Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

References

Author Smith (2019)
Title Comparison of the Antiviral Activity of Bictegravir against HIV-1 and HIV-2 Isolates and Integrase Inhibitor-Resistant HIV-2 Mutants.
Citation Antimicrob Agents Chemother
SelectedGene IN
SelectedSpecies HIV2
SelectedType Lab
NumIsolates 10
Lab Parent Strain ROD

 

Lab IN Isolates : Susceptibility Data


IsolateINIMajorDRMsINIMinorDRMsMethodDrugFold Res.
I_E92Q,A153G,N155H E92Q, N155H  MAGIC-5A single-cycle BIC 1.9 
I_E92Q,N155H E92Q, N155H  MAGIC-5A single-cycle BIC 3.0 
I_E92Q,T97A,N155H E92Q, N155H T97A MAGIC-5A single-cycle BIC 4.4 
I_G140A,Q148R G140A, Q148R  MAGIC-5A single-cycle BIC 2.8 
I_G140S,Q148H G140S, Q148H  MAGIC-5A single-cycle BIC 111 
I_G140S,Q148R, G140S, Q148R  MAGIC-5A single-cycle BIC 34 
I_I84V,E92Q,T97A,A153S,N155H E92Q, N155H T97A MAGIC-5A single-cycle BIC 4.6 
I_Q91R,E92Q,T97A,Y143G,A153S E92Q, Y143G T97A MAGIC-5A single-cycle BIC 1.2 
I_Q91R,T97A,Y143C Y143C T97A MAGIC-5A single-cycle BIC 0.7 
I_Q91R,T97A,Y143C,A153S Y143C T97A MAGIC-5A single-cycle BIC 0.7