Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Onoriode Digban (2019)
Title Analyses of HIV-1 integrase gene sequences among treatment-naive patients in the Eastern Cape, South Africa.
Citation J Med Virol
SelectedGene IN
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 48
NumPts 48
Subtype C

 

Clinical IN Isolates


SubjectIsolateINIsWksINIMajorINIMinorCommonUnusual
IN1 None    V31I, M50T, I72V, T112V, T124A, K136Q, V201I, N222K, L234I, D278A, S283G T218Y 
103 IN103 None    S17N, D25E, L45V, M50I, L101I, G106A, T112V, T124A, T125A, K136Q, G163E, V201I, L234I, D270E, D278A, S283G  
IN2 None    D25E, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, A265V, V281M, S283G  
30 IN30 None    S17N, V31I, I72V, I84M, A98G, L101I, T112V, T124A, T125A, G197R, V201I, K215N, L234I, D270E, S283G A38P, K173T 
32 IN32 None    E11D, S24N, D25E, S39C, F100Y, L101I, T112V, T125A, K136Q, V201I, K211R, K215N, T218I, L234I, N254K, M275V, D278A, S283G, R284G  
44 IN44 None    D3E, K14R, D25E, V31I, L45Q, I72V, A91S, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, K215N, L234I, D278A, S283G  
50 IN50 None    D25E, V31I, I72V, I84M, F100Y, L101I, T112V, T125A, K136Q, K160R, I182V, V201I, K215N, T218I, L234I, R269K, D278A, S283G  
61 IN61 None    K14R, D25E, V31I, S39N, M50I, F100Y, L101I, T112V, S119P, T124N, T125A, K136Q, V201I, T206S, T218I, L234I, V260I, R269K, D278A, S283G  
65 IN65 None    D25E, L68S, K71H, I72V, F100Y, L101I, T112V, S119T, T124A, T125A, K136Q, K188R, Y194C, V201I, T206S, K211N, T218I, D229G, L234I, A265V, R269K, D278A, S283G V75G, E152R, N184H, F185S, K186Q, R187F, G237S 
66 IN66 None    S17N, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283G A38P, R224P, G247W, R269H 
70 IN70 None    S17N, S24A, V31I, I72V, F100Y, L101I, T112V, T124A, T125A, K136H, K188R, V201I, T206S, T218I, L234I, A265V, D278A, S283G  
75 IN75 None    D3E, K14R, S17N, R20K, D25E, F100Y, L101I, T112V, T124A, T125A, K136Q, K173R, V201I, T218I, Q221H, L234I, S255G, S283G D202Y, W235C 
78 78 None    D25E, V31I, L45I, M50I, I72V, F100Y, L101I, T112V, T124A, T125A, K136Q, D167E, V201I, T218M, L234I, R269K, D278A, S283G  
80 IN80 None    D25E, V31I, K34R, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, D278A, S283G  
81 IN81 None    D25E, V31I, M50T, F100Y, L101I, T112V, S119T, T125A, K136Q, V201I, T206S, T218I, K219Q, L234I, A265V, D278A, S283G  
IN9 None    D25E, V31I, L68V, I84M, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A  
D10 D10IN None    D25E, K42Q, M50I, L101I, T112V, T124A, T125A, K136Q, V201I, I220V, L234I, R269K, D278A, S283G  
D11 D11IN None    D6E, D25E, V31I, K34R, M50I, L101I, T112V, T124A, K136Q, V201I, T218I, L234I, A265V, D278A, S283G  
D12 D12IN None    D6E, D25E, L28I, S39C, M50I, I84M, K111R, T112V, T124N, T125A, K136Q, D167E, K188R, G193E, V201I, T206S, K215N, T218L, L234I, D278A, S283G  
D13 D13IN None    D6E, D25E, V31I, M50I, T112V, T124N, T125A, K136Q, V201I, T218I, L234I, I251L, A265V, R269K, D278A, D286N  
D14 D14IN None    D25E, V31I, M50T, E96D, L101I, T112V, T124N, K136Q, G193E, V201I, T218I, L234I, I251L, A265V, R269K, D278A, V281M, S283G, D286N  
D15 D15IN None    E11D, D25E, V31I, M50T, L101I, T112V, S119P, T122I, T124N, K136Q, K173R, V201I, T218I, L234I, I251L, A265V, R269K, D278A, V281M  
D16 D16IN None    D6E, E11D, D25E, V31I, M50T, L101I, T112V, T124N, K136Q, K188R, V201I, T218I, L234I, I251L, A265V, R269K, D278A, V281L  
D17 D17IN None    D25E, V31I, M50T, L101I, T112V, T124N, T125A, K136Q, V201I, T218I, L234I, I251L, A265V, R269K, D278A, V281M  
D2 D2IN None    D6E, D25E, M50I, L101I, T112V, T125A, K136Q, H171Q, V201I, T218I, L234I, R269K, D278A, S283G  
D3 D3IN None    E11D, D25E, V31I, M50I, I72V, L101I, K111R, T112I, T124A, T125A, K136Q, D167E, V201I, K211R, T218I, L234I, V260I, R269K, D278A, S283G  
D4 D4IN None    V31I, M50I, I72V, I84M, L101I, T112I, T124N, T125A, K136Q, D167E, V201I, Y227F, L234I, R269K, D278A  
D5 D5IN None    D25E, V31I, M50I, L101I, T112V, T124N, T125A, K136Q, G163Q, D167E, V201I, L234I, R269K, D278A, S283D  
D6 D6IN None    D6E, D25E, V31I, M50T, I72V, I84M, A91G, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, K219Q, L234I, R269K, D278A, S283G, D286N  
D7 D7IN None    E11D, D25E, V31I, M50I, I72V, I84M, T112V, T124A, K136Q, V201I, T206S, T218I, L234I, A265V, D278N, S283G, D286N  
D8 D8IN None    D6E, D25E, V31I, M50I, V54I, I72V, I84M, E96D, F100Y, L101I, T112V, S119P, T124A, T125A, K127R, K136Q, V201I, T206S, T218I, L234I, R269K, D278A, S283G  
D9 D9IN None    D25E, V31I, K42Q, M50I, I72V, L74M, L101I, T112V, T124A, T125A, K136Q, K188R, V201I, K211N, L234I, D278A, C280S, S283G  
V1 V1 None    K14R, D25E, V31I, M50I, I60V, L63I, F100Y, L101I, T112V, T124N, T125A, K136Q, D167E, S195C, V201I, L234I, R269K, D278A, S283G  
V10 V10IN None    S17N, D25E, V31I, M50I, I60V, I72V, I84L, F100Y, L101I, T112V, I113L, T125A, K136Q, K173R, V201I, K219N, L234I, D278A, S283G  
V100 V100IN None    S24N, D25E, K34R, M50I, K71R, I72V, F100Y, L101I, T112V, T125A, K136Q, V201I, T206S, I220V, L234I, D278A, S283G K14T 
V2 V2 None    S17N, D25E, V31I, M50I, I60V, I72V, I84L, F100Y, L101I, T112V, I113L, T125A, K136Q, K160R, K173R, V201I, K219N, L234I, D278A, S283G W131G 
V25 V25IN None    K14R, D25E, L101I, T112V, T124A, K136Q, V201I, K211R, T218I, Q221H, A265V, D278A, S283G H12Q, E13Y, N18I, L234P, Q285G 
V65 V65IN None    D25E, I72V, Y99F, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, D278A, S283G  
V69 V69IN None    K14R, S24N, D25E, V31I, S39N, I60V, I72V, I84M, P90S, F100Y, L101I, K111T, T112V, T124S, T125A, K136Q, V165I, V201I, L234I, M275V, D278A, S283G, D286N  
V70 V70IN None    K14R, S24N, D25E, V31I, S39N, I60V, I72V, I84M, P90S, F100Y, L101I, K111T, T112V, T124S, T125A, K136Q, V165I, V201I, L234I, L241I, M275V, D278A, S283G  
V74 V74IN None    D25E, V31I, L74I, I84M, T112V, T124A, T125A, D167E, F181L, K188R, S195T, V201I, K211T, L234I, A265V, R269K, D278A, S283G  
V82 V82IN None    E11D, K14R, D25E, L28I, V31I, V32I, M50I, V54L, C56Y, L101I, T112V, T124A, T125V, K136Q, K188R, G193E, V201I, K211T, T218L, L234I, R269K, D278A, S283G I217N 
V83 INV83 None   P142T S17N, S24T, D25E, V31I, Q53H, L68I, I72V, I84M, Y99F, L101I, I113V, T124A, T125A, K136Q, K160R, V201I, L234I, A265V, R269K, D270E, D278A, S283G P58A, W61L, A196S, K258Q, C280A 
V84 V84IN None    K14R, D25E, P30A, I72V, T112V, T124S, T125A, K136Q, V201I, T218I, L234I, S255G, S283G  
V87 V87IN None    K14R, V31I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, L234I, D279A, S283G  
V97 V97IN None    K14R, S17R, S24N, D25E, V31I, M50L, F100Y, L101I, T124A, T125A, K136Q, G163E, V201I, K211T, T218I, L234I, E246D, I268V, Q274R, D278A, S283G  
W3 W3IN None   E157Q V31I, I72V, P90T, L101I, T112V, T125A, K136Q, K160Q, E170A, L172P, V201I, K215N, T218I, L234I, R269K, D278A, S283G M154P 
W5 W5IN None    D41N, M50I, I72V, F100Y, L101I, T112V, T124S, T125A, K136Q, D167E, I200M, V201I, L234I, A265V, R269K, D278A, S283G