Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Winters (1998)
Title A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors.
Citation J Clin Invest
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 9
NumPts 9
Subtype B

 

Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
CA1429 CA8487 IDV 67 M46I, L90M G73ST L10V, I13V, L19I, L63P  
J-A J-A IDV, NFV, SQV, RTV 72 M46I, I54V, V82A L24I, F53FL L10I, L33IV, M36MV, N37D, P39PS, R41RK, I62V, L63P, A71V, I72V  
MW-ins1 jci-1 None    E35D, N37NS, L63P  
MW-ins10 jci-10 Unknown  L90M K20IT, G73GS, T74TP L10I, I13V, I15V, N37C, K45KR, I62V, L63P, A71V, V77VI, I93L  
MW-ins11 jci-11-498 Unknown  M46MI, I84V, L90M G73T L10I, N37S, L63P, I64V  
MW-ins13 jci-13 IDV, PI 24 I54V, V82A, L90M  L10I, K20R, E35D, M36I, N37ND, R41RK, D60E, I62V, L63P, A71V, I72IT  
MW-ins14 jci-14 PI  I54V, I84V, L90M G73S I15V, L19P, K20I, E35G, M36I, I62V, L63P, A71IT  
MW-ins3 jci-3 IDV, PI, Unknown 104 I54V, L90M Q58E, G73T L10V, E35D, M36I, N37D, I62IV, L63P, I64V, A71V  
MW-ins4 jci-4-897 SQV, IDV 104 I84V, L90M L10F T12N, L19T, K20I, E35D, M36I, N37D, R57K, I62V, L63P, A71V, Q92R