Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Salvana (2020)
Title High rates of tenofovir failure in a CRF01_AE-predominant HIV epidemic in the Philippines.
Citation Int J Infect Dis
SelectedGene RT
SelectedSpecies HIV1
SelectedGroup M
SelectedType Clinical
NumIsolates 53
NumPts 53
Subtype CRF01_AE, B, A, C, G + CRF02_AG

 

Clinical RT Isolates


SubjectIsolateNRTIsNNRTIsNRTI MutNNRTI MutCommonUnusual
A-2015-02-007 A-2015-02-007 AZT, 3TC EFV   E6D, K11T, V35T, T39K, K43E, V60I, S68G, S117X, V118I, D123X, F124L, I135X, N136X, N137H, I142V, T165I, K173I, Q174K, D177E, T200A, I202V, Q207D, R211S, K238R, V245E, T286A, I293V, K311R, E312T, I326V, I329V, G335D D121M 
A-2015-02-025 A-2015-02-025 TDF, 3TC EFV D67N, K70E, M184I A98G, K101E, Y181C, G190A, K238T E6D, K11T, V21I, E28A, V35T, T39K, E40K, K43E, V60I, V90I, D121H, K122E, I135T, I142V, R172K, K173I, Q174K, D177E, I178M, V189I, T200A, I202V, Q207A, R211S, V245E, T286A, E291D, I293V, E312T, I326V, I329X, G335D  
A-2015-02-026 A-2015-02-026 TDF, 3TC EFV D67G, K70E, M184V V179D, Y181C E6D, V35T, T39K, E40K, K43E, K103R, V106L, K122E, D123S, I142T, T165K, K173I, Q174K, D177E, I178M, I195T, T200A, Q207D, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D  
A-2015-02-036 A-2015-02-036 TDF, 3TC EFV K65R, L74V  E6D, V35T, T39K, K43E, W88C, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, T200I, Q207A, R211S, K238R, V245E, K249R, T286A, E291D, I293V, E312T, I326V, I329V, G335D  
A-2015-02-037 A-2015-02-037 TDF, 3TC EFV M184I G190E K102R, K122E, D123S, P157A, K173I, Q174K, D177E, V189I, I195L, T200A, E203D, Q207A, R211S, K238R, V245E, A272P, K275R, T286A, E291D, V292I, I293V, E312T, I326V, I329V P247R, Q269E 
A-2015-02-065 A-2015-02-065 TDF, 3TC EFV D67N, K70E, M184V K103N, G190A E6D, K11T, K20R, V35T, T39K, V60I, K64R, K101Q, K102M, K122E, D123N, I142V, K173I, Q174K, D177E, I178M, V179I, T200A, Q207A, L210S, R211S, V245E, K275Q, E291D, V292I, I293V, E297K, K311R, E312T, I326V, I329V, G335D  
A-2015-02-079 A-2015-02-079 TDF, 3TC EFV K65R, V75M, M184V L100I, K103N, H221Y E6D, V35T, T39K, K43E, D86E, K122E, D123S, S162C, K173I, Q174K, D177E, V179I, G196K, T200A, I202V, Q207A, L210M, R211S, K238R, V245E, S251H, A272P, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D  
A-2015-02-084 A-2015-02-084 TDF, 3TC EFV K65R, L74V, Y115F E138G, G190E, H221Y E6D, K11T, T27S, V35T, T39K, K43E, V60I, S68G, K102N, I135V, K173I, Q174K, D177E, T200V, Q207A, R211S, V245E, T286A, A288S, I293V, E312T, I329V, G335D  
A-2015-02-088 A-2015-02-088 TDF, 3TC EFV D67G, K70Q, Y115F, K219Q G190E, H221Y E6D, K11S, V35T, T39K, K43E, V60I, V75L, V90I, K122E, D123S, V148G, K173I, Q174K, D177E, T200A, E203K, Q207A, R211S, K238R, V245E, T286A K281E 
A-2015-02-144 A-2015-02-144 AZT, 3TC EFV M184V K101E, V106I, Y188L E6D, V35T, T39K, K43E, T69A, L109I, K122E, D123S, S162C, K173M, Q174K, D177E, I195L, T200A, Q207A, R211S, K238R, V245E, K275R, V276I, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D  
A-2015-02-149 A-2015-02-149 TDF, 3TC EFV L74I, M184I E138A, G190E E6D, K11T, V21I, V35T, T39K, V60I, S68G, K70X, V90I, K101R, K102N, S105T, K122E, D123S, I135V, K173I, Q174K, D177E, I178M, T200I, Q207A, R211S, K238R, V245E, E291D, V292I, I293V, E312T, Y319N, I326V, I329V, G335D  
A-2015-02-155 A-2015-02-155 AZT, 3TC EFV M184V K103N V21I, V35T, T39K, K43E, V60I, I135V, S162Y, K173L, Q174K, D177E, V179I, T200V, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E298D, E312T, I326V, I329V, G335D  
A-2015-02-165 A-2015-02-165 AZT, 3TC EFV M41L, K65R, L74V, V75I, Y115F, M184V G190Q E6D, V35T, T39K, K43E, S68G, K122E, D123S, K173I, Q174K, D177E, I195L, T200E, E203K, Q207D, R211S, K238R, V245E, A272P, T286A, I293V, E312T, I329V, G335D  
A-2015-02-168 A-2015-02-168 AZT, 3TC EFV K65R, D67N, M184I, K219E G190Q V35T, T39K, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D G262V 
A-2015-02-182 A-2015-02-182 TDF, 3TC EFV A62V, K65N, K219R G190E E6D, V35T, T39K, K43E, S68G, K122E, D123S, I135T, S162Y, K173M, Q174K, D177E, E194D, I195L, T200A, Q207A, R211S, K238R, V245E, K281R, T286A, E291D, V292I, I293V, E297K, E312T, I326V, I329V, G335D  
A-2015-02-219 A-2015-02-219 TDF, 3TC NVP M184I K101E, Y181C, G190A K11T, V21I, V35T, T39K, K43E, K49R, V60I, W88S, K122P, D123N, K173I, Q174K, D177E, I178M, V179I, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, K311N, E312T, I326V, I329V, G335D  
A-2015-02-228 A-2015-02-228 TDF, 3TC EFV M184I K101P, V179L, Y181C, H221Y I195L, Q197K, R211K, S251N, A272S, V276I, V292I, I293V, E312K, I329V  
A-2015-02-229 A-2015-02-229 TDF, 3TC EFV K65R, D67G, Y115F, T215I, K219E G190E S68G, W88C, P97X, K102R, R211S, A272S, A288S, I329V, Q336L  
A-2015-02-271 A-2015-02-271 TDF, 3TC EFV K65R, D67N, V75I G190Q E6D, V35T, T39K, K43E, V60I, K122E, D123S, T139A, K173I, Q174K, D177E, T200V, Q207A, R211S, K238R, V245E, E291D, V292I, I293V, E312T, I326V, I329V, G335D  
A-2015-02-278 A-2015-02-278 TDF, 3TC EFV   E6D, V8I, K11T, V21I, V35T, T39K, K43E, V60I, K122E, D123S, I135T, S162C, K173I, Q174K, D177E, V179I, T200A, E204Q, Q207A, R211S, K238R, V245E, A272S, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D  
A-2015-02-320 A-2015-02-320 TDF, 3TC EFV   E6D, V35T, T39K, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I195IL, T200A, E203D, Q207A, R211S, K238R, V245E, E248D, E291D, V292I, I293V, L310I, E312T, I326V, I329V, G335D  
A-2015-04-002 A-2015-04-002 AZT, 3TC NVP M184V, T215F K101E, G190A E28K, K102R, K122E, D123S, S162C, K173M, Q174K, D177E, T200A, E203D, Q207A, R211S, K238R, V245E, T286A, V292I, I293V, E312T, V314A, I326V, I329V, G335D G262V 
A-2015-04-015 A-2015-04-015 AZT, 3TC NVP K65R, L74V, M184V Y188L E6D, V35T, T39K, K43E, W88C, K122E, D123S, Q174T, D177E, I195L, T200A, I202V, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D L100W, K103V, K275M, G333W 
A-2015-04-031 A-2015-04-031 TDF, 3TC EFV K65R, M184I L100I, V108I, H221Y, M230L E6D, K20R, V35T, T39K, K43E, V60I, K101R, K122E, D123N, S162C, K173I, Q174K, D177E, V179I, V189I, T200A, Q207A, R211S, K238R, V245E, A272G, E291D, V292I, I293V, E312N, I326V, I329V, G335D  
A-2015-04-054 A-2015-04-054 TDF, 3TC NVP K65R K101E, G190S I5L, E6D, V35T, T39K, K43E, N57D, K122E, D123S, S162C, K173I, Q174K, D177E, T200A, Q207A, L210S, R211S, W229S, K238R, V245E G18C, K22T 
A-2015-04-129 A-2015-04-129 TDF, 3TC NVP K65N, V75I, Y115F Y181C E6D, E28A, V35T, T39K, K43E, V60I, K64R, S68N, K122E, D123S, I132L, I142T, S162C, K173I, Q174K, D177E, I178L, T200V, Q207A, R211S, L228R, K238R, V245E, T286A, E291D, I293V, E312T, I326V, I329V, G335D  
A-2015-04-196 A-2015-04-196 TDF, 3TC NVP K65R, M184V, K219E K103N, E138A, Y181C E6D, K20R, V35T, T39K, K49R, V60I, K64R, S68G, W88C, K122E, D123S, S134C, S162C, T165I, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, K238R, V245E, W252R, T286A, I293V, E312T, I326V, I329V, G335D  
A-2015-04-198 A-2015-04-198 TDF, 3TC NVP  K103N E6D, K11S, V21I, V35T, T39K, K43E, V60I, K122E, D123S, I135T, R172K, K173I, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, I293V, E312T, I326V, I329V, G335D  
A-2015-04-208 A-2015-04-208 TDF, 3TC EFV M184V K101E, V106M, G190A V35T, T39K, K43E, L109I, K122E, D123S, S162C, K173I, Q174K, D177E, G196K, T200A, Q207A, L210M, R211S, K238R, V245E, A288S, V292I, I293V, E312T, I326V, I329V, G335N  
A-2015-04-223 A-2015-04-223 TDF, 3TC EFV  V106I E6D, V35T, T39K, K43E, K122E, D123E, T139A, S162C, Q174A, D177E, V189A, I195L, T200A, Q207A, L210M, R211K, K238R, V245E, I293V, E312T, I326V, I329V, G335D, I341F V60D, A114P 
A-2015-04-277 A-2015-04-277 TDF, 3TC EFV K65R, K70T, M184V Y188L E6D, V8I, K11T, V35T, T39Q, S68G, V106L, K122E, D123S, K173I, Q174K, N175Y, D177E, V179I, T200I, K201I, Q207A, R211S, V245E, T286A, A288G, E291D, V292I, I293V, E312T, I329V, G335D I50K 
A-2015-04-291 A-2015-04-291 AZT, 3TC EFV M184V K103N, M230L E6D, V8I, K11T, V35T, T39K, K43E, K49R, V60I, S68N, R72K, K122E, D123N, I135T, K173I, Q174K, D177E, V179I, T200A, E204Q, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E302K, E312T, D320E, I326V, I329V, G335D C38Y, L210A 
A-2015-04-297 A-2015-04-297 AZT, 3TC NVP K65R, Y115F K101E, Y181C, G190A E6D, V21I, V35T, T39N, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, T200A, Q207N, R211S, K238R, V245E, K275Q, E291D, V292I, I293V, E312T, I326V, I329V, G335D L74F 
A-2015-04-302 A-2015-04-302 AZT, 3TC NVP M41L, D67G, K70R, M184V, T215F, K219E V179E, Y181V V21I, V35T, T39A, V60I, T69N, D86E, W88C, A98X, K122E, D123S, I135K, K173L, Q174K, D177E, T200A, Q207E, V245Q, E248D, D250E, A272P, K275R, K281R, L283I, R284K, T286A, E291D, I293V, P294T, L295M, S322T  
A-2015-04-307 A-2015-04-307 TDF, 3TC NVP K65R, Y115F, M184V Y181C, G190A E6D, K11T, V21I, V35T, T39K, K43E, K49R, V60I, W88C, K122E, D123S, I135T, S162H, K173I, Q174K, D177E, V179I, T200A, E204Q, Q207A, R211S, K238R, V245E, V254I, A272S, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D W266R 
A-2015-06-001 A-2015-06-001 TDF, 3TC EFV  V106I T27P, V35I, I135T, I178M, T200I, V245M, A272P, I293V, E297K, K311Q, Q332*  
A-2015-06-003 A-2015-06-003 TDF, 3TC EFV   E6D, V35T, T39K, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, T200A, Q207A, R211S, K238R, V245E, A272P, E291D, V292I, I293V, E312T, I326V, I329V  
A-2015-06-022 A-2015-06-022 TDF, 3TC EFV K70E, M184V K103N, V108I, H221Y, M230L E6D, V35I, K102Q, T107S, S162Y, V179I, G196E, T200I, R211G, A272P, I309L, L325I, I326V  
A-2015-06-024 A-2015-06-024 TDF, 3TC EFV K65R K101E, Y181C, G190A E6D, K11T, V35T, T39K, K43E, V60I, K122E, D123S, K173I, Q174K, D177E, V189I, T200V, Q207A, R211S, K238R, I244V, V245E, A272P, E291D, V292I, I293V, E312T, I326V, I329V, G335D  
A-2015-06-026 A-2015-06-026 AZT, 3TC NVP D67N, M184V, T215Y K101E, G190A E6D, E28K, V35T, T39K, K43E, V60I, K122E, D123S, I135IT, K173I, Q174K, D177E, V179I, T200A, Q207A, R211S, K238R, V245Q, I293V, E312T, I326V, I329V, G335D  
A-2015-06-031 A-2015-06-031 TDF, 3TC NVP K65R, M184V K101E, Y181C, G190A E6D, V35T, T39K, K43E, K122E, D123S, S162C, K173T, Q174K, D177E, T200A, I202V, Q207A, R211S, K238R, V245E, E291D, V292I, I293V, E312T, V317T, S322X, I326V, I329V, G335D  
A-2015-06-037 A-2015-06-037 TDF, 3TC EFV D67N, K70E, M184V V106I, Y181C, H221Y K11R, V35I, I135T, Q174K, N175Y, I178M, L193F, V245M, A272P, I293V, E297K, K311Q  
A-2015-06-047 A-2015-06-047 TDF, 3TC EFV K65R, L74I, M184V L100I, K103N E6K, K122E, S162C, V179T, G196E, Q197K, T200I, I244V, A272S, V292I, I293V, E312K, S322L  
A-2015-06-053 A-2015-06-053 TDF, 3TC EFV   E6D, V35T, T39K, K43E, K122E, D123S, S162C, K173I, Q174K, D177E, I195L, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, P294T, E297G, E312T, I326V, I329V, G335D  
A-2015-06-061 A-2015-06-061 TDF, 3TC EFV  K103N E6D, V8I, K11T, V35T, T39K, K43E, V60I, K122E, D123N, I135T, K173V, Q174K, D177E, I178M, T200A, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E297T, E312T, I326V, I329V, G335D  
A-2016-04-040 A-2016-04-040 TDF, 3TC NVP K65R, V75M, M184V K101E, Y181C, G190A E6D, V35T, T39K, K43E, K122E, D123S, I135K, S162C, K173I, Q174K, D177E, G196R, T200A, E203D, Q207A, R211S, K238R, V245E, K277R, T286A, V292I, I293V, E312T, I326V, I329V, G335D G262V 
A-2016-04-064 A-2016-04-064 TDF, 3TC EFV L74I, M184V A98G, K101E, G190S E6D, V21I, V35T, T39K, K43E, V60I, K122E, D123S, S162C, S163C, K173V, Q174K, D177E, V189I, T200A, Q207A, R211S, K238R, V245E, A272P, T286A, E291D, V292I, I293V, E297M, E312T, I326V, I329V, G335D  
A-2016-04-100 A-2016-04-100 TDF, 3TC NVP K70E, Y115F, M184V Y181C E6D, K11T, V35T, T39K, K43E, K49R, V60I, K101R, K122E, D123S, K173I, Q174K, D177E, I178M, V179I, Q207A, R211S, L228R, V245E, A272P, E291D, V292I, I293V, E312T, I326V, I329V, G335D  
A-2016-04-114 A-2016-04-114 TDF, 3TC EFV K65R, Y115F K103N, Y188L, H221Y E6D, V35T, T39K, K43E, V60I, S68G, D121H, K122E, T139A, K173I, Q174K, D177E, I178M, T200A, Q207A, R211K, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V  
A-2016-04-116 A-2016-04-116 TDF, 3TC EFV K65R Y188C, G190A E6D, K11S, V21I, V35T, T39K, K43E, V60I, V106L, K122E, D123S, I135T, K173T, Q174K, D177E, V179I, E194K, G196E, T200A, I202V, Q207A, R211S, K238R, V245E, E248D, V292I, I293V, E297R, A304E, E312T, I326V, I329V, G335D  
A-2016-04-119 A-2016-04-119 TDF, 3TC EFV D67N, K70E, L74I, M184V K103N, V106A, F227L V35T, E36A, T39E, E40D, S48T, K122E, D123S, T165I, K173A, Q174K, D177E, G196E, T200A, I202V, Q207E, R211K, V245Q, A272P, T286V, E291D, V292I, I293V, G335D  
A-2016-04-130 A-2016-04-130 TDF, 3TC EFV L74I, M184V Y188L E6D, V35T, T39K, K43E, V60I, S68G, V90I, V106L, K122E, D123N, T139A, S163T, K173A, Q174K, D177E, T200A, Q207A, R211S, Y232H, K238R, V245E, T286A  
A-2016-04-232 A-2016-04-232 TDF, 3TC EFV D67G, L74V, Y115F, M184V G190Q E6D, V35T, T39K, K43E, V111I, K122E, D123S, K173I, Q174K, D177E, V189I, I195L, Q207A, R211S, K238R, V245E, T286A, E291D, V292I, I293V, E312T, I326V, I329V, G335D