Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Kelentse (2020)
Title Differences in human immunodeficiency virus-1C viral load and drug resistance mutation between plasma and cerebrospinal fluid in patients with human immunodeficiency virus-associated cryptococcal meningitis in Botswana.
Citation Medicine (Baltimore)
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 52
NumPts 26
Subtype C

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
1057 1057CSF Unknown Unknown   V35T, E36A, T39E, E53Q, K104R, K122E, I135T, S162A, K173A, Q174K, D177E, T200A, I202V, E204D, Q207A, R211K, V245Q, D250E, A272P, K277R, E291D, V292I, I293V  
  1057PLASMA Unknown Unknown   V35T, E36A, T39E, E53Q, K104R, K122E, I135T, S162A, K173A, Q174K, D177E, T200A, I202V, Q207V, R211K, V245Q, D250E, A272P, K277R, E291D, V292I, I293V  
1121 1121PLASMA Unknown Unknown   K20R, V35K, T39E, S48T, V60I, A98S, K122E, K173A, Q174K, T200A, Q207E, R211K, D218DE, V245Q, D250E F87FS, Q269QL, Y271*CG 
  1121CSF Unknown Unknown   V8I, K20R, V35K, T39E, S48T, V60I, A98S, K122E, K173A, Q174K, T200A, Q207E, R211K  
1134 1134PLASMA Unknown Unknown  K101E I5X, V35T, T39E, S48T, K122E, D123N, E138S, I142V, K173T, Q174R, T200A, E204D, Q207E, R211K, F214L, V245I, E248D, A272P, L283I, E291D, V292I, I293V  
  1134CSF Unknown Unknown  V106M V35T, T39E, S48T, K122E, D123N, E138S, I142V, K173T, Q174R, Q197L, T200A, E204D, Q207E, R211K, F214L, V245I, E248D, A272P, L283I, E291D, V292I, I293V  
1215 1215CSF Unknown Unknown   K20R, V35T, E36A, T39E, K122E, K173T, D177E, T200A, Q207E, V245Q, K249Q, S251V, L260I, A272P, K275R, K277R, T286A, E291D, V292I, I293V, P294T  
  1215PLASMA Unknown Unknown   K20R, V35T, E36A, T39E, K122E, K154R, K173T, D177E, T200A, Q207E, V245Q, K249Q, S251V, L260I, A272P, K275R, K277R, T286A, E291D, V292I, I293V, P294T  
1255 1255CSF Unknown Unknown   V35T, T39AE, S48T, K122KE, D123G, K173A, D177E, I178IM, T200TA, I202IV, Q207KN, R211K, V245Q, K281KR, E291D, V292I, I293V, P294T, E305D  
  1255PLASMA Unknown Unknown   V35T, T39E, S48T, T69S, K122E, I142IV, K173A, Q174QK, D177E, T200A, I202V, Q207KR, R211KQ, V245Q, K281R, E291D, V292I, I293V, P294T  
1259 1259CSF Unknown Unknown   V35T, T39E, K122E, D123S, I142V, K173I, Q174K, I178M, T200A, E203D, Q207N, R211K, V245K, D250E, A272P, Q278N, E291D, V292I, I293V P247E 
  1259PLASMA Unknown Unknown   V35T, T39E, K122E, D123S, I142IV, K173IT, Q174QK, I178IM, T200A, E203D, Q207N, R211K, V245K, D250E, A272P, Q278N, E291D, V292I, I293V P247E 
1310 1310CSF Unknown Unknown  E138A V35T, E36A, T39E, S48T, E53D, K122E, D123S, K173T, D177G, T200E, Q207A, R211K, V245Q, K277R, T286A, E291D, V292I, I293V  
  1310PLASMA Unknown Unknown  E138A K20KE, V35T, E36A, T39E, S48T, E53D, K122E, D123S, K173T, D177G, T200E, Q207A, R211K, V245Q, K277R, T286A, E291D, V292I, I293V  
1326 1326PLASMA Unknown Unknown   V35T, E36A, T39E, S48T, K122E, D123N, K173A, P176PS, D177E, I178L, Q197K, T200A, I202V, Q207N, R211K, V245Q, E248T, A272P, K275Q, K277KR, Q278N, K281R, E291D, V292I, I293V  
  1326CSF Unknown Unknown   V35T, E36A, T39E, S48T, K122E, D123N, K173A, D177E, I178L, Q197K, T200A, I202V, Q207N, R211K, V245Q, E248T, K275Q, K277R, Q278N I47IV, Q269Q_Y, I270L, Y271S 
1352 1352PLASMA Unknown Unknown   K20R, V35KR, E36A, T39E, K43KR, S48T, V60I, K122E, D123N, S162C, K173A, D177E, T200A, E203D, Q207N, R211K, V245Q, E248D, D250E T128TP 
  1352CSF Unknown Unknown   K20R, V35K, E36A, T39E, K43KR, S48T, V60I, K122E, D123S, S162C, K173A, D177E, T200A, E203D, Q207N, R211K, V245Q, E248D, D250E, A272P, K277R, T286A, E291D, V292I, I293V  
1362 1362CSF Unknown Unknown   V35T, E36A, T39E, S48T, K122E, S162A, K173T, Q174H, D177E, T200A, Q207E, R211K, V245K, D250E, A272P, T286A, E291D, V292I, I293V  
  1362PLASMA Unknown Unknown   V35T, E36A, T39E, S48T, K122E, I159IV, S162A, K173T, Q174QH, D177DE, T200A, Q207E, R211K, V245K, D250E, A272P, T286A, E291D, V292I, I293V  
1374 1374PLASMA Unknown Unknown   V35T, E36A, T39E, G45E, S48T, K122E, K173A, D177E, T200A, Q207E, V245Q, A272P, K275Q, Q278N, T286A, E291D, V292I, I293V  
  1374CSF Unknown Unknown   V35T, E36EA, T39E, S48T, K122E, K173A, D177E, T200A, Q207E, R211RK, V245Q, A272P, K275Q, Q278N, T286A, E291D, V292I, I293V  
1383 1383PLASMA Unknown Unknown  E138A V35T, T39E, S48T, K122E, D123S, T139A, K173E, D177G, T200A, I202V, Q207D, R211K, V245Q, E248T, A272P, E291D, V292I, I293V  
  1383CSF Unknown Unknown  E138A V35T, T39E, S48T, T69TA, K122E, D123S, T139A, K173E, D177G, T200A, I202V, Q207D, R211K, V245Q, E248T, A272P, E291D, V292I, I293V  
1452 1452CSF Unknown Unknown   K20R, V35T, T39E, S48T, V60I, K104R, K122E, K173S, Q174K, D177E, I178V, G196E, T200A, I202V, Q207E, R211K, F214L, V245Q, D250E, A272P, K281R, E291D, V292I, I293V  
  1452PLASMA Unknown Unknown   K20R, V35T, T39E, S48T, V60I, K122E, K173NS, Q174K, D177E, I178LM, G196E, T200A, I202V, Q207E, R211K, F214L, V245Q, D250E, A272P, K281R, E291D, V292I, I293V  
1500 1500PLASMA Unknown Unknown   E28K, K32E, V35T, E36A, T39E, K103R, K122E, S162C, K173T, Q174K, T200A, Q207E, R211K, L228H, P243T, V245E, D250E, A272P, K277R, T286A, E291D  
  1500CSF Unknown Unknown   E28K, K32E, V35T, E36A, T39E, K103R, K122E, S162C, K173T, Q174K, I178L, T200A, Q207E, R211K, P243T, V245E, D250E, A272P, T286A, E291D I270LV 
1528 1528CSF Unknown Unknown M184MI  V35K, T39E, S48T, K102Q, K122E, D123S, S162C, T200A, Q207E, R211K, V245Q, K277R, E291D, V292I, I293V  
  1528PLASMA Unknown Unknown M184MI  V35K, T39E, S48T, K102Q, K122E, D123S, S162C, T200A, Q207E, R211K, V245Q, K277R, E291D, V292I, I293V  
1724 1724CSF Unknown Unknown   V35T, T39A, E40D, S48T, K102Q, V118I, K122E, I135T, K173A, Q174K, D177Q, I195L, G196M, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P, K277R, L279M, E291D, I293V  
  1724PLASMA Unknown Unknown   V35T, T39A, E40D, S48T, V60VI, K104KR, V118I, K122E, I135T, K173A, Q174KR, D177Q, I195IL, G196MT, T200A, Q207E, R211K, F214L, V245Q, D250E, A272P  
1730 1730PLASMA Unknown Unknown   V8I, K20KR, V21VI, K32N, V35K, E36A, T39E, S48T, V60I, W88C, K122E, S162C, K173A, Q174K, I178L, T200E, E204D, Q207A, R211K, V245Q, D250E, A272P, K275R  
  1730CSF Unknown Unknown   V8I, K20R, V21I, K32N, V35K, E36A, T39E, S48T, V60I, K122E, S162C, K173A, Q174K, T200A, E204D, Q207A, R211K, V245Q, D250E, A272P, K275R  
1736 1736PLASMA Unknown Unknown D67N, K70G, M184V, K219E K101E, K103N, E138A, G190A V35T, E36A, T39E, S68N, S105T, K122E, D123S, I135L, R172K, K173T, D177G, T200A, I202V, Q207K, R211A, V245Q  
  1736CSF Unknown Unknown D67N, K70G, M184V, K219E K101E, K103N, E138A, G190A V35T, E36A, T39E, S68N, S105T, K122E, D123S, I135L, R172K, K173T, D177G, T200A, I202V, Q207K, R211A, V245Q, A272P, K275R, V276I, Q278H, K281R, L283I, T286A, E291D, V292I, I293V  
1748 1748CSF Unknown Unknown   E6EK, V35T, E36A, T39E, S48T, K122E, D123G, I142V, Q145H, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, Q278H, K281R, T286A, E291D, V292I, I293V, P294Q, L301LF  
  1748PLASMA Unknown Unknown   E6K, V35T, E36A, T39E, S48T, K122E, D123G, I142V, Q145H, K173A, D177E, T200A, Q207E, R211K, V245Q, A272P, Q278H, K281R, T286A, E291D, V292I, I293V, P294Q  
1862 1862CSF Unknown Unknown   V35T, E36A, T39E, K122E, D123S, K173A, Q174K, D177E, I178L, T200A, Q207N, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, E297A  
  1862PLASMA Unknown Unknown   K20R, V35T, E36A, T39E, K122E, D123S, K173A, Q174K, D177E, I178L, T200A, R211K, V245Q, A272P, T286A, E291D, V292I, E297A  
1876 1876PLASMA Unknown Unknown   T27S, V35T, T39E, S48T, K66KR, K122E, S162C, K173A, Q174K, D177E, G196D, T200A, Q207E, R211RK, V245T, D250E, A272P, E291D, V292I, I293V, E298X  
  1876CSF Unknown Unknown   V35T, T39E, S48T, K122E, S162C, K173A, Q174K, D177E, G196D, T200A, Q207E, V245T, D250E  
1884 1884CSF Unknown Unknown  E138A K20R, V35T, E36A, T39E, E40D, K122E, D123S, T139A, K173A, T200E, E204K, Q207E, F214L, A272P, T286A, A288T, E291D, V292I, I293V  
  1884PLASMA Unknown Unknown  E138A K20R, V35T, E36A, T39D, W88S, K122E, D123S, T139A, K173A, I178M, S191SF, I195L, T200E, E204K, Q207E, R211K, F214L L260L* 
1895 1895PLASMA Unknown Unknown   V35T, E36A, T39E, S48T, K122E, D123E, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V  
  1895CSF Unknown Unknown   V35T, E36A, T39E, S48T, K122E, D123E, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, K277R, T286A, E291D, V292I, I293V  
1925 1925CSF Unknown Unknown   P4S, V35T, E36A, T39E, S48T, V90I, K122E, D123S, A158S, S162C, K173T, D177E, T200A, R211G, V245Q, A272P, K277R, E291D, V292I, I293V  
  1925PLASMA Unknown Unknown   P4S, V35T, E36A, T39E, S48T, V90I, K122E, D123GS, S162Y, K173AT, D177E, T200A, R211RG, V245Q, A272P, K277R, E291D, V292I, I293V  
1930 1930PLASMA Unknown Unknown   K20R, V35T, E36A, T39E, K122E, D123N, S162N, K173A, Q174K, D177E, I178M, T200A, Q207K, R211V, V245Q, D250E, A272P, K277T, L283I, E291D, V292I, I293V  
  1930CSF Unknown Unknown D67G  K20R, V35T, E36A, T39E, K66E, T69S, K104X, K122E, D123N, S162N, K173A, Q174K, D177E, I178M, T200A, Q207K, R211V, V245Q, D250E, A272P, K277T, L283I, E291D, V292I, I293V  
1972 1972CSF Unknown Unknown   P4PS, V35T, E36EA, T39E, S48T, G93GR, K104R, K122E, D123NS, K173A, D177E, T200A, E204D, Q207E, R211K, F214L, V245Q, T286A, E291D, V292VI, I293V  
  1972PLASMA Unknown Unknown   V35T, E36EA, T39E, S48T, K104R, K122E, D123S, K173A, D177E, I178IV, T200A, Q207E, R211K, F214L, V245Q, T286A, E291D, I293V  

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