Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Gandhi (2020)
Title Long-term Outcomes in a Large Randomized Trial of HIV-1 Salvage Therapy: 96-Week Results of AIDS Clinical Trials Group A5241 (OPTIONS).
Citation J Infect Dis
SelectedGene PR
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 545
NumPts 412
Subtype B, C, CRF02_AG, A, B + G

 

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Page 1   listing Isolate 1 to Isolate 100 from Total 545 Clinical PR Isolates


SubjectIsolatePIsWksPIMajorPIMinorCommonUnusual
1_-60 PI, LPV 418 M46L, I54V, I84V, L90M L10F, G73S, L89V V11I, I13V, I15V, G16A, K20I, M36I, I62IV, L63P, K70R, A71V, I72L, P79A, N83H  
10 10_-85 PI, RTV, APV 286 M46L, G48V, I54L, V82A, I84V Q58E L10I, V11L, I13V, K14KR, G16E, K20V, E35D, M36I, N37D, L63Q, I64V T91TCS 
11 11_-81 PI, DRV, RTV 90 M46I, I50V, V82A, I84V L33F, Q58E, T74P L10I, I13V, K14R, I15V, E34X, M36L, N37S, K55R, R57K, I62V, L63P, C67E, L89F, T91S  
  11_84 PI, DRV, RTV, TPV 114 M46I, I50V, V82A, I84V L33F, Q58E, T74P L10I, I13V, K14R, I15V, E34T, M36L, N37S, K55R, R57K, I62V, L63P, C67E, L89F, T91S  
12 12_-77 PI, RTV, APV 200 G48V, I54L, V82A, I84V L33F L10I, K55R, I62V, L63T, T74S, I85IV, T91A  
  12_742 PI, RTV, APV, DRV 317 G48GV, I54LV, V82A, I84IV L33LF L10I, K55R, I62IV, L63T, A71AV, T74TS, I85IV, T91TA  
13 13_-57 PI, ATV 61   I15V, E35D, M36MI, P39PS, R41RK, R57RK, I62V, L63S, A71V, I72T, T74TA, I93L  
14 14_-58 PI, DRV, RTV 41 I84V, L90LM L33F, T74TP L10I, I13V, I62M, L63P, I64L, I66F, H69Q, A71V  
  14_97 PI, DRV, RTV 63 I84V, L90M L33F L10I, I13V, I62M, L63P, I64L, I66F, H69Q, A71V  
15 15_-89 PI, RTV, DRV 265 M46L, I50V, V82T, L90M L10F, L33F, G73A V11VI, I13V, I15V, K20R, E34Q, E35D, M36I, N37DE, K55KR, I62V, L63P, I64IM, I66V, A71V, F99Y  
  15_106 PI, RTV, DRV, TPV 293 M46L, I50V, V82T, L90M L10F, L33F, G73A V11VI, I13V, I15V, K20R, E34Q, E35D, M36I, N37DE, K55R, I62V, L63P, I64IM, I66V, A71V, F99Y  
16 16_-84 PI, DRV, RTV 100 V32I, M46I, I47V, I54L, I84V, L90M L33F, G73ST L10I, V11I, I13V, E35X, K55N, I62V, L63P, A71I, V77T, V82I, I93L G94GD 
17 17_-50 PI, RTV, ATV 268 M46L, L90M K20T, Q58E, G73S, T74P I15V, L19I, M36MI, R41K, I62V, L63P, A71V, V77I, I93L  
18 18_-69 PI, LPV 262 M46I, L90M  M36I, I62V, L63P, I64L, I93IL  
19 19_-49 PI, ATV 130   I13V, D60DE, L63HQ, I64V  
  19_684 PI, ATV, DRV, RTV 234   I13V, L63HQ, I64V  
2_-43 PI, LPV 121 D30DN, L90LM  I13IV, E35D, M36MI, P39PQ, I62IV, L63P, A71AV, I72IV  
  2_433 PI, LPV, DRV, RTV 189 D30DN, L90LM N88ND I13IV, E35D, M36I, P39PQ, I62V, L63P, H69HN, A71AV, I72IV  
20 20_-68 PI, RTV, ATV 156   G16GE, I62IV, L63A, I64IV, H69Q, V77I, Q92K  
21 21_-56 PI, RTV, ATV 127 I54V, I84V, L90M G73S L10I, V11I, I13V, Q18H, L19LI, A22V, L33I, E35D, M36I, N37DE, I62V, L63P, C67F, H69R, A71V, I72L, P79A, N83S K45GR 
22 22_-69 PI, SQV, RTV 205 L90M K20T L10I, I13V, K14KE, L33LI, E35D, M36I, R41K, I62IV, L63P, A71T, I72IV, T74S, V77I  
  22_197 PI, SQV, RTV, DRV 238 L90M K20T L10I, I13V, L33LI, E35D, M36I, R41K, I62IV, L63P, A71T, I72IV, T74S, V77I  
23 23_-68 PI, LPV 23   L19I, D60E, Q61D, L63S, V77VI  
  23_57 PI, LPV, DRV, RTV 41   L19I, D60E, Q61D, L63S, V77VI  
24 24_-63 PI, RTV, DRV 161   I13V, K20KR, R41K, L63P  
  24_99 PI, RTV, DRV 185   I13IV, K20KR, M36MI, R41K, L63P, V77VI  
25 25_-30 PI, RTV, APV 196 V32I, I47V, I54M L10LF, L33F T12S, L19Q, N37T, R57RK, L63P, V77I, V82VI, I93L  
26 26_-63 PI, LPV 150 M46I, I54V, V82T, L90M L10F, G73S T4TA, I13M, K55R, I62V, L63P, A71V, I72IM, V77I, I93L, C95F  
27 27_-69 PI, RTV, DRV 191 V32I, M46L, I54L, I84V, L90M L33F, K43KT, Q58QE, T74P L10I, V11I, G16A, K20KR, E34Q, E35D, M36I, K55R, R57RK, I62V, L63LP, C67CY, A71V, I72V, V82X, L89F, I93L  
  27_84 PI, RTV, DRV 213 V32I, M46L, I54L, I84V, L90M L33F, Q58E, T74P L10I, V11I, G16A, L19LP, K20KR, E34Q, E35D, M36I, K55R, R57RK, I62V, L63X, C67CY, A71V, I72V, V82VI, L89F, I93L  
28 28_-57 PI, RTV, ATV 142   M36I, D60E, I62V, L63P, H69Q  
29 29_-63 PI, RTV, ATV 181   L10V, I13V, L19IMV, L33V, M36L, N37A, L63LP, I64V  
3_-77 PI, LPV 214 M46MI, I54V, V82A, L90M L33F, T74P L10I, I13IV, E34Q, I62V, L63P, I64M, H69Q, A71V, V77I, I93M  
30 30_-84 PI, RTV, ATV 110 V32I, M46I, I47V, L90M Q58E, G73C L10V, I13IMV, E34Q, E35D, M36IV, I62V, L63P, V77I, I93L  
31 31_-54 PI, RTV, ATV 178 I54IL, L90M K20T, L23LI, L24LF, L33LF, F53L I15V, E35D, M36I, N37T, R41K, R57K, I62V, L63P, I66IL, A71V, T74S, V77I, I93L  
32 32_-83 PI, LPV 219 M46I, I54V, V82A, L90M L33F, F53L, G73S L10I, L19I, E35D, M36I, Q61E, I62V, L63P, A71I, I72T  
33 33_-75 PI, RTV, ATV 12   L19IT, L63P, H69Y, I72T, V77I  
  33_393 PI, RTV, ATV, DRV 79   L19I, L63P, H69Y, I72T, V77I  
34 34_-105 PI, RTV, ATV M46I, I50L, V82A, L90M G73T L10I, V11I, I13IV, K20I, L33V, K45R, K55R, L63P, I64V, A71V, V75VI  
35 35_-63 PI, ATV 36   M36I, N37E, I62V, L63P, A71AT, I93L  
36 36_-51 PI, SQV, RTV, LPV 183 M46I, I54V, V82C, L90M G73T L10I, I15V, K20I, E35D, M36I, N37NT, D60E, I62V, L63P, I66F, C67Y, A71T, I72R, I93L R41Q 
37 37_-54 PI, RTV 66 M46I, I47V, I54V, I84V, L90M G73S V11VI, I13V, L19LV, K20IV, E35G, M36I, I62V, L63P, A71I, I93L  
38 38_434 PI, SQV, RTV, DRV 228 M46L, I54V, V82T L23LI, L33F, Q58E I3IV, L10V, I13IV, E34ED, M36MI, N37D, L63P, A71V, L89M, I93L  
  38_681 PI, SQV, RTV, DRV 263   N37D, L63P, I93L  
39 39_-77 PI, RTV, ATV 75 I84V, L90M L10F, N88D I13V, L33I, E35D, M36I, R57RK, I62IV, L63P, I66L, A71T  
4_-44 PI, LPV 80   E35D, M36I, R41RK, I62IV, L63PS, I72X  
  4_679 PI, LPV, DRV, RTV 184   E35D, N37NS, L63P  
40 40_-61 PI, LPV 33 V32I, M46MI, I47V, I54M, L90M L33F, K43T, G73S, L89V L10I, V11L, T12S, I13V, K14KR, Q18QH, E34Q, N37S, F53Y, Q61H, I62V, L63P, A71I, V77I, V82I, I93L G94D 
41 41_-49 PI, RTV, ATV 33   T12N, L19LI, L63AP, E65ED, K70KR  
42 42_-75 PI, NFV 517 I54V, V82A, L90M  L10I, L19LI, K20M, M36I, I62V, L63P, I64V, I85V  
43 43_-60 PI, LPV 76 V32I, M46I, I47V, I54M, V82A, L90M L33F, L89LV L10LV, I13V, E34EQ, R57K, L63P, A71L, V77I, P79PS, I93L  
44 44_-43 PI, NFV 22 D30N N88D I15V, K20KM, E35ED, M36I, R57K, I62IV, L63P, I66V, I72IV, I93IL  
45 45_-84 PI, RTV, ATV 173 V32I, M46I, I47V, I50L N83D L10I, I13V, A22V, L33I, M36I, R41K, I64V, A71V  
46 46_-78 PI, RTV, APV 57 V32I, M46L, I54L, I84V, L90M L33F, L89V L10V, V11I, T12TP, I13V, K14T, I15V, L19Q, K20V, E35N, M36I, K43X, K55R, L63P, A71V, P79S, Q92QK  
47 47_-62 PI, LPV 382 M46I, I47V, I54V, V82A, I84V L10F, L33F, K43T G16A, L19T, E34Q, K55R, R57K, I62V, L63P, A71T, I72T  
48 48_-58 PI, DRV, RTV 78 V32I, M46I, I47V, I50V, I54L, V82A L10F, L33F, K43T, F53L, G73GS, T74P, L89V I13V, G16A, L63PS, I72V, V77I  
  48_216 PI, DRV, RTV 114 V32I, M46I, I47V, I50V, I54L, V82A L10F, L33F, K43T, F53L, G73GS, T74P, L89V I13V, G16A, L63PS, I72V, V77I  
49 49_-61 PI, SQV, RTV, APV 178 M46L, I54V, V82C, L90M L10FI, L33F, G73ST V11L, T12P, I13V, I15V, L19S, K20R, E35D, M36IL, N37NDH, R41E, D60DE, I62V, L63P, A71T, I72T, I93L  
5_-83 PI, SQV, RTV 262 V32I, M46I, I54L, V82A, L90M K43T, F53L L10I, I15IV, K20R, L33I, E35D, M36I, N37S, R41K, I62V, L63P, H69Y, A71L, I72T, I93L  
50 50_-54 PI, RTV, APV 425 D30N, M46L, I54V, L90M K20T, L33F, N88D Q7QR, L10I, V11L, T12TAS, I13V, K14KR, I15V, E35D, M36I, N37DE, L63T, G68GD, H69HY, A71V, V77I  
51 51_-67 PI, RTV, ATV 79   K14KR, I15IV, I64IV  
  51_113 PI, RTV, ATV, DRV 105   K14R, I15IV, D60DE, I64IV  
52 52_-56 PI, RTV, ATV 49 M46I, I84V, L90M L10F, L24F, G73T K20I, K55KR, L63P, A71V, I93L  
53 53_-63 PI, RTV, TPV 148 I54V, V82T, L90M G73GS K20R, L33I, E35D, M36I, N37ND, R41RK, I62V, L63P, C67F, H69HQ, A71V, I72IV, I93L, C95X  
  53_367 PI, RTV, TPV, DRV 209 M46MI, I50IV, V82VA, L90M L10LF, G73GS I15IV, K20KR, E35ED, M36I, I62V, L63P, C67CF, H69HQ, A71V, I93L  
54 54_-76 PI, ATV 72 M46I, I50IL, V82VA, N88S Q58QE L10IV, D60DE, I62V, L63P, V77I  
55 55_-40 PI, DRV, RTV 50   L19T, L63P, V77I  
  55_104 PI, DRV, RTV 70   L19T, L63P, V77I  
56 56_-56 PI, LPV 94   T12A, I64V  
57 57_-57 PI, RTV, TPV 152 M46L, I54V, V82T, L90M L23I, K43T, G73S, L89V L10I, I13V, G16A, K20R, L33I, E35D, M36I, N37D, I62V, L63P, A71V, P79PS, I93L  
  57_83 PI, RTV, TPV, DRV 172 M46L, I54V, V82T, L90M L23I, K43T, G73S, L89V L10I, I13V, G16A, K20R, L33I, E35D, M36I, N37D, I62V, L63P, A71V, P79PS, I93L, N98NS  
58 58_-63 PI, RTV, APV 40 M46L, I50V, V82A, L90M L23I L10R, I13M, I15V, L19Q, K20V, M36I, K45R, I62V, L63P, I72V, I93L A71ILM 
59 59_288 PI, RTV, ATV, DRV 30   K14KR, L19T, K20KM, N37NH, R41K, L63T, E65D, I72T  
6_-49 PI, APV 113   E35D, N37T, R57RK, D60E, Q61QE, I62IV, L63P  
  6_112 PI, APV, DRV, RTV 136   E35D, N37T, R57RK, D60E, Q61QE, I62IV, L63P  
  6_147 PI, APV, DRV, RTV 141   E35D, N37T, R57RK, D60E, Q61QE, I62IV, L63P  
60 60_-39 PI, RTV, DRV 473 L90LM  I13IV, I15IV, E35D, M36I, I62IV, L63PS, I64V, Q92QK  
61 61_-51 PI, ATV, RTV 271   I15V, N37NS, R41K, D60DE, L63C, I64V, V77I, I93L  
62 62_-63 PI, RTV, ATV 524 M46L, I84V, L90M L10F, N88D G17D, L19I, K20R, L33LI, E35D, M36I, N37ND, K55R, R57RK, L63P, I66IV, A71V, V77I, I85V, T91S  
63 63_-76 PI, SQV, RTV 97 L90M G73IT L10I, K20R, E35D, M36I, I62V, L63P, I64V, H69HY, I93L  
  63_-47 PI, SQV, RTV 101 L90M G73ST L10I, K20R, E35D, M36I, I62V, L63P, I64V, H69HY, I93L  
64 64_-57 PI, DRV, RTV 31  K20T, L89IV L10V, T12K, I13V, M36I, N37D, R41K, H69K, K70R, I72M G16N 
  64_218 PI, DRV, RTV 70  K20IT L10V, T12K, I13V, M36I, N37D, R41K, H69K, K70R, I72M, L89I G16DN 
65 65_-59 PI, SQV, RTV 60   L10LV, P39T, L63P, V77I  
66 66_-77 PI, LPV 212 M46I, I54V, V82A, L90M L10F, L33F, K43T, G73A V11I, I13V, K55R, R57RK, Q61KR, I62V, L63P, I64IM, C67F, A71T, I72E, I93L T91TCS 
67 67_-40 PI, RTV, ATV 13 M46I, I54V, V82T L24I, G73S L10I, R41K, K45KR, L63P, A71IT, I93L  
68 68_-84 PI, RTV, DRV 135 V32I, M46I, I47V, I50V, I54L, V82A, I84V K20T, L33F, K43T, F53L, N88ND L10V, T12K, I13V, E34A, M36I, N37RS, L63P, I64L, I66F, A71V, T74TK, V77I, L89LM  
69 69_-84 PI, RTV, APV 181   E35D, N37E, D60E, L63P, A71T, I72E  
7_-50 PI, SQV, RTV, LPV 270 M46I, I54V, V82A, L90M K43T, F53L L10I, I13V, G16E, K20R, E35D, M36I, R57K, I62V, L63S, A71I, I93L  
70 70_-83 PI, RTV, TPV 206 V32I, M46I, I47V, I54V, V82T, I84IV, L90M  L10V, I13V, K20R, E35D, M36I, N37D, L63P, I64V, A71V, I72V  
71 71_-68 PI, LPV 17 M46L, I54V, V82A, I84V L10F, L24I, L33F I13V, G16A, R41K, K55R, D60E, L63P, A71V, I72IV, T91A, Q92E  
72 72_-50 PI, RTV, DRV 215 I54V, V82A K43T L10I, K20R, E35D, M36I, N37D, R57RK, L63P, A71T, I93L  
73 73_-70 PI, RTV, TPV 135 D30N, I54V, I84V N88D I13V, K14N, L19LI, L33I, E35D, M36I, N37S, R41K, K45Q, K55KR, Q61E, I62V, L63P, A71T, I72T, I93L  
74 74_-66 PI, RTV, ATV 226 G48GA, I54V, V82AT, L90M Q58E, G73ST L10I, L19LI, L63P, C67CF, H69Q, A71IV, V77VI, I93L  
75 75_-86 PI, ATV 82   K20R, M36I, N37D, K55KN, R57K, I64V, I85IV  
76 76_-33 PI, RTV, ATV 92   T4S, T12N, I15IV, L19I, R41RK, L63C, V77I  
  76_124 PI, RTV, ATV, DRV 114   T4S, T12NS, I15IV, L19I, R41RK, L63C, V77I  
8_-40 PI, DRV, RTV 111   T12I, R41K, R57K, I62IV, L63P  
9_-71 PI, DRV, RTV 108 V32I, I54L, L76V, I84V, L90M L33F, K43T, G73S, L89V L10I, V11I, I13V, Q18H, E35EK, R41RK, I62IV, L63P, C67F, H69Q, A71V, I72L, V77I, C95V  
  9_350 PI, DRV, RTV, TPV 169 I54V, I84V, L90M L33F, G73T L10I, V11I, I13V, Q18H, E35D, I62V, L63P, C67F, K70E, A71V, I72L, V77I, I93L