R, V60I, R83K, V90I, V118I, K122KE, I135T, S162DY, E169D, G196E, Q207E, R211K, A272P, I293V  
  CA3296 AZT, 3TC, DDI, D4T NVP M41L, D67N, T69D, M184V, L210W, T215Y K103N M16V, K20R, T39A, K49R, V60I, R83K, V90I, V118I, I135T, S162D, E169D, G196E, I202V, Q207E, R211K, A272P  
CA4089 CA10381 AZT, DDC, 3TC None M41L, M184V, L210W, T215Y  K122E, V245K  
  CA10382 AZT, DDC, 3TC, D4T None M41L, M184V, L210W, T215Y  K43E, K122E, V245K  
CA642 CA10389 AZT, DDI, 3TC, D4T None M41L, D67N, T69D, K70R, M184V, T215F, K219Q  D123E, S162A, D177E, V179VI, R211Q, D218E  
  CA10390 AZT, DDI, 3TC, D4T None M41L, D67N, T69D, K70R, M184V, T215F, K219Q  K122KE, D123E, S162A, D177E, V179VI, H208HY, R211EQ, D218E, A272P, K277R, E297K  
  CA3186 AZT, DDI, 3TC, D4T NVP M41L, D67N, T69D, K70R, M184V, T215F, K219Q V106VA, G190GA K43KE, S48SP, K122KE, D123E, S162A, D177E, V179I, G196GE, R211Q, D218E, A272P, K277R A33AP, I37IT 
CA794 CA1433 AZT, DDI, DDC, D4T, 3TC NVP M41L, A62V, K65KR, D67N, V75I, Q151QL, M184MV, L210W, T215Y  K20R, V21I, V35I, K43Q, E79D, R83K, K122E, G196E, Q197K, D218DE, K223Q, A272P, K277R Y181YN 
CA796 CA4230 AZT, DDI, 3TC, D4T None M41L, D67N, T69D, K70R, V75M, M184V, T215F, K219W  V35T, V60I, K104KN, K122E, V179I, H208Y, D218E, L228H, E248Q  
  CA10424 AZT, DDI, 3TC, D4T, DDC None M41L, D67N, T69D, K70R, V75M, M184V, T215F, K219W  V35T, V60I, K104KN, K122E, V179I, H208Y, D218E, L228H, E248Q  
  CA3124 AZT, DDI, 3TC, D4T, DDC NVP M41L, D67N, T69D, K70R, V75M, M184V, T215F, K219W K103N, Y181C K20KR, V35T, V60I, K122E, I135T, V179VI, H208Y, D218E, L228H, V245E, E248Q  
JL-Pt11 JL-11-pre AZT, DDC, 3TC, D4T None D67N, K70S, F116Y, Q151M, M184V, T215Y  T58S, D121H, K122E, I135V, D177E, K277R F77V 
  JL-11-post AZT, DDC, 3TC, D4T, DDI None D67N, K70S, V75I, F116Y, Q151M, T215Y  T58S, D121H, K122E, I135V, D177E, Q242QH F77V 
JL-Pt4 JL-4-pre AZT, 3TC None D67N, K70R, K219Q  K20R, T69N, V90I, K122KE, D123E, I135T, I178M, G196E, T215X, V245M  
  JL-4-post AZT, 3TC None D67N, K70R, M184V, K219Q  V60I, T69N, D123E, I135T, G196E, V245MT  
JL-Pt6 JL-6-pre AZT, 3TC None M41L, D67N, K70R, M184V, T215Y, K219E  K122KE, D123E, I135V, I178M, V245E  
  JL-6-post AZT, 3TC, D4T None M41L, D67N, K70R, M184V, T215Y, K219E  K122E, D123E, I135V, I178M, V245E, T286A