Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Dueweke (1993)
Title A mutation in reverse transcriptase of bis(heteroaryl)piperazine- resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.
Citation PNAS
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Lab
NumIsolates 5
Lab Parent Strain IIIB

 

Lab RT Isolates : Susceptibility Data


IsolateNRTIDRMsNNRTIDRMsMethodDrugFold Res.
181-236  Y181C Cell line DLV >240 
     Cell line L697661 12 
     Cell line NVP 2.0 
     Cell line R82913 3.0 
HTLV-IIIB   Cell line DLV 1.0 
    Cell line L697661 1.0 
    Cell line NVP 1.0 
    Cell line R82913 1.0 
IIIB-K103N  K103N Cell line DLV 30 
     Cell line L697661 20 
     Cell line NVP >25 
     Cell line R82913 >15 
IIIB-P236L   Cell line DLV 72 
    Cell line L697661 0.1 
    Cell line NVP 0.1 
    Cell line R82913 0.2 
IIIB-Y181C  Y181C Cell line DLV 30 
     Cell line L697661 >75 
     Cell line NVP >25 
     Cell line R82913 10