Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Mikasi (2020)
Title HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon.
Citation AIDS Res Hum Retroviruses
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 41
NumPts 41
Subtype CRF02_AG, A, F, G, C, CRF11_cpx, CRF45_cpx, A + G, CRF09_cpx

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
Ad15 Ad15 None    L74I, L101I, T112V, T124A, T125A, G134D, I135V, K136T, V201I, T206S, Y227F, L234I, N254K, R269K, M275V, D278N, S283G  
Ad32 Ad32 None    K14R, V31I, Q95H, E96D, L101I, G106A, T112V, T124A, T125A, G134N, I135V, K136T, D167E, V201I, T206S, L234I, R269K, S283G  
Ad52 Ad52 None    E11D, K14R, A21T, A23V, V31I, D41N, M50I, I72V, E96D, L101I, T112V, T124A, T125A, G134D, K136N, D167E, V201I, T218I, S230G, L234I, S283G, D288N  
Ad69 Ad69 None    K14R, V31I, L74I, Y99F, L101I, T112I, T124Q, T125A, G134N, K136T, G163N, K173R, V201I, T206S, K219N, L234I, S255K, D256E, S283G A76T 
Ad9 Ad9 None    E11D, V31I, I73IV, L74I, A91T, L101I, T112V, T124A, T125A, G134N, I135V, K136T, F181L, V201I, T206S, L234I, R269K, S283G  
Adult23IN Adult23IN None   A128T K14R, R20K, S39C, M50V, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V165I, V201I, T206S, L234I  
Adult44 Adult44 None    E11D, K14R, A21T, A23V, V31I, D41N, M50I, I72V, E96D, L101I, T112V, T124A, T125A, G134D, K136N, D167E, V201I, S230G, L234I, S283G, D288N  
Baby110IN Baby110IN None    S17N, V31I, M50I, I72V, L74I, L101I, T112V, T124A, G134N, K136T, K173R, V201I, T206S, D207E, L234I, R269K, S283G, R284G, D288N  
Baby13IN Baby13IN None    E11D, S17C, V31I, M50I, I60M, I72V, K111R, T112V, S119P, T122I, T124A, T125A, G134N, K136Q, V201I, T206S, L234I, M275V, S283G, D286N  
Baby14IN Baby14IN None    D25E, V31I, L101I, T112V, S119P, T124TA, T125A, K136Q, V201I, D207N, K211T, Q216R, T218I, K219Q, L234I, N254K, S255G, R269K, D278A, S283G T115TI 
Baby16IN Baby16IN None    K14R, V31I, L101I, T112I, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234I, R269K, S283G  
Baby177IN Baby177IN None    S17N, L101I, T124N, T125V, K136Q, G163T, V201I, I220L, Y227F, L234I, S255N, D256E, S283G  
Baby17IN Baby17IN None    E11D, V31I, I72V, L101I, T112V, T124A, T125A, G134D, I135V, K136T, F181L, V201I, T206S, L234I, A265V, R269K, S283G, D288N  
Baby20IN Baby20IN None    E11D, K14R, V31I, M50I, V88I, L101I, T112I, T124A, T125A, G134D, I135V, K136Q, T206S, I208L, T218K, L234I, V260I, D286A  
Baby21IN Baby21IN None    K14R, L74I, A91E, L101I, T112V, S119R, T124A, T125A, G134N, I135V, K136T, F181L, V201I, T206S, L234I, I251L, A265V, S283G  
Baby220IN Baby220IN None    E11D, K14R, V31I, M50I, V88I, L101I, T112I, T124A, T125A, G134D, I135V, K136Q, T206S, I208L, T218K, L234I, V260I S283R 
Baby24IN Baby24IN None    E11D, K14R, A21T, A23V, V31I, M50I, I72V, E96D, L101I, T112V, T124A, T125A, G134S, K136Q, V201I, L234V, V260I, S283G  
Baby25IN Baby25IN None    S17N, V31I, M50I, I84M, L101I, K111R, T112I, T124A, T125A, K136Q, V201I, K211R, T218I, S230N, L234I, A265V, R269K, S283G  
Baby28IN Baby28IN None    K14R, M50I, L101I, K111R, T112V, T124A, T125A, K136T, D167E, V201I, T206S, L234I, D256E, R269K, D278G, S283G  
Baby29IN Baby29IN None    K14R, V31I, L63LI, L74I, E96D, L101I, T112I, T124A, T125A, G134N, I135V, K136T, V201I, T206S, D232E, L234I, R269K  
Baby2IN Baby2IN None    K14R, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, S255N, D256E, I268L, S283G  
Baby30IN Baby30IN None    E11D, A21T, A23V, V31I, D41N, M50I, I72V, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, Q216H, L234I, S283G, D288N  
Baby31IN Baby31IN None    K14R, R20K, D25E, V31I, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, V281M, S283G  
Baby32IN Baby32IN None    K14R, A23V, V31I, D41N, I72V, I84V, L101I, T112V, T124A, T125A, G134D, I135V, K136Q, D167E, V201I, L234I, S283G  
Baby33IN Baby33IN None   E157Q K14R, V31I, I72V, L101I, T112I, T124G, T125A, I135V, K136T, K160Q, V165I, V201I, T206S, L234I, R269K, S283G  
Baby35IN Baby35IN None    K14R, A23V, V31I, D41N, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, T206S, L234I, S283G, D288N  
Baby39IN Baby39IN None    K14R, A23V, V31I, D41N, I72V, L101I, T112V, T124A, T125A, G134D, I135V, K136Q, D167E, V201I, L234I, S283G  
Baby3IN Baby3IN None    K14R, V31I, L45T, L74M, L101I, T112V, T124A, T125A, G134N, I135V, K136T, D167E, V201I, T206S, K211R, R224W, L234I, R269K, D270H  
Baby44IN Baby44IN None  P145PS  K14R, V31I, S57G, I60V, E69EK, G70GE, I72IV, Q95P, L101I, G106A, K111Q, T112V, S119G, T124A, T125A, G134N, I135V, K136T, Q137H, D167E, V201I, T206S, L234I, R269K, V281M, S283G, D288N G149GR 
Baby47IN Baby47IN None    K14R, S24N, V31I, I72V, L74I, L101I, T124A, T125A, G134N, I135V, K136T, G163E, V201I, T206S, L234I, A265V, D286N  
Baby57IN Baby57IN None    K14R, A21T, V31I, D41N, M50I, I72V, L101I, T112V, I113V, T124A, T125A, G134D, K136Q, D167E, K173R, V201I, T206S, D207E, T218L, K219N, N222K, L234I, S255D, S283G, R284G, D286E, D288N Q62H 
Baby5IN Baby5IN None    K14R, V31I, L101I, T112I, T124A, T125A, G134D, I135V, K136T, V201I, T206S, L234I, R269K, S283G  
Baby8IN Baby8IN None    K14R, N27H, P30S, V31I, M50T, I72V, L101I, K111Q, T112V, T124A, T125A, G134N, I135V, K136T, G163A, K188R, V201I, T206S, K211R, L234I, N254K, S255G, A265V, M275V  
Baby9IN Baby9IN None    K7R, V31I, M50T, I84M, L101I, T112I, T124A, T125V, K136Q, G163E, V201I, T218S, L234I, D256E, S283G  
CM11 CM11 None    K14R, S39C, L101I, T112V, T124A, T125A, G134N, I135V, K136T, S195T, V201I, Q216H, Q221S, L234I, N254K I191IS 
CM31 CM31 None    K14R, S24N, V31I, L101I, T112V, T124N, T125A, G134N, I135V, K136T, F139FL, A169AG, K173R, I182V, Y194YC, V201I, T206S, L234I, S255N, D256E R269RW 
CM47 CM47 None    K14R, V31I, S39C, I84IM, L101I, T112V, T124A, T125A, A133AT, G134N, I135V, K136T, Y143X, G163A, F181FL, T206S, T218TS, L234I L102LF, N117NK, T122TP, C130C*, V201IM 
CM52 CM52 None   T97TA S24SN, M50MI, A91AE, L101I, S119X, T125A, I135V, K136Q, Q137H, G163S, V201I, L234I, I268IL  
CM54 CM54 None    K14R, R20K, S24N, V31I, I72V, I84M, E96D, L101I, T112V, T124A, T125A, G134D, I135V, V176VL, Y194YC, V201I, T206S, I208IL, S230G, L234I, I268IL, V281VG N184NI, R262RG 
CM66 CM66 None    K14R, R20K, L63I, L74I, E96D, L101I, T112V, T124A, T125A, G134N, I135V, K136T, V201I, T206S, L234I, R269K  
CM74 CM74 None    E10G, E11D, K14R, V31I, I72V, L74I, E96D, L101I, T112V, T124A, T125A, G134D, K136Q, D167E, V201I, L234I